Found: 21
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Activation of the PERK branch of the unfolded protein response during production reduces specific productivity in CHO cells via downregulation of PDGFRa and IRE1a signaling.
- Published in:
- Biotechnology Progress, 2023, v. 39, n. 5, p. 1, doi. 10.1002/btpr.3354
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- Article
Combining regulated and constitutive protein expression significantly boosts protein expression by increasing productivity without affecting CHO cell growth.
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- Biotechnology Progress, 2023, v. 39, n. 3, p. 1, doi. 10.1002/btpr.3337
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- Article
Expressing antigen binding fragments with high titers in a targeted integration CHO host by optimizing expression vector gene copy numbers and position: A case study.
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- Biotechnology Progress, 2022, v. 38, n. 6, p. 1, doi. 10.1002/btpr.3290
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- Article
Bax and Bak knockout apoptosis‐resistant Chinese hamster ovary cell lines significantly improve culture viability and titer in intensified fed‐batch culture process.
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- Biotechnology Progress, 2022, v. 38, n. 2, p. 1, doi. 10.1002/btpr.3228
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- Article
A ribonucleoprotein‐based decaplex CRISPR/Cas9 knockout strategy for CHO host engineering.
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- Biotechnology Progress, 2022, v. 38, n. 1, p. 1, doi. 10.1002/btpr.3212
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- Article
Preventing pyruvate kinase muscle expression in Chinese hamster ovary cells curbs lactogenic behavior by altering glycolysis, gating pyruvate generation, and increasing pyruvate flux into the TCA cycle.
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- Biotechnology Progress, 2021, v. 37, n. 5, p. 1, doi. 10.1002/btpr.3193
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- Article
Endothelial intercellular cell adhesion molecule 1 contributes to cell aggregate formation in CHO cells cultured in serum‐free media.
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- Biotechnology Progress, 2020, v. 36, n. 3, p. 1, doi. 10.1002/btpr.2951
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Utilizing a regulated targeted integration cell line development approach to systematically investigate what makes an antibody difficult to express.
- Published in:
- Biotechnology Progress, 2019, v. 35, n. 2, p. N.PAG, doi. 10.1002/btpr.2772
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- Article
Beating the odds: The poisson distribution of all input cells during limiting dilution grossly underestimates whether a cell line is clonally‐derived or not.
- Published in:
- Biotechnology Progress, 2018, v. 34, n. 3, p. 559, doi. 10.1002/btpr.2560
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- Article
Evaluation of heavy chain C-terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells.
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- Biotechnology Progress, 2017, v. 33, n. 3, p. 786, doi. 10.1002/btpr.2444
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- Article
Taming hyperactive h DNase I: Stable inducible expression of a hyperactive salt- and actin-resistant variant of human deoxyribonuclease I in CHO cells.
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- Biotechnology Progress, 2017, v. 33, n. 2, p. 523, doi. 10.1002/btpr.2439
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- Article
Golgi Cisternal Unstacking Stimulates COPI Vesicle Budding and Protein Transport.
- Published in:
- PLoS ONE, 2008, v. 3, n. 2, p. 1, doi. 10.1371/journal.pone.0001647
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- Article
Tailoring translational strength using Kozak sequence variants improves bispecific antibody assembly and reduces product‐related impurities in CHO cells.
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- Biotechnology & Bioengineering, 2020, v. 117, n. 7, p. 1946, doi. 10.1002/bit.27347
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- Article
FX knockout CHO hosts can express desired ratios of fucosylated or afucosylated antibodies with high titers and comparable product quality.
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- Biotechnology & Bioengineering, 2017, v. 114, n. 3, p. 632, doi. 10.1002/bit.26188
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- Article
The Role of GRASP65 in Golgi Cisternal Stacking and Cell Cycle Progression.
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- Traffic, 2010, v. 11, n. 6, p. 827, doi. 10.1111/j.1600-0854.2010.01055.x
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- Article
LC‐HRMS‐based targeted metabolomics for high‐throughput and quantitative analysis of 21 growth inhibition‐related metabolites in Chinese hamster ovary cell fed‐batch cultures.
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- Biomedical Chromatography, 2022, v. 36, n. 5, p. 1, doi. 10.1002/bmc.5348
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- Article
ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65.
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- Journal of Cell Biology, 2008, v. 182, n. 5, p. 837, doi. 10.1083/jcb.200805045
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- Article
Concurrent transfection of randomized transgene configurations into targeted integration CHO host is an advantageous and cost‐effective method for expression of complex molecules.
- Published in:
- Biotechnology Journal, 2021, v. 16, n. 4, p. 1, doi. 10.1002/biot.202000230
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- Article
Pyruvate Kinase Muscle‐1 Expression Appears to Drive Lactogenic Behavior in CHO Cell Lines, Triggering Lower Viability and Productivity: A Case Study.
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- Biotechnology Journal, 2019, v. 14, n. 4, p. N.PAG, doi. 10.1002/biot.201800332
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- Article
High Intracellular Seed Train BiP Levels Correlate With Poor Production Culture Performance in CHO Cells.
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- Biotechnology Journal, 2018, v. 13, n. 10, p. 1, doi. 10.1002/biot.201700746
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- Article
Supplementation of Nucleosides During Selection can Reduce Sequence Variant Levels in CHO Cells Using GS/MSX Selection System.
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- Biotechnology Journal, 2018, v. 13, n. 1, p. 1, doi. 10.1002/biot.201700335
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- Article