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Long-Term Intranasal Insulin Aspart: A Profile of Gene Expression, Memory, and Insulin Receptors in Aged F344 Rats.
Published in:
2020
By:
- Frazier, Hilaree N;
- Ghoweri, Adam O;
- Sudkamp, Emily;
- Johnson, Eleanor S;
- Anderson, Katie L;
- Fox, Grant;
- Vatthanaphone, Keomany;
- Xia, Mengfan;
- Lin, Ruei-Lung;
- Hargis-Staggs, Kendra E;
- Porter, Nada M;
- Pauly, James R;
- Blalock, Eric M;
- Thibault, Olivier
Publication type:
journal article
Impact of Single or Repeated Dose Intranasal Zinc-free Insulin in Young and Aged F344 Rats on Cognition, Signaling, and Brain Metabolism.
Published in:
2017
By:
- Anderson, Katie L.;
- Frazier, Hilaree N.;
- Maimaiti, Shaniya;
- Bakshi, Vikas V.;
- Majeed, Zana R.;
- Brewer, Lawrence D.;
- Porter, Nada M.;
- Ai-Ling Lin;
- Thibault, Olivier;
- Lin, Ai-Ling
Publication type:
journal article
Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging.
Published in:
2016
By:
- Maimaiti, Shaniya;
- Anderson, Katie L.;
- DeMoll, Chris;
- Brewer, Lawrence D.;
- Rauh, Benjamin A.;
- Gant, John C.;
- Blalock, Eric M.;
- Porter, Nada M.;
- Thibault, Olivier
Publication type:
journal article
Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease.
Published in:
Journal of Neuroscience, 2023, v. 43, n. 10, p. 1797, doi. 10.1523/JNEUROSCI.1333-22.2023
By:
- Sompol, Pradoldej;
- Gollihue, Jenna L.;
- Weiss, Blaine E.;
- Ruei-Lung Lin;
- Case, Sami L.;
- Kraner, Susan D.;
- Weekman, Erica M.;
- Gant, John C.;
- Rogers, Colin B.;
- Niedowicz, Dana M.;
- Sudduth, Tiffany L.;
- Powell, David K.;
- Ai-Ling Lin;
- Thibault, Olivier;
- Wilcock, Donna M.;
- Norris, Christopher M.
Publication type:
Article
Astrocyte calcium dysregulation and cerebrovascular impairments in the 5XFAD mouse model of familial Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.083232
By:
- Weiss, Blaine E.;
- Gant, John C;
- Sompol, Pradoldej;
- Thibault, Olivier;
- Kraner, Susan D.;
- Norris, Christopher M.
Publication type:
Article
Low‐Frequency Oscillations During Resting and Task Differentially Associate with Working Memory Performance in Older Adults.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078984
By:
- Venkatesan, Tharunika;
- Fei, Ellen;
- Hammond, Tyler C;
- Zhao, Xiaopeng;
- Thibault, Olivier;
- Sompol, Pradoldej M;
- Norris, Christopher M.;
- Jicha, Gregory A;
- Jiang, Yang
Publication type:
Article
Astrocyte Ca2+ dysregulation and neurovascular coupling deficits in a diet‐based mouse model of small cerebral vessel disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080450
By:
- Weiss, Blaine E.;
- Sompol, Pradoldej M;
- Gant, John C;
- Lin, Ruei‐Lung;
- Nelson, Peter T;
- Thibault, Olivier;
- Wilcock, Donna M.;
- Norris, Christopher M.
Publication type:
Article
Perturbed astrocyte Ca2+ signaling in a diet‐based mouse model of small cerebral vessel disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.069404
By:
- Norris, Christopher M;
- Sompol, Pradoldej M;
- Weiss, Blaine E.;
- Gant, Christopher C;
- Wilcock, Donna M;
- Lin, Ruei‐Lung;
- Thibault, Olivier
Publication type:
Article
Astrocyte activation and neurovascular function in a diet‐based model of vascular contributions to cognitive impairment and dementia (VCID): Molecular and cell biology/vascular factors.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043618
By:
- Sompol, Pradoldej;
- Edelmann, Stephanie E.;
- Lin, Ruei‐Lung;
- Gant, Christopher C.;
- Kraner, Susan D.;
- Weiss, Blaine E.;
- Farr, N. Drew;
- Gollihue, Jenna L.;
- Thibault, Olivier;
- Wilcock, Donna M.;
- Norris, Christopher M.
Publication type:
Article
F1‐07‐02: ASTROCYTE ACTIVATION AND HIPPOCAMPAL SYNAPTIC IMPAIRMENTS IN MOUSE MODELS OF AMYLOID PATHOLOGY AND CEREBROVASCULAR DYSFUNCTION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P188, doi. 10.1016/j.jalz.2019.06.4394
By:
- Sompol, Pradoldej;
- Kraner, Susan D.;
- Gollihue, Jenna L.;
- Thibault, Olivier;
- Wilcock, Donna M.;
- Norris, Chris M.
Publication type:
Article
Aged rats are hypo-responsive to acute restraint: implications for psychosocial stress in aging.
Published in:
Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00013
By:
- Buechel, Heather M.;
- Popovic, Jelena;
- Staggs, Kendra;
- Anderson, Katie L.;
- Thibault, Olivier;
- Blalock, Eric M.
Publication type:
Article
Long-term effects of simvastatin and atorvastatin on a rat model of normal brain aging
Published in:
2009
By:
- Searcy, James L.;
- Latimer, Caitlin S.;
- Thibault, Olivier;
- Blalock, Eric M.;
- Chen, Kuey-Chu;
- Kadish, Inga;
- Landfeild, Philip W.;
- Porter, Nada M.
Publication type:
Abstract
P2-463: LXR agonist treatment of a transgenic mouse model of Alzheimer's disease: Effects on behavioral, electrophysiological and immunohistochemical markers
Published in:
2008
By:
- Searcy, James L.;
- Phelps, Jeremiah T.;
- Blalock, Eric M.;
- Dowling, Amy L.S.;
- Chen, Kuey-Chu C.;
- Landfield, Philip W.;
- Thibault, Olivier;
- Kadish, Inga;
- Porter, Nada M.
Publication type:
Abstract
P2-457: Effect of chronic treatment with the PPAR-G agonist, pioglitazone, in a triple transgenic model of Alzheimer's disease
Published in:
2008
By:
- Phelps, Jeremiah T.;
- Searcy, James L.;
- Pancani, Tristano;
- Blalock, Eric M.;
- Chen, Kuey-Chu;
- Porter, Nada M.;
- Thibault, Olivier
Publication type:
Abstract
Reversal of Glial and Neurovascular Markers of Unhealthy Brain Aging by Exercise in Middle-Aged Female Mice.
Published in:
PLoS ONE, 2011, v. 6, n. 10, p. 1, doi. 10.1371/journal.pone.0026812
By:
- Latimer, Caitlin S.;
- Searcy, James L.;
- Bridges, Michael T.;
- Brewer, Lawrence D.;
- Popović, Jelena;
- Blalock, Eric M.;
- Landfield, Philip W.;
- Thibault, Olivier;
- Porter, Nada M.
Publication type:
Article
Deep Sleep and Parietal Cortex Gene Expression Changes Are Related to Cognitive Deficits with Age.
Published in:
PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0018387
By:
- Buechel, Heather M.;
- Popovic, Jelena;
- Searcy, James L.;
- Porter, Nada M.;
- Thibault, Olivier;
- Blalock, Eric M.
Publication type:
Article
Effects of Long-Term Pioglitazone Treatment on Peripheral and Central Markers of Aging.
Published in:
PLoS ONE, 2010, v. 5, n. 4, p. 1, doi. 10.1371/journal.pone.0010405
By:
- Blalock, Eric M.;
- Phelps, Jeremiah T.;
- Pancani, Tristano;
- Searcy, James L.;
- Anderson, Katie L.;
- Gant, John C.;
- Popovic, Jelena;
- Avdiushko, Margarita G.;
- Cohen, Don A.;
- Kuey-Chu Chen;
- Porter, Nada M.;
- Thibault, Olivier
Publication type:
Article
Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons.
Published in:
Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00668
By:
- Frazier, Hilaree N.;
- Ghoweri, Adam O.;
- Anderson, Katie L.;
- Lin, Ruei-Lung;
- Popa, Gabriel J.;
- Mendenhall, Michael D.;
- Reagan, Lawrence P.;
- Craven, Rolf J.;
- Thibault, Olivier
Publication type:
Article
Aging-Related Gene Expression in Hippocampus Proper Compared with Dentate Gyrus Is Selectively Associated with Metabolic Syndrome Variables in Rhesus Monkeys.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 17, p. 6058, doi. 10.1523/JNEUROSCI.3956-09.2010
By:
- Blalock, Eric M.;
- Grondin, Richard;
- Kuey-Chu Chen;
- Thibault, Olivier;
- Thibault, Veronique;
- Pandya, Jignesh D.;
- Dowling, Amy;
- Zhang, Zhiming;
- Sullivan, Patrick;
- Porter, Nada M.;
- Landfield, Philip W.
Publication type:
Article
Hippocampal and Cognitive Aging across the Lifespan: A Bioenergetic Shift Precedes and Increased Cholesterol Trafficking Parallels Memory Impairment.
Published in:
Journal of Neuroscience, 2009, v. 29, n. 6, p. 1805, doi. 10.1523/JNEUROSCI.4599-08.2009
By:
- Kadish, Inga;
- Thibault, Olivier;
- Blalock, Eric M.;
- Chen, Kuey-C.;
- Gant, John C.;
- Porter, Nada M.;
- Landfield, Philip W.
Publication type:
Article
Hippocampal Expression Analyses Reveal Selective Association of Immediate-Early, Neuroenergetic, and Myelinogenic Pathways with Cognitive Impairment in Aged Rats.
Published in:
Journal of Neuroscience, 2007, v. 27, n. 12, p. 3098, doi. 10.1523/JNEUROSCI.4163-06.2007
By:
- Rowe, Wayne B.;
- Blalock, Eric M.;
- Kuey-Chu Chen;
- Kadish, Inga;
- Daguang Wang;
- Barrett, James E.;
- Thibault, Olivier;
- Porter, Nada M.;
- Rose, Gregory M.;
- Landfield, Philip W.
Publication type:
Article
Early and Simultaneous Emergence of Multiple Hippocampal Biomarkers of Aging Is Mediated by Ca2+-Induced Ca2+ Release.
Published in:
Journal of Neuroscience, 2006, v. 26, n. 13, p. 3482, doi. 10.1523/JNEUROSCI.4171-05.2006
By:
- Gant, John C.;
- Sama, Michelle M.;
- Landfield, Philip W.;
- Thibault, Olivier
Publication type:
Article
In vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome.
Published in:
FASEB Journal, 2017, v. 31, n. 9, p. 4179, doi. 10.1096/fj.201700229R
By:
- Berkowitz, Bruce A.;
- Lenning, Jacob;
- Khetarpal, Nikita;
- Tran, Catherine;
- Wu, Johnny Y.;
- Berri, Ali M.;
- Dernay, Kristin;
- Haacke, E. Mark;
- Shafie-Khorassani, Fatema;
- Podolsky, Robert H.;
- Gant, John C.;
- Maimaiti, Shaniya;
- Thibault, Olivier;
- Murphy, Geoffrey G.;
- Bennett, Brian M.;
- Roberts, Robin
Publication type:
Article
Nicotinic modulation of glutamate receptor function at nerve terminal level: a fine-tuning of synaptic signals.
Published in:
Frontiers in Pharmacology, 2015, v. 6, p. 1, doi. 10.3389/fphar.2015.00089
By:
- Marchi, Mario;
- Grilli, Massimo;
- Pittaluga, Anna M.;
- Bodhinathan, Karthik;
- Thibault, Olivier
Publication type:
Article
Falling Short: The Contribution of Central Insulin Receptors to Gait Dysregulation in Brain Aging.
Published in:
Biomedicines, 2022, v. 10, n. 8, p. N.PAG, doi. 10.3390/biomedicines10081923
By:
- Case, Sami L.;
- Frazier, Hilaree N.;
- Anderson, Katie L.;
- Lin, Ruei-Lung;
- Thibault, Olivier
Publication type:
Article
FK506-Binding Protein 12.6/lb, a Negative Regulator of [Ca2+], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats.
Published in:
Journal of Neuroscience, 2018, v. 38, n. 4, p. 1030, doi. 10.1523/JNEUROSCI.2234-17.2017
By:
- Gant, John C.;
- Blalock, Eric M.;
- Kuey-Chu Chen;
- Thibault, Olivier;
- Porter, Nada M.;
- Landfield, Philip W.;
- Radish, Inga
Publication type:
Article
BRD4 modulates vulnerability of triple-negative breast cancer to targeting of integrin-dependent signaling pathways.
Published in:
Cellular Oncology (2211-3428), 2020, v. 43, n. 6, p. 1049, doi. 10.1007/s13402-020-00537-1
By:
- Zhang, Yang;
- Xu, Bingwei;
- Shi, Junfeng;
- Li, Jieming;
- Lu, Xinlan;
- Xu, Li;
- Yang, Helen;
- Hamad, Nevean;
- Wang, Chi;
- Napier, Dana;
- He, Shuixiang;
- Liu, Chunming;
- Liu, Zeyi;
- Qian, Hai;
- Chen, Li;
- Wei, Xiaowei;
- Zheng, Xucai;
- Huang, Jian-An;
- Thibault, Olivier;
- Craven, Rolf
Publication type:
Article
Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-γ agonists in cultured hippocampal neurons.
Published in:
Journal of Neurochemistry, 2009, v. 109, n. 6, p. 1800, doi. 10.1111/j.1471-4159.2009.06107.x
By:
- Pancani, Tristano;
- Phelps, Jeremiah T.;
- Searcy, James L.;
- Kilgore, Michael W.;
- Kuey-Chu Chen;
- Porter, Nada M.;
- Thibault, Olivier
Publication type:
Article
Age‐ and sex‐dependent alterations in primary somatosensory cortex neuronal calcium network dynamics during locomotion.
Published in:
Aging Cell, 2023, v. 22, n. 8, p. 1, doi. 10.1111/acel.13898
By:
- Case, Sami L.;
- Lin, Ruei‐Lung;
- Thibault, Olivier
Publication type:
Article
Sensitivity of the S1 neuronal calcium network to insulin and Bay‐K 8644 in vivo: Relationship to gait, motivation, and aging processes.
Published in:
Aging Cell, 2022, v. 21, n. 7, p. 1, doi. 10.1111/acel.13661
By:
- Lin, Ruei‐Lung;
- Frazier, Hilaree N.;
- Anderson, Katie L.;
- Case, Sami L.;
- Ghoweri, Adam O.;
- Thibault, Olivier
Publication type:
Article
Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats.
Published in:
Aging Cell, 2020, v. 19, n. 10, p. 1, doi. 10.1111/acel.13220
By:
- Frazier, Hilaree N.;
- Anderson, Katie L.;
- Ghoweri, Adam O.;
- Lin, Ruei-Lung;
- Hawkinson, Tara R.;
- Popa, Gabriel J.;
- Sompol, Pradoldej;
- Mendenhall, Michael D.;
- Norris, Christopher M.;
- Thibault, Olivier
Publication type:
Article
Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store.
Published in:
Aging Cell, 2007, v. 6, n. 3, p. 307, doi. 10.1111/j.1474-9726.2007.00295.x
By:
- Thibault, Olivier;
- Gant, John C.;
- Landfield, Philip W.
Publication type:
Article
Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.
Published in:
Journal of Neuroscience, 2015, v. 35, n. 30, p. 10878, doi. 10.1523/JNEUROSCI.1248-15.2015
By:
- Gant, John C.;
- Kuey-Chu Chen;
- Kadish, Inga;
- Blalock, Eric M.;
- Thibault, Olivier;
- Porter, Nada M.;
- Landfield, Philip W.
Publication type:
Article
Disrupting Function of FK506-Binding Protein 1b/12.6 Induces the Ca2+-Dysregulation Aging Phenotype in Hippocampal Neurons.
Published in:
Journal of Neuroscience, 2011, v. 31, n. 5, p. 1693, doi. 10.1523/JNEUROSCI.4805-10.2011
By:
- Gant, John C.;
- Kuey-Chu Chen;
- Norris, Christopher M.;
- Kadish, Inga;
- Thibault, Olivier;
- Blalock, Eric M.;
- Porter, Nada M.;
- Landfield, Philip W.
Publication type:
Article

Found: 34

Long-Term Intranasal Insulin Aspart: A Profile of Gene Expression, Memory, and Insulin Receptors in Aged F344 Rats.

Impact of Single or Repeated Dose Intranasal Zinc-free Insulin in Young and Aged F344 Rats on Cognition, Signaling, and Brain Metabolism.

Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging.

Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease.

Astrocyte calcium dysregulation and cerebrovascular impairments in the 5XFAD mouse model of familial Alzheimer's disease.

Low‐Frequency Oscillations During Resting and Task Differentially Associate with Working Memory Performance in Older Adults.

Astrocyte Ca2+ dysregulation and neurovascular coupling deficits in a diet‐based mouse model of small cerebral vessel disease.

Perturbed astrocyte Ca2+ signaling in a diet‐based mouse model of small cerebral vessel disease.

Astrocyte activation and neurovascular function in a diet‐based model of vascular contributions to cognitive impairment and dementia (VCID): Molecular and cell biology/vascular factors.

F1‐07‐02: ASTROCYTE ACTIVATION AND HIPPOCAMPAL SYNAPTIC IMPAIRMENTS IN MOUSE MODELS OF AMYLOID PATHOLOGY AND CEREBROVASCULAR DYSFUNCTION.

Aged rats are hypo-responsive to acute restraint: implications for psychosocial stress in aging.

Long-term effects of simvastatin and atorvastatin on a rat model of normal brain aging

P2-463: LXR agonist treatment of a transgenic mouse model of Alzheimer's disease: Effects on behavioral, electrophysiological and immunohistochemical markers

P2-457: Effect of chronic treatment with the PPAR-G agonist, pioglitazone, in a triple transgenic model of Alzheimer's disease

Reversal of Glial and Neurovascular Markers of Unhealthy Brain Aging by Exercise in Middle-Aged Female Mice.

Deep Sleep and Parietal Cortex Gene Expression Changes Are Related to Cognitive Deficits with Age.

Effects of Long-Term Pioglitazone Treatment on Peripheral and Central Markers of Aging.

Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons.

Aging-Related Gene Expression in Hippocampus Proper Compared with Dentate Gyrus Is Selectively Associated with Metabolic Syndrome Variables in Rhesus Monkeys.

Hippocampal and Cognitive Aging across the Lifespan: A Bioenergetic Shift Precedes and Increased Cholesterol Trafficking Parallels Memory Impairment.

Hippocampal Expression Analyses Reveal Selective Association of Immediate-Early, Neuroenergetic, and Myelinogenic Pathways with Cognitive Impairment in Aged Rats.

Early and Simultaneous Emergence of Multiple Hippocampal Biomarkers of Aging Is Mediated by Ca<sup>2+</sup>-Induced Ca<sup>2+</sup> Release.

In vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome.

Nicotinic modulation of glutamate receptor function at nerve terminal level: a fine-tuning of synaptic signals.

Falling Short: The Contribution of Central Insulin Receptors to Gait Dysregulation in Brain Aging.

FK506-Binding Protein 12.6/lb, a Negative Regulator of [Ca<sup>2+</sup>], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats.

BRD4 modulates vulnerability of triple-negative breast cancer to targeting of integrin-dependent signaling pathways.

Distinct modulation of voltage-gated and ligand-gated Ca<sup>2+</sup> currents by PPAR-γ agonists in cultured hippocampal neurons.

Age‐ and sex‐dependent alterations in primary somatosensory cortex neuronal calcium network dynamics during locomotion.

Sensitivity of the S1 neuronal calcium network to insulin and Bay‐K 8644 in vivo: Relationship to gait, motivation, and aging processes.

Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats.

Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store.

Reversal of Aging-Related Neuronal Ca<sup>2+</sup> Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.

Disrupting Function of FK506-Binding Protein 1b/12.6 Induces the Ca<sup>2+</sup>-Dysregulation Aging Phenotype in Hippocampal Neurons.