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PTEN/PI3K/Akt pathway alters sensitivity of T-cell acute lymphoblastic leukemia to l-asparaginase.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-08049-8
By:
- Hlozkova, Katerina;
- Hermanova, Ivana;
- Safrhansova, Lucie;
- Alquezar-Artieda, Natividad;
- Kuzilkova, Daniela;
- Vavrova, Adela;
- Sperkova, Kristyna;
- Zaliova, Marketa;
- Stary, Jan;
- Trka, Jan;
- Starkova, Julia
Publication type:
Article
PTEN/PI3K/Akt pathway alters sensitivity of T-cell acute lymphoblastic leukemia to l-asparaginase.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-08049-8
By:
- Hlozkova, Katerina;
- Hermanova, Ivana;
- Safrhansova, Lucie;
- Alquezar-Artieda, Natividad;
- Kuzilkova, Daniela;
- Vavrova, Adela;
- Sperkova, Kristyna;
- Zaliova, Marketa;
- Stary, Jan;
- Trka, Jan;
- Starkova, Julia
Publication type:
Article
Low levels of minimal residual disease after induction chemotherapy for BCR‐ABL1‐negative acute lymphoblastic leukaemia in adults are clinically relevant.
Published in:
British Journal of Haematology, 2022, v. 196, n. 3, p. 706, doi. 10.1111/bjh.17966
By:
- Šálek, Cyril;
- Folber, František;
- Froňková, Eva;
- Pecherková, Pavla;
- Jelínková, Hana;
- Hrabovský, Štěpán;
- Horáček, Jan M.;
- Cetkovský, Petr;
- Mayer, Jiří;
- Trka, Jan;
- Doubek, Michael
Publication type:
Article
Effective Response Metric: a novel tool to predict relapse in childhood acute lymphoblastic leukaemia using time‐series gene expression profiling.
Published in:
British Journal of Haematology, 2018, v. 181, n. 5, p. 653, doi. 10.1111/bjh.15252
By:
- Yeoh, Allen E.‐J.;
- Li, Zhenhua;
- Dong, Difeng;
- Lu, Yi;
- Jiang, Nan;
- Trka, Jan;
- Tan, Ah Moy;
- Lin, Hai Peng;
- Quah, Thuan Chong;
- Ariffin, Hany;
- Wong, Limsoon
Publication type:
Article
PHF6 mutations in paediatric acute myeloid leukaemia.
Published in:
British Journal of Haematology, 2016, v. 175, n. 5, p. 967, doi. 10.1111/bjh.13891
By:
- Rooij, Jasmijn D. E.;
- Heuvel ‐ Eibrink, Marry M.;
- Rijdt, Nina K. A. M.;
- Verboon, Lonneke J.;
- Haas, Valerie;
- Trka, Jan;
- Baruchel, Andre;
- Reinhardt, Dirk;
- Pieters, Rob;
- Fornerod, Maarten;
- Zwaan, Christian Michel
Publication type:
Article
Implications of delayed bone marrow aspirations at the end of treatment induction for risk stratification and outcome in children with acute lymphoblastic leukaemia.
Published in:
British Journal of Haematology, 2016, v. 173, n. 5, p. 742, doi. 10.1111/bjh.13989
By:
- Zuna, Jan;
- Moericke, Anja;
- Arens, Mari;
- Koehler, Rolf;
- Panzer‐Grümayer, Renate;
- Bartram, Claus R.;
- Fischer, Susanna;
- Fronkova, Eva;
- Zaliova, Marketa;
- Schrauder, André;
- Stanulla, Martin;
- Zimmermann, Martin;
- Trka, Jan;
- Stary, Jan;
- Attarbaschi, Andishe;
- Mann, Georg;
- Schrappe, Martin;
- Cario, Gunnar
Publication type:
Article
The use of formalin-fixed, paraffin-embedded lymph node samples for the detection of minimal residual disease in mantle cell lymphoma.
Published in:
British Journal of Haematology, 2015, v. 169, n. 1, p. 145, doi. 10.1111/bjh.13182
By:
- Kalinova, Marketa;
- Fronkova, Eva;
- Klener, Pavel;
- Forsterova, Kristina;
- Lokvenc, Milan;
- Mejstrikova, Ester;
- Belada, David;
- Mocikova, Heidi;
- Trneny, Marek;
- Kodet, Roman;
- Trka, Jan
Publication type:
Article
Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginase.
Published in:
2020
By:
- Hlozkova, Katerina;
- Pecinova, Alena;
- Alquezar-Artieda, Natividad;
- Pajuelo-Reguera, David;
- Simcikova, Marketa;
- Hovorkova, Lenka;
- Rejlova, Katerina;
- Zaliova, Marketa;
- Mracek, Tomas;
- Kolenova, Alexandra;
- Stary, Jan;
- Trka, Jan;
- Starkova, Julia
Publication type:
journal article
Two novel fusion genes, AIF1L‐ETV6 and ABL1‐AIF1L, result together with ETV6‐ABL1 from a single chromosomal rearrangement in acute lymphoblastic leukemia with prenatal origin.
Published in:
Genes, Chromosomes & Cancer, 2018, v. 57, n. 9, p. 471, doi. 10.1002/gcc.6
By:
- Lukes Jr, Julius;
- Potuckova, Eliska;
- Sramkova, Lucie;
- Stary, Jan;
- Starkova, Julia;
- Trka, Jan;
- Votava, Felix;
- Zuna, Jan;
- Zaliova, Marketa
Publication type:
Article
Posttreatment positivity of BCR::ABL1 in acute lymphoblastic leukemia: Should we keep track?
Published in:
American Journal of Hematology, 2023, v. 98, n. 10, p. E269, doi. 10.1002/ajh.27022
By:
- Zuna, Jan;
- Hovorkova, Lenka;
- Krotka, Justina;
- Winkowska, Lucie;
- Novak, Zbynek;
- Sramkova, Lucie;
- Stary, Jan;
- Trka, Jan;
- Cazzaniga, Giovanni;
- Cario, Gunnar;
- Zaliova, Marketa
Publication type:
Article
The TREC/KREC Assay for the Diagnosis and Monitoring of Patients with DiGeorge Syndrome.
Published in:
PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0114514
By:
- Froňková, Eva;
- Klocperk, Adam;
- Svatoň, Michael;
- Nováková, Michaela;
- Kotrová, Michaela;
- Kayserová, Jana;
- Kalina, Tomáš;
- Keslová, Petra;
- Votava, Felix;
- Vinohradská, Hana;
- Freiberger, Tomáš;
- Mejstříková, Ester;
- Trka, Jan;
- Šedivá, Anna
Publication type:
Article
Molecular Basis of Cisplatin Resistance in Testicular Germ Cell Tumors.
Published in:
Cancers, 2019, v. 11, n. 9, p. 1316, doi. 10.3390/cancers11091316
By:
- Bakardjieva-Mihaylova, Violeta;
- Skvarova Kramarzova, Karolina;
- Slamova, Martina;
- Svaton, Michael;
- Rejlova, Katerina;
- Zaliova, Marketa;
- Dobiasova, Alena;
- Fiser, Karel;
- Stuchly, Jan;
- Grega, Marek;
- Rosova, Blanka;
- Zachoval, Roman;
- Klezl, Petr;
- Eis, Vaclav;
- Kindlova, Eva;
- Buchler, Tomas;
- Trka, Jan;
- Boublikova, Ludmila
Publication type:
Article
Slower molecular response to treatment predicts poor outcome in patients with TEL/AML1 positive acute lymphoblastic leukemia.
Published in:
Cancer (0008543X), 2003, v. 97, n. 1, p. 105, doi. 10.1002/cncr.11043
By:
- Madžo, Jozef;
- Zuna, Jan;
- Mužíková, Kateřina;
- Kalinová, Markéta;
- Krejčí, Ondřej;
- Hrušák, Ondřej;
- Otová, Berta;
- Starý, Jan;
- Trka, Jan
Publication type:
Article
BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations.
Published in:
Journal of Clinical Investigation, 2015, v. 125, n. 6, p. 2363, doi. 10.1172/JCI81163
By:
- Basak, Anindita;
- Hancarova, Miroslava;
- Ulirsch, Jacob C.;
- Balci, Tugce B.;
- Trkova, Marie;
- Pelisek, Michal;
- Vlckova, Marketa;
- Muzikova, Katerina;
- Cermak, Jaroslav;
- Trka, Jan;
- Dyment, David A.;
- Orkin, Stuart H.;
- Daly, Mark J.;
- Sedlacek, Zdenek;
- Sankaran, Vijay G.
Publication type:
Article
Testicular Cancer in Monozygotic Twin Brothers with Urticaria Pigmentosa.
Published in:
2018
By:
- PÉČOVÁ, Tatiana;
- VORČÁKOVÁ, Karolína;
- ŽALIOVÁ, Markéta;
- BURJANIVOVÁ, Tatiana;
- MALICHEROVÁ, Bibiana;
- PLANK, Lukáš;
- TRKA, Jan;
- PÉČOVÁ, Klaudia;
- ADAMICOVÁ, Katarína;
- PÉČ, Martin;
- PÉČ, Juraj
Publication type:
Case Study
Is Next-Generation Sequencing the way to go for Residual Disease Monitoring in Acute Lymphoblastic Leukemia?
Published in:
Molecular Diagnosis & Therapy, 2017, v. 21, n. 5, p. 481, doi. 10.1007/s40291-017-0277-9
By:
- Kotrova, Michaela;
- Trka, Jan;
- Kneba, Michael;
- Brüggemann, Monika
Publication type:
Article
Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia.
Published in:
Human Molecular Genetics, 2014, v. 23, n. 3, p. 590, doi. 10.1093/hmg/ddt447
By:
- Meissner, Barbara;
- Bartram, Thies;
- Eckert, Cornelia;
- Trka, Jan;
- Panzer-Grümayer, Renate;
- Hermanova, Ivana;
- Ellinghaus, Eva;
- Franke, Andre;
- Möricke, Anja;
- Schrauder, André;
- Teigler-Schlegel, Andrea;
- Dörge, Petra;
- von Stackelberg, Arend;
- Basso, Giuseppe;
- Bartram, Claus R.;
- Kirschner-Schwabe, Renate;
- Bornhäuser, Beat;
- Bourquin, Jean-Pierre;
- Cazzaniga, Giovanni;
- Hauer, Julia
Publication type:
Article
Intragenic ERG Deletions Do Not Explain the Biology of ERG-Related Acute Lymphoblastic Leukemia.
Published in:
PLoS ONE, 2016, v. 11, n. 8, p. 1, doi. 10.1371/journal.pone.0160385
By:
- Potuckova, Eliska;
- Zuna, Jan;
- Hovorkova, Lenka;
- Starkova, Julia;
- Stary, Jan;
- Trka, Jan;
- Zaliova, Marketa
Publication type:
Article
ETV6/RUNX1-like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype.
Published in:
Genes, Chromosomes & Cancer, 2017, v. 56, n. 8, p. 608, doi. 10.1002/gcc.22464
By:
- Zaliova, Marketa;
- Kotrova, Michaela;
- Bresolin, Silvia;
- Stuchly, Jan;
- Stary, Jan;
- Hrusak, Ondrej;
- te Kronnie, Geertruy;
- Trka, Jan;
- Zuna, Jan;
- Vaskova, Martina
Publication type:
Article
mi R expression profiling at diagnosis predicts relapse in pediatric precursor B-cell acute lymphoblastic leukemia.
Published in:
Genes, Chromosomes & Cancer, 2016, v. 55, n. 4, p. 328, doi. 10.1002/gcc.22334
By:
- Avigad, Smadar;
- Verly, Iedan RN;
- Lebel, Asaf;
- Kordi, Oshrit;
- Shichrur, Keren;
- Ohali, Anat;
- Hameiri‐Grossman, Michal;
- Kaspers, Gertjan JL;
- Cloos, Jacqueline;
- Fronkova, Eva;
- Trka, Jan;
- Luria, Drorit;
- Kodman, Yona;
- Mirsky, Hadar;
- Gaash, Dafna;
- Jeison, Marta;
- Avrahami, Galia;
- Elitzur, Sarah;
- Gilad, Gil;
- Stark, Batia
Publication type:
Article
Acute leukemias with ETV6/ABL1 ( TEL/ABL) fusion: Poor prognosis and prenatal origin.
Published in:
Genes, Chromosomes & Cancer, 2010, v. 49, n. 10, p. 873, doi. 10.1002/gcc.20796
By:
- Zuna, Jan;
- Zaliova, Marketa;
- Muzikova, Katerina;
- Meyer, Claus;
- Lizcova, Libuse;
- Zemanova, Zuzana;
- Brezinova, Jana;
- Votava, Felix;
- Marschalek, Rolf;
- Stary, Jan;
- Trka, Jan
Publication type:
Article
Covert preleukemia driven by MLL gene fusion.
Published in:
Genes, Chromosomes & Cancer, 2009, v. 48, n. 1, p. 98, doi. 10.1002/gcc.20622
By:
- Zuna, Jan;
- Burjanivova, Tatiana;
- Mejstrikova, Ester;
- Zemanova, Zuzana;
- Muzikova, Katerina;
- Meyer, Claus;
- Horsley, Sharon W.;
- Kearney, Lyndal;
- Colman, Susan;
- Ptoszkova, Hana;
- Marschalek, Rolf;
- Hrusak, Ondrej;
- Stary, Jan;
- Greaves, Mel;
- Trka, Jan
Publication type:
Article
Potential loss of prognostic significance of minimal residual disease assessment after R-CHOP-based induction in elderly patients with mantle cell lymphoma in the era of rituximab maintenance.
Published in:
2018
By:
- Klener, Pavel;
- Fronkova, Eva;
- Kalinova, Marketa;
- Belada, David;
- Forsterova, Kristina;
- Pytlik, Robert;
- Blahovcova, Petra;
- Simkovic, Martin;
- Salek, David;
- Mocikova, Heidi;
- Prochazka, Vit;
- Janikova, Andrea;
- Vaskova, Martina;
- Mejstrikova, Ester;
- Kodet, Roman;
- Trka, Jan;
- Trneny, Marek
Publication type:
journal article
WT1 protein expression in childhood acute leukemia.
Published in:
American Journal of Hematology, 2008, v. 83, n. 5, p. 382, doi. 10.1002/ajh.21123
By:
- Kerst, Gunter;
- Bergold, Nina;
- Gieseke, Friederike;
- Coustan-Smith, Elaine;
- Lang, Peter;
- Kalinova, Marketa;
- Handgretinger, Rupert;
- Trka, Jan;
- Müller, Ingo
Publication type:
Article
Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations.
Published in:
Journal of Hematology & Oncology, 2014, v. 7, n. 1, p. 1, doi. 10.1186/s13045-014-0094-0
By:
- Kramarzova, Karolina Skvarova;
- Fiser, Karel;
- Mejstrikova, Ester;
- Rejlova, Katerina;
- Zaliova, Marketa;
- Fornerod, Maarten;
- Drabkin, Harry A.;
- van den Heuvel-Eibrink, Marry M.;
- Stary, Jan;
- Trka, Jan;
- Starkova, Julia
Publication type:
Article
Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations.
Published in:
Journal of Hematology & Oncology, 2014, v. 7, n. 1, p. 174, doi. 10.1186/s13045-014-0094-0
By:
- Skvarova Kramarzova, Karolina;
- Fiser, Karel;
- Mejstrikova, Ester;
- Rejlova, Katerina;
- Zaliova, Marketa;
- Fornerod, Maarten;
- Drabkin, Harry A.;
- van den Heuvel-Eibrink, Marry M.;
- Stary, Jan;
- Trka, Jan;
- Starkova, Julia
Publication type:
Article
Absence of SBDS mutations in sporadic paediatric acute myeloid leukaemia.
Published in:
British Journal of Haematology, 2013, v. 160, n. 4, p. 559, doi. 10.1111/bjh.12134
By:
- Aalbers, Anna M.;
- Calado, Rodrigo T.;
- Young, Neal S.;
- Zwaan, C. Michel;
- Kajigaya, Sachiko;
- Baruchel, Andre;
- Geleijns, Karin;
- Haas, Valerie;
- Kaspers, Gertjan J. L.;
- Reinhardt, Dirk;
- Trka, Jan;
- Kuijpers, Taco W.;
- Pieters, Rob;
- Velden, Vincent H. J.;
- den Heuvel‐Eibrink, Marry M.
Publication type:
Article
Detection of prognostically relevant genetic abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: recommendations from the Biology and Diagnosis Committee of the International Berlin-Frankfürt-Münster study group.
Published in:
British Journal of Haematology, 2010, v. 151, n. 2, p. 132, doi. 10.1111/j.1365-2141.2010.08314.x
By:
- Harrison, Christine J.;
- Haas, Oskar;
- Harbott, Jochen;
- Biondi, Andrea;
- Stanulla, Martin;
- Trka, Jan;
- Izraeli, Shai
Publication type:
Article
Ikaros ( IKZF1) alterations and minimal residual disease at day 15 assessed by flow cytometry predict prognosis of childhood BCR/ ABL-negative acute lymphoblastic leukemia.
Published in:
Pediatric Blood & Cancer, 2013, v. 60, n. 3, p. 420, doi. 10.1002/pbc.24299
By:
- Volejnikova, Jana;
- Mejstrikova, Ester;
- Dörge, Petra;
- Meissner, Barbara;
- Zimmermannova, Olga;
- Svojgr, Karel;
- Stanulla, Martin;
- Cario, Gunnar;
- Schrappe, Martin;
- Stary, Jan;
- Hrusak, Ondrej;
- Trka, Jan;
- Fronkova, Eva
Publication type:
Article
Differentially expressed miRNAs in cytogenetic and molecular subtypes of pediatric acute myeloid leukemia.
Published in:
2012
By:
- Danen-van Oorschot AA;
- Kuipers JE;
- Arentsen-Peters S;
- Schotte D;
- de Haas V;
- Trka J;
- Baruchel A;
- Reinhardt D;
- Pieters R;
- Michel Zwaan C;
- van den Heuvel-Eibrink MM;
- Danen-van Oorschot, Astrid A;
- Kuipers, Jenny E;
- Arentsen-Peters, Susan;
- Schotte, Diana;
- de Haas, Valerie;
- Trka, Jan;
- Baruchel, André;
- Reinhardt, Dirk;
- Pieters, Rob
Publication type:
journal article
Differentially expressed miRNAs in cytogenetic and molecular subtypes of pediatric acute myeloid leukemia.
Published in:
Pediatric Blood & Cancer, 2012, v. 58, n. 5, p. 715, doi. 10.1002/pbc.23279
By:
- Danen-van Oorschot, Astrid A.;
- Kuipers, Jenny E.;
- Arentsen-Peters, Susan;
- Schotte, Diana;
- de Haas, Valerie;
- Trka, Jan;
- Baruchel, André;
- Reinhardt, Dirk;
- Pieters, Rob;
- Michel Zwaan, C.;
- van den Heuvel-Eibrink, Marry M.
Publication type:
Article
TEL/AML1-positive patients lacking TEL exon 5 resemble canonical TEL/AML1 cases.
Published in:
Pediatric Blood & Cancer, 2011, v. 56, n. 2, p. 217, doi. 10.1002/pbc.22686
By:
- Zaliova, Marketa;
- Meyer, Claus;
- Cario, Gunnar;
- Vaskova, Martina;
- Marschalek, Rolf;
- Stary, Jan;
- Zuna, Jan;
- Trka, Jan
Publication type:
Article
HOX gene expression in phenotypic and genotypic subgroups and low HOXA gene expression as an adverse prognostic factor in pediatric ALL.
Published in:
Pediatric Blood & Cancer, 2010, v. 55, n. 6, p. 1072, doi. 10.1002/pbc.22749
By:
- Starkova, Julia;
- Zamostna, Blanka;
- Mejstrikova, Ester;
- Krejci, Roman;
- Drabkin, Harry A.;
- Trka, Jan
Publication type:
Article
Detection of residual B precursor lymphoblastic leukemia by uniform gating flow cytometry.
Published in:
Pediatric Blood & Cancer, 2010, v. 54, n. 1, p. 62, doi. 10.1002/pbc.22261
By:
- Mejstříková, Ester;
- Froňková, Eva;
- Kalina, Tomáš;
- Omelka, Marek;
- Batinić, Drago;
- Dubravčić, Klara;
- Pospíšilová, Klára;
- Vášková, Martina;
- Luria, Drorit;
- Cheng, Suk Hang;
- Ng, Margaret;
- Leung, Yonna;
- Kappelmayer, Janos;
- Kiss, Flora;
- Izraeli, Shai;
- Stark, Batia;
- Schrappe, Martin;
- Trka, Jan;
- Starý, Jan;
- Hrušák, Ondřej
Publication type:
Article
Detectable minimal residual disease before allogeneic hematopoietic stem cell transplantation predicts extremely poor prognosis in children with acute lymphoblastic leukemia.
Published in:
Pediatric Blood & Cancer, 2007, v. 48, n. 1, p. 93, doi. 10.1002/pbc.20794
By:
- Sramkova, Lucie;
- Muzikova, Katerina;
- Fronkova, Eva;
- Krejci, Ondrej;
- Sedlacek, Petr;
- Formankova, Renata;
- Mejstrikova, Ester;
- Stary, Jan;
- Trka, Jan
Publication type:
Article
Prenatal origin of childhood AML occurs less frequently than in childhood ALL.
Published in:
BMC Cancer, 2006, v. 6, p. 100, doi. 10.1186/1471-2407-6-100
By:
- Burjanivova, Tatiana;
- Madzo, Jozef;
- Muzikova, Katerina;
- Meyer, Claus;
- Schneider, Bjoern;
- Votava, Felix;
- Marschalek, Rolf;
- Stary, Jan;
- Trka, Jan;
- Zuna, Jan
Publication type:
Article
Myeloid antigens in childhood lymphoblastic leukemia:clinical data point to regulation of CD66c distinct from other myeloid antigens.
Published in:
BMC Cancer, 2005, v. 5, p. 38, doi. 10.1186/1471-2407-5-38
By:
- Kalina, Tomas;
- Vaskova, Martina;
- Mejstrikova, Ester;
- Madzo, Jozef;
- Trka, Jan;
- Stary, Jan;
- Hrusak, Ondrej
Publication type:
Article

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