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Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan.
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- Parasites & Vectors, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13071-021-04947-4
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- Article
Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan.
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- Parasites & Vectors, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13071-021-04947-4
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- Article
Population Dynamics and Structural Effects at Short and Long Range Support the Hypothesis of the Selective Advantage of the G614 SARS-CoV-2 Spike Variant.
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- Molecular Biology & Evolution, 2021, v. 38, n. 5, p. 1966, doi. 10.1093/molbev/msaa337
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Design of Disruptors of the Hsp90–Cdc37 Interface.
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- Molecules, 2020, v. 25, n. 2, p. 360, doi. 10.3390/molecules25020360
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Mapping multiple potential ATP binding sites on the matrix side of the bovine ADP/ATP carrier by the combined use of MD simulation and docking.
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- Journal of Molecular Modeling, 2012, v. 18, n. 6, p. 2377, doi. 10.1007/s00894-011-1255-5
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- Article
Computational Analysis of Dengue Virus Envelope Protein (E) Reveals an Epitope with Flavivirus Immunodiagnostic Potential in Peptide Microarrays.
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- International Journal of Molecular Sciences, 2019, v. 20, n. 8, p. 1921, doi. 10.3390/ijms20081921
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- Article
A Novel Mecp2<sup>Y120D</sup> Knock-in Model Displays Similar Behavioral Traits But Distinct Molecular Features Compared to the Mecp2-Null Mouse Implying Precision Medicine for the Treatment of Rett Syndrome.
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- Molecular Neurobiology, 2019, v. 56, n. 7, p. 4838, doi. 10.1007/s12035-018-1412-2
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A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors.
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- Protein Science: A Publication of the Protein Society, 2015, v. 24, n. 9, p. 1370, doi. 10.1002/pro.2708
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Geometrical constraints limiting the poly(ADP-ribose) conformation investigated by molecular dynamics simulation.
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- Biopolymers, 2014, v. 101, n. 1, p. 78, doi. 10.1002/bip.22280
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Replacement of the Human Topoisomerase Linker Domain with the Plasmodial Counterpart Renders the Enzyme Camptothecin Resistant.
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- PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0068404
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Binding of an Indenoisoquinoline to the Topoisomerase- DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction.
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- PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0051354
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- Article
Development of Derivatives of 3, 39-Diindolylmethane as Potent Leishmania donovani Bi-Subunit Topoisomerase IB Poisons.
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- PLoS ONE, 2011, v. 6, n. 12, p. 1, doi. 10.1371/journal.pone.0028493
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- Article
Structural and Dynamical Effects Induced by the Anticancer Drug Topotecan on the Human Topoisomerase I -- DNA Complex.
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- PLoS ONE, 2010, v. 5, n. 6, p. 1, doi. 10.1371/journal.pone.0010934
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- Article
Characterization of the differences in the cyclopiazonic acid binding mode to mammalian and P. Falciparum Ca<sup>2+</sup> pumps: A computational study.
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- Proteins, 2015, v. 83, n. 3, p. 564, doi. 10.1002/prot.24734
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Frontispiece: Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads.
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- Chemistry - A European Journal, 2017, v. 23, n. 22, p. n/a, doi. 10.1002/chem.201782262
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Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads.
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- Chemistry - A European Journal, 2017, v. 23, n. 22, p. 5188, doi. 10.1002/chem.201700169
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- Article
Simulations of DNA topoisomerase 1B bound to supercoiled DNA reveal changes in the flexibility pattern of the enzyme and a secondary protein–DNA binding site.
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- Nucleic Acids Research, 2014, v. 42, n. 14, p. 9304, doi. 10.1093/nar/gku654
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- Article
ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism.
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- Nucleic Acids Research, 2011, v. 39, n. 8, p. 3295, doi. 10.1093/nar/gkq1284
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Interaction between natural compounds and human topoisomerase I.
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- Biological Chemistry, 2012, v. 393, n. 11, p. 1327, doi. 10.1515/hsz-2012-0240
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Peptides for Infectious Diseases: From Probe Design to Diagnostic Microarrays.
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- Antibodies (2073-4468), 2019, v. 8, n. 1, p. 23, doi. 10.3390/antib8010023
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A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance.
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- Nucleic Acids Research, 2008, v. 36, n. 17, p. 5635, doi. 10.1093/nar/gkn557
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Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations.
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- Nucleic Acids Research, 2008, v. 36, n. 17, p. 5645, doi. 10.1093/nar/gkn558
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- Article
Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin.
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- Journal of Amino Acids, 2012, p. 1, doi. 10.1155/2012/206083
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Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers.
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- Journal of Experimental & Clinical Cancer Research (17569966), 2014, v. 33, n. 1, p. 1, doi. 10.1186/s13046-014-0071-z
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Evidences of a natively unfolded state for the human topoisomerase IB N-terminal domain.
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- Amino Acids, 2011, v. 41, n. 4, p. 945, doi. 10.1007/s00726-010-0794-x
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Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico.
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- Molecular Cancer, 2013, v. 12, n. 1, p. 1, doi. 10.1186/1476-4598-12-100
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- Article