Found: 2048
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Getting the metabolites right.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.70149
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Shape-invariant encoding of dynamic primate facial expressions in human perception.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.61197
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Bacterial death and TRADD-N domains help define novel apoptosis and immunity mechanisms shared by prokaryotes and metazoans.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.70394
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A high rate of COVID-19 vaccine hesitancy in a large-scale survey on Arabs.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.68038
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Genetic variation, environment and demography intersect to shape Arabidopsis defense metabolite variation across Europe.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.67784
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Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.66398
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Convalescent plasma use in the USA was inversely correlated with COVID-19 mortality.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.69866
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The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.68217
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Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.67489
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Biosynthesis of a sulfated exopolysaccharide, synechan, and bloom formation in the model cyanobacterium Synechocystis sp. strain PCC 6803.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.66538
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Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.61700
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Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world's smallest mammalian divers.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.66797
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Micron-scale geometrical features of microtubules as regulators of microtubule organization.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.63880
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Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.6366
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R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.65895
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Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.65554
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Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.65390
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Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.64881
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Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.55665
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Repression by the Arabidopsis TOPLESS corepressor requires association with the core mediator complex.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.66739
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Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.65545
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Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.64204
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Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.58688
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KSR1- and ERK- dependent translational regulation of the epithelial-to-mesenchymal transition.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.66608
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Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter- chromosomal movement.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.66238
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Transcoelomic spread of cancer cells across the peritoneal cavity occurs in most initially diagnosed ovarian cancer (OC) patients and accounts for most cancer-related death. However, how OC cells interact with peritoneal stromal cells to evade the immune surveillance remains largely unexplored. Here, through an in vivo genome-wide CRISPR/Cas9 screen, we identified IL20RA, which decreased dramatically in OC patients during peritoneal metastasis, as a key factor preventing the transcoelomic metastasis of OC. Reconstitution of IL20RA in highly metastatic OC cells greatly suppresses the transcoelomic metastasis. OC cells, when disseminate into the peritoneal cavity, greatly induce peritoneum mesothelial cells to express IL-20 and IL-24, which in turn activate the IL20RA downstream signaling in OC cells to produce mature IL-18, eventually resulting in the polarization of macrophages into the M1-like subtype to clear the cancer cells. Thus, we show an IL-20/IL20RA-mediated crosstalk between OC and mesothelial cells that supports a metastasis-repressing immune microenvironment.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.66222
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High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.65534
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An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.64744
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Alcohol consumption in the general population is associated with structural changes in multiple organ systems.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.65325
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Handling of intracellular K<sup>+</sup> determines voltage dependence of plasmalemmal monoamine transporter function.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.67996
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The push-to-open mechanism of the tethered mechanosensitive ion channel NompC.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.58388
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Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated channel P2X2 upon hyperpolarization.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.65822
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Introduction to the EQIPD quality system.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.63294
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Genetic code expansion enables visualization of Salmonella type three secretion system components and secreted effectors.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.67789
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Asymptomatic Bordetella pertussis infections in a longitudinal cohort of young African infants and their mothers.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.65663
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Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.67315
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Detecting adaptive introgression in human evolution using convolutional neural networks.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.64669
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Asymmetric localization of the cell division machinery during Bacillus subtilis sporulation.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.62204
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Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.61461
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Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.58342
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Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.67776
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Allosteric conformational ensembles have unlimited capacity for integrating information.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.65498
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Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.60108
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Working together.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.66921
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The critical importance of vouchers in genomics.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.68264
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SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.67481
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RSC primes the quiescent genome for hypertranscription upon cell-cycle re-entry.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.67033
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Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.66921
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Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.66612
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Tendon and motor phenotypes in the Crtap<sup>-/-</sup> mouse model of recessive osteogenesis imperfecta.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.63488
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