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Pharmacokinetic-Pharmacodynamic Modelling of Systemic IL13 Blockade by Monoclonal Antibody Therapy: A Free Assay Disguised as Total.
- Published in:
- Pharmaceutics, 2021, v. 13, n. 4, p. 519, doi. 10.3390/pharmaceutics13040519
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- Publication type:
- Article
The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models.
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- BMC Systems Biology, 2013, v. 7, n. 1, p. 1, doi. 10.1186/1752-0509-7-95
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- Publication type:
- Article
The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling.
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- 2015
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- Publication type:
- journal article
A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer.
- Published in:
- AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0350-x
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- Publication type:
- Article
A Mathematical Model of the Effect of Immunogenicity on Therapeutic Protein Pharmacokinetics.
- Published in:
- AAPS Journal, 2013, v. 15, n. 4, p. 1141, doi. 10.1208/s12248-013-9517-z
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- Publication type:
- Article
Modeling, Simulation, and Translation Framework for the Preclinical Development of Monoclonal Antibodies.
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- AAPS Journal, 2013, v. 15, n. 2, p. 551, doi. 10.1208/s12248-013-9464-8
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- Publication type:
- Article
Population pharmacokinetics of recombinant factor XIII in cynomolgus monkeys.
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- AAPS Journal, 2005, v. 7, n. 3, p. E693, doi. 10.1208/aapsj070370
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- Publication type:
- Article
Metabolism-based cyclophosphamide dosing for hematopoietic cell transplant
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- Clinical Pharmacology & Therapeutics, 2005, v. 78, n. 3, p. 298, doi. 10.1016/j.clpt.2005.05.005
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- Publication type:
- Article
Diminishing the risk of nonrelapse mortality in hematopoietic stem cell transplantation: Prediction of exposure to the cyclophosphamide metabolite Carboxyethylphosphoramide mustard<sup>*</sup>.
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- Clinical Pharmacology & Therapeutics, 2004, v. 76, n. 3, p. 270, doi. 10.1016/j.clpt.2004.05.006
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- Publication type:
- Article
The effect of age on insulin sensitivity and insulin secretion in first-degree relatives of type 1 diabetic patients: a population analysis.
- Published in:
- 2009
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- Publication type:
- journal article
Ketorolac tromethamine: stereo-specific pharmacokinetics and single-dose use in postoperative infants aged 2-6 months.
- Published in:
- Pediatric Anesthesia, 2011, v. 21, n. 3, p. 325, doi. 10.1111/j.1460-9592.2010.03484.x
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- Publication type:
- Article
Mixture model approach to tumor classification based on pharmacokinetic measures of tumor permeability.
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- Journal of Magnetic Resonance Imaging, 2005, v. 22, n. 4, p. 549, doi. 10.1002/jmri.20412
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- Publication type:
- Article
The status of pharmacometrics in pregnancy: highlights from the 3<sup>rd</sup> American conference on pharmacometrics.
- Published in:
- British Journal of Clinical Pharmacology, 2012, v. 74, n. 6, p. 932, doi. 10.1111/j.1365-2125.2012.04280.x
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- Publication type:
- Article
Mathematical modeling of receptor occupancy data: A valuable technology for biotherapeutic drug development.
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- Cytometry. Part B, 2016, v. 90, n. 2, p. 230, doi. 10.1002/cyto.b.21318
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- Publication type:
- Article
Comparison of Statistical Data Models for Identifying Differentially Expressed Genes Using a Generalized Likelihood Ratio Test.
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- Gene Regulation & Systems Biology, 2008, n. 2, p. 125, doi. 10.4137/GRSB.S381
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- Publication type:
- Article
A QSP Model for Predicting Clinical Responses to Monotherapy, Combination and Sequential Therapy Following CTLA-4, PD-1, and PD-L1 Checkpoint Blockade.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-47802-4
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- Publication type:
- Article
Detecting bliss synergy in in vivo combination studies with a tumor kinetic model.
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- Pharmaceutical Statistics, 2019, v. 18, n. 6, p. 688, doi. 10.1002/pst.1952
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- Publication type:
- Article
Alpha-Lipoic Acid Treatment Decreases Serum Lactate and Pyruvate Concentrations and Improves Glucose Effectiveness in Lean and Obese Patients With Type 2 Diabetes.
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- Diabetes Care, 1999, v. 22, n. 2, p. 280, doi. 10.2337/diacare.22.2.280
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- Publication type:
- Article
An Approach to Determining Intracranial Pressure Variability Capable of Predicting Decreased Intracranial Adaptive Capacity in Patients With Traumatic Brain Injury.
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- Biological Research for Nursing, 2010, v. 11, n. 4, p. 317, doi. 10.1177/1099800409349164
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- Publication type:
- Article
INTRACRANIAL PRESSURE WAVEFORM MORPHOLOGY AND INTRACRANIAL ADAPTIVE CAPACITY.
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- American Journal of Critical Care, 2008, v. 17, n. 6, p. 545, doi. 10.4037/ajcc2008.17.6.545
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- Publication type:
- Article
Opportunities for Quantitative Translational Modeling in Oncology.
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- Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 3, p. 447, doi. 10.1002/cpt.1963
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- Publication type:
- Article
Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment Puzzle.
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- Clinical Pharmacology & Therapeutics, 2019, v. 106, n. 1, p. 148, doi. 10.1002/cpt.1211
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- Publication type:
- Article
A Challenge for Clinical Pharmacologists: How Can We Measure Scientific Impact of Publications in Drug Development and in Regulatory Decision Making?
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- Clinical Pharmacology & Therapeutics, 2019, v. 105, n. 5, p. 1071, doi. 10.1002/cpt.1236
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- Publication type:
- Article
Dose‐Exposure‐Response Relationship of the Investigational Anti‐Interleukin‐13 Monoclonal Antibody Tralokinumab in Patients With Severe, Uncontrolled Asthma.
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- Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 5, p. 826, doi. 10.1002/cpt.803
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- Publication type:
- Article
Population Pharmacokinetics of Durvalumab in Cancer Patients and Association With Longitudinal Biomarkers of Disease Status.
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- Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 4, p. 631, doi. 10.1002/cpt.982
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- Article
Population pharmacokinetic/dynamic model of lymphosuppression after fludarabine administration.
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- Cancer Chemotherapy & Pharmacology, 2015, v. 75, n. 1, p. 67, doi. 10.1007/s00280-014-2618-2
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- Publication type:
- Article
A novel integrated QSP model of in vivo human glucose regulation to support the development of a glucagon/GLP‐1 dual agonist.
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- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 3, p. 302, doi. 10.1002/psp4.12752
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- Publication type:
- Article
Step‐by‐step comparison of ordinary differential equation and agent‐based approaches to pharmacokinetic‐pharmacodynamic models.
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- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 2, p. 133, doi. 10.1002/psp4.12703
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- Publication type:
- Article
Recruiting the Immune System Against Disease: Lessons for Clinical and Systems Pharmacology.
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- CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 7, p. 436, doi. 10.1002/psp4.12416
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- Publication type:
- Article
Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network.
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- CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 5, p. 259, doi. 10.1002/psp4.12381
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- Publication type:
- Article
Model‐Based Discovery and Development of Biopharmaceuticals: A Case Study of Mavrilimumab.
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- CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 1, p. 5, doi. 10.1002/psp4.12245
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- Publication type:
- Article
Characterisation of cotadutide's dual GLP‐1/glucagon receptor agonistic effects on glycaemic control using an in vivo human glucose regulation quantitative systems pharmacology model.
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- British Journal of Pharmacology, 2024, v. 181, n. 12, p. 1874, doi. 10.1111/bph.16336
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- Publication type:
- Article
Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies.
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- 2005
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- Publication type:
- journal article
A Limited Sampling Schedule to Estimate Mycophenolic Acid Area Under the Concentration-Time Curve in Hematopoietic Cell Transplantation Recipients.
- Published in:
- Journal of Clinical Pharmacology, 2012, v. 52, n. 11, p. 1654, doi. 10.1177/0091270011429567
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- Publication type:
- Article
Development of a Population Pharmacokinetics-Based Sampling Schedule to Target Daily Intravenous Busulfan for Outpatient Clinic Administration.
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- Journal of Clinical Pharmacology, 2010, v. 50, n. 11, p. 1292, doi. 10.1177/0091270009357430
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- Publication type:
- Article
Population Pharmacokinetics of yclophosphamide and Metabolites in Children With Neuroblastoma: A Report From the Children's Oncology Group.
- Published in:
- Journal of Clinical Pharmacology, 2009, v. 49, n. 1, p. 88, doi. 10.1177/0091270008325928
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- Publication type:
- Article
Organ Dose Estimates for Hyperthyroid Patients Treated with <sup>131</sup>I: An Update of the Thyrotoxicosis Follow-Up Study.
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- Radiation Research, 2015, v. 184, n. 6, p. 595, doi. 10.1667/RR14160.1
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- Article
Forearm nitric oxide balance, vascular relaxation, and glucose metabolism in NIDDM patients.
- Published in:
- 1997
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- Publication type:
- journal article
A review of quantitative modeling of B cell responses to antigenic challenge.
- Published in:
- Journal of Pharmacokinetics & Pharmacodynamics, 2014, v. 41, n. 5, p. 445, doi. 10.1007/s10928-014-9388-7
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- Publication type:
- Article
Population PK–PD model for Fc-osteoprotegerin in healthy postmenopausal women.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2008, v. 35, n. 4, p. 379, doi. 10.1007/s10928-008-9093-5
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- Publication type:
- Article
Simulating pharmacokinetic and pharmacodynamic fuzzy-parameterized models: a comparison of numerical methods.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2007, v. 34, n. 5, p. 595, doi. 10.1007/s10928-007-9061-5
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- Publication type:
- Article
Pubertal changes in HOMA and QUICKI: relationship to hepatic and peripheral insulin sensitivity.
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- Pediatric Diabetes, 2004, v. 5, n. 3, p. 122, doi. 10.1111/j.1399-543X.2004.00050.x
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- Publication type:
- Article
The System for Population Kinetics: Open Source Software for Population Analysis.
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- International Journal of Open Source Software & Processes, 2009, v. 1, n. 3, p. 29, doi. 10.4018/jossp.2009070103
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- Publication type:
- Article
Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly.
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- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01114-1
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- Publication type:
- Article
Exposure–Response Analysis of Overall Survival for Tremelimumab in Unresectable Malignant Mesothelioma: The Confounding Effect of Disease Status.
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- CTS: Clinical & Translational Science, 2019, v. 12, n. 5, p. 450, doi. 10.1111/cts.12633
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- Publication type:
- Article
Multiscale Modeling in the Clinic: Drug Design and Development.
- Published in:
- Annals of Biomedical Engineering, 2016, v. 44, n. 9, p. 2591, doi. 10.1007/s10439-016-1563-0
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- Publication type:
- Article
Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success.
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- Annals of Biomedical Engineering, 2016, v. 44, n. 9, p. 2626, doi. 10.1007/s10439-016-1691-6
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- Publication type:
- Article
Kinetic Modeling of Contrast-Enhanced MRI: An Automated Technique for Assessing Inflammation in the Rheumatoid Arthritis Wrist.
- Published in:
- Annals of Biomedical Engineering, 2007, v. 35, n. 5, p. 781
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- Publication type:
- Article
Physiologically Based Pharmacokinetic Modeling of Drug Disposition in Rat and Human: A Fuzzy Arithmetic Approach.
- Published in:
- Pharmaceutical Research, 2008, v. 25, n. 8, p. 1771, doi. 10.1007/s11095-007-9447-5
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- Publication type:
- Article
Individual Prior Information in a Physiological Model of ²H[sub 8]-Toluene Kinetics: An Empirical Bayes Estimation Strategy.
- Published in:
- Risk Analysis: An International Journal, 1999, v. 19, n. 6, p. 1127, doi. 10.1023/A:1007034712016
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- Publication type:
- Article