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A cleavage rule for selection of increased-fidelity SpCas9 variants with high efficiency and no detectable off-targets.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41393-5
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- Article
Position-dependent sequence motif preferences of SpCas9 are largely determined by scaffold-complementary spacer motifs.
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- Nucleic Acids Research, 2023, v. 51, n. 11, p. 5847, doi. 10.1093/nar/gkad323
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- Article
Cpf1 nucleases demonstrate robust activity to induce DNA modification by exploiting homology directed repair pathways in mammalian cells.
- Published in:
- Biology Direct, 2016, v. 11, p. 1, doi. 10.1186/s13062-016-0147-0
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- Article
A convenientmethod to pre-screen candidate guide RNAs for CRISPR/Cas9 gene editing by NHEJ-mediated integration of a 'self-cleaving' GFP-expression plasmid.
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- DNA Research, 2017, v. 24, n. 6, p. 609, doi. 10.1093/dnares/dsx029
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- Article
Detecting native folds in mixtures of proteins that contain disulfide bonds.
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- Nature Biotechnology, 2008, v. 26, n. 4, p. 427, doi. 10.1038/nbt1380
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- Article
Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage.
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- Genome Biology, 2017, v. 18, p. 1, doi. 10.1186/s13059-017-1318-8
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- Article
Restriction Enzyme Body Doubles and PCR Cloning: On the General Use of Type IIS Restriction Enzymes for Cloning.
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- PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090896
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- Article
The prion protein family member Shadoo induces spontaneous ionic currents in cultured cells.
- Published in:
- Scientific Reports, 2016, p. 36441, doi. 10.1038/srep36441
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- Article
Membrane Domain Localization and Interaction of the Prion-Family Proteins, Prion and Shadoo with Calnexin.
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- Membranes, 2021, v. 11, n. 12, p. 978, doi. 10.3390/membranes11120978
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- Article
SuperFi-Cas9 exhibits remarkable fidelity but severely reduced activity yet works effectively with ABE8e.
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- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34527-8
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- Article
BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26461-y
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- Article
PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully prime edited cells.
- Published in:
- eLife, 2022, p. 1, doi. 10.7554/eLife.69504
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- Article
The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo.
- Published in:
- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-82647-w
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- Article
A method for characterizing Cas9 variants via a one-million target sequence library of self-targeting sgRNAs.
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- Nucleic Acids Research, 2021, v. 49, n. 6, p. e31, doi. 10.1093/nar/gkaa1220
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- Article
Improved LbCas12a variants with altered PAM specificities further broaden the genome targeting range of Cas12a nucleases.
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- Nucleic Acids Research, 2020, v. 48, n. 7, p. 3722, doi. 10.1093/nar/gkaa110
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- Article
Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5′G-extended sgRNAs.
- Published in:
- Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15021-5
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- Article
Prion Protein Does Not Confer Resistance to Hippocampus-Derived Zpl Cells against the Toxic Effects of Cu<sup>2+</sup>, Mn<sup>2+</sup>, Zn<sup>2+</sup> and Co<sup>2+</sup> Not Supporting a General Protective Role for PrP in Transition Metal Induced Toxicity
- Published in:
- PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0139219
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- Article