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Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome.
Published in:
Frontiers in Aging Neuroscience, 2021, v. 13, p. 1, doi. 10.3389/fnagi.2021.700280
By:
- Chen, Xu-Qiao;
- Xing, Zhuo;
- Chen, Quang-Di;
- Salvi, Richard J.;
- Zhang, Xuming;
- Tycko, Benjamin;
- Mobley, William C.;
- Yu, Y. Eugene
Publication type:
Article
Genetic mapping of APP and amyloid‐β biology modulation by trisomy 21.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.063898
By:
- Mumford, Paige;
- Tosh, Justin;
- Anderle, Silvia;
- Gkanatsiou, Eleni;
- Lau, Gloria;
- Noy, Sue;
- Cleverley, Karen;
- Saito, Takashi;
- Saido, Takaomi C.;
- Yu, Eugene Y.;
- Brinkmalm, Gunnar;
- Portelius, Erik;
- Blennow, Kaj;
- Zetterberg, Henrik;
- Tybulewicz, Victor;
- Fisher, Elizabeth;
- Wiseman, Frances K
Publication type:
Article
Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1203, doi. 10.1002/alz.12463
By:
- Sawa, Mariko;
- Overk, Cassia;
- Becker, Ann;
- Derse, Dominique;
- Albay, Ricardo;
- Weldy, Kim;
- Salehi, Ahmad;
- Beach, Thomas G.;
- Doran, Eric;
- Head, Elizabeth;
- Yu, Y. Eugene;
- Mobley, William C
Publication type:
Article
A Deficiency in the Region Homologous to Human 17q21.33-q23.2 Causes Heart Defects in Mice.
Published in:
Genetics, 2006, v. 173, n. 1, p. 297, doi. 10.1534/genetics.105.054833
By:
- Yu, Y. Eugene;
- Morishima, Masae;
- Pao, Annie;
- Ding-Yan Wang;
- Xiao-Yan Wen;
- Baldini, Antonio;
- Bradley, Allan
Publication type:
Article
Altered tongue muscle contractile properties coincide with altered swallow function in the adult Ts65Dn mouse model of down syndrome.
Published in:
Frontiers in Neurology, 2024, p. 1, doi. 10.3389/fneur.2024.1384572
By:
- Glass, Tiffany J.;
- Russell, John A.;
- Fisher, Erin H.;
- Ostadi, Marziyeh;
- Aori, Nanyumuzi;
- Yu, Y. Eugene;
- Connor, Nadine P.
Publication type:
Article
Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration.
Published in:
2018
By:
- Watson-Scales, Sheona;
- Kalmar, Bernadett;
- Lana-Elola, Eva;
- Gibbins, Dorota;
- La Russa, Federica;
- Wiseman, Frances;
- Williamson, Matthew;
- Saccon, Rachele;
- Slender, Amy;
- Olerinyova, Anna;
- Mahmood, Radma;
- Nye, Emma;
- Cater, Heather;
- Wells, Sara;
- Yu, Y. Eugene;
- Bennett, David L. H.;
- Greensmith, Linda;
- Fisher, Elizabeth M. C.;
- Tybulewicz, Victor L. J.
Publication type:
Abstract
Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.
Published in:
PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0134861
By:
- Belichenko, Pavel V.;
- Kleschevnikov, Alexander M.;
- Becker, Ann;
- Wagner, Grant E.;
- Lysenko, Larisa V.;
- Yu, Y. Eugene;
- Mobley, William C.
Publication type:
Article
Homozygous inactivation of the LGI1 gene results in hypomyelination in the peripheral and central nervous systems.
Published in:
Journal of Neuroscience Research, 2010, v. 88, n. 15, p. 3328, doi. 10.1002/jnr.22496
By:
- Silva, Jeane;
- Sharma, Suash;
- Hughes, Bernard;
- Yu, Y. Eugene;
- Cowell, John K.
Publication type:
Article
Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models.
Published in:
Genome Biology, 2015, v. 16, p. 1, doi. 10.1186/s13059-015-0827-6
By:
- Mendioroz, Maite;
- Do, Catherine;
- Xiaoling Jiang;
- Chunhong Liu;
- Darbary, Huferesh K.;
- Lang, Charles F.;
- Lin, John;
- Thomas, Anna;
- Abu-Amero, Sayeda;
- Stanier, Philip;
- Temkin, Alexis;
- Yale, Alexander;
- Meng-Min Liu;
- Yang Li;
- Salas, Martha;
- Kerkel, Kristi;
- Capone, George;
- Silverman, Wayne;
- Yu, Y. Eugene;
- Moore, Gudrun
Publication type:
Article
Genetic dissection of the Down syndrome critical region.
Published in:
Human Molecular Genetics, 2015, v. 24, n. 22, p. 6540, doi. 10.1093/hmg/ddv364
By:
- Xiaoling Jiang;
- Chunhong Liu;
- Tao Yu;
- Li Zhang;
- Kai Meng;
- Zhuo Xing;
- Belichenko, Pavel V.;
- Kleschevnikov, Alexander M.;
- Pao, Annie;
- Peresie, Jennifer;
- Wie, Sarah;
- Mobley, William C.;
- Yu, Y. Eugene
Publication type:
Article
Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits.
Published in:
Human Molecular Genetics, 2014, v. 23, n. 3, p. 578, doi. 10.1093/hmg/ddt446
By:
- Zhang, Li;
- Meng, Kai;
- Jiang, Xiaoling;
- Liu, Chunhong;
- Pao, Annie;
- Belichenko, Pavel V.;
- Kleschevnikov, Alexander M.;
- Josselyn, Sheena;
- Liang, Ping;
- Ye, Ping;
- Mobley, William C.;
- Yu, Y. Eugene
Publication type:
Article
Mouse-based genetic modeling and analysis of Down syndrome.
Published in:
British Medical Bulletin, 2016, v. 120, n. 1, p. 111, doi. 10.1093/bmb/ldw040
By:
- Zhuo Xing;
- Yichen Li;
- Pao, Annie;
- Bennett, Abigail S.;
- Tycko, Benjamin;
- Mobley, William C.;
- Yu, Y. Eugene
Publication type:
Article
Mouse Models for Down Syndrome-Associated Developmental Cognitive Disabilities.
Published in:
Developmental Neuroscience, 2011, v. 33, n. 5, p. 404, doi. 10.1159/000329422
By:
- Liu, Chunhong;
- Belichenko, Pavel V.;
- Zhang, Li;
- Fu, Dawei;
- Kleschevnikov, Alexander M.;
- Baldini, Antonio;
- Antonarakis, Stylianos E.;
- Mobley, William C.;
- Yu, Y. Eugene
Publication type:
Article
SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome.
Published in:
Biomedicines, 2024, v. 12, n. 3, p. 543, doi. 10.3390/biomedicines12030543
By:
- Pechous, Roger D.;
- Malaviarachchi, Priyangi A.;
- Xing, Zhuo;
- Douglas, Avrium;
- Crane, Samantha D.;
- Theriot, Hayley M.;
- Zhang, Zijing;
- Ghaffarieh, Alireza;
- Huang, Lu;
- Yu, Y. Eugene;
- Zhang, Xuming
Publication type:
Article
Hearing impairment in murine model of Down syndrome.
Published in:
Frontiers in Genetics, 2022, v. 13, p. 1, doi. 10.3389/fgene.2022.936128
By:
- Guang-Di Chen;
- Li Li;
- McCall, Andrew;
- Ding, Dalian;
- Zhuo Xing;
- Yu, Y. Eugene;
- Salvi, Richard
Publication type:
Article
Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability.
Published in:
Human Molecular Genetics, 2010, v. 19, n. 9, p. 1702, doi. 10.1093/hmg/ddq047
By:
- Yu, Y. Eugene;
- Wen, Lei;
- Silva, Jeane;
- Li, Zhongyou;
- Head, Karen;
- Sossey-Alaoui, Khalid;
- Pao, Annie;
- Mei, Lin;
- Cowell, John K.
Publication type:
Article
Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities.
Published in:
Human Molecular Genetics, 2007, v. 16, n. 11, p. 1359, doi. 10.1093/hmg/ddm086
By:
- Li, Zhongyou;
- Yu, Tao;
- Morishima, Masae;
- Pao, Annie;
- LaDuca, Jeffrey;
- Conroy, Jeffrey;
- Nowak, Norma;
- Matsui, Sei-Ichi;
- Shiraishi, Isao;
- Yu, Y. Eugene
Publication type:
Article
Coat Color-Facilitated Efficient Generation and Analysis of a Mouse Model of Down Syndrome Triplicated for All Human Chromosome 21 Orthologous Regions.
Published in:
Genes, 2021, v. 12, n. 8, p. 1215, doi. 10.3390/genes12081215
By:
- Li, Yichen;
- Xing, Zhuo;
- Yu, Tao;
- Pao, Annie;
- Daadi, Marcel;
- Yu, Y. Eugene
Publication type:
Article

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