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NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells.
Published in:
Signal Transduction & Targeted Therapy, 2020, v. 5, n. 1, p. 1, doi. 10.1038/s41392-019-0102-5
By:
- Fenerich, Bruna Alves;
- Fernandes, Jaqueline Cristina;
- Rodrigues Alves, Ana Paula Nunes;
- Coelho-Silva, Juan Luiz;
- Scopim-Ribeiro, Renata;
- Scheucher, Priscila Santos;
- Eide, Christopher A.;
- Tognon, Cristina E.;
- Druker, Brian J.;
- Rego, Eduardo Magalhães;
- Machado-Neto, João Agostinho;
- Traina, Fabiola
Publication type:
Article
Mediators of receptor tyrosine kinase activation in infantile fibrosarcoma: a Children's Oncology Group study.
Published in:
Journal of Pathology, 2012, v. 228, n. 1, p. 119, doi. 10.1002/path.4010
By:
- Gadd, Samantha;
- Beezhold, Patricia;
- Jennings, Lawrence;
- George, David;
- Leuer, Katrin;
- Huang, Chiang-Ching;
- Huff, Vicki;
- Tognon, Cristina;
- Sorensen, Poul HB;
- Triche, Timothy;
- Coffin, Cheryl M;
- Perlman, Elizabeth J
Publication type:
Article
CDK12/13 dual inhibitors are potential therapeutics for acute myeloid leukemia.
Published in:
British Journal of Haematology, 2023, v. 202, n. 1, p. 195, doi. 10.1111/bjh.18843
By:
- Savoy, Lindsey;
- Long, Nicola;
- Lee, Hyunjung;
- Chen, Reid;
- Allen, Basil;
- Lin, Hsin‐Yun;
- Tognon, Cristina;
- V. Malhotra, Sanjay;
- Tyner, Jeffrey W.;
- Zhang, Haijiao
Publication type:
Article
Secondary fusion proteins as a mechanism of BCR::ABL1 kinase‐independent resistance in chronic myeloid leukaemia.
Published in:
British Journal of Haematology, 2023, v. 200, n. 3, p. 323, doi. 10.1111/bjh.18515
By:
- Barnes, Evan J.;
- Eide, Christopher A.;
- Kaempf, Andy;
- Bottomly, Daniel;
- Romine, Kyle A.;
- Wilmot, Beth;
- Saunders, Dominick;
- McWeeney, Shannon K.;
- Tognon, Cristina E.;
- Druker, Brian J.
Publication type:
Article
NT157, an IGF1R-IRS1/2 inhibitor, exhibits antineoplastic effects in pre-clinical models of chronic myeloid leukemia.
Published in:
Investigational New Drugs, 2021, v. 39, n. 3, p. 736, doi. 10.1007/s10637-020-01028-8
By:
- Scopim-Ribeiro, Renata;
- Machado-Neto, João Agostinho;
- Eide, Christopher A.;
- Coelho-Silva, Juan Luiz;
- Fenerich, Bruna Alves;
- Fernandes, Jaqueline Cristina;
- Scheucher, Priscila Santos;
- Savage Stevens, Samantha L.;
- de Melo Campos, Paula;
- Olalla Saad, Sara T.;
- de Carvalho Palma, Leonardo;
- de Figueiredo-Pontes, Lorena Lobo;
- Simões, Belinda Pinto;
- Rego, Eduardo Magalhães;
- Tognon, Cristina E.;
- Druker, Brian J.;
- Traina, Fabiola
Publication type:
Article
A noncanonical FLT3 gatekeeper mutation disrupts gilteritinib binding and confers resistance.
Published in:
American Journal of Hematology, 2021, v. 96, n. 7, p. E226, doi. 10.1002/ajh.26174
By:
- Joshi, Sunil K.;
- Sharzehi, Setareh;
- Pittsenbarger, Janét;
- Bottomly, Daniel;
- Tognon, Cristina E.;
- McWeeney, Shannon K.;
- Druker, Brian J.;
- Traer, Elie
Publication type:
Article
ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation.
Published in:
Oncogene, 2002, v. 21, n. 37, p. 5684, doi. 10.1038/sj.onc.1205669
By:
- Morrison, Kevin B.;
- Tognon, Cristina E.;
- Garnett, Mathew J.;
- Deal, Cheri;
- Sorensen, Poul HB
Publication type:
Article
Metformin exerts multitarget antileukemia activity in JAK2<sup>V617F</sup>-positive myeloproliferative neoplasms.
Published in:
Cell Death & Disease, 2018, v. 9, n. 3, p. 1, doi. 10.1038/s41419-017-0256-4
By:
- Machado-Neto, João Agostinho;
- Fenerich, Bruna Alves;
- Scopim-Ribeiro, Renata;
- Eide, Christopher A.;
- Coelho-Silva, Juan Luiz;
- Dechandt, Carlos Roberto Porto;
- Fernandes, Jaqueline Cristina;
- Rodrigues Alves, Ana Paula Nunes;
- Scheucher, Priscila Santos;
- Simões, Belinda Pinto;
- Alberici, Luciane Carla;
- de Figueiredo Pontes, Lorena Lôbo;
- Tognon, Cristina E.;
- Druker, Brian J.;
- Rego, Eduardo Magalhães;
- Traina, Fabiola
Publication type:
Article
Identification of targeted therapies for rare adult mature T-cell leukemia using functional ex vivo screening of primary patient samples.
Published in:
American Journal of Hematology, 2017, v. 92, n. 5, p. E64, doi. 10.1002/ajh.24669
By:
- Borate, Uma;
- Norris, Brianna A.;
- Lo, Pierrette;
- Tognon, Cristina;
- Tyner, Jeffrey;
- Spurgeon, Stephen
Publication type:
Article
Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia.
Published in:
NPJ Precision Oncology, 2021, v. 5, n. 1, p. 1, doi. 10.1038/s41698-021-00209-9
By:
- White, Brian S.;
- Khan, Suleiman A.;
- Mason, Mike J.;
- Ammad-ud-din, Muhammad;
- Potdar, Swapnil;
- Malani, Disha;
- Kuusanmäki, Heikki;
- Druker, Brian J.;
- Heckman, Caroline;
- Kallioniemi, Olli;
- Kurtz, Stephen E.;
- Porkka, Kimmo;
- Tognon, Cristina E.;
- Tyner, Jeffrey W.;
- Aittokallio, Tero;
- Wennerberg, Krister;
- Guinney, Justin
Publication type:
Article
Expression and stability of hypoxia inducible factor 1α in osteosarcoma.
Published in:
Pediatric Blood & Cancer, 2012, v. 59, n. 7, p. 1215, doi. 10.1002/pbc.24191
By:
- El Naggar, Amal;
- Clarkson, Paul;
- Zhang, Fan;
- Mathers, Joan;
- Tognon, Cristina;
- Sorensen, Poul H.
Publication type:
Article
Comprehensive molecular characterization of a rare case of Philadelphia chromosome--positive acute myeloid leukemia.
Published in:
Cold Spring Harbor Molecular Case Studies, 2022, v. 8, n. 6, p. 1, doi. 10.1101/mcs.a006218
By:
- Rosenberg, Mara W.;
- Savage, Samantha L.;
- Eide, Christopher A.;
- Schultz, Anna Reister;
- Cook, Rachel J.;
- Press, Richard D.;
- Rempfer, Carole;
- Eickelberg, Garrett;
- Wilmot, Beth;
- McWeeney, Shannon K.;
- Tyner, Jeffrey W.;
- Druker, Brian J.;
- Tognon, Cristina E.
Publication type:
Article
Functional characterization of two rare BCR-FGFR1<sup>+</sup> leukemias.
Published in:
Cold Spring Harbor Molecular Case Studies, 2020, v. 6, n. 2, p. 1, doi. 10.1101/mcs.a004838
By:
- Barnes, Evan J.;
- Leonard, Jessica;
- Medeiros, Bruno C.;
- Druker, Brian J.;
- Tognon, Cristina E.
Publication type:
Article
Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity.
Published in:
PLoS ONE, 2019, v. 14, n. 3, p. 1, doi. 10.1371/journal.pone.0205623
By:
- Rozanov, Dmitri;
- Cheltsov, Anton;
- Nilsen, Aaron;
- Boniface, Christopher;
- Forquer, Isaac;
- Korkola, James;
- Gray, Joe;
- Tyner, Jeffrey;
- Tognon, Cristina E.;
- Mills, Gordon B.;
- Spellman, Paul
Publication type:
Article
Detecting and targetting oncogenic fusion proteins in the genomic era.
Published in:
Biology of the Cell (Wiley-Blackwell), 2015, v. 107, n. 5, p. 111, doi. 10.1111/boc.201400096
By:
- Davare, Monika A.;
- Tognon, Cristina E.
Publication type:
Article
IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors.
Published in:
Science Signaling, 2012, v. 5, n. 255, p. 1, doi. 10.1126/scisignal.2003184
By:
- Evdokimova, Valentina;
- Tognon, Cristina E.;
- Benatar, Tania;
- Wenyi Yang;
- Krutikov, Konstantin;
- Pollak, Michael;
- Sorensen, Poul H. B.;
- Seth, Arun
Publication type:
Article
Proteomic and phosphoproteomic measurements enhance ability to predict ex vivo drug response in AML.
Published in:
Clinical Proteomics, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12014-022-09367-9
By:
- Gosline, Sara J. C.;
- Tognon, Cristina;
- Nestor, Michael;
- Joshi, Sunil;
- Modak, Rucha;
- Damnernsawad, Alisa;
- Posso, Camilo;
- Moon, Jamie;
- Hansen, Joshua R.;
- Hutchinson-Bunch, Chelsea;
- Pino, James C.;
- Gritsenko, Marina A.;
- Weitz, Karl K.;
- Traer, Elie;
- Tyner, Jeffrey;
- Druker, Brian;
- Agarwal, Anupriya;
- Piehowski, Paul;
- McDermott, Jason E.;
- Rodland, Karin
Publication type:
Article

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