Found: 3

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  • The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease.

    Published in:
    EMBO Molecular Medicine, 2018, v. 10, n. 11, p. N.PAG, doi. 10.15252/emmm.201809316
    By:
    • Neumann, Ulf;
    • Ufer, Mike;
    • Jacobson, Laura H;
    • Rouzade‐Dominguez, Marie‐Laure;
    • Huledal, Gunilla;
    • Kolly, Carine;
    • Lüönd, Rainer M;
    • Machauer, Rainer;
    • Veenstra, Siem J;
    • Hurth, Konstanze;
    • Rueeger, Heinrich;
    • Tintelnot‐Blomley, Marina;
    • Staufenbiel, Matthias;
    • Shimshek, Derya R;
    • Perrot, Ludovic;
    • Frieauff, Wilfried;
    • Dubost, Valerie;
    • Schiller, Hilmar;
    • Vogg, Barbara;
    • Beltz, Karen
    Publication type:
    Article

  • Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity.

    Published in:
    Advanced Therapeutics, 2020, v. 3, n. 9, p. 1, doi. 10.1002/adtp.202000078
    By:
    • Hughes, Nicola;
    • Erbel, Paul;
    • Bornancin, Frédéric;
    • Wiesmann, Christian;
    • Schiering, Nikolaus;
    • Villard, Frédéric;
    • Decock, Arnaud;
    • Rubi, Bertran;
    • Melkko, Samu;
    • Spanka, Carsten;
    • Buschmann, Nicole;
    • Pissot‐Soldermann, Carole;
    • Simic, Oliver;
    • Beerli, René;
    • Sorge, Mickael;
    • Tintelnot‐Blomley, Marina;
    • Beltz, Karen;
    • Régnier, Catherine H.;
    • Quancard, Jean;
    • Schlapbach, Achim
    Publication type:
    Article

  • A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.

    Published in:
    Molecular Neurodegeneration, 2015, v. 10, n. 1, p. 1, doi. 10.1186/s13024-015-0033-8
    By:
    • Neumann, Ulf;
    • Rueeger, Heinrich;
    • Machauer, Rainer;
    • Veenstra, Siem Jacob;
    • Lueoend, Rainer M.;
    • Tintelnot-Blomley, Marina;
    • Laue, Grit;
    • Beltz, Karen;
    • Vogg, Barbara;
    • Schmid, Peter;
    • Frieauff, Wilfried;
    • Shimshek, Derya R.;
    • Staufenbiel, Matthias;
    • Jacobson, Laura H.
    Publication type:
    Article