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Increased toxicity and reduced clearance of lidocaine by cimetidine.
Published in:
1982
By:
- Feely, John;
- Wilkinson, Grant R.;
- McAllister, Charles B.;
- Wood, Alastair J. J.;
- Feely, J;
- Wilkinson, G R;
- McAllister, C B;
- Wood, A J
Publication type:
journal article
Pharmacogenetics of Long-Term Responses to Antiretroviral Regimens Containing Efavirenz and/or Nelfinavir: An Adult AIDS Clinical Trials Group Study.
Published in:
Journal of Infectious Diseases, 2005, v. 192, n. 11, p. 1931, doi. 10.1086/497610
By:
- Haas, David W.;
- Smeaton, Laura M.;
- Shafer, Robert W.;
- Robbins, Gregory K.;
- Morse, Gene D.;
- Labbé, Line;
- Wilkinson, Grant R.;
- Clifford, David B.;
- D'Aquila, Richard T.;
- De Gruttola, Victor;
- Pollard, Richard B.;
- Merigan, Thomas C.;
- Hirsch, Martin S.;
- George, Jr., Alfred L.;
- Donahue, John P.;
- Kim, Richard B.
Publication type:
Article
Normal Disposition of Oxazepam in Acute Viral Hepatitis and Cirrhosis.
Published in:
Annals of Internal Medicine, 1976, v. 84, n. 4, p. 420, doi. 10.7326/0003-4819-84-4-420
By:
- Shull Jr., Harrison J.;
- Wilkinson, Grant R.;
- Johnson, Raymond;
- Schenker, Steven
Publication type:
Article
Sedative Plasma Concentrations and Delirium Risk in Critical Illness.
Published in:
2018
By:
- Stollings, Joanna L.;
- Thompson, Jennifer L.;
- Ferrell, Benjamin A.;
- Scheinin, Mika;
- Wilkinson, Grant R.;
- Hughes, Christopher G.;
- Shintani, Ayumi K.;
- Ely, E. Wesley;
- Girard, Timothy D.;
- Pandharipande, Pratik P.;
- Patel, Mayur B.
Publication type:
journal article
Associations between CYP2B6 Polymorphisms and Pharmacokinetics after a Single Dose of Nevirapine or Efavirenz in African Americans.
Published in:
Journal of Infectious Diseases, 2009, v. 199, n. 6, p. 872, doi. 10.1086/597125
By:
- Haas, David W.;
- Gebretsadik, Tebeb;
- Mayo, Gail;
- Menon, Usha N.;
- Acosta, Edward P.;
- Shintani, Ayumi;
- Floyd, Michael;
- Stein, C. Michael;
- Wilkinson, Grant R.
Publication type:
Article
The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity*.
Published in:
Clinical Pharmacology & Therapeutics, 2006, v. 80, n. 3, p. 228, doi. 10.1016/j.clpt.2006.06.002
By:
- Kurnik, Daniel;
- Wood, Alastair J. J.;
- Wilkinson, Grant R.
Publication type:
Article
In vivo comparisons of constitutive cytochrome P450 3A activity assessed by alprazolam, triazolam, and midazolam*.
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 76, n. 4, p. 341, doi. 10.1016/j.clpt.2004.07.003
By:
- Masica, Andrew L.;
- Mayo, Gail;
- Wilkinson, Grant R.
Publication type:
Article
Genetic variability in cytochrome P450 3A5 and in vivo cytochrome P450 3A activity: Some answers but still questions*.
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 76, n. 2, p. 99, doi. 10.1016/j.clpt.2004.04.005
By:
- Wilkinson, Grant R.
Publication type:
Article
CYP2C9 and Oral Anticoagulation Therapy with Acenocoumarol and Warfarin: Similarities yet Differences*.
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 5, p. 376, doi. 10.1016/j.clpt.2004.01.007
By:
- Takahashi, Harumi;
- Wilkinson, Grant R.;
- Padrini, Roberto;
- Echizen, Hirotoshi
Publication type:
Article
Population differences in S-warfarin metabolism between CYP2C9 genotype-matched Caucasian and Japanese patients*.
Published in:
Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 3, p. 253, doi. 10.1067/mcp.2003.26a
By:
- Takahashi, Harumi;
- Wilkinson, Grant R.;
- Caraco, Yoseph;
- Muszkat, Mordechai;
- Kim, Richard B.;
- Kashima, Toshitaka;
- Kimura, Sosuke;
- Echizen, Hirotoshi
Publication type:
Article
Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects*.
Published in:
Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 1, p. 41, doi. 10.1067/mcp.2003.10
By:
- Dresser, George K.;
- Schwarz, Ute I.;
- Wilkinson, Grant R.;
- Kim, Richard B.
Publication type:
Article
Cytochrome P450 2E1 and 3A activities do not differ between Mexicans and European Americans*.
Published in:
Clinical Pharmacology & Therapeutics, 2002, v. 72, n. 3, p. 288, doi. 10.1067/mcp.2002.127398
By:
- Poland, Russell A.;
- Lin, Keh-Ming;
- Nuccio, Cenci;
- Wilkinson, Grant R.
Publication type:
Article
Identification of functionally variant MDR1 alleles among European Americans and African Americans*.
Published in:
Clinical Pharmacology & Therapeutics, 2001, v. 70, n. 2, p. 189, doi. 10.1067/mcp.2001.117412
By:
- Kim, Richard B.;
- Leake, Brenda F.;
- Choo, Edna F.;
- Dresser, George K.;
- Kubba, Samir V.;
- Schwarz, Ute I.;
- Taylor, Amanda;
- Xie, Hong-Guang;
- McKinsey, Joel;
- Zhou, Sheng;
- Lan, Lu-Bin;
- Schuetz, John D.;
- Schuetz, Erin G.;
- Wilkinson, Grant R.
Publication type:
Article
CYP3A activity in European American and Japanese men using midazolam as an in vivo probe*.
Published in:
Clinical Pharmacology & Therapeutics, 2001, v. 69, n. 5, p. 333, doi. 10.1067/mcp.2001.115447
By:
- Tateishi, Tomonori;
- Watanabe, Minoru;
- Nakura, Hironori;
- Asoh, Masako;
- Shirai, Hiroaki;
- Mizorogi, Yoshihiro;
- Kobayashi, Shinichi;
- Thummel, Kenneth E.;
- Wilkinson, Grant R.
Publication type:
Article
CYP3A activity in African American and European American men: Population differences and functional effect of the CYP3A4*1B 5′-promoter region polymorphism*.
Published in:
Clinical Pharmacology & Therapeutics, 2000, v. 68, n. 1, p. 82, doi. 10.1067/mcp.2000.108506
By:
- Wandel, Christoph;
- Witte, John S.;
- Hall, Jefferey M.;
- Stein, C. Michael;
- Wood, Alastair J. J.;
- Wilkinson, Grant R.
Publication type:
Article
Assessment of CYP2D6 and CYP2C19 activity in vivo in humans: A cocktail study with dextromethorphan and chloroguanide alone and in combination*.
Published in:
Clinical Pharmacology & Therapeutics, 1999, v. 66, n. 6, p. 582, doi. 10.1053/cp.1999.v66.103401001
By:
- Tennezé, Laurent;
- Verstuyft, Céline;
- Becquemont, Laurent;
- Poirier, Jean-Marie;
- Wilkinson, Grant R.;
- Funck-Brentano, Christian
Publication type:
Article
Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A*.
Published in:
Clinical Pharmacology & Therapeutics, 1999, v. 66, n. 3, p. 224, doi. 10.1016/S0009-9236(99)70029-9
By:
- Kinirons, Mark T.;
- O'Shea, Diarmuid;
- Kim, Richard B.;
- Groopman, John D.;
- Thummel, Kenneth E.;
- Wood, Alastair J. J.;
- Wilkinson, Grant R.
Publication type:
Article
Selective effect of liver disease on the activities of specific metabolizing enzymes: Investigation of cytochromes P450 2C19 and 2D6*.
Published in:
Clinical Pharmacology & Therapeutics, 1998, v. 64, n. 1, p. 8, doi. 10.1016/S0009-9236(98)90017-0
By:
- Adedoyin, Adedayo;
- Arns, Patricia A.;
- Richards, W.O.;
- Wilkinson, Grant R.;
- Branch, Robert A.
Publication type:
Article
Mephenytoin disposition and serum bile acids as indices of hepatic function in chronic viral hepatitis*.
Published in:
Clinical Pharmacology & Therapeutics, 1997, v. 62, n. 5, p. 527, doi. 10.1016/S0009-9236(97)90048-5
By:
- Arns, Patricia A.;
- Adedoyin, Adedayo;
- DiBisceglie, Adrian M.;
- Waggoner, Jeanne G.;
- Hoofnagle, Jay H.;
- Wilkinson, Grant R.;
- Branch, Robert A.
Publication type:
Article
Dietary salt increases first-pass elimination of oral quinidine*.
Published in:
Clinical Pharmacology & Therapeutics, 1997, v. 61, n. 3, p. 292, doi. 10.1016/S0009-9236(97)90161-2
By:
- Darbar, Dawood;
- Dell'Orto, Simonetta;
- Mörike, Klaus;
- Wilkinson, Grant R.;
- Roden, Dan M.
Publication type:
Article
Differences between white subjects and Chinese subjects in the in vivo inhibition of cytochrome P450s 2C19, 2D6, and 3A by omeprazole*.
Published in:
Clinical Pharmacology & Therapeutics, 1996, v. 60, n. 4, p. 396, doi. 10.1016/S0009-9236(96)90196-4
By:
- Caraco, Yoseph;
- Wilkinson, Grant R.;
- Wood, Alastair J. J.
Publication type:
Article
Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*.
Published in:
Clinical Pharmacology & Therapeutics, 1996, v. 59, n. 5, p. 491, doi. 10.1016/S0009-9236(96)90177-0
By:
- Thummel, Kenneth E.;
- O'Shea, Diarmuid;
- Paine, Mary F.;
- Shen, Danny D.;
- Kunze, Kent L.;
- Perkins, James D.;
- Wilkinson, Grant R.
Publication type:
Article
Comparison of the dapsone recovery ratio and the erythromycin breath test as in vivo probes of CYP3A activity in patients with rheumatoid arthritis receiving cyclosporine*.
Published in:
Clinical Pharmacology & Therapeutics, 1996, v. 59, n. 1, p. 47, doi. 10.1016/S0009-9236(96)90023-5
By:
- Stein, C. Michael;
- Kinirons, Mark T.;
- Pincus, Theodore;
- Wilkinson, Grant R.;
- Wood, Alastair J. J.
Publication type:
Article
Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms*.
Published in:
Clinical Pharmacology & Therapeutics, 1995, v. 57, n. 6, p. 645, doi. 10.1016/0009-9236(95)90227-9
By:
- Kim, Richard B.;
- O'Shea, Diarmuid;
- Wilkinson, Grant R.
Publication type:
Article
Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: A putative probe of CYP2E1 activity.
Published in:
Clinical Pharmacology & Therapeutics, 1994, v. 56, n. 4, p. 359, doi. 10.1038/clpt.1994.150
By:
- O'Shea, Diamuird;
- Davis, Stephen N;
- Kim, Richard B;
- Wilkinson, Grant R
Publication type:
Article
Frequency distribution of dapsone N-hydroxylase, a putative probe for P4503A4 activity, in a white population.
Published in:
Clinical Pharmacology & Therapeutics, 1994, v. 55, n. 5, p. 492, doi. 10.1038/clpt.1994.62
By:
- May, D Gail;
- Porter, James;
- Wilkinson, Grant R;
- Branch, Robert A
Publication type:
Article
Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men.
Published in:
Clinical Pharmacology & Therapeutics, 1993, v. 54, n. 6, p. 621, doi. 10.1038/clpt.1993.199
By:
- Kinirons, Mark T;
- O'Shea, Diarmuid;
- Downing, Trisha E;
- Fitzwilliam, Ailsa T;
- Joellenbeck, Lois;
- Groopman, John D;
- Wilkinson, Grant R;
- Wood, Alastair J J
Publication type:
Article
Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: A case report.
Published in:
Clinical Pharmacology & Therapeutics, 1993, v. 53, n. 1, p. 89, doi. 10.1038/clpt.1993.13
By:
- Bluhm, Renata E;
- Wilkinson, Grant R;
- Shelton, Richard;
- Branch, Robert A
Publication type:
Article
The disposition of dapsone in cirrhosis.
Published in:
Clinical Pharmacology & Therapeutics, 1992, v. 51, n. 6, p. 689, doi. 10.1038/clpt.1992.81
By:
- May, D Gail;
- Arns, Patricia A;
- Richards, William O;
- Porter, James;
- Ryder, Diane;
- Fleming, Carolyn M;
- Wilkinson, Grant R;
- Branch, Robert A
Publication type:
Article
Differential effects of quinidine on the disposition of nifedipine, sparteine, and mephenytoin in humans.
Published in:
Clinical Pharmacology & Therapeutics, 1991, v. 50, n. 5, p. 520, doi. 10.1038/clpt.1991.177
By:
- Schellens, Jan H M;
- Ghabrial, Hany;
- van der Wart, Hans H F;
- Bakker, Eke N;
- Wilkinson, Grant R;
- Breimer, Douwe D
Publication type:
Article
The contribution of N-hydroxylation and acetylation to dapsone pharmacokinetics in normal subjects.
Published in:
Clinical Pharmacology & Therapeutics, 1990, v. 48, n. 6, p. 619, doi. 10.1038/clpt.1990.204
By:
- May, D Gail;
- Porter, James A;
- Uetrecht, Jack P;
- Wilkinson, Grant R;
- Branch, Robert A
Publication type:
Article
Scleroderma is associated with differences in individual routes of drug metabolism: A study with dapsone, debrisoquin, and mephenytoin.
Published in:
Clinical Pharmacology & Therapeutics, 1990, v. 48, n. 3, p. 286, doi. 10.1038/clpt.1990.151
By:
- May, D Gail;
- Black, Carol M;
- Olsen, Nancy J;
- Csuka, Mary E;
- Tanner, S Bobo;
- Bellino, Lisa;
- Porter, James A;
- Wilkinson, Grant R;
- Branch, Robert A
Publication type:
Article
Differences in plasma binding of drugs between Caucasians and Chinese subjects.
Published in:
Clinical Pharmacology & Therapeutics, 1990, v. 48, n. 1, p. 10, doi. 10.1038/clpt.1990.111
By:
- Zhou, Hong-Hao;
- Adedoyin, Adedayo;
- Wilkinson, Grant R
Publication type:
Article
Influence of debrisoquin phenotype on the inducibility of propranolol metabolism.
Published in:
Clinical Pharmacology & Therapeutics, 1989, v. 45, n. 4, p. 439, doi. 10.1038/clpt.1989.52
By:
- Shaheen, Omar;
- Biollaz, Jerome;
- Koshakji, Richard P;
- Wilkinson, Grant R;
- Wood, Alastair J J
Publication type:
Article
Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities.
Published in:
Clinical Pharmacology & Therapeutics, 1989, v. 45, n. 1, p. 72, doi. 10.1038/clpt.1989.11
By:
- Ward, Stephen A;
- Walle, Thomas;
- Walle, U Kristina;
- Wilkinson, Grant R;
- Branch, Robert A
Publication type:
Article
In vivo inhibition of human CYP1A2 activity by oltipraz.
Published in:
2001
By:
- Sofowora, Gbemiga G.;
- Choo, Edna F.;
- Mayo, Gail;
- Shyr, Yu;
- Wilkinson, Grant R.;
- Sofowora, G G;
- Choo, E F;
- Mayo, G;
- Shyr, Y;
- Wilkinson, G R
Publication type:
journal article
Modulation of CYP2EI activity by isoniazid in rapid and slow N-acetylators.
Published in:
British Journal of Clinical Pharmacology, 1997, v. 43, n. 1, p. 99, doi. 10.1111/j.1365-2125.1997.tb00144.x
By:
- O'Shea, Diarmuid;
- Kim, Richard B.;
- Wilkinson, Grant R.
Publication type:
Article
Disposition of diazepam in young and elderly subjects after acute and chronic dosing.
Published in:
British Journal of Clinical Pharmacology, 1996, v. 42, n. 2, p. 147, doi. 10.1046/j.1365-2125.1996.03642.x
By:
- HERMAN, ROBERT J.;
- WILKINSON, GRANT R.
Publication type:
Article
Single Plasma Concentrations of 1'-Hydroxymidazolam or the Ratio of 1'-Hydroxymidazolam:Midazolam Do Not Predict Midazolam Clearance in Healthy Subjects.
Published in:
Journal of Clinical Pharmacology, 2002, v. 42, n. 10, p. 1079, doi. 10.1177/009127002237986
By:
- Rogers, Janyce F.;
- Nafziger, Anne N.;
- Kashuba, Angela D. M.;
- Streetman, Daniel S.;
- Rocci, Mario L.;
- Choo, Edna F.;
- Wilkinson, Grant R.;
- Bertino, Joseph S.
Publication type:
Article
Limited Sampling Strategy to Predict AUC of the CYP3A Phenotyping Probe Midazolam in Adults: Application to Various Assay Techniques.
Published in:
Journal of Clinical Pharmacology, 2002, v. 42, n. 4, p. 376, doi. 10.1177/0091270002424002
By:
- Kim, Jooran S.;
- Nafziger, Anne N.;
- Tsunoda, Shirley M.;
- Choo, Edna F.;
- Streetman, Daniel S.;
- Kashuba, Angela D. M.;
- Kulawy, Robert W.;
- Beck, Debra J.;
- Rocci, Mario L.;
- Wilkinson, Grant R.;
- Greenblatt, David J.;
- Bertino, Joseph S.
Publication type:
Article
Pyridoxal 5′-Phosphate (PLP).
Published in:
Nutrition Reviews, 1977, v. 35, n. 11, p. 315, doi. 10.1111/j.1753-4887.1977.tb06509.x
By:
- Schenker, Steven;
- Stone, William J.;
- Wagner, Conrad;
- Wilkinson, Grant R.
Publication type:
Article
Reduction of liver plasma flow by caffeine and theophylline.
Published in:
Clinical Pharmacology & Therapeutics, 1986, v. 40, n. 5, p. 506, doi. 10.1038/clpt.1986.215
By:
- Onrot, Jack;
- Shaheen, Omar;
- Biaggioni, Italo;
- Goldberg, Michael R;
- Feely, John;
- Wilkinson, Grant R;
- Hollister, Alan S;
- Robertson, David
Publication type:
Article
Encainide disposition in patients with chronic cirrhosis.
Published in:
Clinical Pharmacology & Therapeutics, 1986, v. 40, n. 2, p. 148, doi. 10.1038/clpt.1986.155
By:
- Bergstrand, Robert H;
- Wang, Ted;
- Roden, Dan M;
- Avant, George R;
- Sutton, Wade W;
- Siddoway, Lyle A;
- Wolfenden, Harold;
- Woosley, Raymond L;
- Wilkinson, Grant R;
- Wood, Alastair J J
Publication type:
Article
Furosemide kinetics and dynamics in patients with cirrhosis.
Published in:
Clinical Pharmacology & Therapeutics, 1986, v. 40, n. 1, p. 14, doi. 10.1038/clpt.1986.132
By:
- Villeneuve, Jean-Pierre;
- Verbeeck, Roger K;
- Wilkinson, Grant R;
- Branch, Robert A
Publication type:
Article
Encainide disposition in patients with renal failure.
Published in:
Clinical Pharmacology & Therapeutics, 1986, v. 40, n. 1, p. 64, doi. 10.1038/clpt.1986.140
By:
- Bergstrand, Robert H;
- Wang, Ted;
- Roden, Dan M;
- Stone, William J;
- Wolfenden, Harold T;
- Woosley, Raymond L;
- Wilkinson, Grant R;
- Wood, Alastair J J
Publication type:
Article
Co-inheritance of the polymorphic metabolism of encainide and debrisoquin.
Published in:
Clinical Pharmacology & Therapeutics, 1986, v. 39, n. 3, p. 282, doi. 10.1038/clpt.1986.40
By:
- Woosley, Raymond L;
- Roden, Dan M;
- Dai, Guizhu;
- Wang, Ted;
- Altenbern, Douglas;
- Oates, James;
- Wilkinson, Grant R
Publication type:
Article
Effect of thyrotoxicosis on liver blood flow and propranolol disposition after long-term dosing.
Published in:
Clinical Pharmacology & Therapeutics, 1983, v. 33, n. 5, p. 603, doi. 10.1038/clpt.1983.81
By:
- Wells, Peter G;
- Feely, John;
- Wilkinson, Grant R;
- Wood, Alastair J J
Publication type:
Article
Furosemide disposition in cirrhosis.
Published in:
Clinical Pharmacology & Therapeutics, 1982, v. 31, n. 6, p. 719, doi. 10.1038/clpt.1982.101
By:
- Verbeeck, Roger K;
- Patwardhan, Rashmi V;
- Villeneuve, Jean-Pierre;
- Wilkinson, Grant R;
- Branch, Robert A
Publication type:
Article
Meperidine disposition in man: Influence of urinary pH and route of administration.
Published in:
Clinical Pharmacology & Therapeutics, 1981, v. 30, n. 5, p. 619, doi. 10.1038/clpt.1981.213
By:
- Verbeeck, Roger K;
- Branch, Robert A;
- Wilkinson, Grant R
Publication type:
Article
Deuterium labelling of the antidepressant drug doxepin for disposition studies in human subjects.
Published in:
Journal of Labelled Compounds & Radiopharmaceuticals, 1990, v. 28, n. 9, p. 1037, doi. 10.1002/jlcr.2580280908
By:
- Prakash, Chandra;
- Saleh, Samir;
- Taber, Douglass F.;
- Wilkinson, Grant R.;
- Blair, Ian A.
Publication type:
Article

Found: 52