We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prognostic significance of heat shock protein-27 expression in hepatocellular carcinoma and its relation to histologic grading and survival.
- Authors
King, Kuang-Liang; Li, Anna F-Y; Chau, Gar-Yang; Chi, Chin-Wen; Wu, Chew-Wun; Huang, Chen-Lung; Lui, Wing-Yiu; King, K L; Li, A F; Chau, G Y; Chi, C W; Wu, C W; Huang, C L; Lui, W Y
- Abstract
<bold>Background: </bold>The expression of heat shock protein-27 (HSP-27) has been detected in some human tumors. In this study the authors investigated HSP-27 expression in patients with hepatocellular carcinoma (HCC) and examined its prognostic significance.<bold>Methods: </bold>Expression of HSP-27 was studied in 58 HCC and adjacent noncancerous liver tissues by immunohistochemical stain. The relation between its expression and eight known prognostic factors was evaluated.<bold>Results: </bold>Of the 58 HCC tissues studied, the presence of HSP-27 was demonstrated in 45 tissues (77.6%); low expression (</= 25%) was demonstrated in 17 tissues and high expression (> 25%) was demonstrated in 28 tissues. A significantly higher distribution of HSP-27 expression in HCC tissues compared with adjacent noncancerous liver tissues was obtained (P < 0.0001). Patients with high HSP-27 expression had a significantly higher histologic tumor grade than those with low HSP-27 expression (P = 0.001). The 5-year disease free survival rate of patients with high HSP-27 expression was 21.4% versus 59.3% for patients with low HSP-27 expression (P < 0.001). A similar relation was observed with overall survival (33.3% vs. 64. 8%; P = 0.009). HSP-27 expression was also identified to be a significant and powerful prognostic indicator for disease free survival (odds ratio = 2.25; P = 0.034) and for overall survival (odds ratio = 2.72; P = 0.015).<bold>Conclusions: </bold>The current study data suggest that HSP-27 expression is a powerful prognostic indicator and is related to histologic grade and survival of patients with HCC.
- Publication
Cancer (0008543X), 2000, Vol 88, Issue 11, p2464
- ISSN
0008-543X
- Publication type
Academic Journal