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Cohort Profile: East London Genes & Health (ELGH), a community-based population genomics and health study in British Bangladeshi and British Pakistani people.
Published in:
2020
By:
- Finer, Sarah;
- Martin, Hilary C;
- Khan, Ahsan;
- Hunt, Karen A;
- MacLaughlin, Beverley;
- Ahmed, Zaheer;
- Ashcroft, Richard;
- Durham, Ceri;
- MacArthur, Daniel G;
- McCarthy, Mark I;
- Robson, John;
- Trivedi, Bhavi;
- Griffiths, Chris;
- Wright, John;
- Trembath, Richard C;
- Heel, David A van;
- van Heel, David A
Publication type:
journal article
Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32095-5
By:
- Huang, Qin Qin;
- Sallah, Neneh;
- Dunca, Diana;
- Trivedi, Bhavi;
- Hunt, Karen A.;
- Hodgson, Sam;
- Lambert, Samuel A.;
- Arciero, Elena;
- Wright, John;
- Griffiths, Chris;
- Trembath, Richard C.;
- Hemingway, Harry;
- Inouye, Michael;
- Finer, Sarah;
- van Heel, David A.;
- Lumbers, R. Thomas;
- Martin, Hilary C.;
- Kuchenbaecker, Karoline
Publication type:
Article
The combination of transcriptomics and informatics identifies pathways targeted by miR-204 during neurogenesis and axon guidance.
Published in:
Nucleic Acids Research, 2014, v. 42, n. 12, p. 7793, doi. 10.1093/nar/gku498
By:
- Conte, Ivan;
- Merella, Stefania;
- Garcia-Manteiga, Jose Manuel;
- Migliore, Chiara;
- Lazarevic, Dejan;
- Carrella, Sabrina;
- Marco-Ferreres, Raquel;
- Avellino, Raffaella;
- Davidson, Nathan Paul;
- Emmett, Warren;
- Sanges, Remo;
- Bockett, Nicholas;
- Van Heel, David;
- Meroni, Germana;
- Bovolenta, Paola;
- Stupka, Elia;
- Banfi, Sandro
Publication type:
Article
Fine-scale population structure and demographic history of British Pakistanis.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27394-2
By:
- Arciero, Elena;
- Dogra, Sufyan A.;
- Malawsky, Daniel S.;
- Mezzavilla, Massimo;
- Tsismentzoglou, Theofanis;
- Huang, Qin Qin;
- Hunt, Karen A.;
- Mason, Dan;
- Sharif, Saghira Malik;
- van Heel, David A.;
- Sheridan, Eamonn;
- Wright, John;
- Small, Neil;
- Carmi, Shai;
- Iles, Mark M.;
- Martin, Hilary C.
Publication type:
Article
Calcium Channel TRPV6 Expression in Human Duodenum: Different Relationships to the Vitamin D System and Aging in Men and Women.
Published in:
Journal of Bone & Mineral Research, 2006, v. 21, n. 11, p. 1770, doi. 10.1359/jbmr.060721
By:
- Walters, Julian RF;
- Balesaria, Sara;
- Chavele, Konstantia-Maria;
- Taylor, Vivienne;
- Berry, Jacqueline L;
- Khair, Umma;
- Barley, Natalie F;
- van Heel, David A;
- Field, Jennifer;
- Hayat, Jamal O;
- Bhattacharjee, Abhik;
- Jeffery, Rosemary;
- Poulsom, Richard
Publication type:
Article
Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.
Published in:
Nature Genetics, 2015, v. 47, n. 6, p. 577, doi. 10.1038/ng.3268
By:
- Gutierrez-Achury, Javier;
- Zhernakova, Alexandra;
- Romanos, Jihane;
- Wijmenga, Cisca;
- Pulit, Sara L;
- Trynka, Gosia;
- Hunt, Karen A;
- van Heel, David A;
- Raychaudhuri, Soumya;
- de Bakker, Paul I W
Publication type:
Article
New susceptibility genes for ulcerative colitis.
Published in:
Nature Genetics, 2008, v. 40, n. 6, p. 686, doi. 10.1038/ng0608-686
By:
- Dubois, Patrick C.;
- van Heel, David A.
Publication type:
Article
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
Published in:
Nature Genetics, 2007, v. 39, n. 7, p. 827, doi. 10.1038/ng2058
By:
- van Heel, David A.;
- Franke, Lude;
- Hunt, Karen A.;
- Gwilliam, Rhian;
- Zhernakova, Alexandra;
- Inouye, Mike;
- Wapenaar, Martin C.;
- Barnardo, Martin C. N. M.;
- Bethel, Graeme;
- Holmes, Geoffrey K. T.;
- Feighery, Con;
- Jewell, Derek;
- Kelleher, Dermot;
- Kumar, Parveen;
- Travis, Simon;
- Walters, Julian R. F.;
- Sanders, David S.;
- Howdle, Peter;
- Swift, Jill;
- Playford, Raymond J.
Publication type:
Article
Exome Sequencing of 75 Individuals from Multiply Affected Coeliac Families and Large Scale Resequencing Follow Up.
Published in:
PLoS ONE, 2015, v. 10, n. 1, p. 1, doi. 10.1371/journal.pone.0116845
By:
- Mistry, Vanisha;
- Bockett, Nicholas A.;
- Levine, Adam P.;
- Mirza, Muddassar M.;
- Hunt, Karen A.;
- Ciclitira, Paul J.;
- Hummerich, Holger;
- Neuhausen, Susan L.;
- Simpson, Michael A.;
- Plagnol, Vincent;
- van Heel, David A.
Publication type:
Article
Effective Detection of Human Leukocyte Antigen Risk Alleles in Celiac Disease Using Tag Single Nucleotide Polymorphisms.
Published in:
PLoS ONE, 2008, v. 3, n. 5, p. 1, doi. 10.1371/journal.pone.0002270
By:
- Monsuur, Alienke J.;
- de Bakker, Paul I. W.;
- Zhernakova, Alexandra;
- Pinto, Dalila;
- Verduijn, Willem;
- Romanos, Jihane;
- Auricchio, Renata;
- Lopez, Ana;
- van Heel, David A.;
- Crusius, J. Bart A.;
- Wijmenga, Cisca
Publication type:
Article
Genetic insights into common pathways and complex relationships among immune-mediated diseases.
Published in:
Nature Reviews Genetics, 2013, v. 14, n. 9, p. 661, doi. 10.1038/nrg3502
By:
- Parkes, Miles;
- Cortes, Adrian;
- van Heel, David A.;
- Brown, Matthew A.
Publication type:
Article
CYP2C19 loss‐of‐function alleles are not associated with higher prevalence of gastrointestinal bleeds in those who have been prescribed antidepressants: Analysis in a British‐South Asian cohort.
Published in:
British Journal of Clinical Pharmacology, 2023, v. 89, n. 11, p. 3432, doi. 10.1111/bcp.15762
By:
- Magavern, Emma F.;
- van Heel, David A.;
- Smedley, Damian;
- Caulfield, Mark J.
Publication type:
Article
A common CTLA4 haplotype associated with coeliac disease.
Published in:
European Journal of Human Genetics, 2005, v. 13, n. 4, p. 440, doi. 10.1038/sj.ejhg.5201357
By:
- Hunt, Karen A.;
- McGovern, Dermot P. B.;
- Kumar, Parveen J.;
- Ghosh, Subrata;
- Travis, Simon P. L.;
- Walters, Julian R. F.;
- Jewell, Derek P.;
- Playford, Raymond J.;
- van Heel, David A.
Publication type:
Article
Replication and extension studies of inflammatory bowel disease susceptibility regions confirm linkage to chromosome 6p (IBD3).
Published in:
European Journal of Human Genetics, 2001, v. 9, n. 8, p. 627, doi. 10.1038/sj.ejhg.5200687
By:
- Dechairo, Bryan;
- Dimon, Claire;
- van Heel, David;
- Mackay, Ian;
- Edwards, Mark;
- Scambler, Peter;
- Jewell, Derek;
- Cardon, Lon;
- Lench, Nicholas;
- Carey, Alisoun
Publication type:
Article
Integrating polygenic risk scores in the prediction of type 2 diabetes risk and subtypes in British Pakistanis and Bangladeshis: A population-based cohort study.
Published in:
PLoS Medicine, 2022, v. 19, n. 5, p. 1, doi. 10.1371/journal.pmed.1003981
By:
- Hodgson, Sam;
- Huang, Qin Qin;
- Sallah, Neneh;
- Griffiths, Chris J.;
- Newman, William G.;
- Trembath, Richard C.;
- Wright, John;
- Lumbers, R. Thomas;
- Kuchenbaecker, Karoline;
- van Heel, David A.;
- Mathur, Rohini;
- Martin, Hilary C.;
- Finer, Sarah;
- Genes & Health Research Team
Publication type:
Article
Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo.
Published in:
2007
By:
- Cartwright N;
- Murch O;
- McMaster SK;
- Paul-Clark MJ;
- van Heel DA;
- Ryffel B;
- Quesniaux VFJ;
- Evans TW;
- Thiemermann C;
- Mitchell JA;
- Cartwright, Neil;
- Murch, Oliver;
- McMaster, Shaun K;
- Paul-Clark, Mark J;
- van Heel, David A;
- Ryffel, Bernhard;
- Quesniaux, Valerie F J;
- Evans, Timothy W;
- Thiemermann, Christoph;
- Mitchell, Jane A
Publication type:
journal article
Selective NOD1 Agonists Cause Shock and Organ Injury/Dysfunction In Vivo.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2007, v. 175, n. 6, p. 595, doi. 10.1164/rccm.200608-1103OC
By:
- Cartwright, Nell;
- Murch, Oliver;
- McMaster, Shaun K.;
- Paul-Clark, Mark J.;
- van Heel, David A.;
- Ryffel, Bernhard;
- Quesniaux, Valerie F. J.;
- Evans, Timothy W.;
- Thiemermann, Christoph;
- Mitchell, Jane A.
Publication type:
Article
Polygenic risk score prediction of multiple sclerosis in individuals of South Asian ancestry.
Published in:
Brain Communications, 2023, v. 5, n. 2, p. 1, doi. 10.1093/braincomms/fcad041
By:
- Breedon, Joshua R.;
- Marshall, Charles R.;
- Giovannoni, Gavin;
- van Heel, David A.;
- Dobson, Ruth;
- Jacobs, Benjamin M.
Publication type:
Article
Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease.
Published in:
Science Translational Medicine, 2010, v. 2, n. 41, p. 1, doi. 10.1126/scitranslmed.3001012
By:
- Tye-Din, Jason A.;
- Stewart, Jessica A.;
- Dromey, James A.;
- Beissbarth, Tim;
- van Heel, David A.;
- Tatham, Arthur;
- Henderson, Kate;
- Mannering, Stuart I.;
- Gianfrani, Carmen;
- Jewell, Derek P.;
- Hill, Adrian V. S.;
- McCluskey, James;
- Rossjohn, Jamie;
- Anderson, Robert P.
Publication type:
Article
Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03109-y
By:
- Corbin, Laura J.;
- Tan, Vanessa Y.;
- Hughes, David A.;
- Wade, Kaitlin H.;
- Paul, Dirk S.;
- Tansey, Katherine E.;
- Butcher, Frances;
- Dudbridge, Frank;
- Howson, Joanna M.;
- Jallow, Momodou W.;
- John, Catherine;
- Kingston, Nathalie;
- Lindgren, Cecilia M.;
- O’Donavan, Michael;
- O’Rahilly, Stephen;
- Owen, Michael J.;
- Palmer, Colin N. A.;
- Pearson, Ewan R.;
- Scott, Robert A.;
- van Heel, David A.
Publication type:
Article
Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00323-y
By:
- Narasimhan, Vagheesh M.;
- Rahbari, Raheleh;
- Scally, Aylwyn;
- Wuster, Arthur;
- Mason, Dan;
- Xue, Yali;
- Wright, John;
- Trembath, Richard C.;
- Maher, Eamonn R.;
- van Heel, David A.;
- Auton, Adam;
- Hurles, Matthew E.;
- Tyler-Smith, Chris;
- Durbin, Richard
Publication type:
Article
Unraveling the Regulatory Mechanisms Underlying Tissue-Dependent Genetic Variation of Gene Expression.
Published in:
PLoS Genetics, 2012, v. 8, n. 1, p. 1, doi. 10.1371/journal.pgen.1002431
By:
- Jingyuan Fu;
- Wolfs, Marcel G. M.;
- Deelen, Patrick;
- Westra, Harm-Jan;
- Fehrmann, Rudolf S. N.;
- Te Meerman, Gerard J.;
- Buurman, Wim A.;
- Rensen, Sander S. M.;
- Groen, Harry J. M.;
- Weersma, Rinse K.;
- Van den Berg, Leonard H.;
- Veldink, Jan;
- Ophoff, Roel A.;
- Snieder, Harold;
- van Heel, David;
- Jansen, Ritsert C.;
- Hofker, Marten H.;
- Wijmenga, Cisca;
- Franke, Lude
Publication type:
Article
Pervasive Sharing of Genetic Effects in Autoimmune Disease.
Published in:
PLoS Genetics, 2011, v. 7, n. 8, p. 1, doi. 10.1371/journal.pgen.1002254
By:
- Cotsapas, Chris;
- Voight, Benjamin F.;
- Rossin, Elizabeth;
- Lage, Kasper;
- Neale, Benjamin M.;
- Wallace, Chris;
- Abecasis, Gonçalo R.;
- Barrett, Jeffrey C.;
- Behrens, Timothy;
- Cho, Judy;
- De Jager, Philip L.;
- Elder, James T.;
- Graham, Robert R.;
- Gregersen, Peter;
- Klareskog, Lars;
- Siminovitch, Katherine A.;
- van Heel, David A.;
- Wijmenga, Cisca;
- Worthington, Jane;
- Todd, John A.
Publication type:
Article
A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease.
Published in:
PLoS Genetics, 2011, v. 7, n. 1, p. 1, doi. 10.1371/journal.pgen.1001283
By:
- Festen, Eleonora A. M.;
- Goyette, Philippe;
- Green, Todd;
- Boucher, Gabrielle;
- Beauchamp, Claudine;
- Trynka, Gosia;
- Dubois, Patrick C.;
- Lagacé, Caroline;
- Stokkers, Pieter C. F.;
- Hommes, Daan W.;
- Barisani, Donatella;
- Palmieri, Orazio;
- Annese, Vito;
- van Heel, David A.;
- Weersma, Rinse K.;
- Daly, Mark J.;
- Wijmenga, Cisca;
- Rioux, John D.
Publication type:
Article
A revised sequence of the human β7 integrin gene (ITGB7) promoter region obtained by inverse PCR.
Published in:
Immunogenetics, 2000, v. 51, n. 10, p. 863, doi. 10.1007/s002510000218
By:
- van Heel, David A.;
- Allen, Maxine;
- Jewell, Derek P.;
- Carey, Alisoun H.
Publication type:
Article
Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing.
Published in:
Human Molecular Genetics, 2010, v. 19, n. 1, p. 122, doi. 10.1093/hmg/ddp473
By:
- Heap, Graham A.;
- Yang, Jennie H.M.;
- Downes, Kate;
- Healy, Barry C.;
- Hunt, Karen A.;
- Bockett, Nicholas;
- Franke, Lude;
- Dubois, Patrick C.;
- Mein, Charles A.;
- Dobson, Richard J.;
- Albert, Thomas J.;
- Rodesch, Matthew J.;
- Clayton, David G.;
- Todd, John A.;
- van Heel, David A.;
- Plagnol, Vincent
Publication type:
Article
The genetics of chronic inflammatory diseases.
Published in:
Human Molecular Genetics, 2009, v. 18, n. R1, p. R101, doi. 10.1093/hmg/ddp001
By:
- Heap, Graham A.;
- van Heel, David A.
Publication type:
Article
Association study of the IL18RAP locus in three European populations with coeliac disease.
Published in:
Human Molecular Genetics, 2009, v. 18, n. 6, p. 1148, doi. 10.1093/hmg/ddn438
By:
- Koskinen, Lotta L.E.;
- Einarsdottir, Elisabet;
- Dukes, Emma;
- Heap, Graham A. R.;
- Dubois, Patrick;
- Korponay-Szabo, Ilma R.;
- Kaukinen, Katri;
- Kurppa, Kalle;
- Ziberna, Fabiana;
- Vatta, Serena;
- Not, Tarcisio;
- Ventura, Alessandro;
- Sistonen, Pertti;
- Ádány, Róza;
- Pocsai, Zsuzsa;
- Széles, György;
- Mäki, Markku;
- Kere, Juha;
- Wijmenga, Cisca;
- van Heel, David A.
Publication type:
Article
Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease.
Published in:
Human Molecular Genetics, 2005, v. 14, n. 10, p. 1245, doi. 10.1093/hmg/ddi135
By:
- McGovern, Dermot P.B.;
- Hysi, Pirro;
- Ahmad, Tariq;
- van Heel, David A.;
- Moffatt, Miriam F.;
- Carey, Alisoun;
- Cookson, William O.C.;
- Jewell, Derek P.
Publication type:
Article
Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs.
Published in:
Human Molecular Genetics, 2004, v. 13, n. 7, p. 763, doi. 10.1093/hmg/ddh090
By:
- van Heel, David A.;
- Fisher, Sheila A.;
- Kirby, Andrew;
- Daly, Mark J.;
- Rioux, John D.;
- Lewis, Cathryn M.
Publication type:
Article
The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants.
Published in:
Human Molecular Genetics, 2003, v. 12, n. 20, p. 2569, doi. 10.1093/hmg/ddg281
By:
- van Heel, David A.;
- Dechairo, Bryan M.;
- Dawson, Gary;
- McGovern, Dermot P.B.;
- Negoro, Kenichi;
- Carey, Alisoun H.;
- Cardon, Lon R.;
- Mackay, Ian;
- Jewell, Derek P.;
- Lench, Nicholas J.
Publication type:
Article
Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF-κB transcription factors.
Published in:
Human Molecular Genetics, 2002, v. 11, n. 11, p. 1281, doi. 10.1093/hmg/11.11.1281
By:
- van Heel, David A.;
- Udalova, Irina A.;
- De Silva, Arjuna P.;
- McGovern, Dermot P.;
- Kinouchi, Yoshitaka;
- Hull, Jeremy;
- Lench, Nicholas J.;
- Cardon, Lon R.;
- Carey, Alisoun H.;
- Jewell, Derek P.;
- Kwiatkowski, Dominic
Publication type:
Article
A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48938-2
By:
- Jermy, Bradley;
- Läll, Kristi;
- Wolford, Brooke N.;
- Wang, Ying;
- Zguro, Kristina;
- Cheng, Yipeng;
- Kanai, Masahiro;
- Kanoni, Stavroula;
- Yang, Zhiyu;
- Hartonen, Tuomo;
- Monti, Remo;
- Wanner, Julian;
- Youssef, Omar;
- FinnGen;
- Lippert, Christoph;
- van Heel, David;
- Okada, Yukinori;
- McCartney, Daniel L.;
- Hayward, Caroline;
- Marioni, Riccardo E.
Publication type:
Article
MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects.
Published in:
Bioinformatics, 2011, v. 27, n. 15, p. 2104, doi. 10.1093/bioinformatics/btr323
By:
- Westra, Harm-Jan;
- Jansen, Ritsert C.;
- Fehrmann, Rudolf S. N.;
- te Meerman, Gerard J.;
- van Heel, David;
- Wijmenga, Cisca;
- Franke, Lude
Publication type:
Article
Response.
Published in:
European Journal of Immunology, 2006, v. 36, n. 10, p. 2818, doi. 10.1002/eji.200636631
By:
- van Heel, David A;
- Playford, Raymond J
Publication type:
Article
Normal responses to specific NOD1-activating peptidoglycan agonists in the presence of the NOD2 frameshift and other mutations in Crohn's disease.
Published in:
European Journal of Immunology, 2006, v. 36, n. 6, p. 1629, doi. 10.1002/eji.200535636
By:
- van Heel, David A.;
- Hunt, Karen A.;
- Ghosh, Subrata;
- Hervé, Mireille;
- Playford, Raymond J.
Publication type:
Article
Modulation of dendritic cell phenotype and functionin an in vitro model of the intestinal epithelium.
Published in:
European Journal of Immunology, 2006, v. 36, n. 4, p. 864, doi. 10.1002/eji.200535497
By:
- Butler, Matt;
- Ng, Chi-Yan;
- van Heel, David A.;
- Lombardi, Giovanna;
- Lechler, Robert;
- Playford, Raymond J.;
- Ghosh, Subrata
Publication type:
Article
Synergistic enhancement of Toll-like receptor responses by NOD1 activation.
Published in:
European Journal of Immunology, 2005, v. 35, n. 8, p. 2471, doi. 10.1002/eji.200526296
By:
- van Heel, David A.;
- Ghosh, Subrata;
- Butler, Matt;
- Hunt, Karen;
- Foxwell, Brian Michael J.;
- Mengin-Lecreulx, Dominique;
- Playford, Raymond J.
Publication type:
Article
Sex Differences in HLA DQ in Celiac Disease.
Published in:
2009
By:
- Dubois, Patrick;
- Hunt, Karen;
- van Heel, David
Publication type:
Letter

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