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Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway.
- Published in:
- Molecular Medicine, 2022, v. 28, n. 1, p. 1, doi. 10.1186/s10020-021-00427-8
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- Publication type:
- Article
A mutation in the E2 subunit of the mitochondrial pyruvate dehydrogenase complex in Arabidopsis reduces plant organ size and enhances the accumulation of amino acids and intermediate products of the TCA Cycle.
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- Planta: An International Journal of Plant Biology, 2012, v. 236, n. 2, p. 387, doi. 10.1007/s00425-012-1620-3
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- Publication type:
- Article
Novel therapeutic compound acridine-retrotuftsin action on biological forms of melanoma and neuroblastoma.
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- Journal of Cancer Research & Clinical Oncology, 2019, v. 145, n. 1, p. 165, doi. 10.1007/s00432-018-2776-4
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- Publication type:
- Article
Intraabdominal adhesion formation is associated with differential mRNA expression of metabolic genes PDHb and SDHa.
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- Archives of Gynecology & Obstetrics, 2012, v. 286, n. 3, p. 683, doi. 10.1007/s00404-012-2364-9
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- Publication type:
- Article
Estrogen receptor alpha‐mediated mitochondrial damage in intrahepatic bile duct epithelial cells leading to the pathogenesis of primary biliary cholangitis.
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- Environmental Toxicology, 2023, v. 38, n. 12, p. 2803, doi. 10.1002/tox.23906
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- Publication type:
- Article
Dyskeratosis Congenita Links Telomere Attrition to Age-Related Systemic Energetics.
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- Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2023, v. 78, n. 5, p. 780, doi. 10.1093/gerona/glad018
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- Article
Metabolic stroke-like events in a girl with pyruvate dehydrogenase complex deficiency caused by a novel de novo mutation in PDHA1.
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- Neurological Sciences, 2024, v. 45, n. 6, p. 2913, doi. 10.1007/s10072-024-07355-5
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- Publication type:
- Article
ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors.
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- Cancer & Metabolism, 2023, v. 11, n. 1, p. 1, doi. 10.1186/s40170-023-00320-4
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- Article
Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth.
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- Cancer & Metabolism, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40170-021-00275-4
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- Article
p-STAT3 is a PDC-E2 interacting partner in human cholangiocytes and hepatocytes with potential pathobiological implications.
- Published in:
- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-01060-5
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- Article
Elevated plasma citrulline: look for dihydrolipoamide dehydrogenase deficiency.
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- European Journal of Pediatrics, 2014, v. 173, n. 2, p. 243, doi. 10.1007/s00431-013-2153-x
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- Article
The moonlighting activities of dihydrolipoamide dehydrogenase: Biotechnological and biomedical applications.
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- Journal of Molecular Recognition, 2021, v. 34, n. 11, p. 1, doi. 10.1002/jmr.2924
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- Publication type:
- Article
Comprehensive Profile of Acute Mitochondrial Dysfunction in a Preclinical Model of Severe Penetrating TBI.
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- Frontiers in Neurology, 2019, p. N.PAG, doi. 10.3389/fneur.2019.00605
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- Article
THE FIRST-PRINCIPLES STABILITY STUDY OF PdC AND CdC COMPOUNDS.
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- International Journal of Modern Physics B: Condensed Matter Physics; Statistical Physics; Applied Physics, 2013, v. 27, n. 6, p. 1, doi. 10.1142/S0217979213500161
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- Publication type:
- Article
Circ_0005397/miR-326 and linc00152/miR-216b share the signaling pathway of PDK2 to promote pancreatic adenocarcinoma oncogenesis.
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- Archives of Medical Science, 2024, v. 20, n. 4, p. 1363, doi. 10.5114/aoms/190517
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- Publication type:
- Article
Serial Magnetic Resonance Imaging (MRI) in Pyruvate Dehydrogenase Complex Deficiency.
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- Journal of Child Neurology, 2020, v. 35, n. 2, p. 137, doi. 10.1177/0883073819881940
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- Publication type:
- Article
Clinical and biochemical characterization of four patients with mutations in ECHS1.
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- Orphanet Journal of Rare Diseases, 2015, v. 10, n. 1, p. 1, doi. 10.1186/s13023-015-0290-1
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- Publication type:
- Article
Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase.
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- Orphanet Journal of Rare Diseases, 2013, v. 8, n. 1, p. 1, doi. 10.1186/1750-1172-8-192
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- Article
HIBCH mutations can cause Leigh-like disease with combined deficiency of multiple mitochondrial respiratory chain enzymes and pyruvate dehydrogenase.
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- 2013
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- Publication type:
- journal article
MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy.
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- Brain: A Journal of Neurology, 2023, v. 146, n. 3, p. 858, doi. 10.1093/brain/awac444
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- Publication type:
- Article
Increasing reducing power output (NADH) of glucose catabolism for reduction of xylose to xylitol by genetically engineered Escherichia coli AI05.
- Published in:
- World Journal of Microbiology & Biotechnology, 2013, v. 29, n. 7, p. 1225, doi. 10.1007/s11274-013-1285-5
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- Publication type:
- Article
Summary of recommendations for the management of infantile seizures: Task Force Report for the ILAE Commission of Pediatrics.
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- Epilepsia (Series 4), 2015, v. 56, n. 8, p. 1185, doi. 10.1111/epi.13057
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- Publication type:
- Article
Phosphonate Inhibitors of Pyruvate Dehydrogenase Perturb Homeostasis of Amino Acids and Protein Succinylation in the Brain.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 21, p. 13186, doi. 10.3390/ijms232113186
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- Publication type:
- Article
Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 23, p. 13068, doi. 10.3390/ijms222313068
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- Publication type:
- Article
Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 16, p. 8610, doi. 10.3390/ijms22168610
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- Publication type:
- Article
Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 2, p. 764, doi. 10.3390/ijms22020764
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- Publication type:
- Article
Programmed Editing of Rice (Oryza sativa L.) OsSPL16 Gene Using CRISPR/Cas9 Improves Grain Yield by Modulating the Expression of Pyruvate Enzymes and Cell Cycle Proteins.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 1, p. 249, doi. 10.3390/ijms22010249
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- Article
PPARδ and FOXO1 Mediate Palmitate-Induced Inhibition of Muscle Pyruvate Dehydrogenase Complex and CHO Oxidation, Events Reversed by Electrical Pulse Stimulation.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 16, p. 5942, doi. 10.3390/ijms21165942
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- Publication type:
- Article
Transcriptional and Metabolic Changes Associated with Phytoglobin Expression during Germination of Barley Seeds.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 8, p. 2796, doi. 10.3390/ijms21082796
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- Publication type:
- Article
Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells.
- Published in:
- International Journal of Molecular Sciences, 2019, v. 20, n. 21, p. 5500, doi. 10.3390/ijms20215500
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- Publication type:
- Article
Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii.
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- BMC Biology, 2020, v. 18, n. 1, p. 1, doi. 10.1186/s12915-020-00791-7
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- Article
A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens.
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- PLoS Pathogens, 2024, v. 20, n. 10, p. 1, doi. 10.1371/journal.ppat.1012451
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- Publication type:
- Article
Inhibition of the ubiquitin-proteasome system reduces the abundance of pyruvate dehydrogenase kinase 1 in cultured myotubes.
- Published in:
- Journal of Muscle Research & Cell Motility, 2024, v. 45, n. 3, p. 155, doi. 10.1007/s10974-024-09679-3
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- Publication type:
- Article
Draft Genome Sequence of Thermophilic Bacillus sp. TYF-LIM-B05 Directly Producing Ethanol from Various Carbon Sources Including Lignocellulose.
- Published in:
- Current Microbiology, 2020, v. 77, n. 3, p. 491, doi. 10.1007/s00284-019-01833-2
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- Publication type:
- Article
Metabolic control analysis of l-lactate synthesis pathway in Rhizopus oryzae As 3.2686.
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- Bioprocess & Biosystems Engineering, 2015, v. 38, n. 11, p. 2189, doi. 10.1007/s00449-015-1458-8
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- Publication type:
- Article
Reengineering of the human pyruvate dehydrogenase complex: from disintegration to highly active agglomerates.
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- Biochemical Journal, 2017, v. 474, n. 5, p. 865, doi. 10.1042/BCJ20160916
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- Publication type:
- Article
Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.
- Published in:
- Biochemical Journal, 2015, v. 467, n. 2, p. 271, doi. 10.1042/BJ20141447
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- Publication type:
- Article
GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton.
- Published in:
- Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03487-6
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- Publication type:
- Article
Crystal structure of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase.
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- Acta Crystallographica: Section F, Structural Biology Communications, 2020, v. 76, n. 7, p. 292, doi. 10.1107/S2053230X20007943
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- Publication type:
- Article
Amino acid ratio combinations as biomarkers for discriminating patients with pyruvate dehydrogenase complex deficiency from other inborn errors of metabolism.
- Published in:
- Molecular Genetics & Genomic Medicine, 2024, v. 12, n. 1, p. 1, doi. 10.1002/mgg3.2283
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- Publication type:
- Article
Pyruvate dehydrogenase deficiency disease detected by the enzyme activity of peripheral leukocytes.
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- Molecular Genetics & Genomic Medicine, 2021, v. 9, n. 8, p. 1, doi. 10.1002/mgg3.1728
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- Publication type:
- Article
Clinical exome sequencing reveals a mutation in PDHA1 in Leigh syndrome: A case of a Chinese boy with lethal neuropathy.
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- Molecular Genetics & Genomic Medicine, 2021, v. 9, n. 4, p. 1, doi. 10.1002/mgg3.1651
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- Publication type:
- Article
Flaxseed Reduces Cancer Risk by Altering Bioenergetic Pathways in Liver: Connecting SAM Biosynthesis to Cellular Energy.
- Published in:
- Metabolites (2218-1989), 2023, v. 13, n. 8, p. 945, doi. 10.3390/metabo13080945
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- Publication type:
- Article
Glutamine Homeostasis and Its Role in the Adaptive Strategies of the Blind Mole Rat, Spalax.
- Published in:
- Metabolites (2218-1989), 2021, v. 11, n. 11, p. 755, doi. 10.3390/metabo11110755
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- Publication type:
- Article
Metabolic Detoxification of 2-Oxobutyrate by Remodeling Escherichia coli Acetate Bypass.
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- Metabolites (2218-1989), 2021, v. 11, n. 1, p. 30, doi. 10.3390/metabo11010030
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- Article
Lipidomic Analysis of Plastidial Octanoyltransferase Mutants of Arabidopsis thaliana.
- Published in:
- Metabolites (2218-1989), 2019, v. 9, n. 10, p. 209, doi. 10.3390/metabo9100209
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- Publication type:
- Article
Human Serum Mediated Bacteriophage Life Cycle Switch in Aggregatibacter actinomycetemcomitans Is Linked to Pyruvate Dehydrogenase Complex.
- Published in:
- Life (2075-1729), 2023, v. 13, n. 2, p. 436, doi. 10.3390/life13020436
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- Publication type:
- Article
Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta‐catenin pathway.
- Published in:
- Clinical & Translational Medicine, 2017, v. 6, n. 1, p. 1, doi. 10.1186/s40169-017-0144-7
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- Publication type:
- Article
PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis.
- Published in:
- Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.862316
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- Article
Antigen Reactivity and Clinical Significance of Autoantibodies Directed Against the Pyruvate Dehydrogenase Antigen Complex in Patients With Connective Tissue Disease.
- Published in:
- Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.822996
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- Publication type:
- Article