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Clinical utility of PDX cohorts to reveal biomarkers of intrinsic resistance and clonal architecture changes underlying acquired resistance to cetuximab in HNSCC.
- Published in:
- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00908-0
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- Publication type:
- Article
Overcoming unintended immunogenicity in immunocompetent mouse models of metastasis: the case of GFP.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00929-9
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- Publication type:
- Article
Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00887-2
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- Publication type:
- Article
Colorectal liver metastasis: molecular mechanism and interventional therapy.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00922-2
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- Publication type:
- Article
Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00926-y
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- Article
Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00889-0
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- Publication type:
- Article
Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00881-8
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- Publication type:
- Article
Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00873-8
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- Article
Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00917-z
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- Article
Cryo-EM advances in RNA structure determination.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00916-0
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- Article
Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00867-y
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- Publication type:
- Article
Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00872-9
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- Publication type:
- Article
Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00870-3
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- Article
Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma.
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- 2022
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- Publication type:
- Letter
The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00907-1
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- Publication type:
- Article
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00866-z
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- Publication type:
- Article
Nuclear genome-derived circular RNA circPUM1 localizes in mitochondria and regulates oxidative phosphorylation in esophageal squamous cell carcinoma.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00865-0
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- Publication type:
- Article
Omicron adopts a different strategy from Delta and other variants to adapt to host.
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- 2022
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- Publication type:
- Letter
Omicron adopts a different strategy from Delta and other variants to adapt to host.
- Published in:
- 2022
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- Publication type:
- Letter
Ionizable liposomal siRNA therapeutics enables potent and persistent treatment of Hepatitis B.
- Published in:
- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00859-y
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- Publication type:
- Article
An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00912-4
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- Article
Emerging new therapeutic antibody derivatives for cancer treatment.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00868-x
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- Publication type:
- Article
Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00857-0
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- Publication type:
- Article
Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00910-6
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- Publication type:
- Article
Molecular regulations of circadian rhythm and implications for physiology and diseases.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00899-y
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- Publication type:
- Article
ACE2-Targeting antibody suppresses SARS-CoV-2 Omicron and Delta variants.
- Published in:
- 2022
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- Publication type:
- Letter
Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer.
- Published in:
- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00856-1
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- Publication type:
- Article
LncRNAs LCETRL3 and LCETRL4 at chromosome 4q12 diminish EGFR-TKIs efficiency in NSCLC through stabilizing TDP43 and EIF2S1.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00847-2
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- Publication type:
- Article
Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages.
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- 2022
- By:
- Publication type:
- Letter
Correction: Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment.
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- 2022
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- Publication type:
- Correction Notice
NK cell dysfunction in severe COVID-19: TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity.
- Published in:
- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00892-5
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- Publication type:
- Article
EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma.
- Published in:
- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00855-2
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- Publication type:
- Article
A non-ACE2-blocking neutralizing antibody against Omicron-included SARS-CoV-2 variants.
- Published in:
- 2022
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- Publication type:
- Letter
Structural biology of SARS-CoV-2: open the door for novel therapies.
- Published in:
- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00884-5
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- Publication type:
- Article
Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00820-z
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- Publication type:
- Article
Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00831-w
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- Publication type:
- Article
Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00824-9
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- Publication type:
- Article
Whole-genome sequencing reveals the evolutionary trajectory of HBV-related hepatocellular carcinoma early recurrence.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00838-3
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- Publication type:
- Article
From prodrug to pro-prodrug: hypoxia-sensitive antibody–drug conjugates.
- Published in:
- 2022
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- Publication type:
- Letter
PDCD1 (PD-1) is a direct target of miR-15a-5p and miR-16-5p.
- Published in:
- 2022
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- Publication type:
- Letter
Barring the gates to the battleground: DDR1 promotes immune exclusion in solid tumors.
- Published in:
- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00877-4
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- Publication type:
- Article
Signals from the interface: protein nanoclusters stabilize biomolecular condensates.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00876-5
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- Publication type:
- Article
A new perspective on immune evasion: escaping immune surveillance by inactivating tumor suppressors.
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- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-022-00875-6
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- Publication type:
- Article
ASTE1 frameshift mutation triggers the immune response in Epstein-Barr virus-associated gastric cancer.
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- 2022
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- Publication type:
- Letter
Correction: Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine.
- Published in:
- 2022
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- Publication type:
- Correction Notice
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities.
- Published in:
- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00762-6
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- Publication type:
- Article
SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2.
- Published in:
- 2022
- By:
- Publication type:
- Letter
Correction: Targeted prebiotics alter the obese gut microbiome in humans.
- Published in:
- 2022
- By:
- Publication type:
- Correction Notice
Phenotypic characteristics and T cell receptor properties in melanoma: deciphering the correlation at single-cell resolution.
- Published in:
- Signal Transduction & Targeted Therapy, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41392-021-00864-1
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- Publication type:
- Article
A binding-enhanced but enzymatic activity-eliminated human ACE2 efficiently neutralizes SARS-CoV-2 variants.
- Published in:
- 2022
- By:
- Publication type:
- Letter