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CXCL4 is a novel inducer of human Th17 cells and correlates with IL‐17 and IL‐22 in psoriatic arthritis.
Published in:
European Journal of Immunology, 2018, v. 48, n. 3, p. 522, doi. 10.1002/eji.201747195
By:
- Affandi, Alsya J.;
- Silva‐Cardoso, Sandra C.;
- Garcia, Samuel;
- Leijten, Emmerik F. A.;
- van Kempen, Tessa S.;
- Marut, Wioleta;
- van Roon, Joel A. G.;
- Radstake, Timothy R. D. J.
Publication type:
Article
Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis.
Published in:
Journal of Clinical Medicine, 2021, v. 10, n. 3, p. 491, doi. 10.3390/jcm10030491
By:
- Chouri, Eleni;
- Wang, Maojie;
- Hillen, Maarten R.;
- Angiolilli, Chiara;
- Silva-Cardoso, Sandra C.;
- Wichers, Catharina G. K.;
- van der Kroef, Maarten;
- Bekker, Cornelis P. J.;
- Cossu, Marta;
- van Bon, Lenny;
- Affandi, Alsya J.;
- Carvalheiro, Tiago;
- Pandit, Aridaman;
- van Roon, Joel A. G.;
- Beretta, Lorenzo;
- Burgering, Boudewijn M. T.;
- Radstake, Timothy R. D. J.;
- Rossato, Marzia;
- Sato, Shinichi
Publication type:
Article
In patients with primary Sjögren's syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.1017157
By:
- Hinrichs, Anneline C.;
- Kruize, Aike A.;
- Leavis, Helen L.;
- van Roon, Joel A. G.
Publication type:
Article
Trained Immunity in Primary Sjögren's Syndrome: Linking Type I Interferons to a Pro-Atherogenic Phenotype.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.840751
By:
- Huijser, Erika;
- van Helden-Meeuwsen, Cornelia G.;
- Grashof, Dwin G. B.;
- Tarn, Jessica R.;
- Brkic, Zana;
- Huisman, Josje M. A.;
- Wahadat, M. Javad;
- van de Werken, Harmen J. G.;
- Lopes, Ana P.;
- van Roon, Joel A. G.;
- van Daele, Paul L. A.;
- Kamphuis, Sylvia;
- Wan-Fai Ng;
- Bekkering, Siroon;
- Joosten, Leo A. B.;
- Dik, Willem A.;
- Versnel, Marjan A.
Publication type:
Article
CCL5 Release by CCR9+ CD8 T Cells: A Potential Contributor to Immunopathology of Primary Sjögren's Syndrome.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.887972
By:
- Hinrichs, Anneline C.;
- Blokland, Sofie L. M.;
- Kruize, Aike A.;
- Lafeber, Floris P. J.;
- Leavis, Helen L.;
- van Roon, Joel A. G.
Publication type:
Article
The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade.
Published in:
PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0130830
By:
- Hillen, Maarten R.;
- Hartgring, Sarita A. Y.;
- Willis, Cynthia R.;
- Radstake, Timothy R. D. J.;
- Hack, Cornelis E.;
- Lafeber, Floris P. J. G.;
- van Roon, Joel A. G
Publication type:
Article
Interleukin-7 and Toll-Like Receptor 7 Induce Synergistic B Cell and T Cell Activation.
Published in:
PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0094756
By:
- Bikker, Angela;
- Kruize, Aike A.;
- van der Wurff-Jacobs, Kim M. G.;
- Peters, Rogier P.;
- Kleinjan, Marije;
- Redegeld, Frank;
- de Jager, Wilco;
- Lafeber, Floris P. J. G.;
- van Roon, Joël A. G.
Publication type:
Article
Plasmacytoid DCs From Patients With Sjögren's Syndrome Are Transcriptionally Primed for Enhanced Pro-inflammatory Cytokine Production.
Published in:
Frontiers in Immunology, 2019, p. 1, doi. 10.3389/fimmu.2019.02096
By:
- Hillen, Maarten R.;
- Pandit, Aridaman;
- Blokland, Sofie L. M.;
- Hartgring, Sarita A. Y.;
- Bekker, Cornelis P. J.;
- van der Heijden, Eefje H. M.;
- Servaas, Nila H.;
- Rossato, Marzia;
- Kruize, Aike A.;
- van Roon, Joel A. G.;
- Radstake, Timothy R. D. J.
Publication type:
Article
MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sjögren's Syndrome by Targeting Mitogen- and Stress-Activated Protein Kinase-1.
Published in:
Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01335
By:
- Lopes, Ana P.;
- van Roon, Joel A. G.;
- Blokland, Sofie L. M.;
- Wang, Maojie;
- Chouri, Eleni;
- Hartgring, Sarita A. Y.;
- van der Wurff-Jacobs, Kim M. G.;
- Kruize, Aike A.;
- Burgering, Boudewijn M. T.;
- Rossato, Marzia;
- Radstake, Timothy R. D. J.;
- Hillen, Maarten R.
Publication type:
Article
Synovial T cell hyporesponsiveness to myeloid dendritic cells is reversed by preventing PD-1/PD-L1 interactions.
Published in:
Arthritis Research & Therapy, 2014, v. 16, n. 5, p. 497, doi. 10.1186/s13075-014-0497-x
By:
- Moret, Frederique M.;
- van der Wurff-Jacobs, Kim M. G.;
- Bijlsma, Johannes W. J.;
- Lafeber, Floris P. J. G.;
- van Roon, Joel A. G.
Publication type:
Article
Interleukin-7-aggravated joint inflammation and tissue destruction in collagen-induced arthritis is associated with T-cell and B-cell activation.
Published in:
Arthritis Research & Therapy, 2012, v. 14, n. 3, p. 1, doi. 10.1186/ar3870
By:
- Hartgring, Sarita A. Y.;
- Willis, Cynthia R.;
- Bijlsma, Johannes W. J.;
- Lafeber, Floris P. J. G.;
- van Roon, Joel A. G.
Publication type:
Article
The Transcriptomic Profile of Monocytes from Patients With Sjögren's Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators.
Published in:
Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.701656
By:
- Lopes, Ana P.;
- Bekker, Cornelis P. J.;
- Hillen, Maarten R.;
- Blokland, Sofie L. M.;
- Hinrichs, Anneline C.;
- Pandit, Aridaman;
- Kruize, Aike A.;
- Radstake, Timothy R. D. J.;
- van Roon, Joel A. G.
Publication type:
Article
Transcriptome Analysis of CCR9+ T Helper Cells From Primary Sjögren's Syndrome Patients Identifies CCL5 as a Novel Effector Molecule.
Published in:
Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.702733
By:
- Hinrichs, Anneline C.;
- Blokland, Sofie L. M.;
- Lopes, Ana P.;
- Wichers, Catharina G. K.;
- Kruize, Aike A.;
- Pandit, Aridaman;
- Radstake, Timothy R. D. J.;
- van Roon, Joel A. G.
Publication type:
Article
Hyperresponsive cytosolic DNA-sensing pathway in monocytes from primary Sjögren's syndrome.
Published in:
Rheumatology, 2022, v. 61, n. 8, p. 3491, doi. 10.1093/rheumatology/keac016
By:
- Huijser, Erika;
- Bodewes, Iris L A;
- Lourens, Mirthe S;
- Helden-Meeuwsen, Cornelia G van;
- Bosch, Thierry P P van den;
- Grashof, Dwin G B;
- Werken, Harmen J G van de;
- Lopes, Ana P;
- Roon, Joel A G van;
- Daele, Paul L A van;
- Brkic, Zana;
- Dik, Willem A;
- Versnel, Marjan A
Publication type:
Article
Emerging roles for chemokines and cytokines as orchestrators of immunopathology in Sjögren's syndrome.
Published in:
Rheumatology, 2021, v. 60, n. 7, p. 3072, doi. 10.1093/rheumatology/key438
By:
- Blokland, Sofie L. M;
- Flessa, Christina-Maria;
- Roon, Joel A. G van;
- Mavragani, Clio P
Publication type:
Article
Epigenetically quantified immune cells in salivary glands of Sjögren's syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopathology.
Published in:
Rheumatology, 2020, v. 59, n. 2, p. 335, doi. 10.1093/rheumatology/kez268
By:
- Blokland, Sofie L M;
- Vliet-Moret, Fréderique M van;
- Hillen, Maarten R;
- Pandit, Aridaman;
- Goldschmeding, Roel;
- Kruize, Aike A;
- Bouma, Gerben;
- Maurik, André van;
- Olek, Sven;
- Hoffmueller, Ulrich;
- Roon, Joel A G van;
- Radstake, Timothy R D J
Publication type:
Article
Dysregulated miRNome of plasmacytoid dendritic cells from patients with Sjögren's syndrome is associated with processes at the centre of their function.
Published in:
Rheumatology, 2019, v. 58, n. 12, p. 2305, doi. 10.1093/rheumatology/kez195
By:
- Hillen, Maarten R;
- Chouri, Eleni;
- Wang, Maojie;
- Blokland, Sofie L M;
- Hartgring, Sarita A Y;
- Concepcion, Arno N;
- Kruize, Aike A;
- Burgering, Boudewijn M T;
- Rossato, Marzia;
- Roon, Joel A G van;
- Radstake, Timothy R D J
Publication type:
Article
Increased expression of Fas on group 2 and 3 innate lymphoid cells is associated with an interferon signature in systemic lupus erythematosus and Sjögren's syndrome.
Published in:
Rheumatology, 2019, v. 58, n. 10, p. 1740, doi. 10.1093/rheumatology/kez116
By:
- Blokland, Sofie L M;
- Hoogen, Lucas L van den;
- Leijten, Emmerik F A;
- Hartgring, Sarita A Y;
- Fritsch, Ruth;
- Kruize, Aike A;
- Roon, Joel A G van;
- Radstake, Timothy R D J
Publication type:
Article
microRNA downregulation in plasmacytoid dendritic cells in interferon-positive systemic lupus erythematosus and antiphospholipid syndrome.
Published in:
Rheumatology, 2018, v. 57, n. 9, p. 1669, doi. 10.1093/rheumatology/key159
By:
- Hoogen, Lucas L van den;
- Rossato, Marzia;
- Lopes, Ana P;
- Pandit, Aridaman;
- Bekker, Cornelis P J;
- Fritsch-Stork, Ruth D E;
- Roon, Joel A G van;
- Radstake, Timothy R D J
Publication type:
Article
Neutrophil extracellular trap release is associated with antinuclear antibodies in systemic lupus erythematosus and anti-phospholipid syndrome.
Published in:
Rheumatology, 2018, v. 57, n. 7, p. 1228, doi. 10.1093/rheumatology/key067
By:
- van der Linden, Maarten;
- Hoogen, Lucas L van den;
- Westerlaken, Geertje H A;
- Fritsch-Stork, Ruth D E;
- Roon, Joël A G van;
- Radstake, Timothy R D J;
- Meyaard, Linde
Publication type:
Article
Systemic and local granzyme B levels are associated with disease activity, kidney damage and interferon signature in systemic lupus erythematosus.
Published in:
Rheumatology, 2017, v. 56, n. 12, p. 2129, doi. 10.1093/rheumatology/kex332
By:
- Kok, Helena M.;
- van den Hoogen, Lucas L.;
- van Roon, Joel A. G.;
- Adriaansen, Elisabeth J. M.;
- Fritsch-Stork, Ruth D. E.;
- Nguyen, Tri Q.;
- Goldschmeding, Roel;
- Radstake, Timothy R. D. J.;
- Bovenschen, Niels
Publication type:
Article
Thymic stromal lymphopoietin as a novel mediator amplifying immunopathology in rheumatic disease.
Published in:
Rheumatology, 2015, v. 54, n. 10, p. 1771, doi. 10.1093/rheumatology/kev241
By:
- Hillen, Maarten R.;
- Radstake, Timothy R. D. J.;
- Hack, Cornelis E.;
- van Roon, Joel A. G.
Publication type:
Article
IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7Rα.
Published in:
2012
By:
- Bikker, Angela;
- Moret, Fréderique M.;
- Kruize, Aike A.;
- Bijlsma, Johannes W. J.;
- Lafeber, Floris P. J. G.;
- van Roon, Joël A. G.
Publication type:
Journal Article
IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7Rα.
Published in:
Rheumatology, 2012, v. 51, n. 6, p. 996, doi. 10.1093/rheumatology/ker448
By:
- Bikker, Angela;
- Moret, Fréderique M.;
- Kruize, Aike A.;
- Bijlsma, Johannes W. J.;
- Lafeber, Floris P. J. G.;
- van Roon, Joël A. G.
Publication type:
Article
Changes in macrophage inhibitory factor correlate with changes in bone mineral density in glucocorticoid-treated patients with rheumatoid arthritis.
Published in:
2011
By:
- Hoes, Jos N.;
- Van der Goes, Marlies C.;
- Jacobs, Johannes W. G.;
- Lafeber, Floris P. G. J.;
- Bijlsma, Johannes W. J.;
- Van Roon, Joel A. G.
Publication type:
Journal Article
Changes in macrophage inhibitory factor correlate with changes in bone mineral density in glucocorticoid-treated patients with rheumatoid arthritis.
Published in:
Rheumatology, 2011, v. 50, n. 10, p. 1921, doi. 10.1093/rheumatology/ker268
By:
- Hoes, Jos N.;
- Van der Goes, Marlies C.;
- Jacobs, Johannes W. G.;
- Lafeber, Floris P. G. J.;
- Bijlsma, Johannes W. J.;
- Van Roon, Joel A. G.
Publication type:
Article
Numbers of CD25+Foxp3+ T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients.
Published in:
Rheumatology, 2010, v. 49, n. 11, p. 2084, doi. 10.1093/rheumatology/keq237
By:
- Van Roon, Joël A. G.;
- Hartgring, Sarita A. Y.;
- Van der Wurff-Jacobs, Kim M. G.;
- Bijlsma, Johannes W. J.;
- Lafeber, Floris P. J. G.
Publication type:
Article
Decreased expression of TSLP in labial salivary glands of patients with primary Sjögren's syndrome is associated with local- and systemic disease parameters.
Published in:
2012
By:
- Hillen, Maarten R.;
- Bikker, Angela;
- Kruize, Aike A.;
- Wenting-van Wijk, Marion;
- Lafeber, Floris P. J. G.;
- Hack, C. Erik;
- Radstake, Timothy R. D. J.;
- van Roon, Joel A. G.
Publication type:
Abstract
Increased frequencies of circulating CXCL10-, CXCL8- and CCL4-producing monocytes and Siglec-3-expressing myeloid dendritic cells in systemic sclerosis patients.
Published in:
Inflammation Research, 2018, v. 67, n. 2, p. 169, doi. 10.1007/s00011-017-1106-7
By:
- Carvalheiro, Tiago;
- Horta, Sara;
- van Roon, Joel A. G.;
- Santiago, Mariana;
- Salvador, Maria J.;
- Trindade, Hélder;
- Radstake, Timothy R. D. J.;
- da Silva, José A. P.;
- Paiva, Artur
Publication type:
Article
Increased CCL25 and T Helper Cells Expressing CCR9 in the Salivary Glands of Patients With Primary Sjögren's Syndrome: Potential New Axis in Lymphoid Neogenesis.
Published in:
Arthritis & Rheumatology, 2017, v. 69, n. 10, p. 2038, doi. 10.1002/art.40182
By:
- Blokland, Sofie L. M.;
- Hillen, Maarten R.;
- Kruize, Aike A.;
- Meller, Stephan;
- Homey, Bernhard;
- Smithson, Glennda M.;
- Radstake, Timothy R. D. J.;
- van Roon, Joel A. G.
Publication type:
Article
Association of MicroRNA-618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis.
Published in:
Arthritis & Rheumatology, 2017, v. 69, n. 9, p. 1891, doi. 10.1002/art.40163
By:
- Rossato, Marzia;
- Affandi, Alsya J.;
- Thordardottir, Soley;
- Wichers, Catharina G. K.;
- Cossu, Marta;
- Broen, Jasper C. A.;
- Moret, Frederique M.;
- Bossini‐Castillo, Lara;
- Chouri, Eleni;
- van Bon, Lenny;
- Wolters, Femke;
- Marut, Wioleta;
- van der Kroef, Maarten;
- Silva‐Cardoso, Sandra;
- Bekker, Cornelis P. J.;
- Dolstra, Harry;
- van Laar, Jacob M.;
- Martin, Javier;
- van Roon, Joel A. G.;
- Reedquist, Kris A.
Publication type:
Article
Editorial: Closing in on the Role of Thymic Stromal Lymphopoietin Inhibition as a Therapeutic Entry Point for Systemic Sclerosis.
Published in:
Arthritis & Rheumatology, 2016, v. 68, n. 11, p. 2571, doi. 10.1002/art.39815
By:
- Affandi, Alsya J.;
- van Roon, Joel A. G.
Publication type:
Article
Association of Increased Treg Cell Levels With Elevated Indoleamine 2,3-Dioxygenase Activity and an Imbalanced Kynurenine Pathway in Interferon-Positive Primary Sjögren's Syndrome.
Published in:
Arthritis & Rheumatology, 2016, v. 68, n. 7, p. 1688, doi. 10.1002/art.39629
By:
- Maria, Naomi I.;
- van Helden‐Meeuwsen, Cornelia G.;
- Brkic, Zana;
- Paulissen, Sandra M. J.;
- Steenwijk, Eline C.;
- Dalm, Virgil A.;
- van Daele, Paul L.;
- Martin van Hagen, P.;
- Kroese, Frans G. M.;
- van Roon, Joel A. G.;
- Harkin, Andrew;
- Dik, Willem A.;
- Drexhage, Hemmo A.;
- Lubberts, Erik;
- Versnel, Marjan A.
Publication type:
Article
Enrichment of Activated Group 3 Innate Lymphoid Cells in Psoriatic Arthritis Synovial Fluid.
Published in:
Arthritis & Rheumatology, 2015, v. 67, n. 10, p. 2673, doi. 10.1002/art.39261
By:
- Leijten, Emmerik F. A.;
- van Kempen, Tessa S.;
- Boes, Marianne;
- Michels‐van Amelsfort, Jocea M. R.;
- Hijnen, Dirkjan;
- Hartgring, Sarita A. Y.;
- van Roon, Joel A. G.;
- Wenink, Mark H.;
- Radstake, Timothy R. D. J.
Publication type:
Article
Decreased circulating CXCR3 + CCR9+T helper cells are associated with elevated levels of their ligands CXCL10 and CCL25 in the salivary gland of patients with Sjögren's syndrome to facilitate their concerted migration.
Published in:
Scandinavian Journal of Immunology, 2020, v. 91, n. 3, p. 1, doi. 10.1111/sji.12852
By:
- Blokland, Sofie L. M.;
- Kislat, Andreas;
- Homey, Bernhard;
- Smithson, Glennda M.;
- Kruize, Aike A.;
- Radstake, Timothy R. D. J.;
- van Roon, Joel A. G.
Publication type:
Article
Interleukin-10 protects against blood-induced joint damage.
Published in:
British Journal of Haematology, 2008, v. 142, n. 6, p. 953, doi. 10.1111/j.1365-2141.2008.07278.x
By:
- Jansen, Nathalie W. D.;
- Roosendaal, Goris;
- Hooiveld, Michel J. J.;
- Bijlsma, Johannes W. J.;
- Van Roon, Joël A. G.;
- Theobald, Matthias;
- Lafeber, Floris P. J. G.
Publication type:
Article
Decreased expression of thymic stromal lymphopoietin in salivary glands of patients with primary Sjögren's syndrome is associated with increased disease activity.
Published in:
Modern Rheumatology, 2016, v. 26, n. 1, p. 105, doi. 10.3109/14397595.2015.1054089
By:
- Hillen, Maarten R.;
- Kruize, Aike A.;
- Bikker, Angela;
- Wijk, Marion Wenting-van;
- Radstake, Timothy R. D. J.;
- Hack, Cornelis E.;
- Lafeber, Floris P. J. G.;
- van Roon, Joel A. G.
Publication type:
Article
CCR9/CXCR5 Co-Expressing CD4 T Cells Are Increased in Primary Sjögren's Syndrome and Are Enriched in PD-1/ICOS-Expressing Effector T Cells.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 15, p. 11952, doi. 10.3390/ijms241511952
By:
- Hinrichs, Anneline C.;
- Kruize, Aike A.;
- Lafeber, Floris P. J. G.;
- Leavis, Helen L.;
- van Roon, Joel A. G.
Publication type:
Article
Circulating small non-coding RNAs reflect IFN status and B cell hyperactivity in patients with primary Sjögren’s syndrome.
Published in:
PLoS ONE, 2018, v. 13, n. 2, p. 1, doi. 10.1371/journal.pone.0193157
By:
- Lopes, Ana P.;
- Hillen, Maarten R.;
- Chouri, Eleni;
- Blokland, Sofie L. M.;
- Bekker, Cornelis P. J.;
- Kruize, Aike A.;
- Rossato, Marzia;
- van Roon, Joel A. G.;
- Radstake, Timothy R. D. J.
Publication type:
Article
IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain.
Published in:
Journal of Neuroscience, 2016, v. 38, n. 28, p. 7353, doi. 10.1523/JNEUROSCI.0092-16.2016
By:
- Eijkelkamp, Niels;
- Steen-Louws, Cristine;
- Hartgring, Sarita A. Y.;
- Willemen, Hanneke L. D. M.;
- Prado, Judith;
- Lafeber, Floris P. J. G.;
- Heijnen, Cobi J.;
- Hack, C. E.;
- van Roon, Joel A. G.;
- Kavelaars, Annemieke
Publication type:
Article

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