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An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56.
Published in:
Angewandte Chemie, 2017, v. 129, n. 13, p. 3590, doi. 10.1002/ange.201611907
By:
- Pettinger, Jonathan;
- Le Bihan, Yann‐Vaï;
- Widya, Marcella;
- van Montfort, Rob L. M.;
- Jones, Keith;
- Cheeseman, Matthew D.
Publication type:
Article
An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56.
Published in:
Angewandte Chemie International Edition, 2017, v. 56, n. 13, p. 3536, doi. 10.1002/anie.201611907
By:
- Pettinger, Jonathan;
- Le Bihan, Yann-Vaï;
- Widya, Marcella;
- Van Montfort, Rob L. M.;
- Jones, Keith;
- Cheeseman, Matthew D.
Publication type:
Article
Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.
Published in:
Biochemical Journal, 2019, v. 476, n. 18, p. 2521, doi. 10.1042/BCJ20190383
By:
- Felisberto-Rodrigues, Catarina;
- Thomas, Jemima C.;
- McAndrew, Craig;
- Le Bihan, Yann-Vaï;
- Burke, Rosemary;
- Workman, Paul;
- van Montfort, Rob L. M.
Publication type:
Article
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Published in:
Scientific Reports, 2016, p. 34701, doi. 10.1038/srep34701
By:
- Jones, Alan M.;
- Westwood, Isaac M.;
- Osborne, James D.;
- Matthews, Thomas P.;
- Cheeseman, Matthew D.;
- Rowlands, Martin G.;
- Jeganathan, Fiona;
- Burke, Rosemary;
- Lee, Diane;
- Kadi, Nadia;
- Liu, Manjuan;
- Richards, Meirion;
- McAndrew, Craig;
- Yahya, Norhakim;
- Dobson, Sarah E.;
- Jones, Keith;
- Workman, Paul;
- Collins, Ian;
- van Montfort, Rob L. M.
Publication type:
Article
Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2.
Published in:
PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0065689
By:
- Silva-Santisteban, M. Cris;
- Westwood, Isaac M.;
- Boxall, Kathy;
- Brown, Nathan;
- Peacock, Sam;
- McAndrew, Craig;
- Barrie, Elaine;
- Richards, Meirion;
- Mirza, Amin;
- Oliver, Antony W.;
- Burke, Rosemary;
- Hoelder, Swen;
- Jones, Keith;
- Aherne, G. Wynne;
- Blagg, Julian;
- Collins, Ian;
- Garrett, Michelle D.;
- van Montfort, Rob L. M.
Publication type:
Article
Analysis of water patterns in protein kinase binding sites.
Published in:
Proteins, 2011, v. 79, n. 7, p. 2109, doi. 10.1002/prot.23032
By:
- Barillari, Caterina;
- Duncan, Anna L.;
- Westwood, Isaac M.;
- Blagg, Julian;
- van Montfort, Rob L. M.
Publication type:
Article
Front Cover: A Degron Blocking Strategy Towards Improved CRL4CRBN Recruiting PROTAC Selectivity (ChemBioChem 23/2023).
Published in:
ChemBioChem, 2023, v. 24, n. 23, p. 1, doi. 10.1002/cbic.202300692
By:
- Bouguenina, Habib;
- Scarpino, Andrea;
- O'Hanlon, Jack A.;
- Warne, Justin;
- Wang, Hannah Z.;
- Wah Hak, Laura Chan;
- Sadok, Amine;
- McAndrew, P. Craig;
- Stubbs, Mark;
- Pierrat, Olivier A.;
- Hahner, Tamas;
- Cabry, Marc P.;
- Le Bihan, Yann‐Vaï;
- Mitsopoulos, Costas;
- Sialana, Fernando J.;
- Roumeliotis, Theodoros I.;
- Burke, Rosemary;
- van Montfort, Rob L. M.;
- Choudhari, Jyoti;
- Chopra, Rajesh
Publication type:
Article
A Degron Blocking Strategy Towards Improved CRL4CRBN Recruiting PROTAC Selectivity.
Published in:
ChemBioChem, 2023, v. 24, n. 23, p. 1, doi. 10.1002/cbic.202300351
By:
- Bouguenina, Habib;
- Scarpino, Andrea;
- O'Hanlon, Jack A.;
- Warne, Justin;
- Wang, Hannah Z.;
- Wah Hak, Laura Chan;
- Sadok, Amine;
- McAndrew, P. Craig;
- Stubbs, Mark;
- Pierrat, Olivier A.;
- Hahner, Tamas;
- Cabry, Marc P.;
- Le Bihan, Yann‐Vaï;
- Mitsopoulos, Costas;
- Sialana, Fernando J.;
- Roumeliotis, Theodoros I.;
- Burke, Rosemary;
- van Montfort, Rob L. M.;
- Choudhari, Jyoti;
- Chopra, Rajesh
Publication type:
Article
Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B.
Published in:
Nature, 2003, v. 423, n. 6941, p. 773, doi. 10.1038/nature01681
By:
- van Montfort, Rob L. M.;
- Congreve, Miles;
- Tisi, Dominic;
- Carr, Robin;
- Jhoti, Harren
Publication type:
Article
Synthesis of a Ribose-Incorporating Medium Ring Scaffold via a Challenging Ring-Closing Metathesis Reaction.
Published in:
European Journal of Organic Chemistry, 2016, v. 2016, n. 26, p. 4496, doi. 10.1002/ejoc.201600756
By:
- Rankin, Stuart S.;
- Caldwell, John J.;
- Cronin, Nora B.;
- van Montfort, Rob L. M.;
- Collins, Ian
Publication type:
Article
Structure-based drug design: aiming for a perfect fit.
Published in:
Essays in Biochemistry, 2017, v. 61, n. 5, p. 431, doi. 10.1042/EBC20170052
By:
- van Montfort, Rob L. M.;
- Workman, Paul
Publication type:
Article
Crystal structure and assembly of a eukaryotic small heat shock protein.
Published in:
Nature Structural Biology, 2001, v. 8, n. 12, p. 1025, doi. 10.1038/nsb722
By:
- van Montfort, Rob L. M.;
- Basha, Eman;
- Friedrich, Kenneth L.;
- Slingsby, Christine;
- Vierling, Elizabeth
Publication type:
Article
The functional importance of structural differences between the mannitol-specific IIAmannitol and the regulatory IIAnitrogen.
Published in:
Protein Science: A Publication of the Protein Society, 1998, v. 7, n. 10, p. 2210, doi. 10.1002/pro.5560071019
By:
- Van Montfort, Rob L. M.;
- Dijkstra, Bauke W.
Publication type:
Article
Revealing the delta lady.
Published in:
2010
By:
- Workman, Paul;
- van Montfort, Rob L. M.
Publication type:
Correction Notice
PI(3) Kinases: Revealing the delta lady.
Published in:
Nature Chemical Biology, 2010, v. 6, n. 2, p. 82, doi. 10.1038/nchembio.305
By:
- Workman, Paul;
- van Montfort, Rob L. M.
Publication type:
Article

Found: 15

An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56.

An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56.

Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.

A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.

Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2.

Analysis of water patterns in protein kinase binding sites.

Front Cover: A Degron Blocking Strategy Towards Improved CRL4<sup>CRBN</sup> Recruiting PROTAC Selectivity (ChemBioChem 23/2023).

A Degron Blocking Strategy Towards Improved CRL4<sup>CRBN</sup> Recruiting PROTAC Selectivity.

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B.

Synthesis of a Ribose-Incorporating Medium Ring Scaffold via a Challenging Ring-Closing Metathesis Reaction.

Structure-based drug design: aiming for a perfect fit.

Crystal structure and assembly of a eukaryotic small heat shock protein.

The functional importance of structural differences between the mannitol-specific IIA<sup>mannitol</sup> and the regulatory IIA<sup>nitrogen</sup>.

Revealing the delta lady.

PI(3) Kinases: Revealing the delta lady.