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Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism.
- Published in:
- EMBO Molecular Medicine, 2013, v. 5, n. 4, p. 563, doi. 10.1002/emmm.201201953
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- Publication type:
- Article
Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development.
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- Journal of Pathology, 2022, v. 258, n. 4, p. 382, doi. 10.1002/path.6009
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- Publication type:
- Article
Phosphoinositide 3-kinase: a new kid on the block in vascular anomalies.
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- Journal of Pathology, 2016, v. 240, n. 4, p. 387, doi. 10.1002/path.4802
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- Article
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation.
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- EMBO Journal, 2002, v. 21, n. 19, p. 5097, doi. 10.1093/emboj/cdf512
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- Article
Autophosphorylation of p110d phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo.
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- EMBO Journal, 1999, v. 18, n. 5, p. 1292, doi. 10.1093/emboj/18.5.1292
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- Publication type:
- Article
Phosphoinositide lipids in primary cilia biology.
- Published in:
- Biochemical Journal, 2020, v. 477, n. 18, p. 3541, doi. 10.1042/BCJ20200277
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- Publication type:
- Article
Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K-AGC protein kinase connection.
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- Biochemical Journal, 2014, v. 464, n. 2, p. e7, doi. 10.1042/BJ20141218
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- Article
AKT-ing out: SGK kinases come to the fore.
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- Biochemical Journal, 2013, v. 452, n. 3, p. 11, doi. 10.1042/BJ20130617
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- Article
Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth.
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- Biochemical Journal, 2013, v. 450, n. 3, p. 619, doi. 10.1042/BJ20121525
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- Publication type:
- Article
Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter.
- Published in:
- Biochemical Journal, 2012, v. 443, n. 3, p. 857, doi. 10.1042/BJ20112214
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- Publication type:
- Article
Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma.
- Published in:
- Nature Medicine, 2008, v. 14, n. 5, p. 565, doi. 10.1038/nm1766
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- Publication type:
- Article
Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice.
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- Diabetologia, 2016, v. 59, n. 7, p. 1503, doi. 10.1007/s00125-016-3963-y
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- Article
PI3K signalling: the path to discovery and understanding.
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- Nature Reviews Molecular Cell Biology, 2012, v. 13, n. 3, p. 195, doi. 10.1038/nrm3290
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- Publication type:
- Article
The emerging mechanisms of isoform-specific PI3K signalling.
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- Nature Reviews Molecular Cell Biology, 2010, v. 11, n. 5, p. 329, doi. 10.1038/nrm2882
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- Publication type:
- Article
Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate.
- Published in:
- Scientific Reports, 2017, p. 39985, doi. 10.1038/srep39985
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- Publication type:
- Article
Regulation of p110δ PI 3-Kinase Gene Expression.
- Published in:
- PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005145
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- Article
Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif.
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- Journal of Molecular Medicine, 2008, v. 86, n. 4, p. 401, doi. 10.1007/s00109-008-0302-x
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- Article
PI3KC2β inactivation stabilizes VE‐cadherin junctions and preserves vascular integrity.
- Published in:
- EMBO Reports, 2021, v. 22, n. 6, p. 1, doi. 10.15252/embr.202051299
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- Article
Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability.
- Published in:
- Biomolecules (2218-273X), 2019, v. 9, n. 8, p. 331, doi. 10.3390/biom9080331
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- Article
Class III PI3K Vps34 Controls Thyroid Hormone Production by Regulating Thyroglobulin Iodination, Lysosomal Proteolysis, and Tissue Homeostasis.
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- Thyroid, 2020, v. 30, n. 1, p. 133, doi. 10.1089/thy.2019.0182
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- Article
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07812-8
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- Article
SSTR2 in Nasopharyngeal Carcinoma: Relationship with Latent EBV Infection and Potential as a Therapeutic Target.
- Published in:
- Cancers, 2021, v. 13, n. 19, p. 4944, doi. 10.3390/cancers13194944
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- Article
Inhibition of p110δ PI3K prevents inflammatory response and restenosis after artery injury.
- Published in:
- Bioscience Reports, 2017, v. 37, n. 5, p. 1, doi. 10.1042/BSR20171112
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- Article
Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury.
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- Cardiovascular Research, 2019, v. 115, n. 8, p. 1343, doi. 10.1093/cvr/cvy298
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- Article
PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart.
- Published in:
- Cardiovascular Research, 2015, v. 105, n. 3, p. 292, doi. 10.1093/cvr/cvv016
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- Publication type:
- Article
The p110δ isoform of PI 3-kinase negatively controls RhoA and PTEN.
- Published in:
- EMBO Journal, 2007, v. 26, n. 13, p. 3050, doi. 10.1038/sj.emboj.7601763
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- Article
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration.
- Published in:
- 2008
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- Publication type:
- Letter
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation.
- Published in:
- Nature, 2006, v. 441, n. 7091, p. 366, doi. 10.1038/nature04694
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- Article
PI3K in lymphocyte development, differentiation and activation.
- Published in:
- Nature Reviews Immunology, 2003, v. 3, n. 4, p. 317, doi. 10.1038/nri1056
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- Article
The mouse made easy.
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- Nature Cell Biology, 2005, v. 7, n. 5, p. 461, doi. 10.1038/ncb0505-461
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- Publication type:
- Article
Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition.
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- 2005
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- Publication type:
- Letter
Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages.
- Published in:
- Nature Cell Biology, 1999, v. 1, n. 1, p. 69, doi. 10.1038/9045
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- Publication type:
- Article
High levels of p110δ PI3K expression in solid tumor cells suppress PTEN activity, generating cellular sensitivity to p110δ inhibitors through PTEN activation.
- Published in:
- FASEB Journal, 2012, v. 26, n. 6, p. 2498, doi. 10.1096/fj.11-198192
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- Article
Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110δ isoform of PI 3-kinase.
- Published in:
- FASEB Journal, 2012, v. 26, n. 2, p. 691, doi. 10.1096/fj.11-189753
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- Publication type:
- Article
Michael D. Waterfield.
- Published in:
- Biochemical Journal, 2023, v. 480, n. 18, p. 1475, doi. 10.1042/BCJ20230368
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- Article
Corrigendum: Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
- Published in:
- Nature Immunology, 2014, v. 15, n. 2, p. 205, doi. 10.1038/ni0214-205b
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- Publication type:
- Article
Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
- Published in:
- Nature Immunology, 2013, v. 14, n. 11, p. 1127, doi. 10.1038/ni.2708
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- Publication type:
- Article
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
- Published in:
- Nature Immunology, 2013, v. 14, n. 8, p. 877, doi. 10.1038/ni0813-877d
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- Publication type:
- Article
The p110? isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
- Published in:
- Nature Immunology, 2012, v. 13, n. 11, p. 1045, doi. 10.1038/ni.2426
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- Publication type:
- Article
Class III Phosphoinositide 3-Kinase/VPS34 and Dynamin are Critical for Apical Endocytic Recycling.
- Published in:
- Traffic, 2013, v. 14, n. 8, p. 933, doi. 10.1111/tra.12079
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- Article
Phosphoinositide 3-kinase: friend and foe in cardiovascular disease.
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- Frontiers in Pharmacology, 2015, p. 1, doi. 10.3389/fphar.2015.00169
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- Publication type:
- Article
Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization.
- Published in:
- Nature Communications, 2015, v. 6, n. 1, p. 5937, doi. 10.1038/ncomms6937
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- Publication type:
- Article
PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model.
- Published in:
- Nature Communications, 2014, v. 5, n. 3, p. 3450, doi. 10.1038/ncomms4450
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- Publication type:
- Article
Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors.
- Published in:
- Genome Biology, 2013, v. 14, n. 4, p. 1, doi. 10.1186/gb-2013-14-4-r37
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- Publication type:
- Article
Essential role for the p110dphosphoinositide 3-kinase in the allergic response.
- Published in:
- Nature, 2004, v. 431, n. 7011, p. 1007, doi. 10.1038/nature02991
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- Article
Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion.
- Published in:
- Journal of Cell Biology, 2010, v. 190, n. 6, p. 1053, doi. 10.1083/jcb.201001028
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- Publication type:
- Article
The PI3K p110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1.
- Published in:
- Journal of Cell Biology, 2010, v. 188, n. 6, p. 863, doi. 10.1083/jcb.200907135
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- Publication type:
- Article
PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction.
- Published in:
- 2019
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- Publication type:
- journal article
PI3K-C2β limits mTORC1 signaling and angiogenic growth.
- Published in:
- Science Signaling, 2023, v. 16, n. 813, p. 1, doi. 10.1126/scisignal.adg1913
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- Publication type:
- Article
Cracking the context-specific PI3K signaling code.
- Published in:
- Science Signaling, 2020, v. 13, n. 613, p. 1, doi. 10.1126/scisignal.aay2940
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- Article