Found: 26
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Stability of the Effect of a Standardized Meal on QTc.
- Published in:
- 2017
- By:
- Publication type:
- journal article
Comparison of Digital 12-Lead ECG and Digital 12-Lead Holter ECG Recordings in Healthy Male Subjects: Results from a Randomized, Double-Blinded, Placebo-Controlled Clinical Trial.
- Published in:
- 2016
- By:
- Publication type:
- journal article
C286, an orally available retinoic acid receptor β agonist drug, regulates multiple pathways to achieve spinal cord injury repair.
- Published in:
- Frontiers in Molecular Neuroscience, 2024, p. 1, doi. 10.3389/fnmol.2024.1411384
- By:
- Publication type:
- Article
Comparison of the Effects of Single and Repeated Oral Doses of Lansoprazole and Rabeprazole on Ambulatory 24-Hour Intragastric pH in Healthy Volunteers.
- Published in:
- Clinical Drug Investigation, 2006, v. 26, n. 1, p. 21, doi. 10.2165/00044011-200626010-00003
- By:
- Publication type:
- Article
Practical risk management in early phase clinical trials.
- Published in:
- European Journal of Clinical Pharmacology, 2019, v. 75, n. 4, p. 483, doi. 10.1007/s00228-018-02607-8
- By:
- Publication type:
- Article
A Phase 1 Study to Investigate the Effects of Cortexolone 17α‐Propionate, Also Known as Clascoterone, on the QT Interval Using the Meal Effect to Demonstrate ECG Assay Sensitivity.
- Published in:
- Clinical Pharmacology in Drug Development, 2021, v. 10, n. 6, p. 572, doi. 10.1002/cpdd.935
- By:
- Publication type:
- Article
Safety, Tolerability, and Dose Proportionality of a Novel Transdermal Fentanyl Matrix Patch and Bioequivalence With a Matrix Fentanyl Patch: Two Phase 1 Single‐Center Open‐Label, Randomized Crossover Studies in Healthy Japanese Volunteers.
- Published in:
- Clinical Pharmacology in Drug Development, 2021, v. 10, n. 3, p. 260, doi. 10.1002/cpdd.846
- By:
- Publication type:
- Article
Confirmation of the Cardiac Safety of PGF<sub>2α</sub> Receptor Antagonist OBE022 in a First‐in‐Human Study in Healthy Subjects, Using Intensive ECG Assessments.
- Published in:
- Clinical Pharmacology in Drug Development, 2018, v. 7, n. 8, p. 889, doi. 10.1002/cpdd.447
- By:
- Publication type:
- Article
Time- and Race-Specific Haematological Reference Intervals for Healthy Volunteer Trials: A Retrospective Analysis of Pooled Data From Multiple Phase I Trials.
- Published in:
- Frontiers in Pharmacology, 2020, p. 1, doi. 10.3389/fphar.2020.00314
- By:
- Publication type:
- Article
Effects on 24-Hour Intragastric pH: A Comparison of Lansoprazole Administered Nasogastrically in Apple Juice and Pantoprazole Administered Intravenously.
- Published in:
- American Journal of Gastroenterology (Springer Nature), 2001, v. 96, n. 7, p. 2058, doi. 10.1111/j.1572-0241.2001.03939.x
- By:
- Publication type:
- Article
The Cardiovascular Effects of a Meal: J‐T<sub>peak</sub> and T<sub>peak</sub>‐T<sub>end</sub> Assessment and Further Insights Into the Physiological Effects.
- Published in:
- Journal of Clinical Pharmacology, 2019, v. 59, n. 6, p. 799, doi. 10.1002/jcph.1374
- By:
- Publication type:
- Article
Diurnal Profile of the QTc Interval Following Moxifloxacin Administration.
- Published in:
- Journal of Clinical Pharmacology, 2019, v. 59, n. 1, p. 35, doi. 10.1002/jcph.1283
- By:
- Publication type:
- Article
Estimation of the Power of the Food Effect on QTc to Show Assay Sensitivity.
- Published in:
- Journal of Clinical Pharmacology, 2018, v. 58, n. 1, p. 81, doi. 10.1002/jcph.975
- By:
- Publication type:
- Article
Confirmation of the cardiac safety of nolasiban in a randomised cohort of healthy female volunteers.
- Published in:
- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-85650-3
- By:
- Publication type:
- Article
Thorough QT study of the effect of intravenous amisulpride on QTc interval in Caucasian and Japanese healthy subjects.
- Published in:
- British Journal of Clinical Pharmacology, 2017, v. 83, n. 2, p. 339, doi. 10.1111/bcp.13128
- By:
- Publication type:
- Article
Pharmacokinetics, Safety and Cognitive Function Profile of Rupatadine 10, 20 and 40 mg in Healthy Japanese Subjects: A Randomised Placebo-Controlled Trial.
- Published in:
- PLoS ONE, 2016, v. 11, n. 9, p. 1, doi. 10.1371/journal.pone.0163020
- By:
- Publication type:
- Article
Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL‐286, a novel retinoic acid receptor‐β agonist for treatment of spinal cord injury, in male healthy participants.
- Published in:
- British Journal of Clinical Pharmacology, 2023, v. 89, n. 12, p. 3573, doi. 10.1111/bcp.15854
- By:
- Publication type:
- Article
Coadministration of the prostaglandin F2α receptor antagonist preterm labour drug candidate OBE022 with magnesium sulfate, atosiban, nifedipine and betamethasone.
- Published in:
- British Journal of Clinical Pharmacology, 2019, v. 85, n. 7, p. 1516, doi. 10.1111/bcp.13925
- By:
- Publication type:
- Article
Pharmacokinetics, safety and tolerability of OBE022, a selective prostaglandin F2α receptor antagonist tocolytic: A first‐in‐human trial in healthy postmenopausal women.
- Published in:
- British Journal of Clinical Pharmacology, 2018, v. 84, n. 8, p. 1839, doi. 10.1111/bcp.13622
- By:
- Publication type:
- Article
Comparing the consistency of electrocardiogram interval measurements by resting ECG versus 12‐lead Holter.
- Published in:
- Annals of Noninvasive Electrocardiology, 2021, v. 26, n. 5, p. 1, doi. 10.1111/anec.12851
- By:
- Publication type:
- Article
Concentration-effect modeling based on change from baseline to assess the prolonging effect of drugs on QTc together with an estimate of the circadian time course.
- Published in:
- Journal of Clinical Pharmacology, 2014, v. 54, n. 12, p. 1400, doi. 10.1002/jcph.347
- By:
- Publication type:
- Article
Analyzing the relationship of QT interval and exposure to Nitazoxanide, a prospective candidate for influenza antiviral therapy-A formal TQT study.
- Published in:
- Journal of Clinical Pharmacology, 2014, v. 54, n. 9, p. 987, doi. 10.1002/jcph.300
- By:
- Publication type:
- Article
Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study.
- Published in:
- European Heart Journal, 2021, v. 42, n. 2, p. 178, doi. 10.1093/eurheartj/ehaa898
- By:
- Publication type:
- Article
Both osmolality-dependent and independent mechanisms are associated with acute hyperglycemia-induced cardiovascular adverse reactions: Analysis of the mutual interactions leading to cardiovascular phenotypes in dogs.
- Published in:
- Journal of Toxicological Sciences, 2023, v. 48, n. 3, p. 169, doi. 10.2131/jts.48.169
- By:
- Publication type:
- Article
The Power of Phase I Studies to Detect Clinical Relevant QTc Prolongation: A Resampling Simulation Study.
- Published in:
- 2015
- By:
- Publication type:
- journal article
Single Doses up to 800 mg of E-52862 Do Not Prolong the QTc Interval – A Retrospective Validation by Pharmacokinetic-Pharmacodynamic Modelling of Electrocardiography Data Utilising the Effects of a Meal on QTc to Demonstrate ECG Assay Sensitivity.
- Published in:
- PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0136369
- By:
- Publication type:
- Article