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Alterations in acute myeloid leukaemia bone marrow stromal cell exosome content coincide with gains in tyrosine kinase inhibitor resistance.
Published in:
British Journal of Haematology, 2016, v. 172, n. 6, p. 983, doi. 10.1111/bjh.13551
By:
- Viola, Shelton;
- Traer, Elie;
- Huan, Jianya;
- Hornick, Noah I.;
- Tyner, Jeffrey W.;
- Agarwal, Anupriya;
- Loriaux, Marc;
- Johnstone, Brian;
- Kurre, Peter
Publication type:
Article
Phase Ib study of sabatolimab (MBG453), a novel immunotherapy targeting TIM‐3 antibody, in combination with decitabine or azacitidine in high‐ or very high‐risk myelodysplastic syndromes.
Published in:
American Journal of Hematology, 2024, v. 99, n. 2, p. E32, doi. 10.1002/ajh.27161
By:
- Brunner, Andrew M.;
- Esteve, Jordi;
- Porkka, Kimmo;
- Knapper, Steve;
- Traer, Elie;
- Scholl, Sebastian;
- Garcia‐Manero, Guillermo;
- Vey, Norbert;
- Wermke, Martin;
- Janssen, Jeroen J. W. M.;
- Narayan, Rupa;
- Fleming, Shaun;
- Loo, Sun;
- Tovar, Natalia;
- Kontro, Mika;
- Ottmann, Oliver G.;
- Naidu, Purushotham;
- Sun, Haiying;
- Han, May;
- White, Roisin
Publication type:
Article
The FLT3<sup>N701K</sup> mutation causes clinical AML resistance to gilteritinib and triggers TKI sensitivity switch to quizartinib.
Published in:
American Journal of Hematology, 2023, v. 98, n. 12, p. E364, doi. 10.1002/ajh.27096
By:
- Joshi, Sunil K.;
- Pittsenbarger, Janét;
- Kennedy, Vanessa E.;
- Peretz, Cheryl A. C.;
- Perl, Alexander E.;
- Smith, Catherine C.;
- Tyner, Jeffrey W.;
- Druker, Brian J.;
- Traer, Elie
Publication type:
Article
A noncanonical FLT3 gatekeeper mutation disrupts gilteritinib binding and confers resistance.
Published in:
American Journal of Hematology, 2021, v. 96, n. 7, p. E226, doi. 10.1002/ajh.26174
By:
- Joshi, Sunil K.;
- Sharzehi, Setareh;
- Pittsenbarger, Janét;
- Bottomly, Daniel;
- Tognon, Cristina E.;
- McWeeney, Shannon K.;
- Druker, Brian J.;
- Traer, Elie
Publication type:
Article
TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response.
Published in:
PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0129566
By:
- Rozanov, Dmitri;
- Cheltsov, Anton;
- Sergienko, Eduard;
- Vasile, Stefan;
- Golubkov, Vladislav;
- Aleshin, Alexander E.;
- Levin, Trevor;
- Traer, Elie;
- Hann, Byron;
- Freimuth, Julia;
- Alexeev, Nikita;
- Alekseyev, Max A.;
- Budko, Sergey P;
- Bächinger, Hans Peter;
- Spellman, Paul
Publication type:
Article
Building on Foundations: Venetoclax-Based Combinations in the Treatment of Acute Myeloid Leukemia.
Published in:
Cancers, 2023, v. 15, n. 14, p. 3589, doi. 10.3390/cancers15143589
By:
- Oyogoa, Emmanuella;
- Traer, Elie;
- Tyner, Jeffrey;
- Lachowiez, Curtis
Publication type:
Article
Targeted Next-Generation Sequencing in Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia Aids Diagnosis in Challenging Cases and Identifies Frequent Spliceosome Mutations in Transformed Acute Myeloid Leukemia.
Published in:
2016
By:
- Reinig, Erica;
- Fei Yang;
- Traer, Elie;
- Arora, Ranjana;
- Brown, Shari;
- Rattray, Rogan;
- Braziel, Rita;
- Fan, Guang;
- Press, Richard;
- Dunlap, Jennifer;
- Yang, Fei
Publication type:
journal article
How Much and How Long: Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukemia.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2010, v. 10, p. S20, doi. 10.3816/CLML.2010.s.003
By:
- Traer, Elie;
- Deininger, Michael W.
Publication type:
Article
Targeting BCL-2 and ABL/LYN in Philadelphia chromosome–positive acute lymphoblastic leukemia.
Published in:
Science Translational Medicine, 2016, v. 8, n. 354, p. 1, doi. 10.1126/scitranslmed.aaf5309
By:
- Leonard, Jessica T.;
- Rowley, Joelle S. J.;
- Eide, Christopher A.;
- Traer, Elie;
- Hayes-Lattin, Brandon;
- Loriaux, Marc;
- Spurgeon, Stephen E.;
- Druker, Brian J.;
- Tyner, Jeffrey W.;
- Chang, Bill H.
Publication type:
Article
MDS-404: Population Pharmacokinetics Modeling and Evaluation of Clinical Efficacy and Safety of Sabatolimab: Dose Selection and Dose-Response Analysis.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S349, doi. 10.1016/S2152-2650(21)01810-3
By:
- Garcia-Manero, Guillermo;
- Wei, Andrew H.;
- Porkka, Kimmo;
- Knapper, Steve;
- Vey, Norbert;
- Scholl, Sebastian;
- Wermke, Martin;
- Janssen, Jeroen;
- Traer, Elie;
- Sun Loo;
- Narayan, Rupa;
- Tovar, Natalia;
- Kontro, Mika;
- Ottmann, Oliver;
- Siyan Xu;
- Lewandowski, Andrew;
- Stein, Andrew;
- Naidu, Purushotham;
- Na Zhang;
- Mohammed, Anisa
Publication type:
Article
MDS-420: Sabatolimab Plus Hypomethylating Agents (HMAs) in Patients with High-/Very High-risk Myelodysplastic Syndrome (HR/vHR-MDS) and Newly Diagnosed Acute Myeloid Leukemia (ND-AML): Subgroup Analysis of a Phase 1 Study.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S350, doi. 10.1016/S2152-2650(21)01811-5
By:
- Garcia-Manero, Guillermo;
- Wei, Andrew H.;
- Porkka, Kimmo;
- Knapper, Steve;
- Traer, Elie;
- Scholl, Sebastian;
- Vey, Norbert;
- Wermke, Martin;
- Janssen, Jeroen;
- Narayan, Rupa;
- Sun Loo;
- Tovar, Natalia;
- Kontro, Mika;
- Ottmann, Oliver;
- Naidu, Purushotham;
- Orlando, Elena;
- Patei, Nidhi;
- Makofske, Jessica;
- Fei Ma;
- Na Zhang
Publication type:
Article
Poster: MDS-404: Population Pharmacokinetics Modeling and Evaluation of Clinical Efficacy and Safety of Sabatolimab: Dose Selection and Dose-Response Analysis.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S230, doi. 10.1016/S2152-2650(21)01448-8
By:
- Garcia-Manero, Guillermo;
- Wei, Andrew H.;
- Porkka, Kimmo;
- Knapper, Steve;
- Vey, Norbert;
- Scholl, Sebastian;
- Wermke, Martin;
- Janssen, Jeroen;
- Traer, Elie;
- Sun Loo;
- Narayan, Rupa;
- Tovar, Natalia;
- Kontro, Mika;
- Ottmann, Oliver;
- Siyan Xu;
- Lewandowski, Andrew;
- Stein, Andrew;
- Naidu, Purushotham;
- Na Zhang;
- Mohammed, Anisa
Publication type:
Article
Poster: MDS-420: Sabatolimab Plus Hypomethylating Agents (HMAs) in Patients with High-/Very High-risk Myelodysplastic Syndrome (HR/vHR-MDS) and Newly Diagnosed Acute Myeloid Leukemia (ND-AML): Subgroup Analysis of a Phase 1 Study.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S230, doi. 10.1016/S2152-2650(21)01447-6
By:
- Garcia-Manero, Guillermo;
- Wei, Andrew H.;
- Porkka, Kimmo;
- Knapper, Steve;
- Traer, Elie;
- Scholl, Sebastian;
- Vey, Norbert;
- Wermke, Martin;
- Janssen, Jeroen;
- Narayan, Rupa;
- Sun Loo;
- Tovar, Natalia;
- Kontro, Mika;
- Ottmann, Oliver;
- Naidu, Purushotham;
- Orlando, Elena;
- Patel, Nidhi;
- Makofske, Jessica;
- Fei Ma;
- Na Zhang
Publication type:
Article
Ivosidenib (AG-120) in Mutant IDH1 Relapsed/Refractory Acute Myeloid Leukemia: Results of a Phase 1 Study.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2018, v. 18, p. S204, doi. 10.1016/j.clml.2018.07.057
By:
- DiNardo, Courtney D.;
- Stein, Eytan M.;
- de Botton, Stéphane;
- Roboz, Gail J.;
- Altman, Jessica K.;
- Mims, Alice S.;
- Swords, Ronan;
- Collins, Robert H.;
- Mannis, Gabriel N.;
- Pollyea, Daniel A.;
- Donnellan, Will;
- Fathi, Amir T.;
- Pigneux, Arnaud;
- Erba, Harry P.;
- Prince, Gabrielle T.;
- Stein, Anthony S.;
- Uy, Geoffrey L.;
- Foran, James M.;
- Traer, Elie;
- Stuart, Robert K.
Publication type:
Article
IDH Inhibitors in AML—Promise and Pitfalls.
Published in:
Current Hematologic Malignancy Reports, 2021, v. 16, n. 2, p. 207, doi. 10.1007/s11899-021-00619-3
By:
- McMurry, Hannah;
- Fletcher, Luke;
- Traer, Elie
Publication type:
Article
The combination of NPM1, DNMT3A, and IDH1/2 mutations leads to inferior overall survival in AML.
Published in:
American Journal of Hematology, 2019, v. 94, n. 8, p. 913, doi. 10.1002/ajh.25517
By:
- Dunlap, Jennifer B.;
- Leonard, Jessica;
- Rosenberg, Mara;
- Cook, Rachel;
- Press, Richard;
- Fan, Guang;
- Raess, Philipp W.;
- Druker, Brian J.;
- Traer, Elie
Publication type:
Article
Mutant calreticulin-expressing cells induce monocyte hyperreactivity through a paracrine mechanism.
Published in:
American Journal of Hematology, 2016, v. 91, n. 2, p. 211, doi. 10.1002/ajh.24245
By:
- Garbati, Michael R.;
- Welgan, Catherine A.;
- Landefeld, Sally H.;
- Newell, Laura F.;
- Agarwal, Anupriya;
- Dunlap, Jennifer B.;
- Chourasia, Tapan K.;
- Lee, Hyunjung;
- Elferich, Johannes;
- Traer, Elie;
- Rattray, Rogan;
- Cascio, Michael J.;
- Press, Richard D.;
- Bagby, Grover C.;
- Tyner, Jeffrey W.;
- Druker, Brian J.;
- Dao, Kim-Hien T.
Publication type:
Article
Profile of Quizartinib for the Treatment of Adult Patients with Relapsed/Refractory FLT3-ITD-Positive Acute Myeloid Leukemia: Evidence to Date.
Published in:
Cancer Management & Research, 2020, v. 12, p. 151, doi. 10.2147/CMAR.S196568
By:
- Fletcher, Luke;
- Joshi, Sunil K;
- Traer, Elie
Publication type:
Article
Functional and genetic screening of acute myeloid leukemia associated with mediastinal germ cell tumor identifies MEK inhibitor as an active clinical agent.
Published in:
Journal of Hematology & Oncology, 2016, v. 9, p. 1, doi. 10.1186/s13045-016-0258-1
By:
- Leonard, Jessica T.;
- Raess, Philipp W.;
- Dunlap, Jennifer;
- Hayes-Lattin, Brandon;
- Tyner, Jeffrey W.;
- Traer, Elie
Publication type:
Article
Cytogenetically Cryptic Acute Promyelocytic Leukemia: A Diagnostic Challenge.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 17, p. 13075, doi. 10.3390/ijms241713075
By:
- Mohebnasab, Maedeh;
- Li, Peng;
- Hong, Bo;
- Dunlap, Jennifer;
- Traer, Elie;
- Fan, Guang;
- Press, Richard D.;
- Moore, Stephen R.;
- Xie, Wei
Publication type:
Article
Cholesterol esterification inhibition and imatinib treatment synergistically inhibit growth of BCR-ABL mutation-independent resistant chronic myelogenous leukemia.
Published in:
PLoS ONE, 2017, v. 12, n. 7, p. 1, doi. 10.1371/journal.pone.0179558
By:
- Bandyopadhyay, Shovik;
- Li, Junjie;
- Traer, Elie;
- Tyner, Jeffrey W.;
- Zhou, Amy;
- Oh, Stephen T.;
- Cheng, Ji-Xin
Publication type:
Article
Proteomic and phosphoproteomic measurements enhance ability to predict ex vivo drug response in AML.
Published in:
Clinical Proteomics, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12014-022-09367-9
By:
- Gosline, Sara J. C.;
- Tognon, Cristina;
- Nestor, Michael;
- Joshi, Sunil;
- Modak, Rucha;
- Damnernsawad, Alisa;
- Posso, Camilo;
- Moon, Jamie;
- Hansen, Joshua R.;
- Hutchinson-Bunch, Chelsea;
- Pino, James C.;
- Gritsenko, Marina A.;
- Weitz, Karl K.;
- Traer, Elie;
- Tyner, Jeffrey;
- Druker, Brian;
- Agarwal, Anupriya;
- Piehowski, Paul;
- McDermott, Jason E.;
- Rodland, Karin
Publication type:
Article

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