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Precise and Facile Endotracheal Lung-tumor-implantation Mouse Model Visualized by GFP Expression.
Published in:
In Vivo, 2023, v. 37, n. 4, p. 1477, doi. 10.21873/invivo.13231
By:
- YUSUKE AOKI;
- KOBAYASHI, KEITA J.;
- VARSHNEY, NUNDINI;
- KUBOTA, YUTARO;
- MASAKI, NORIYUKI;
- OBARA, KOYA;
- WANG, JUSTIN D.;
- YASUNORI TOME;
- BOUVET, MICHAEL;
- KOTARO NISHIDA;
- HOFFMAN, ROBERT M.
Publication type:
Article
Non-invasively Imageable Tibia-tumor-fragment Implantation Experimental-bone-metastasis Mouse Model of GFP-expressing Prostate Cancer.
Published in:
In Vivo, 2022, v. 36, n. 4, p. 1647, doi. 10.21873/invivo.12876
By:
- AOKI, YUSUKE;
- MASAKI, NORIYUKI;
- TOME, YASUNORI;
- KUBOTA, YUTARO;
- AOKI, YASUYO;
- BOUVET, MICHAEL;
- NISHIDA, KOTARO;
- HOFFMAN, ROBERT M.
Publication type:
Article
A new era in the management of spinal metastasis.
Published in:
Frontiers in Oncology, 2024, p. 1, doi. 10.3389/fonc.2024.1374915
By:
- Tadatsugu Morimoto;
- Yu Toda;
- Michiyuki Hakozaki;
- Permsak Paholpak;
- Kazuyuki Watanabe;
- Kinshi Kato;
- Masatsugu Tsukamoto;
- Hirohito Hirata;
- Yoichi Kaneuchi;
- Yasunori Tome;
- Satomi Nagamine;
- Kotaro Nishida;
- Hiroo Katsuya;
- Yoshihiro Matsumoto;
- Koji Otani;
- Masaaki Mawatari;
- Takuya Nikaido
Publication type:
Article
Oncological and functional outcomes of modified arthroscopic resection for intra-articular tenosynovial giant cell tumor of the knee using multiple portals.
Published in:
Journal of Orthopaedic Surgery (10225536), 2023, v. 31, n. 3, p. 1, doi. 10.1177/10225536231220413
By:
- Kotaro Higa;
- Fuminari Uehara;
- Chinatsu Azuma;
- Hiromichi Oshiro;
- Yasunori Tome;
- Kotaro Nishida
Publication type:
Article
Humeral head histopathological changes in cuff tear arthropathy.
Published in:
Journal of Orthopaedic Surgery (10225536), 2019, v. 27, n. 1, p. 1, doi. 10.1177/2309499018816428
By:
- Toma, Takashi;
- Suenaga, Naoki;
- Taniguchi, Noboru;
- Oizumi, Naomi;
- Yamaguchi, Hiroshi;
- Tome, Yasunori;
- Kanaya, Fuminori
Publication type:
Article
The influence of COVID-19 epidemic on the number of orthopaedic surgeries in Japan.
Published in:
Journal of Orthopaedic Science, 2024, v. 29, n. 5, p. 1319, doi. 10.1016/j.jos.2023.08.016
By:
- Yamada, Koji;
- Shinozaki, Tomohiro;
- Ito, Junji;
- Nakajima, Susumu;
- Nakagawa, Koichi;
- Furuya, Takeo;
- Wada, Kanichiro;
- Kobayashi, Naomi;
- Shiba, Naoto;
- Kajino, Yoshitomo;
- Kawamura, Naohiro;
- Hamada, Daisuke;
- Tome, Yasunori;
- Nishimoto, Akira;
- Sakai, Toshinori;
- Hasegawa, Kazutoshi;
- Iijima, Yuki;
- Takeshita, Katsushi;
- Nakashima, Yasuharu
Publication type:
Article
Fluorescence-Guided Surgery of Retroperitoneal-Implanted Human Fibrosarcoma in Nude Mice Delays or Eliminates Tumor Recurrence and Increases Survival Compared to Bright-Light Surgery.
Published in:
PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0116865
By:
- Uehara, Fuminari;
- Hiroshima, Yukihiko;
- Miwa, Shinji;
- Tome, Yasunori;
- Yano, Shuya;
- Yamamoto, Mako;
- Matsumoto, Yasunori;
- Maehara, Hiroki;
- Tanaka, Kazuhiro;
- Bouvet, Michael;
- Kanaya, Fuminori;
- Hoffman, Robert M.
Publication type:
Article
In vivo gene transfer between interacting human osteosarcoma cell lines is associated with acquisition of enhanced metastatic potential.
Published in:
Journal of Cellular Biochemistry, 2009, v. 108, n. 2, p. 362, doi. 10.1002/jcb.22259
By:
- Tome, Yasunori;
- Tsuchiya, Hiroyuki;
- Hayashi, Katsuhiro;
- Yamauchi, Kensuke;
- Sugimoto, Naotoshi;
- Kanaya, Fuminori;
- Tomita, Katsuro;
- Hoffman, Robert M.
Publication type:
Article
Long-Term Results of Kyocera Modular Limb Salvage System after Resection of Tumors in the Distal Part of the Femur: Report from Japanese Musculoskeletal Oncology Group Study.
Published in:
Cancers, 2022, v. 14, n. 4, p. 870, doi. 10.3390/cancers14040870
By:
- Nakamura, Tomoki;
- Matsumine, Akihiko;
- Toda, Yu;
- Takenaka, Satoshi;
- Outani, Hidetatsu;
- Fujiwara, Tomohiro;
- Nishida, Yoshihiro;
- Tsukushi, Satoshi;
- Tome, Yasunori;
- Kawamoto, Teruya;
- Kito, Munehisa;
- Shinohara, Naohiro;
- Tomita, Masato;
- Torigoe, Tomoaki;
- Sudo, Akihiro;
- Kawano, Hirotaka
Publication type:
Article
Denosumab administration for bone metastases from solid tumors: a retrospective cross-sectional study.
Published in:
BMC Cancer, 2023, v. 23, n. 1, p. 1, doi. 10.1186/s12885-023-11495-w
By:
- Mizuta, Kohei;
- Oshiro, Hiromichi;
- Katsuki, Ryo;
- Tsuha, Yuichi;
- Aoki, Yusuke;
- Tome, Yasunori;
- Nishida, Kotaro
Publication type:
Article
Color‐coded chemotherapy: S/G2‐phase‐trapping by methioninase pre‐treatment, indicated by FUCCI imaging, enables highly effective cancer chemotherapy (923.11).
Published in:
FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.923.11
By:
- Yano, Shuya;
- Tome, Yasunori;
- Digman, Michelle;
- Momiyama, Masashi;
- Suetsugu, Atsushi;
- Gratton, Enrico;
- Hoffman, Robert
Publication type:
Article
Imaging characteristics of tenosynovial giant cell tumors on 18F-fluorodeoxyglucose positron emission tomography/computed tomography: a retrospective observational study.
Published in:
BMC Musculoskeletal Disorders, 2023, v. 24, n. 1, p. 1, doi. 10.1186/s12891-023-06730-1
By:
- Mizuta, Kohei;
- Oshiro, Hiromichi;
- Tsuha, Yuichi;
- Tome, Yasunori;
- Nishida, Kotaro
Publication type:
Article
Imaging the interaction of αv integrin‐GFP in osteosarcoma cells with RFP‐expressing host stromal cells and tumor‐scaffold collagen in the primary and metastatic tumor microenvironment.
Published in:
Journal of Cellular Biochemistry, 2019, v. 120, n. 1, p. 283, doi. 10.1002/jcb.27353
By:
- Tome, Yasunori;
- Kiyuna, Tasuku;
- Uehara, Fuminari;
- Bouvet, Michael;
- Tsuchiya, Hiroyuki;
- Kanaya, Fuminori;
- Hoffman, Robert M.
Publication type:
Article
Tumor‐targeting Salmonella typhimurium A1‐R arrests a doxorubicin‐resistant PDGFRA‐amplified patient‐derived orthotopic xenograft mouse model of pleomorphic liposarcoma.
Published in:
Journal of Cellular Biochemistry, 2018, v. 119, n. 9, p. 7827, doi. 10.1002/jcb.27183
By:
- Kiyuna, Tasuku;
- Tome, Yasunori;
- Murakami, Takashi;
- Zhao, Ming;
- Miyake, Kentaro;
- Igarashi, Kentaro;
- Kawaguchi, Kei;
- Miyake, Masuyo;
- Oshiro, Hiromichi;
- Higuchi, Takashi;
- Li, Yunfeng;
- Dry, Sarah M.;
- Nelson, Scott D.;
- Russell, Tara A.;
- Eckardt, Mark A.;
- Singh, Arun S.;
- Kanaya, Fuminori;
- Eilber, Fritz C.;
- Hoffman, Robert M.
Publication type:
Article
Analysis of Stroma Labeling During Multiple Passage of a Sarcoma Imageable Patient-Derived Orthotopic Xenograft (iPDOX) in Red Fluorescent Protein Transgenic Nude Mice.
Published in:
Journal of Cellular Biochemistry, 2017, v. 118, n. 10, p. 3367, doi. 10.1002/jcb.25991
By:
- Kiyuna, Tasuku;
- Murakami, Takashi;
- Tome, Yasunori;
- Kawaguchi, Kei;
- Igarashi, Kentaro;
- Miyake, Kentaro;
- Kanaya, Fuminori;
- Singh, Arun;
- Eilber, Fritz C.;
- Hoffman, Robert M.
Publication type:
Article
Labeling the Stroma of a Patient-Derived Orthotopic Xenograft (PDOX) Mouse Model of Undifferentiated Pleomorphic Soft-Tissue Sarcoma With Red Fluorescent Protein for Rapid Non-Invasive Imaging for Drug Screening.
Published in:
Journal of Cellular Biochemistry, 2017, v. 118, n. 2, p. 361, doi. 10.1002/jcb.25643
By:
- Kiyuna, Tasuku;
- Murakami, Takashi;
- Tome, Yasunori;
- Igarashi, Kentaro;
- Kawaguchi, Kei;
- Russell, Tara;
- Eckardt, Mark A.;
- Crompton, Joseph;
- Singh, Arun;
- Bernthal, Nicholas;
- Bukata, Susan;
- Federman, Noah;
- Kanaya, Fuminori;
- Eilber, Fritz C.;
- Hoffman, Robert M.
Publication type:
Article
Use of αv Integrin Linked to GFP to Image Molecular Dynamics in Trafficking Cancer-Cell Emboli.
Published in:
Journal of Cellular Biochemistry, 2017, v. 118, n. 1, p. 26, doi. 10.1002/jcb.25603
By:
- Tome, Yasunori;
- Yano, Shuya;
- Sugimoto, Naotoshi;
- Mii, Sumiyuki;
- Bouvet, Michael;
- Tsuchiya, Hiroyuki;
- Kanaya, Fuminori;
- Hoffman, Robert M.
Publication type:
Article
Cover Image, Volume 118, Number 1, January 2017.
Published in:
2017
By:
- Tome, Yasunori;
- Yano, Shuya;
- Sugimoto, Naotoshi;
- Mii, Sumiyuki;
- Bouvet, Michael;
- Tsuchiya, Hiroyuki;
- Kanaya, Fuminori;
- Hoffman, Robert M.
Publication type:
Other
Comparison of UVB and UVC Effects on the DNA Damage-Response Protein 53BP1 in Human Pancreatic Cancer.
Published in:
Journal of Cellular Biochemistry, 2014, v. 115, n. 10, p. 1724, doi. 10.1002/jcb.24837
By:
- Uehara, Fuminari;
- Miwa, Shinji;
- Tome, Yasunori;
- Hiroshima, Yukihiko;
- Yano, Shuya;
- Yamamoto, Mako;
- Efimova, Elena;
- Matsumoto, Yasunori;
- Maehara, Hiroki;
- Bouvet, Michael;
- Kanaya, Fuminori;
- Hoffman, Robert M.
Publication type:
Article
Osteosarcoma Cells Enhance Angiogenesis Visualized by Color-Coded Imaging in the In Vivo Gelfoam® Assay.
Published in:
Journal of Cellular Biochemistry, 2014, v. 115, n. 9, p. 1490, doi. 10.1002/jcb.24799
By:
- Uehara, Fuminari;
- Tome, Yasunori;
- Miwa, Shinji;
- Hiroshima, Yukihiko;
- Yano, Shuya;
- Yamamoto, Mako;
- Mii, Sumiyuki;
- Maehara, Hiroki;
- Bouvet, Michael;
- Kanaya, Fuminori;
- Hoffman, Robert M.
Publication type:
Article
3-Dimensional Tissue Is Formed From Cancer Cells In Vitro on Gelfoam®, But Not on MatrigelTM.
Published in:
Journal of Cellular Biochemistry, 2014, v. 115, n. 8, p. 1362, doi. 10.1002/jcb.24780
By:
- Tome, Yasunori;
- Uehara, Fuminari;
- Mii, Sumiyuki;
- Yano, Shuya;
- Zhang, Lei;
- Sugimoto, Naotoshi;
- Maehara, Hiroki;
- Bouvet, Michael;
- Tsuchiya, Hiroyuki;
- Kanaya, Fuminori;
- Hoffman, Robert M.
Publication type:
Article
Imaging UVC-induced DNA damage response in models of minimal cancer.
Published in:
Journal of Cellular Biochemistry, 2013, v. 114, n. 11, p. 2493, doi. 10.1002/jcb.24599
By:
- Miwa, Shinji;
- Yano, Shuya;
- Hiroshima, Yukihiko;
- Tome, Yasunori;
- Uehara, Fuminari;
- Mii, Sumiyuki;
- Efimova, Elena V.;
- Kimura, Hiroaki;
- Hayashi, Katsuhiro;
- Tsuchiya, Hiroyuki;
- Hoffman, Robert M.
Publication type:
Article
Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy.
Published in:
Journal of Cellular Biochemistry, 2013, v. 114, n. 11, p. 2454, doi. 10.1002/jcb.24593
By:
- Miwa, Shinji;
- Yano, Shuya;
- Tome, Yasunori;
- Sugimoto, Naotoshi;
- Hiroshima, Yukihiko;
- Uehara, Fuminari;
- Mii, Sumiyuki;
- Kimura, Hiroaki;
- Hayashi, Katsuhiro;
- Efimova, Elena V.;
- Fujiwara, Toshiyoshi;
- Tsuchiya, Hiroyuki;
- Hoffman, Robert M.
Publication type:
Article
The role of hair follicle nestin-expressing stem cells during whisker sensory-nerve growth in long-term 3D culture.
Published in:
Journal of Cellular Biochemistry, 2013, v. 114, n. 7, p. 1674, doi. 10.1002/jcb.24509
By:
- Mii, Sumiyuki;
- Duong, Jennifer;
- Tome, Yasunori;
- Uchugonova, Aisada;
- Liu, Fang;
- Amoh, Yasuyuki;
- Saito, Norimitsu;
- Katsuoka, Kensei;
- Hoffman, Robert M.
Publication type:
Article
Expression of PD-L1 Is Increased by Methionine Restriction Using Recombinant Methioninase in Human Colorectal Cancer Cells.
Published in:
Cancer Genomics & Proteomics (1109-6535), 2024, v. 21, n. 4, p. 395, doi. 10.21873/cgp.20457
By:
- KOHEI MIZUTA;
- BYUNG MO KANG;
- QINGHONG HAN;
- YUTARO KUBOTA;
- SEI MORINAGA;
- MOTOKAZU SATO;
- BOUVET, MICHAEL;
- YASUNORI TOME;
- KOTARO NISHIDA;
- HOFFMAN, ROBERT M.
Publication type:
Article
The Combination of Methioninase and Ethionine Exploits Methionine Addiction to Selectively Eradicate Osteosarcoma Cells and Not Normal Cells and Synergistically Down-regulates the Expression of C-MYC.
Published in:
Cancer Genomics & Proteomics (1109-6535), 2023, v. 20, p. 679, doi. 10.21873/cgp.20415
By:
- YUSUKE AOKI;
- YUTARO KUBOTA;
- QINGHONG HAN;
- NORIYUKI MASAKI;
- KOYA OBARA;
- BOUVET, MICHAEL;
- CHAWLA, SANT P.;
- YASUNORI TOME;
- KOTARO NISHIDA;
- HOFFMAN, ROBERT M.
Publication type:
Article
Oncogenes and Methionine Addiction of Cancer: Role of c-MYC.
Published in:
Cancer Genomics & Proteomics (1109-6535), 2023, v. 20, n. 2, p. 165, doi. 10.21873/cgp.20371
By:
- YUSUKE AOKI;
- QINGHONG HAN;
- YUTARO KUBOTA;
- NORIYUKI MASAKI;
- OBARA, KOYA;
- YASUNORI TOME;
- BOUVET, MICHAEL;
- KOTARO NISHIDA;
- HOFFMAN, ROBERT M.
Publication type:
Article
Deletion of MTAP Highly Sensitizes Osteosarcoma Cells to Methionine Restriction With Recombinant Methioninase.
Published in:
Cancer Genomics & Proteomics (1109-6535), 2022, v. 19, n. 3, p. 299, doi. 10.21873/cgp.20321
By:
- YUSUKE AOKI;
- YASUNORI TOME;
- QINGHONG HAN;
- JUN YAMAMOTO;
- KAZUYUKI HAMADA;
- NORIYUKI MASAKI;
- YUTARO KUBOTA;
- BOUVET, MICHAEL;
- KOTARO NISHIDA;
- HOFFMAN, ROBERT M.
Publication type:
Article
Over-methylation of Histone H3 Lysines Is a Common Molecular Change Among the Three Major Types of Soft-tissue Sarcoma in Patient-derived Xenograft (PDX) Mouse Models.
Published in:
Cancer Genomics & Proteomics (1109-6535), 2021, v. 18, n. 6, p. 715, doi. 10.21873/cgp.20292
By:
- YUSUKE AOKI;
- JUN YAMAMOTO;
- YASUNORI TOME;
- KAZUYUKI HAMADA;
- NORIYUKI MASAKI;
- SACHIKO INUBUSHI;
- YOSHIHIKO TASHIRO;
- MICHAEL BOUVET;
- ITARU ENDO;
- KOTARO NISHIDA;
- HOFFMAN, ROBERT M.
Publication type:
Article
Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model.
Published in:
2018
By:
- Kiyuna, Tasuku;
- Tome, Yasunori;
- Murakami, Takashi;
- Kawaguchi, Kei;
- Igarashi, Kentaro;
- Miyake, Kentaro;
- Miyake, Masuyo;
- Li, Yunfeng;
- Nelson, Scott D.;
- Dry, Sarah M.;
- Singh, Arun S.;
- Russell, Tara A.;
- Elliott, Irmina;
- Singh, Shree Ram;
- Kanaya, Fuminori;
- Eilber, Fritz C.;
- Hoffman, Robert M.
Publication type:
journal article
An mTOR and VEGFR inhibitor combination arrests a doxorubicin resistant lung metastatic osteosarcoma in a PDOX mouse model.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-87553-9
By:
- Oshiro, Hiromichi;
- Tome, Yasunori;
- Miyake, Kentaro;
- Higuchi, Takashi;
- Sugisawa, Norihiko;
- Kanaya, Fuminori;
- Nishida, Kotaro;
- Hoffman, Robert M.
Publication type:
Article
Imaging the inhibition by anti-β1 integrin antibody of lung seeding of single osteosarcoma cells in live mice.
Published in:
International Journal of Cancer, 2012, v. 131, n. 9, p. 2027, doi. 10.1002/ijc.27475
By:
- Kimura, Hiroaki;
- Tome, Yasunori;
- Momiyama, Masashi;
- Hayashi, Katsuhiro;
- Tsuchiya, Hiroyuki;
- Bouvet, Michael;
- Hoffman, Robert M.
Publication type:
Article
Relationship between the morphology of osteophytes and cartilage lesions in anterior ankle impingement in athletes: a cross-sectional study.
Published in:
Journal of Foot & Ankle Research, 2023, v. 16, n. 1, p. 1, doi. 10.1186/s13047-023-00633-z
By:
- Yabiku, Hiroki;
- Matsui, Tomohiro;
- Sugimoto, Takeshi;
- Mase, Yasuyoshi;
- Higa, Kotaro;
- Uehara, Fuminari;
- Toma, Takashi;
- Azuma, Chinatsu;
- Tome, Yasunori;
- Nishida, Kotaro;
- Kumai, Tsukasa
Publication type:
Article
Veno-accompanying artery fasciocutaneous flaps following wide excision of soft tissue tumors in the lower legs.
Published in:
2022
By:
- Aoki, Yusuke;
- Tome, Yasunori;
- Oshiro, Hiromichi;
- Kinjo, Masaki;
- Okubo, Hirotaka;
- Nakasone, Motoko;
- Nishida, Kotaro
Publication type:
journal article
The Combination of Methionine Restriction and Docetaxel Synergistically Arrests Androgen-independent Prostate Cancer But Not Normal Cells.
Published in:
Cancer Diagnosis & Prognosis, 2024, v. 4, n. 4, p. 402, doi. 10.21873/cdp.10339
By:
- KOHEI MIZUTA;
- RYOSUKE MORI;
- QINGHONG HAN;
- SEI MORINAGA;
- MOTOKAZU SATO;
- BYUNG MO KANG;
- BOUVET, MICHAEL;
- YASUNORI TOME;
- KOTARO NISHIDA;
- HOFFMAN, ROBERT M.
Publication type:
Article
Differential Diagnosis of Lipomatous Tumors Using 18F-Fluorodeoxygulcose Positron Emission Tomography/Computed Tomography: A Retrospective Observational Study.
Published in:
Cancer Diagnosis & Prognosis, 2024, v. 4, n. 2, p. 141, doi. 10.21873/cdp.10300
By:
- HIROMICHI OSHIRO;
- KOHEI MIZUTA;
- YUICHI TSUHA;
- YUSUKE AOKI;
- RYO KATSUKI;
- YASUNORI TOME;
- KOTARO NISHIDA
Publication type:
Article
Rare coexistence of multiple osteochondromas and solitary osteoid osteoma: A case report.
Published in:
2024
By:
- Katsuki, Ryo;
- Oshiro, Hiromichi;
- Aoki, Yusuke;
- Mizuta, Kohei;
- Tome, Yasunori;
- Nishida, Kotaro
Publication type:
Case Study
Reconstructed bone fracture 28 years after hip rotationplasty for Ewing sarcoma: A case report.
Published in:
2023
By:
- Tsuha, Yuichi;
- Oshiro, Hiromichi;
- Mizuta, Kohei;
- Tome, Yasunori;
- Nishida, Kotaro
Publication type:
Case Study
Reconstruction of the lateral collateral ligament using the plantaris tendon after wide excision of soft tissue sarcoma of the knee: A case report.
Published in:
2023
By:
- Tsuha, Yuichi;
- Oshiro, Hiromichi;
- Mizuta, Kohei;
- Tamaki, Tomoko;
- Tome, Yasunori;
- Wada, Naoki;
- Nishida, Kotaro
Publication type:
Case Study
Reconstruction of the elbow using pedicle joint freezing after wide excision for soft tissue sarcoma: A case report.
Published in:
Molecular & Clinical Oncology, 2021, v. 14, n. 6, p. N.PAG, doi. 10.3892/mco.2021.2277
By:
- Hashimoto, Yuta;
- Tome, Yasunori;
- Oshiro, Hiromichi;
- Aoki, Yusuke;
- Maehara, Hiroki;
- Nishida, Kotaro
Publication type:
Article
Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal phenotype and alteration of histone-H3 lysine-methylation.
Published in:
Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.1009548
By:
- Yusuke Aoki;
- Qinghong Han;
- Yasunori Tome;
- Jun Yamamoto;
- Yutaro Kubota;
- Noriyuki Masaki;
- Koya Obara;
- Kazuyuki Hamada;
- Wang, Justin D.;
- Sachiko Inubushi;
- Bouvet, Michael;
- Clarke, Steven G.;
- Kotaro Nishida;
- Hoffman, Robert M.
Publication type:
Article

Found: 41