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Artificial intelligence utility for drug development: ChatGPT and beyond.
- Published in:
- 2024
- By:
- Publication type:
- Product Review
Effect of polycaprolactone/carbon nanotube scaffold implantation along with liposomal ellagic acid in hippocampal synaptogenesis after spinal cord injury.
- Published in:
- Nanomedicine Journal, 2023, v. 10, n. 3, p. 197, doi. 10.22038/NMJ.2023.72151.1776
- By:
- Publication type:
- Article
NG2 and NG2-positive cells delineate focal cerebral infarct demarcation in rats.
- Published in:
- Neuropathology, 2013, v. 33, n. 1, p. 30, doi. 10.1111/j.1440-1789.2012.01322.x
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- Publication type:
- Article
Protein microarray analysis identifies cyclic nucleotide phosphodiesterase as an interactor of Nogo-A.
- Published in:
- Neuropathology, 2010, v. 30, n. 1, p. 7, doi. 10.1111/j.1440-1789.2009.01035.x
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- Publication type:
- Article
Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice.
- Published in:
- Cells (2073-4409), 2024, v. 13, n. 12, p. 1000, doi. 10.3390/cells13121000
- By:
- Publication type:
- Article
Role of Phosphodiesterase 1 in the Regulation of Real-Time cGMP Levels and Contractility in Adult Mouse Cardiomyocytes.
- Published in:
- Cells (2073-4409), 2023, v. 12, n. 23, p. 2759, doi. 10.3390/cells12232759
- By:
- Publication type:
- Article
CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms.
- Published in:
- Cells (2073-4409), 2023, v. 12, n. 11, p. 1543, doi. 10.3390/cells12111543
- By:
- Publication type:
- Article
An EPAC1/PDE1C-Signaling Axis Regulates Formation of Leading-Edge Protrusion in Polarized Human Arterial Vascular Smooth Muscle Cells.
- Published in:
- Cells (2073-4409), 2019, v. 8, n. 12, p. 1473, doi. 10.3390/cells8121473
- By:
- Publication type:
- Article
An improved DNA-based test for detection of the codon 616 mutation in the alpha cyclic GMP phosphodiesterase gene that causes progressive retinal atrophy in the Cardigan Welsh Corgi.
- Published in:
- Veterinary Ophthalmology, 2002, v. 5, n. 2, p. 103, doi. 10.1046/j.1463-5224.2002.00223.x
- By:
- Publication type:
- Article
The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release.
- Published in:
- 2009
- By:
- Publication type:
- journal article
The G protein preference of orexin receptors is currently an unresolved issue.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38764-3
- By:
- Publication type:
- Article
Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.
- Published in:
- PLoS Neglected Tropical Diseases, 2017, v. 11, n. 7, p. 1, doi. 10.1371/journal.pntd.0005680
- By:
- Publication type:
- Article
CYCLIC NUCLEOTID PHOSPHODIESTERASES: ROLES IN HEALTH AND DISEASES.
- Published in:
- 2012
- By:
- Publication type:
- Abstract
Human cyclic nucleotide phosphodiesterases possess a much broader substrate-specificity than previously appreciated
- Published in:
- FEBS Letters, 2011, v. 585, n. 20, p. 3259, doi. 10.1016/j.febslet.2011.09.004
- By:
- Publication type:
- Article
Evolution of multiple phosphodiesterase isoforms in stickleback involved in cAMP signal transduction pathway.
- Published in:
- BMC Systems Biology, 2009, v. 3, p. 1, doi. 10.1186/1752-0509-3-23
- By:
- Publication type:
- Article
Repurposing Human PDE4 Inhibitors for Neglected Tropical Diseases. Evaluation of Analogs of the Human PDE4 Inhibitor GSK-256066 as Inhibitors of PDEB1 of Trypanosoma brucei.
- Published in:
- Chemical Biology & Drug Design, 2015, v. 85, n. 5, p. 549, doi. 10.1111/cbdd.12443
- By:
- Publication type:
- Article
C[sub 2]-Ceramide Influences the Expression and Insulin-Mediated Regulation of Cyclic Nucleotide Phosphodiesterase 3B and Lipolysis in 3T3-L1 Adipocytes.
- Published in:
- Diabetes, 2002, v. 51, n. 3, p. 631, doi. 10.2337/diabetes.51.3.631
- By:
- Publication type:
- Article
The N-terminal domain of the myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase: direct molecular interaction with the calcium sensor calmodulin.
- Published in:
- Journal of Neurochemistry, 2012, v. 123, n. 4, p. 515, doi. 10.1111/jnc.12000
- By:
- Publication type:
- Article
Differential phosphodiesterase expression and cytosolic Ca<sup>2+</sup> in human CNS tumour cells and in non-malignant and malignant cells of rat origin.
- Published in:
- Journal of Neurochemistry, 2005, v. 93, n. 2, p. 321, doi. 10.1111/j.1471-4159.2005.03028.x
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- Publication type:
- Article
Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5.
- Published in:
- Journal of Neuroinflammation, 2012, v. 9, n. 1, p. 253, doi. 10.1186/1742-2094-9-253
- By:
- Publication type:
- Article
Sildenafil enhances cisplatin-induced apoptosis in human breast adenocarcinoma cells.
- Published in:
- Journal of Cancer Research & Therapeutics, 2020, v. 16, n. 6, p. 1412, doi. 10.4103/jcrt.JCRT_675_19
- By:
- Publication type:
- Article
Emerging Potential of the Phosphodiesterase (PDE) Inhibitor Ibudilast for Neurodegenerative Diseases: An Update on Preclinical and Clinical Evidence.
- Published in:
- Molecules, 2022, v. 27, n. 23, p. 8448, doi. 10.3390/molecules27238448
- By:
- Publication type:
- Article
Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine-Based Radioligand for the Imaging of Phosphodiesterase 2A with Positron Emission Tomography.
- Published in:
- Molecules, 2019, v. 24, n. 22, p. 4149, doi. 10.3390/molecules24224149
- By:
- Publication type:
- Article
Effects of Nitrosyl Iron Complexes with Thiocarbamide and Its Aliphatic Derivatives on Activities of Ca-ATPase of Sarcoplasmic Reticulum and cGMP Phosphodiesterase.
- Published in:
- Bulletin of Experimental Biology & Medicine, 2017, v. 163, n. 1, p. 54, doi. 10.1007/s10517-017-3736-8
- By:
- Publication type:
- Article
Identification of Lithium-Regulated Genes in Cultured Lymphoblasts of Lithium Responsive Subjects with Bipolar Disorder.
- Published in:
- Neuropsychopharmacology, 2004, v. 29, n. 4, p. 799, doi. 10.1038/sj.npp.1300383
- By:
- Publication type:
- Article
Genetic variation in phosphodiesterase (PDE) 7B in chronic lymphocytic leukemia: overview of genetic variants of cyclic nucleotide PDEs in human disease.
- Published in:
- Journal of Human Genetics, 2011, v. 56, n. 9, p. 676, doi. 10.1038/jhg.2011.80
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- Publication type:
- Article
Cilostazol: A Viewpoint by Yukichi Okuda.
- Published in:
- Drugs & Aging, 1999, v. 14, n. 1, p. 72
- By:
- Publication type:
- Article
Phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes.
- Published in:
- Metabolic Brain Disease, 2009, v. 24, n. 3, p. 481
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- Publication type:
- Article
PDE4 Inhibitors: Profiling Hits through the Multitude of Structural Classes.
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 14, p. 11518, doi. 10.3390/ijms241411518
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- Publication type:
- Article
Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers.
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 8, p. 7617, doi. 10.3390/ijms24087617
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- Publication type:
- Article
To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 7, p. 6817, doi. 10.3390/ijms24076817
- By:
- Publication type:
- Article
The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 19, p. 11452, doi. 10.3390/ijms231911452
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- Publication type:
- Article
The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic Approaches.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 18, p. N.PAG, doi. 10.3390/ijms231810616
- By:
- Publication type:
- Article
Cellular Redox Metabolism Is Modulated by the Distinct Localization of Cyclic Nucleotide Phosphodiesterase 5A Isoforms.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 15, p. 8587, doi. 10.3390/ijms23158587
- By:
- Publication type:
- Article
New Horizons in Plant Cell Signaling.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 10, p. 5826, doi. 10.3390/ijms23105826
- By:
- Publication type:
- Article
Identification of Phosphorylated Calpain 3 in Rat Brain Mitochondria under mPTP Opening.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 19, p. 10613, doi. 10.3390/ijms221910613
- By:
- Publication type:
- Article
Dual Activation of Phosphodiesterase 3 and 4 Regulates Basal Cardiac Pacemaker Function and Beyond.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 16, p. 8414, doi. 10.3390/ijms22168414
- By:
- Publication type:
- Article
Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 8, p. 3832, doi. 10.3390/ijms22083832
- By:
- Publication type:
- Article
Phosphodiesterases Expression during Murine Cardiac Development.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 5, p. 2593, doi. 10.3390/ijms22052593
- By:
- Publication type:
- Article
Influence of Phosphodiesterase Inhibition on CRE- and EGR1-Dependent Transcription in a Mouse Hippocampal Cell Line.
- Published in:
- International Journal of Molecular Sciences, 2020, v. 21, n. 22, p. 8658, doi. 10.3390/ijms21228658
- By:
- Publication type:
- Article
Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia.
- Published in:
- International Journal of Molecular Sciences, 2020, v. 21, n. 21, p. 7970, doi. 10.3390/ijms21217970
- By:
- Publication type:
- Article
Advances, Perspectives and Potential Engineering Strategies of Light-Gated Phosphodiesterases for Optogenetic Applications.
- Published in:
- International Journal of Molecular Sciences, 2020, v. 21, n. 20, p. 7544, doi. 10.3390/ijms21207544
- By:
- Publication type:
- Article
Dominant-Negative Attenuation of cAMP-Selective Phosphodiesterase PDE4D Action Affects Learning and Behavior.
- Published in:
- International Journal of Molecular Sciences, 2020, v. 21, n. 16, p. 5704, doi. 10.3390/ijms21165704
- By:
- Publication type:
- Article
Biphasic Effect of Sildenafil on Energy Sensing is Mediated by Phosphodiesterases 2 and 3 in Adipocytes and Hepatocytes.
- Published in:
- International Journal of Molecular Sciences, 2019, v. 20, n. 12, p. 2992, doi. 10.3390/ijms20122992
- By:
- Publication type:
- Article
Modulation of Compartmentalised Cyclic Nucleotide Signalling via Local Inhibition of Phosphodiesterase Activity.
- Published in:
- International Journal of Molecular Sciences, 2016, v. 17, n. 10, p. 1672, doi. 10.3390/ijms17101672
- By:
- Publication type:
- Article
Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase.
- Published in:
- Nature, 2009, v. 459, n. 7249, p. 1015, doi. 10.1038/nature07966
- By:
- Publication type:
- Article
Sildenafil: A Review of its Use in Pulmonary Arterial Hypertension.
- Published in:
- Drugs, 2008, v. 68, n. 3, p. 383, doi. 10.2165/00003495-200868030-00009
- By:
- Publication type:
- Article
Therapeutic Applications of Sildenafil Citrate in the Management of Paediatric Pulmonary Hypertension.
- Published in:
- Drugs, 2007, v. 67, n. 1, p. 57, doi. 10.2165/00003495-200767010-00005
- By:
- Publication type:
- Article
Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages.
- Published in:
- PLoS Neglected Tropical Diseases, 2020, v. 14, n. 7, p. 1, doi. 10.1371/journal.pntd.0008447
- By:
- Publication type:
- Article
Gene Conversion Transfers the GAF-A Domain of Phosphodiesterase TbrPDEB1 to One Allele of TbrPDEB2 of Trypanosoma brucei.
- Published in:
- PLoS Neglected Tropical Diseases, 2009, v. 3, n. 6, p. 1, doi. 10.1371/journal.pntd.0000455
- By:
- Publication type:
- Article