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Arginine-Depleting Enzymes – An Increasingly Recognized Treatment Strategy for Therapy-Refractory Malignancies.
- Published in:
- Cellular Physiology & Biochemistry (Karger AG), 2018, v. 51, n. 2, p. 854, doi. 10.1159/000495382
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- Publication type:
- Article
Cancer cell sensitivity to arginine deprivation in vitro is not determined by endogenous levels of arginine metabolic enzymes.
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- Cell Biology International, 2010, v. 34, n. 11, p. 1085, doi. 10.1042/CBI20100451
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- Publication type:
- Article
The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer.
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- Cancer & Metabolism, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40170-021-00264-7
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- Publication type:
- Article
Liver-directed adeno-associated virus serotype 8 gene transfer rescues a lethal murine model of citrullinemia type 1.
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- Gene Therapy, 2013, v. 20, n. 12, p. 1188, doi. 10.1038/gt.2013.53
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- Publication type:
- Article
Citrullinemia Type I - A Case Report.
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- Journal of Bangladesh College of Physicians & Surgeons, 2015, v. 33, n. 2, p. 98
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- Publication type:
- Article
Clinical course of 63 patients with neonatal onset urea cycle disorders in the years 2001-2013.
- Published in:
- 2016
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- Publication type:
- journal article
The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma.
- Published in:
- International Journal of Molecular Sciences, 2017, v. 18, n. 6, p. 1175, doi. 10.3390/ijms18061175
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- Publication type:
- Article
Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM.
- Published in:
- 2018
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- Publication type:
- journal article
Molecular characterization of argininosuccinate synthase and argininosuccinate lyase from the liver of the African lungfish Protopterus annectens, and their mRNA expression levels in the liver, kidney, brain and skeletal muscle during aestivation.
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- Journal of Comparative Physiology B: Biochemical, Systemic & Environmental Physiology, 2014, v. 184, n. 7, p. 835, doi. 10.1007/s00360-014-0842-z
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- Publication type:
- Article
Citrullinemia type I and hypertrophic pyloric stenosis in a 1-month old male infant.
- Published in:
- 2013
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- Publication type:
- Case Study
Genetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress Management.
- Published in:
- PLoS Neglected Tropical Diseases, 2016, v. 10, n. 3, p. 1, doi. 10.1371/journal.pntd.0004308
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- Publication type:
- Article
Targeting Arginine-Dependent Cancers with Arginine-Degrading Enzymes: Opportunities and Challenges.
- Published in:
- Cancer Research & Treatment, 2013, v. 45, n. 4, p. 251, doi. 10.4143/crt.2013.45.4.251
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- Publication type:
- Article
Endothelial Arginine Resynthesis Contributes to the Maintenance of Vasomotor Function in Male Diabetic Mice.
- Published in:
- PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0102264
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- Publication type:
- Article
Expression Pattern and Biochemical Properties of Zebrafish N-Acetylglutamate Synthase.
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- PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0085597
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- Publication type:
- Article
Hepatic Adaptation Compensates Inactivation of Intestinal Arginine Biosynthesis in Suckling Mice.
- Published in:
- PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0067021
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- Publication type:
- Article
Bothrops jararaca Peptide with Anti-Hypertensive Action Normalizes Endothelium Dysfunction Involved in Physiopathology of Preeclampsia.
- Published in:
- PLoS ONE, 2011, v. 6, n. 8, p. 1, doi. 10.1371/journal.pone.0023680
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- Publication type:
- Article
L-citrulline supplementation reverses the impaired airway relaxation in neonatal rats exposed to hyperoxia.
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- Respiratory Research, 2012, v. 13, n. 8, p. 1, doi. 10.1186/1465-9921-13-68
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- Publication type:
- Article
Three-dimensional environment renders cancer cells profoundly less susceptible to a single amino acid starvation.
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- Amino Acids, 2013, v. 45, n. 5, p. 1221, doi. 10.1007/s00726-013-1586-x
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- Publication type:
- Article
Expression and function of arginine-producing and consuming-enzymes in the kidney.
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- Amino Acids, 2012, v. 42, n. 4, p. 1237, doi. 10.1007/s00726-011-0897-z
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- Publication type:
- Article
Adeno-associated Virus-mediated Rescue of Neonatal Lethality in Argininosuccinate Synthetase-deficient Mice.
- Published in:
- Molecular Therapy, 2013, v. 21, n. 10, p. 1823, doi. 10.1038/mt.2013.139
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- Publication type:
- Article
Expression profile and down-regulation of argininosuccinate synthetase in hepatocellular carcinoma in a transgenic mouse model.
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- Journal of Biomedical Science, 2015, v. 22, n. 1, p. 190, doi. 10.1186/s12929-015-0114-6
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- Publication type:
- Article
A transgenic approach to study argininosuccinate synthetase gene expression.
- Published in:
- Journal of Biomedical Science, 2014, v. 21, n. 1, p. 1, doi. 10.1186/1423-0127-21-42
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- Publication type:
- Article
First manifestation of citrullinemia type I as Sandifer syndrome.
- Published in:
- 2017
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- Publication type:
- Case Study
Investigating the role of dicer 2 ( dcr2) in gene silencing and the regulation of mycoviruses in Botrytis cinerea.
- Published in:
- Microbiology (00262617), 2014, v. 83, n. 1/2, p. 140, doi. 10.1134/S0026261714020180
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- Publication type:
- Article
Gene expression in the chicken caecum is dependent on microbiota composition.
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- Veterinary Research, 2017, v. 48, p. 1, doi. 10.1186/s13567-017-0493-7
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- Publication type:
- Article
Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase.
- Published in:
- British Journal of Cancer, 2012, v. 106, n. 9, p. 1481, doi. 10.1038/bjc.2012.106
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- Publication type:
- Article
Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase.
- Published in:
- British Journal of Cancer, 2012, v. 106, n. 2, p. 324, doi. 10.1038/bjc.2011.524
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- Publication type:
- Article
Reversal of endothelial dysfunction in aorta of streptozotocin-nicotinamide-induced type-2 diabetic rats by S-Allylcysteine.
- Published in:
- Molecular & Cellular Biochemistry, 2017, v. 432, n. 1/2, p. 25, doi. 10.1007/s11010-017-2994-0
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- Publication type:
- Article
IDENTIFICATION OF CITRULLINAEMIA CARRIER AND DETECTION OF A NEW SILENT MUTATION AT 240bp POSITION IN ASS1 GENE OF NORMAL HOLSTEIN CATTLE.
- Published in:
- Genetika (0534-0012), 2014, v. 46, n. 2, p. 515, doi. 10.2298/GENSR1402515K
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- Publication type:
- Article
Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma.
- Published in:
- PLoS ONE, 2017, v. 12, n. 2, p. 1, doi. 10.1371/journal.pone.0171985
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- Publication type:
- Article
Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma.
- Published in:
- PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0150044
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- Publication type:
- Article
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.
- Published in:
- Nature, 2015, v. 527, n. 7578, p. 379, doi. 10.1038/nature15529
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- Publication type:
- Article
L-citrulline for protection of endothelial function from ADMA-induced injury in porcine coronary artery.
- Published in:
- Scientific Reports, 2015, p. 10987, doi. 10.1038/srep10987
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- Publication type:
- Article
Argininosuccinate synthetase 1 suppression and arginine restriction inhibit cell migration in gastric cancer cell lines.
- Published in:
- Scientific Reports, 2015, p. 9783, doi. 10.1038/srep09783
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- Publication type:
- Article
Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency.
- Published in:
- Stem Cell Research & Therapy, 2017, v. 8, p. 1, doi. 10.1186/s13287-017-0628-9
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- Publication type:
- Article
Leishmania donovani Argininosuccinate Synthase Is an Active Enzyme Associated with Parasite Pathogenesis.
- Published in:
- PLoS Neglected Tropical Diseases, 2012, v. 6, n. 10, p. 1, doi. 10.1371/journal.pntd.0001849
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- Publication type:
- Article
Deprivation of arginine by recombinant human arginase in prostate cancer cells.
- Published in:
- Journal of Hematology & Oncology, 2012, v. 5, n. 1, p. 17, doi. 10.1186/1756-8722-5-17
- Publication type:
- Article
Low expressions of ASS1 and OTC in glioblastoma suggest the potential clinical use of recombinant human arginase (rhArg).
- Published in:
- 2016
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- Publication type:
- Letter
CORRELATION BETWEEN THE EXPRESSION OF ARGININOSUCCINATE SYNTHETASE GENE AND DRUG RESISTANCE MECHANISM OF CHRONIC MYELOGENOUS LEUKAEMIA.
- Published in:
- Farmacia, 2017, v. 65, n. 2, p. 241
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- Publication type:
- Article
Decreased argininosuccinate synthetase expression in Thai patients with cholangiocarcinoma and the effects of ADI-PEG20 treatment in CCA cell lines.
- Published in:
- Oncology Letters, 2018, v. 16, n. 2, p. 1529, doi. 10.3892/ol.2018.8807
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- Publication type:
- Article
Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-κB signaling.
- Published in:
- BMC Cancer, 2014, v. 14, p. 1, doi. 10.1186/1471-2407-14-686
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- Publication type:
- Article
Down-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy.
- Published in:
- BMC Cancer, 2014, v. 14, p. 1, doi. 10.1186/1471-2407-14-621
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- Publication type:
- Article
Imaging of Tumor Vascularization Using Fluorescence Molecular Tomography to Monitor Arginine Deiminase Treatment in Melanoma.
- Published in:
- Molecular Imaging, 2013, v. 12, n. 1, p. 67, doi. 10.2310/7290.2012.00009
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- Publication type:
- Article
Expression of argininosuccinate synthetase in patients with hepatocellular carcinoma.
- Published in:
- Journal of Gastroenterology & Hepatology, 2013, v. 28, n. 2, p. 365, doi. 10.1111/jgh.12043
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- Publication type:
- Article
Role of nitric oxide in the synthesis of guanidinosuccinic acid, at activator of the N-methyl-d-asparate receptor.
- Published in:
- Kidney International, 2001, v. 59, p. S93, doi. 10.1046/j.1523-1755.2001.59780093.x
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- Publication type:
- Article