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Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies.
- Published in:
- Biopharmaceutics & Drug Disposition, 2012, v. 33, n. 2, p. 85, doi. 10.1002/bdd.1769
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- Article
Physiologically based pharmacokinetic (PBPK) modeling: It is here to stay!
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- Biopharmaceutics & Drug Disposition, 2012, v. 33, n. 2, p. 47, doi. 10.1002/bdd.1776
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- Article
Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice.
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- Biopharmaceutics & Drug Disposition, 2012, v. 33, n. 2, p. 99, doi. 10.1002/bdd.1771
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- Article
From preclinical to human - prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example.
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- Biopharmaceutics & Drug Disposition, 2012, v. 33, n. 2, p. 111, doi. 10.1002/bdd.1782
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- Article
Using Simcyp to project human oral pharmacokinetic variability in early drug research to mitigate mechanism-based adverse events.
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- Biopharmaceutics & Drug Disposition, 2012, v. 33, n. 2, p. 72, doi. 10.1002/bdd.1768
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- Article
Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs?
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- Biopharmaceutics & Drug Disposition, 2012, v. 33, n. 2, p. 55, doi. 10.1002/bdd.1767
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- Article
An industrial perspective on contemporary applications of PBPK models in drug discovery and development.
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- Biopharmaceutics & Drug Disposition, 2012, v. 33, n. 2, p. 53, doi. 10.1002/bdd.1778
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- Article
PBPK as a tool in regulatory review.
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- Biopharmaceutics & Drug Disposition, 2012, v. 33, n. 2, p. 51, doi. 10.1002/bdd.1777
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- Article