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Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies.
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- Molecular Microbiology, 2008, v. 68, n. 1, p. 37, doi. 10.1111/j.1365-2958.2008.06131.x
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- Article
Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.
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- Nature Structural & Molecular Biology, 2010, v. 17, n. 5, p. 602, doi. 10.1038/nsmb.1818
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- Article
Structurally Simple Farnesyltransferase Inhibitors Arrest the Growth of Malaria ParasitesThis work was supported by the Medicines for Malaria Venture (MMV) and NIH grants CA67771 and AI054384. S.-Y.C. thanks the Postdoctoral Fellowship Program of Korea Science & Engineering Foundation (KOSEF). O.H. gratefully acknowledges a postdoctoral fellowship of the German Academy of Natural Scientists Leopoldina (BMBF-LPD 9901/8-77). We thank David Floyd, Lou Lombardo and David Williams from Bristol-Myers Squibb for helpful suggestions.
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- Angewandte Chemie, 2005, v. 117, n. 31, p. 4981, doi. 10.1002/ange.200500674
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- Article
Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
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- PLoS Neglected Tropical Diseases, 2014, v. 8, n. 4, p. 1, doi. 10.1371/journal.pntd.0002775
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- Article
Structures of <i>Trypanosoma brucei</i> Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
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- PLoS Neglected Tropical Diseases, 2014, v. 8, n. 4, p. 1, doi. 10.1371/journal.pntd.0002775
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- Article
Multivalent Drug Design and Inhibition of Cholera Toxin by Specific and Transient Protein–Ligand Interactions.
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- 2008
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- Letter
Characterization of Atrazine Biotransformation by Human and Murine Glutathione S-Transferases.
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- Toxicological Sciences, 2004, v. 80, n. 2, p. 230, doi. 10.1093/toxsci/kfh152
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- Article
The crystal structure of the drug target <italic>Mycobacterium tuberculosis</italic> methionyl‐tRNA synthetase in complex with a catalytic intermediate.
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- Acta Crystallographica: Section F, Structural Biology Communications, 2018, v. 74, n. 4, p. 245, doi. 10.1107/S2053230X18003151
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- Article
A critical evaluation of several global optimization algorithms for the purpose of molecular docking.
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- Journal of Computational Chemistry, 1999, v. 20, n. 16, p. 1740, doi. 10.1002/(SICI)1096-987X(199912)20:16<1740::AID-JCC6>3.0.CO;2-A
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- Article
Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 Å resolution reveals intriguing extra electron density in the active site.
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- Proteins, 2006, v. 62, n. 3, p. 570, doi. 10.1002/prot.20801
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- Article
Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors.
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- Journal of Clinical Investigation, 2012, v. 122, n. 6, p. 2301, doi. 10.1172/JCI61822
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- Article
Structurally Simple Farnesyltransferase Inhibitors Arrest the Growth of Malaria ParasitesThis work was supported by the Medicines for Malaria Venture (MMV) and NIH grants CA67771 and AI054384. S.-Y.C. thanks the Postdoctoral Fellowship Program of Korea Science & Engineering Foundation (KOSEF). O.H. gratefully acknowledges a postdoctoral fellowship of the German Academy of Natural Scientists Leopoldina (BMBF-LPD 9901/8-77). We thank David Floyd, Lou Lombardo and David Williams from Bristol-Myers Squibb for helpful suggestions.
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- Angewandte Chemie International Edition, 2005, v. 44, n. 31, p. 4903, doi. 10.1002/anie.200500674
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- Article
A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation.
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- Journal of Infectious Diseases, 2014, v. 209, n. 2, p. 275, doi. 10.1093/infdis/jit522
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- Article