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Type‐2 airway inflammation in mild asthma patients with high blood eosinophils and high fractional exhaled nitric oxide.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1259, doi. 10.1111/cts.13078
By:
- Southworth, Thomas;
- Van Geest, Marleen;
- Singh, Dave
Publication type:
Article
Pharmacists as facilitators of pharmacogenomic guidance for antidepressant drug selection and dosing.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1206, doi. 10.1111/cts.13057
By:
- Bishop, Jeffrey R.
Publication type:
Article
Reimagining the peer‐review system for translational health science journals.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1210, doi. 10.1111/cts.13050
By:
- Smith, Elise M.
Publication type:
Article
Validation of a quantitative systems pharmacology model of calcium homeostasis using elagolix Phase 3 clinical trial data in women with endometriosis.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1611, doi. 10.1111/cts.13040
By:
- Stodtmann, Sven;
- Nader, Ahmed;
- Polepally, Akshanth R.;
- Suleiman, Ahmed A.;
- Winzenborg, Insa;
- Noertersheuser, Peter;
- Ng, Juki;
- Mostafa, Nael M.;
- Shebley, Mohamad
Publication type:
Article
Comprehensive in vitro pro‐arrhythmic assays demonstrate that omecamtiv mecarbil has low pro‐arrhythmic risk.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1600, doi. 10.1111/cts.13039
By:
- Qu, Yusheng;
- Gao, BaoXi;
- Arimura, Ziva;
- Fang, Mei;
- Vargas, Hugo M.
Publication type:
Article
Diagnostic and prognostic capabilities of a biomarker and EMR‐based machine learning algorithm for sepsis.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1578, doi. 10.1111/cts.13030
By:
- Taneja, Ishan;
- Damhorst, Gregory L.;
- Lopez‐Espina, Carlos;
- Zhao, Sihai Dave;
- Zhu, Ruoqing;
- Khan, Shah;
- White, Karen;
- Kumar, James;
- Vincent, Andrew;
- Yeh, Leon;
- Majdizadeh, Shirin;
- Weir, William;
- Isbell, Scott;
- Skinner, James;
- Devanand, Manubolo;
- Azharuddin, Syed;
- Meenakshisundaram, Rajamurugan;
- Upadhyay, Riddhi;
- Syed, Anwaruddin;
- Bauman, Thomas
Publication type:
Article
Safety, tolerability, pharmacokinetics, and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1524, doi. 10.1111/cts.13016
By:
- Grippo, Joseph F.;
- Folitar, Ilia;
- Passe, Sharon;
- Jiang, Qiudi;
- Rodriguez, Ignacio;
- Fettner, Scott H.;
- Calleja, Elizabeth
Publication type:
Article
Angiotensin 1‐7 protects against ventilator‐induced diaphragm dysfunction.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1512, doi. 10.1111/cts.13015
By:
- Yoshihara, Toshinori;
- Deminice, Rafael;
- Hyatt, Hayden W.;
- Ozdemir, Mustafa;
- Nguyen, Branden L.;
- Powers, Scott K.
Publication type:
Article
COVID‐19 vaccines and treatments: When speed is necessary and not enough.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1201, doi. 10.1111/cts.13010
By:
- Grasela, Thaddeus H.;
- Price, David A.;
- Wagner, John A.
Publication type:
Article
First‐in‐human trial assessing the pharmacokinetic‐pharmacodynamic profile of a novel recombinant human chorionic gonadotropin in healthy women and men of reproductive age.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1590, doi. 10.1111/cts.13037
By:
- Broksø Kyhl, Lars‐Erik;
- Hesse, Christiane;
- Larsson, Per;
- Bruzelius, Katharina;
- Mannaerts, Bernadette
Publication type:
Article
Pharmacokinetics and tolerability of apremilast in healthy Korean adult men.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1505, doi. 10.1111/cts.13013
By:
- Huh, Ki Young;
- Choi, Yewon;
- Nissel, Jim;
- Palmisano, Maria;
- Wang, Xiaomin;
- Liu, Liangang;
- Ramirez‐Valle, Francisco;
- Lee, Howard
Publication type:
Article
Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1490, doi. 10.1111/cts.13012
By:
- Diouf, Barthelemy;
- Wing, Claudia;
- Panetta, John C.;
- Eddins, Donnie;
- Lin, Wenwei;
- Yang, Wenjian;
- Fan, Yiping;
- Pei, Deqing;
- Cheng, Cheng;
- Delaney, Shannon M.;
- Zhang, Wei;
- Bonten, Erik J.;
- Crews, Kristine R.;
- Paugh, Steven W.;
- Li, Lie;
- Freeman, Burgess B.;
- Autry, Robert J.;
- Beard, Jordan A.;
- Ferguson, Daniel C.;
- Janke, Laura J.
Publication type:
Article
Associations between uncertainties identified by the European Medicines Agency and national decision making on reimbursement by HTA agencies.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1566, doi. 10.1111/cts.13027
By:
- Bloem, Lourens T.;
- Vreman, Rick A.;
- Peeters, Niels W. L.;
- Hoekman, Jarno;
- Elst, Menno E.;
- Leufkens, Hubert G. M.;
- Klungel, Olaf H.;
- Goettsch, Wim G.;
- Mantel‐Teeuwisse, Aukje K.
Publication type:
Article
A population pharmacodynamic Markov mixed‐effects model for determining remimazolam‐induced sedation when co‐administered with fentanyl in procedural sedation.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1554, doi. 10.1111/cts.13023
By:
- Zhou, Jie;
- Curd, Laura;
- Lohmer, Lauren R. L.;
- Delpratt, Natalie;
- Ossig, Joachim;
- Schippers, Frank;
- Stoehr, Thomas;
- Schmith, Virginia D.
Publication type:
Article
Model‐based approach to sampling optimization in studies of antibacterial drugs for infants and young children.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1543, doi. 10.1111/cts.13018
By:
- Orito, Yuji;
- Kakara, Makoto;
- Okada, Akira;
- Nagai, Naomi
Publication type:
Article
Regulatory guidelines do not accurately predict tolvaptan and metabolite interactions at BCRP, OATP1B1, and OAT3 transporters.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1535, doi. 10.1111/cts.13017
By:
- Shoaf, Susan E.;
- Bricmont, Patricia;
- Repella Gordon, Jennifer
Publication type:
Article
A metabolomic analysis of thiol response for standard and modified N‐acetyl cysteine treatment regimens in patients with acetaminophen overdose.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1476, doi. 10.1111/cts.13009
By:
- Dear, James W;
- Ng, Mei Li;
- Bateman, D. Nicholas;
- Leroy Sivappiragasam, Pakkiri;
- Choi, Hyungwon;
- Khoo, Benjamin Bing Jie;
- Ibrahim, Baharudin;
- Drum, Chester Lee
Publication type:
Article
Population pharmacokinetic analysis of apomorphine sublingual film or subcutaneous apomorphine in healthy subjects and patients with Parkinson's disease.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1464, doi. 10.1111/cts.13008
By:
- Agbo, Felix;
- Crass, Ryan L.;
- Chiu, Yu‐Yuan;
- Chapel, Sunny;
- Galluppi, Gerald;
- Blum, David;
- Navia, Bradford
Publication type:
Article
Integrating real‐world data and modeling to project changes in femoral neck bone mineral density and fracture risk in premenopausal women.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1452, doi. 10.1111/cts.13006
By:
- Beck, Denise;
- Winzenborg, Insa;
- Gao, Wei;
- Mostafa, Nael M.;
- Noertersheuser, Peter;
- Chiuve, Stephanie E.;
- Owens, Charlotte;
- Shebley, Mohamad
Publication type:
Article
Clinical pharmacology and dosing regimen optimization of neonatal opioid withdrawal syndrome treatments.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1231, doi. 10.1111/cts.12994
By:
- Tang, Fei;
- Ng, Chee M.;
- Bada, Henrietta S.;
- Leggas, Markos
Publication type:
Article
Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto's thyroiditis: A prospective randomized‐controlled trial.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1390, doi. 10.1111/cts.12993
By:
- Hu, Yifang;
- Feng, Wenwen;
- Chen, Huanhuan;
- Shi, He;
- Jiang, Lin;
- Zheng, Xuqin;
- Liu, Xiaoyun;
- Zhang, Wensong;
- Ge, Yaoqi;
- Liu, Yun;
- Cui, Dai
Publication type:
Article
Beyond exposure‐response: A tutorial on statistical considerations in dose‐ranging studies.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1250, doi. 10.1111/cts.12998
By:
- Laird, Glen;
- Xu, Lei;
- Liu, Meng;
- Liu, Jin
Publication type:
Article
Relationship of hemoglobin level and plasma coproporphyrin‐I concentrations as an endogenous probe for phenotyping OATP1B.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1403, doi. 10.1111/cts.12996
By:
- Suzuki, Yosuke;
- Sasamoto, Yuri;
- Koyama, Teruhide;
- Yoshijima, Chisato;
- Oda, Ayako;
- Nakatochi, Masahiro;
- Kubo, Michiaki;
- Momozawa, Yukihide;
- Uehara, Ritei;
- Ohno, Keiko
Publication type:
Article
Is this the end for ranitidine? NDMA presence continues to confound.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1197, doi. 10.1111/cts.12995
By:
- Wagner, Jennifer A.;
- Dinh, Jean C.;
- Lightdale, Jennifer R.;
- Gold, Benjamin D.;
- Colombo, Jennifer M.
Publication type:
Article
A pharmacokinetic simulation study to assess the performance of a sparse blood sampling approach to quantify early drug exposure.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1444, doi. 10.1111/cts.13004
By:
- Sathe, Abhishek G.;
- Brundage, Richard C.;
- Ivaturi, Vijay;
- Cloyd, James C.;
- Chamberlain, James M.;
- Elm, Jordan J.;
- Silbergleit, Robert;
- Kapur, Jaideep;
- Coles, Lisa D.
Publication type:
Article
A retrospective analysis of actionable pharmacogenetic/genomic biomarker language in FDA labels.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1412, doi. 10.1111/cts.13000
By:
- Yamazaki, Shinji
Publication type:
Article
Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1431, doi. 10.1111/cts.12992
By:
- Vora, Bianca;
- Brackman, Deanna J.;
- Zou, Ling;
- Garcia‐Cremades, Maria;
- Sirota, Marina;
- Savic, Radojka M.;
- Giacomini, Kathleen M.
Publication type:
Article
A randomized, double‐blind, placebo‐ and positive‐controlled crossover study of the effects of durlobactam on cardiac repolarization in healthy subjects.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1423, doi. 10.1111/cts.12991
By:
- O'Donnell, John;
- Maloney, Kathleen;
- Steidler, Melissa;
- Morrison, Royce;
- Isaacs, Robin
Publication type:
Article
Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1380, doi. 10.1111/cts.12989
By:
- Wang, Xinwen;
- Her, Lucy;
- Xiao, Jingcheng;
- Shi, Jian;
- Wu, Audrey H.;
- Bleske, Barry E.;
- Zhu, Hao‐Jie
Publication type:
Article
Lipid droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1369, doi. 10.1111/cts.12988
By:
- Abbey, Deepti;
- Conlon, Donna;
- Rainville, Christopher;
- Elwyn, Susannah;
- Quiroz‐Figueroa, Katherine;
- Billheimer, Jeffrey;
- Schultz, David C.;
- Hand, Nicholas J.;
- Cherry, Sara;
- Rader, Daniel J.
Publication type:
Article
Metabolomics analysis of the serum from children with urolithiasis using UPLC‐MS.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1327, doi. 10.1111/cts.12984
By:
- Wen, Junxiang;
- Cao, Yinyin;
- Li, Yang;
- Zhu, Fenhua;
- Yuan, Meifen;
- Xu, Jin;
- Li, Jian
Publication type:
Article
Impact of pretreatment dihydropyrimidine dehydrogenase genotype‐guided fluoropyrimidine dosing on chemotherapy associated adverse events.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1338, doi. 10.1111/cts.12981
By:
- Wigle, Theodore J.;
- Povitz, Brandi L.;
- Medwid, Samantha;
- Teft, Wendy A.;
- Legan, Robin M.;
- Lenehan, John;
- Nevison, Stephanie;
- Panuganty, Veera;
- Keller, Denise;
- Mailloux, Jaymie;
- Siebring, Victoria;
- Sarma, Sisira;
- Choi, Yun‐hee;
- Welch, Stephen;
- Winquist, Eric;
- Schwarz, Ute I.;
- Kim, Richard B.
Publication type:
Article
Pharmacokinetic equivalence of CT‐P17 to high‐concentration (100 mg/ml) reference adalimumab: A randomized phase I study in healthy subjects.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1280, doi. 10.1111/cts.12967
By:
- Yu, Kyung‐Sang;
- Jang, In‐Jin;
- Lim, Hyeong‐Seok;
- Hong, Jang Hee;
- Kim, Min‐Gul;
- Park, Min Kyu;
- Cho, Doo‐Yeoun;
- Park, Min Soo;
- Chung, Jae Yong;
- Ghim, Jong‐Lyul;
- Lee, SeungHwan;
- Yoon, Seok Kyu;
- Kwon, In Sun;
- Lee, Sang Joon;
- Kim, Sung Hyun;
- Bae, Yun Ju;
- Cha, Jung Bin;
- Furst, Daniel E.;
- Keystone, Edward;
- Kay, Jonathan
Publication type:
Article
Evolving drug regulatory landscape in China: A clinical pharmacology perspective.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1222, doi. 10.1111/cts.12987
By:
- Tang, Weifeng;
- Huang, Ying;
- Zhou, Diansong;
- Huang, Yao;
- Chen, Yingxue;
- Ren, Song;
- Li, Yan;
- Wu, Shengqian;
- Zhao, Xiaoying;
- Song, Xuyang;
- Wang, Haidong;
- Jin, Yuwen;
- Yu, Hongtao;
- Zhang, Li;
- Li, Yunfei;
- Boulton, David;
- Shen, Kevin
Publication type:
Article
Estimating peptide half‐life in serum from tunable, sequence‐related physicochemical properties.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1349, doi. 10.1111/cts.12985
By:
- Cavaco, Marco;
- Valle, Javier;
- Flores, Isabel;
- Andreu, David;
- A. R. B. Castanho, Miguel
Publication type:
Article
Pharmacogenomics guided versus standard antidepressant treatment in a community pharmacy setting: A randomized controlled trial.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1359, doi. 10.1111/cts.12986
By:
- Papastergiou, John;
- Quilty, Lena C.;
- Li, Wilson;
- Thiruchselvam, Thulasi;
- Jain, Esha;
- Gove, Peter;
- Mandlsohn, Leilany;
- den Bemt, Bart;
- Pojskic, Nedzad
Publication type:
Article
Issue Information.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1193, doi. 10.1111/cts.12821
Publication type:
Article
First‐in‐human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN‐101, a dual CD28/ICOS antagonist, in healthy adult subjects.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1314, doi. 10.1111/cts.12983
By:
- Yang, Jing;
- Lickliter, Jason D.;
- Hillson, Jan L.;
- Means, Gary D.;
- Sanderson, Russell J.;
- Carley, Kay;
- Tercero, Almudena;
- Manjarrez, Kristi L.;
- Wiley, Jennifer R.;
- Peng, Stanford L.
Publication type:
Article
Evaluating risk factors for acute graft versus host disease in pediatric hematopoietic stem cell transplant patients receiving tacrolimus.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1303, doi. 10.1111/cts.12982
By:
- Phan, Michael;
- Chavan, Rishikesh;
- Beuttler, Richard;
- Benipayo, Nicole;
- Magedman, Grace;
- Buchbinder, David;
- Tomaszewski, Daniel;
- Yang, Sun
Publication type:
Article
Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1292, doi. 10.1111/cts.12970
By:
- Fohner, Alison E.;
- Dalton, Rachel;
- Skagen, Kasse;
- Jackson, Konner;
- Claw, Katrina G.;
- Hopkins, Scarlett E.;
- Robinson, Renee;
- Khan, Burhan A.;
- Prasad, Bhagwat;
- Schuetz, Erin G.;
- Nickerson, Deborah A.;
- Thornton, Timothy A.;
- Dillard, Denise A.;
- Boyer, Bert B.;
- Thummel, Kenneth E.;
- Woodahl, Erica L.
Publication type:
Article
Quantitative protein expression of blood‐brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1265, doi. 10.1111/cts.12978
By:
- Bao, Xun;
- Wu, Jianmei;
- Jiang, Jun;
- Tien, An‐Chi;
- Sanai, Nader;
- Li, Jing
Publication type:
Article
Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of Vixotrigine in Healthy Volunteers.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1272, doi. 10.1111/cts.12935
By:
- Naik, Himanshu;
- Steiner, Deb J.;
- Versavel, Mark;
- Palmer, Joanne;
- Fong, Regan
Publication type:
Article

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