Hormone therapy for preventing cardiovascular disease in post-menopausal women. Comment & Response B To the Editor b We are disappointed that a recent USPSTF Recommendation Statement[1] failed to recommend menopausal hormone therapy for primary prevention of chronic diseases in postmenopausal persons. Menopausal hormone therapy use decreased substantially after publication of the WHI study in 2002, resulting in a detrimental effect on women's health and longevity.