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Effect of isavuconazole on the pharmacokinetics of sunitinib and its mechanism.
- Published in:
- BMC Cancer, 2024, v. 24, n. 1, p. 1, doi. 10.1186/s12885-024-12904-4
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- Article
Preclinical pharmacokinetic studies and prediction of human PK profiles for Deg-AZM, a clinical-stage new transgelin agonist.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1423175
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- Article
Advancing structural elucidation of conjugation drug metabolites in metabolite profiling with novel electron‐activated dissociation.
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- Rapid Communications in Mass Spectrometry: RCM, 2024, v. 38, n. 20, p. 1, doi. 10.1002/rcm.9890
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- Article
Effects of three flavonoids on the metabolism of lenvatinib.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1438259
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- Article
Electrochemical Probing of Human Liver Subcellular S9 Fractions for Drug Metabolite Synthesis.
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- Metabolites (2218-1989), 2024, v. 14, n. 8, p. 429, doi. 10.3390/metabo14080429
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- Article
Identification of the Biotransformation Pathways of a Potential Oral Male Contraceptive, 11β-Methyl-19-Nortestosterone (11β-MNT) and Its Prodrugs: An In Vitro Study Highlights the Contribution of Polymorphic Intestinal UGT2B17.
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- Pharmaceutics, 2024, v. 16, n. 8, p. 1032, doi. 10.3390/pharmaceutics16081032
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- Article
An Evaluation of Sex-Specific Pharmacokinetics and Bioavailability of Kokusaginine: An In Vitro and In Vivo Investigation.
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- Pharmaceuticals (14248247), 2024, v. 17, n. 8, p. 1053, doi. 10.3390/ph17081053
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- Article
Evaluation of Nitric Oxide-Donating Properties of 11 H -indeno[1,2- b ]quinoxalin-11-one Oxime (IQ-1) by Electron Paramagnetic Resonance Spectroscopy.
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- Molecules, 2024, v. 29, n. 16, p. 3820, doi. 10.3390/molecules29163820
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- Article
Interspecies metabolic diversity of artocarpin in vitro mammalian liver microsomes.
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- Bioscience, Biotechnology & Biochemistry, 2020, v. 84, n. 4, p. 661, doi. 10.1080/09168451.2019.1701405
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Identification of Cytochrome P450 Enzymes Responsible for Oxidative Metabolism of Synthetic Cannabinoid (1-Hexyl-1 H -Indol-3-yl)-1-naphthalenyl-methanone (JWH-019).
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- Catalysts (2073-4344), 2023, v. 13, n. 6, p. 1008, doi. 10.3390/catal13061008
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Metabolic characterization of the new benzimidazole synthetic opioids - nitazenes.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1434573
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Development of radioiodine-labeled mequitazine for evaluation of hepatic CYP2D activity.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1397288
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- Article
The influence of drug-induced metabolic enzyme activity inhibition and CYP3A4 gene polymorphism on aumolertinib metabolism.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1392849
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In vitro and in vivo metabolism of psilocybin's active metabolite psilocin.
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- Frontiers in Pharmacology, 2024, p. 01, doi. 10.3389/fphar.2024.1391689
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- Article
The impacts of natural product miltirone and the CYP2D6 pharmacogenetic phenotype on fluoxetine metabolism.
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- Frontiers in Pharmacology, 2024, p. 01, doi. 10.3389/fphar.2024.1373048
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- Article
Effect of P. corylifolia on the pharmacokinetic profile of tofacitinib and the underlying mechanism.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1351882
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- Article
Metabolism of F18, a Derivative of Calanolide A, in Human Liver Microsomes and Cytosol.
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- Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00479
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- Article
Elucidation of Arctigenin Pharmacokinetics and Tissue Distribution after Intravenous, Oral, Hypodermic and Sublingual Administration in Rats and Beagle Dogs: Integration of In Vitro and In Vivo Findings.
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- Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00376
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Cover Picture: Data Curation can Improve the Prediction Accuracy of Metabolic Intrinsic Clearance (Mol. Inf. 1‐2/2019).
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- Molecular Informatics, 2019, v. 38, n. 1/2, p. N.PAG, doi. 10.1002/minf.201980101
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Data Curation can Improve the Prediction Accuracy of Metabolic Intrinsic Clearance.
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- Molecular Informatics, 2019, v. 38, n. 1/2, p. N.PAG, doi. 10.1002/minf.201800086
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- Article
Pharmacokinetic study of the interaction between luteolin and magnoflorine in rats.
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- Chemical Biology & Drug Design, 2024, v. 103, n. 1, p. 1, doi. 10.1111/cbdd.14356
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- Article
Effect of ophiopogonin D on the pharmacokinetics and transport of cryptotanshinone during their co‐administration and the potential mechanism.
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- Chemical Biology & Drug Design, 2023, v. 102, n. 3, p. 557, doi. 10.1111/cbdd.14269
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- Article
Structure‐based discovery of (S)‐2‐amino‐6‐(4‐fluorobenzyl)‐5,6,11,11a‐tetrahydro‐1H‐imidazo[1′,5′:1,6]pyrido[3,4‐b]indole‐1,3(2H)‐dione as low nanomolar, orally bioavailable autotaxin inhibitor
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- Chemical Biology & Drug Design, 2022, v. 99, n. 3, p. 496, doi. 10.1111/cbdd.14017
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- Article
Metabolic determination of decursinol using human liver microsome.
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- Tropical Journal of Pharmaceutical Research, 2021, v. 20, n. 6, p. 1165, doi. 10.4314/tjpr.v20i6.10
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- Article
Characterization and identification of in vitro metabolites of (-)-epicatechin using ultra-high performance liquid chromatography-mass spectrometry.
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- Tropical Journal of Pharmaceutical Research, 2017, v. 16, n. 12, p. 2985, doi. 10.4314/tjpr.v16i12.24
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- Article
Identification of metabolites of gardenin A in rat liver microsomes using ultra-high performance liquid chromatography coupled with linear ion-trap Orbitrap mass spectrometry.
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- Tropical Journal of Pharmaceutical Research, 2017, v. 16, n. 2, p. 421, doi. 10.4314/tjpr.v16i2.22
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- Article
Enantioselective analyses of chloroquine and hydroxychloroquine in rat liver microsomes through chiral liquid chromatography–tandem mass spectrometry.
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- Chirality, 2022, v. 34, n. 1, p. 126, doi. 10.1002/chir.23384
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- Article
Design, Synthesis, Biological Evaluation, and Molecular Dynamics Simulation of Influenza Polymerase PB2 Inhibitors.
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- Molecules, 2023, v. 28, n. 4, p. 1849, doi. 10.3390/molecules28041849
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- Article
Rapid LC-MS/MS Bosutinib Quantification with Applications in Metabolic Stability Estimation.
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- Molecules, 2023, v. 28, n. 4, p. 1641, doi. 10.3390/molecules28041641
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- Article
Identification of the Putative Binding Site of a Benzimidazole Opioid (Etazene) and Its Metabolites at µ-Opioid Receptor: A Human Liver Microsomal Assay and Systematic Computational Study.
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- Molecules, 2023, v. 28, n. 4, p. 1601, doi. 10.3390/molecules28041601
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- Article
An Insight into the Metabolism of 2,5-Disubstituted Monotetrazole Bearing Bisphenol Structures: Emerging Bisphenol A Structural Congeners.
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- Molecules, 2023, v. 28, n. 3, p. 1465, doi. 10.3390/molecules28031465
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- Article
In Vitro Metabolism and CYP-Modulating Activity of Lavender Oil and Its Major Constituents.
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- Molecules, 2023, v. 28, n. 2, p. 755, doi. 10.3390/molecules28020755
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- Article
Benzophenone Derivatives with Histamine H 3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease.
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- Molecules, 2023, v. 28, n. 1, p. 238, doi. 10.3390/molecules28010238
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- Article
A Novel Green Micellar HPLC-UV Method for the Estimation of Vandetanib in Pure Form, Human Urine, Human Plasma and Human Liver Microsomes Matrices with Application to Metabolic Stability Evaluation.
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- Molecules, 2022, v. 27, n. 24, p. 9038, doi. 10.3390/molecules27249038
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- Article
Silymarin Protects against Acute Liver Injury Induced by Acetaminophen by Downregulating the Expression and Activity of the CYP2E1 Enzyme.
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- Molecules, 2022, v. 27, n. 24, p. 8855, doi. 10.3390/molecules27248855
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- Article
Investigation of In Vitro and In Vivo Metabolism of α-Amanitin in Rats Using Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometric Method.
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- Molecules, 2022, v. 27, n. 23, p. 8612, doi. 10.3390/molecules27238612
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HPLC with Fluorescence and Photodiode Array Detection for Quantifying Capmatinib in Biological Samples: Application to In Vivo and In Vitro Studies.
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- Molecules, 2022, v. 27, n. 23, p. 8582, doi. 10.3390/molecules27238582
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- Article
High-Throughput Metabolic Soft-Spot Identification in Liver Microsomes by LC/UV/MS: Application of a Single Variable Incubation Time Approach.
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- Molecules, 2022, v. 27, n. 22, p. 8058, doi. 10.3390/molecules27228058
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- Article
Comparative Metabolomic Profiling of the Metabolic Differences of Δ9-Tetrahydrocannabinol and Cannabidiol.
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- Molecules, 2022, v. 27, n. 21, p. 7573, doi. 10.3390/molecules27217573
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- Article
The Analytical Strategy of "Ion Induction and Deduction Based on Net-Hubs" for the Comprehensive Characterization of Naringenin Metabolites In Vivo and In Vitro Using a UHPLC-Q-Exactive Orbitrap Mass Spectrometer.
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- Molecules, 2022, v. 27, n. 21, p. 7282, doi. 10.3390/molecules27217282
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- Article
In Vivo Anticancer Evaluation of 6b, a Non-Covalent Imidazo[1,2- a ]quinoxaline-Based Epidermal Growth Factor Receptor Inhibitor against Human Xenograft Tumor in Nude Mice.
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- Molecules, 2022, v. 27, n. 17, p. 5540, doi. 10.3390/molecules27175540
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- Article
Kinetic Characteristics of Curcumin and Germacrone in Rat and Human Liver Microsomes: Involvement of CYP Enzymes.
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- Molecules, 2022, v. 27, n. 14, p. N.PAG, doi. 10.3390/molecules27144482
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- Article
UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of Tectorigenin and Irigenin In Vitro.
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- Molecules, 2022, v. 27, n. 13, p. 4104, doi. 10.3390/molecules27134104
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- Article
Development and Validation of an HPLC-UV Method for the Quantification of 4′-Hydroxydiclofenac Using Salicylic Acid: Future Applications for Measurement of In Vitro Drug–Drug Interaction in Rat Liver Microsomes.
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- Molecules, 2022, v. 27, n. 11, p. 3587, doi. 10.3390/molecules27113587
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- Article
Discovery of Dipyridamole Analogues with Enhanced Metabolic Stability for the Treatment of Idiopathic Pulmonary Fibrosis.
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- Molecules, 2022, v. 27, n. 11, p. 3452, doi. 10.3390/molecules27113452
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- Article
Biotransformation of Liquiritigenin into Characteristic Metabolites by the Gut Microbiota.
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- Molecules, 2022, v. 27, n. 10, p. 3057, doi. 10.3390/molecules27103057
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- Article
Metabolite Identification of a Novel Anti-Leishmanial Agent OJT007 in Rat Liver Microsomes Using LC-MS/MS.
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- Molecules, 2022, v. 27, n. 9, p. 2854, doi. 10.3390/molecules27092854
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- Article
Potential Effects of Ibuprofen, Remdesivir and Omeprazole on Dexamethasone Metabolism in Control Sprague Dawley Male Rat Liver Microsomes (Drugs Often Used Together Alongside COVID-19 Treatment).
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- Molecules, 2022, v. 27, n. 7, p. 2238, doi. 10.3390/molecules27072238
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- Article
Evaluation of Two Novel Hydantoin Derivatives Using Reconstructed Human Skin Model Episkin TM : Perspectives for Application as Potential Sunscreen Agents.
- Published in:
- Molecules, 2022, v. 27, n. 6, p. 1850, doi. 10.3390/molecules27061850
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Development and Validation of a Novel HPLC Method to Analyse Metabolic Reaction Products Catalysed by the CYP3A2 Isoform: In Vitro Inhibition of CYP3A2 Enzyme Activity by Aspirin (Drugs Often Used Together in COVID-19 Treatment).
- Published in:
- Molecules, 2022, v. 27, n. 3, p. 927, doi. 10.3390/molecules27030927
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- Article