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Pancreatic β-cells package double C2-like domain beta protein into extracellular vesicles via tandem C2 domains.
- Published in:
- Frontiers in Endocrinology, 2024, p. 1, doi. 10.3389/fendo.2024.1451279
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- Publication type:
- Article
Discrimination of GLUT4 vesicle trafficking from fusion using a temperature-sensitive Munc18c mutant.
- Published in:
- EMBO Journal, 2000, v. 19, n. 14, p. 3565, doi. 10.1093/emboj/19.14.3565
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- Publication type:
- Article
Mechanisms by Which Skeletal Muscle Myokines Ameliorate Insulin Resistance.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 9, p. 4636, doi. 10.3390/ijms23094636
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- Publication type:
- Article
Conventional and Unconventional Mechanisms by which Exocytosis Proteins Oversee β-cell Function and Protection.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 4, p. 1833, doi. 10.3390/ijms22041833
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- Publication type:
- Article
Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet _-cells.
- Published in:
- Biochemical Journal, 2014, v. 464, n. 2, p. 251, doi. 10.1042/BJ20140845
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- Publication type:
- Article
Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28061-w
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- Publication type:
- Article
DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle.
- Published in:
- Diabetologia, 2019, v. 62, n. 5, p. 845, doi. 10.1007/s00125-019-4824-2
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- Publication type:
- Article
Novel approaches to restore beta cell function in prediabetes and type 2 diabetes.
- Published in:
- Diabetologia, 2018, v. 61, n. 9, p. 1895, doi. 10.1007/s00125-018-4658-3
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- Publication type:
- Article
Editorial: Connecting the Dots Between Obesity, Diabetes and Cancer.
- Published in:
- 2020
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- Publication type:
- Editorial
Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10.
- Published in:
- Nature, 2001, v. 410, n. 6831, p. 944, doi. 10.1038/35073608
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- Publication type:
- Article
Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis.
- Published in:
- Journal of Cell Biology, 2011, v. 193, n. 1, p. 185, doi. 10.1083/jcb.201007176
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- Publication type:
- Article
Toward Ameliorating Insulin Resistance: Targeting a Novel PAK1 Signaling Pathway Required for Skeletal Muscle Mitochondrial Function.
- Published in:
- Antioxidants, 2023, v. 12, n. 9, p. 1658, doi. 10.3390/antiox12091658
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- Publication type:
- Article
Promoting Glucose Transporter-4 vesicle Trafficking along Cytoskeletal Tracks: PAK-ing Them Out.
- Published in:
- Frontiers in Endocrinology, 2017, p. 1, doi. 10.3389/fendo.2017.00329
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- Publication type:
- Article
Syntaxin 4 and Syntaxin 1A Differentially Interact with the Actin Cytoskeleton to Regulate Biphasic Insulin Secretion.
- Published in:
- Diabetes, 2007, v. 56, p. A434
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- Publication type:
- Article
WNK1 Is a Novel Regulator of Munc18c-Syntaxin 4 Complex Formation in SNARE-Mediated Vesicle Exocytosis.
- Published in:
- Diabetes, 2007, v. 56, p. A4
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- Publication type:
- Article
SNARE-Dependent Exocytosis Is Facilitated by Association of Munc18c with Doc2β.
- Published in:
- Diabetes, 2007, v. 56, p. A4
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- Publication type:
- Article
Essential role for membrane lipid rafts in interleukin-1beta-induced nitric oxide release from insulin-secreting cells: potential regulation by caveolin-1+.
- Published in:
- 2005
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- Publication type:
- journal article
Munc18c heterozygous knockout mice display increased susceptibility for severe glucose intolerance.
- Published in:
- 2005
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- Publication type:
- journal article
Syntaxin 4 transgenic mice exhibit enhanced insulin-mediated glucose uptake in skeletal muscle.
- Published in:
- 2004
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- Publication type:
- journal article
Insulin resistance in tetracycline-repressible Munc18c transgenic mice.
- Published in:
- 2003
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- Publication type:
- journal article
Emerging Roles of Small GTPases in Islet β-Cell Function.
- Published in:
- Cells (2073-4409), 2021, v. 10, n. 6, p. 1503, doi. 10.3390/cells10061503
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- Publication type:
- Article
Exocytosis Proteins: Typical and Atypical Mechanisms of Action in Skeletal Muscle.
- Published in:
- Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.915509
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- Publication type:
- Article
Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis.
- Published in:
- Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.821849
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- Publication type:
- Article
Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle
- Published in:
- FEBS Letters, 2012, v. 586, n. 16, p. 2428, doi. 10.1016/j.febslet.2012.05.061
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- Publication type:
- Article
Inflammatory stress of pancreatic beta cells drives release of extracellular heat-shock protein 90 α.
- Published in:
- Immunology, 2017, v. 151, n. 2, p. 198, doi. 10.1111/imm.12723
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- Publication type:
- Article
Exocytosis Protein DOC2B as a Biomarker of Type 1 Diabetes.
- Published in:
- 2018
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- Publication type:
- journal article
Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn-2, a Negative Regulator of Insulin Secretion.
- Published in:
- PLoS Genetics, 2011, v. 7, n. 10, p. 1, doi. 10.1371/journal.pgen.1002323
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- Publication type:
- Article
PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet β-cells
- Published in:
- FEBS Open Bio, 2012, v. 2, p. 273, doi. 10.1016/j.fob.2012.09.001
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- Publication type:
- Article
PAK1 limits the expression of the pro‐apoptotic protein Bad in pancreatic islet β‐cells.
- Published in:
- FEBS Open Bio, 2012, v. 2, n. 1, p. 273, doi. 10.1016/j.fob.2012.09.001
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- Publication type:
- Article
Glucosamine-induced insulin resistance is coupled to O-linked glycosylation of Munc18c
- Published in:
- FEBS Letters, 2003, v. 534, n. 1-3, p. 54, doi. 10.1016/S0014-5793(02)03774-2
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- Publication type:
- Article
Mitochondrial Dysfunction, Oxidative Stress, and Inter-Organ Miscommunications in T2D Progression.
- Published in:
- International Journal of Molecular Sciences, 2024, v. 25, n. 3, p. 1504, doi. 10.3390/ijms25031504
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- Publication type:
- Article
A Novel Role for DOC2B in Ameliorating Palmitate-Induced Glucose Uptake Dysfunction in Skeletal Muscle Cells via a Mechanism Involving β-AR Agonism and Cofilin.
- Published in:
- International Journal of Molecular Sciences, 2024, v. 25, n. 1, p. 137, doi. 10.3390/ijms25010137
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- Publication type:
- Article
Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for β-Cell Function During Aging.
- Published in:
- Diabetes, 2024, v. 73, n. 9, p. 1447, doi. 10.2337/db23-0490
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- Publication type:
- Article
DOC2b Enhances β-Cell Function via a Novel Tyrosine Phosphorylation-Dependent Mechanism.
- Published in:
- 2022
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- Publication type:
- journal article
Syntaxin 4 Enrichment in β-Cells Prevents Conversion to Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice.
- Published in:
- 2021
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- Publication type:
- journal article
128-OR: DOC2b Boosts Insulin Secretion via a Yes Kinase-Dependent Mechanism.
- Published in:
- Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-128-OR
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- Publication type:
- Article
Syntaxin 4 Mediates NF-κB Signaling and Chemokine Ligand Expression via Specific Interaction With IκBβ.
- Published in:
- 2021
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- Publication type:
- journal article
Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass.
- Published in:
- 2018
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- Publication type:
- journal article
Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets.
- Published in:
- 2018
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- Publication type:
- journal article
Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function.
- Published in:
- 2018
- By:
- Publication type:
- journal article
The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth.
- Published in:
- Diabetes, 2014, v. 63, n. 6, p. 1994, doi. 10.2337/db13-1001
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- Publication type:
- Article
Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity.
- Published in:
- 2012
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- Publication type:
- journal article
Doc2b Is a Key Effector of Insulin Secretion and Skeletal Muscle Insulin Sensitivity.
- Published in:
- Diabetes, 2012, v. 61, n. 10, p. 2424, doi. 10.2337/db11-1525
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- Publication type:
- Article
Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release.
- Published in:
- Diabetes, 2009, v. 58, n. 5, p. 1165, doi. 10.2337/db08-1059
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- Publication type:
- Article