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BAR502/fibrate conjugates: synthesis, biological evaluation and metabolic profile.
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- Frontiers in Chemistry, 2024, p. 1, doi. 10.3389/fchem.2024.1425867
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- Article
Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists.
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- Scientific Reports, 2016, p. 19008, doi. 10.1038/srep19008
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- Article
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism.
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- Scientific Reports, 2015, p. 16605, doi. 10.1038/srep16605
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- Article
Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma.
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- Cells (2073-4409), 2022, v. 11, n. 21, p. 3482, doi. 10.3390/cells11213482
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- Article
Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases.
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- Frontiers in Pharmacology, 2017, v. 8, p. 1, doi. 10.3389/fphar.2017.00162
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- Article
Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation.
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- Nutrients, 2019, v. 11, n. 5, p. 1, doi. 10.3390/nu11051132
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- Article
The First Total Synthesis of Solomonsterol B, a Marine Pregnane X Receptor Agonist.
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- European Journal of Organic Chemistry, 2012, v. 2012, n. 27, p. 5187, doi. 10.1002/ejoc.201200619
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- Article
Quantum Mechanical Calculation of Coupling Constants in the Configurational Analysis of Flexible Systems: Determination of the Configuration of Callipeltin A.
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- European Journal of Organic Chemistry, 2006, v. 2006, n. 3, p. 604, doi. 10.1002/ejoc.200500740
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- Article
Isolation of Plakinamine I: A New Steroidal Alkaloid from the Marine Sponge Corticium sp. and Synthesis of an Analogue Model Compound.
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- European Journal of Organic Chemistry, 2005, v. 2005, n. 20, p. 4359, doi. 10.1002/ejoc.200500364
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- Article
Stereochemical Studies on Sphinxolide: Advances in the J-Based NMR Determination of the Relative Configuration of Flexible Systems.
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- European Journal of Organic Chemistry, 2001, v. 2001, n. 1, p. 39, doi. 10.1002/1099-0690(200101)2001:1<39::AID-EJOC39>3.0.CO;2-9
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- Article
Atorvastatin protects against liver and vascular damage in a model of diet induced steatohepatitis by resetting FXR and GPBAR1 signaling.
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- FASEB Journal, 2022, v. 36, n. 1, p. 1, doi. 10.1096/fj.202101397R
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- Article
The bile acid activated receptors GPBAR1 and FXR exert antagonistic effects on autophagy.
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- FASEB Journal, 2021, v. 35, n. 1, p. 1, doi. 10.1096/fj.202001386R
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- Article
Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis.
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- FASEB Journal, 2019, v. 33, n. 2, p. 2809, doi. 10.1096/fj.201801373RR
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- Article
Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition.
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- FASEB Journal, 2012, v. 26, n. 7, p. 3021, doi. 10.1096/fj.11-195701
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- Article
Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties.
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- Molecules, 2019, v. 24, n. 6, p. 1043, doi. 10.3390/molecules24061043
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- Article
Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1.
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- Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-38840-z
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- Article
Analysis of Gastric Cancer Transcriptome Allows the Identification of Histotype Specific Molecular Signatures With Prognostic Potential.
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- Frontiers in Oncology, 2021, v. 11, p. N.PAG, doi. 10.3389/fonc.2021.663771
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- Article
Coupling Interrupted Fischer and Multicomponent Joullié‐Ugi to Chase Chemical Diversity: from Batch to Sustainable Flow Synthesis of Peptidomimetics.
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- ChemMedChem, 2021, v. 16, n. 24, p. 3795, doi. 10.1002/cmdc.202100474
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- Article
Discovering New G-Quadruplex DNA Catalysts in Enantioselective Sulfoxidation Reaction.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 3, p. 1092, doi. 10.3390/ijms23031092
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- Article
Bile Acids Activated Receptors Regulate Innate Immunity.
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- Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.01853
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Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma.
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- Frontiers in Oncology, 2023, v. 13, p. 1, doi. 10.3389/fonc.2023.1140730
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- Article
Perthamide C Inhibits eNOS and iNOS Expression and Has Immunomodulating Activity In Vivo.
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- PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0057801
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- Article
The Bile Acid Sensor FXR Is Required for Immune-Regulatory Activities of TLR-9 in Intestinal Inflammation.
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- PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054472
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- Article
Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis.
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- PLoS ONE, 2012, v. 7, n. 1, p. 1, doi. 10.1371/journal.pone.0030443
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- Article
Preliminary Structure-Activity Relationship on Theonellasterol, a New Chemotype of FXR Antagonist, from the Marine Sponge Theonella swinhoei.
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- Marine Drugs, 2012, v. 10, n. 11, p. 2448, doi. 10.3390/md10112448
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Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei.
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- Marine Drugs, 2011, v. 9, n. 6, p. 1133, doi. 10.3390/md9061133
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- Article
Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists.
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- Scientific Reports, 2017, p. 43290, doi. 10.1038/srep43290
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- Article
BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis.
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- Scientific Reports, 2017, p. 42801, doi. 10.1038/srep42801
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Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis.
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- Scientific Reports, 2017, p. 41055, doi. 10.1038/srep41055
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Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands.
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- Scientific Reports, 2016, p. 29320, doi. 10.1038/srep29320
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- Article
Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists.
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- Molecules, 2023, v. 28, n. 6, p. 2840, doi. 10.3390/molecules28062840
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- Article
Discovery of a Potent and Orally Active Dual GPBAR1/CysLT<sub>1</sub>R Modulator for the Treatment of Metabolic Fatty Liver Disease.
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- Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.858137
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- Article
Cover Feature: Characterisation of the Dynamic Interactions between Complex N‐Glycans and Human CD22 (ChemBioChem 1‐2/2020).
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- ChemBioChem, 2020, v. 21, n. 1/2, p. 3, doi. 10.1002/cbic.201900762
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Characterisation of the Dynamic Interactions between Complex N‐Glycans and Human CD22.
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- ChemBioChem, 2020, v. 21, n. 1/2, p. 129, doi. 10.1002/cbic.201900295
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Chemical Proteomics Reveals Heat Shock Protein 60 To Be the Main Cellular Target of the Marine Bioactive Sesterterpene Suvanine.
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- ChemBioChem, 2012, v. 13, n. 13, p. 1953, doi. 10.1002/cbic.201200291
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- Article
Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH.
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- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-28647-4
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- Article
Next-Generation Sequencing Analysis of Gastric Cancer Identifies the Leukemia Inhibitory Factor Receptor as a Driving Factor in Gastric Cancer Progression and as a Predictor of Poor Prognosis.
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- Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.939969
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- Article
Defective Bile Acid Signaling Promotes Vascular Dysfunction, Supporting a Role for G-Protein Bile Acid Receptor 1/Farnesoid X Receptor Agonism and Statins in the Treatment of Nonalcoholic Fatty Liver Disease.
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- Journal of the American Heart Association, 2023, v. 12, n. 23, p. 1, doi. 10.1161/JAHA.123.031241
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- Article
Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H<sub>2</sub>S Generation and Endothelin-1.
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- PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0141082
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- Article
Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling.
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- PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0129866
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- Article
Theonella : A Treasure Trove of Structurally Unique and Biologically Active Sterols.
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- Marine Drugs, 2023, v. 21, n. 5, p. 291, doi. 10.3390/md21050291
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- Article
Bioactive Cembrane Derivatives from the Indian Ocean Soft Coral, Sinularia kavarattiensis.
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- Marine Drugs, 2014, v. 12, n. 7, p. 4045, doi. 10.3390/md12074045
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- Article
Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis.
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- Marine Drugs, 2014, v. 12, n. 1, p. 36, doi. 10.3390/md12010036
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- Article
Oxygenated Polyketides from Plakinastrella mamillaris as a New Chemotype of PXR Agonists.
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- Marine Drugs, 2013, v. 11, n. 7, p. 2314, doi. 10.3390/md11072314
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- Article