OpenURL Connection Search

Select item for more details and to access through your institution.

11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-36541-w
By:
- Othonos, Nantia;
- Pofi, Riccardo;
- Arvaniti, Anastasia;
- White, Sarah;
- Bonaventura, Ilaria;
- Nikolaou, Nikolaos;
- Moolla, Ahmad;
- Marjot, Thomas;
- Stimson, Roland H.;
- van Beek, André P.;
- van Faassen, Martijn;
- Isidori, Andrea M.;
- Bateman, Elizabeth;
- Sadler, Ross;
- Karpe, Fredrik;
- Stewart, Paul M.;
- Webster, Craig;
- Duffy, Joanne;
- Eastell, Richard;
- Gossiel, Fatma
Publication type:
Article
Effects of Obesity and Insulin on Tissue-Specific Recycling Between Cortisol and Cortisone in Men.
Published in:
2021
By:
- Anderson, Anna J.;
- Andrew, Ruth;
- Homer, Natalie Z. M.;
- Hughes, Katherine A.;
- Boyle, Luke D.;
- Nixon, Mark;
- Karpe, Fredrik;
- Stimson, Roland H.;
- Walker, Brian R.
Publication type:
journal article
GDF15 Is Elevated in Conditions of Glucocorticoid Deficiency and Is Modulated by Glucocorticoid Replacement.
Published in:
2019
By:
- Melvin, Audrey;
- Chantzichristos, Dimitrios;
- Kyle, Catriona J;
- Mackenzie, Scott D;
- Walker, Brian R;
- Johannsson, Gudmundur;
- Stimson, Roland H;
- O'Rahilly, Stephen
Publication type:
journal article
Collagen 24 α1 Is Increased in Insulin-Resistant Skeletal Muscle and Adipose Tissue.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 16, p. 5738, doi. 10.3390/ijms21165738
By:
- Weng, Xiong;
- Lin, De;
- Huang, Jeffrey T. J.;
- Stimson, Roland H.;
- Wasserman, David H.;
- Kang, Li
Publication type:
Article
Identification of human glucocorticoid response markers using integrated multi- omic analysis from a randomized crossover trial.
Published in:
eLife, 2021, p. 1, doi. 10.7554/eLife.62236
By:
- Chantzichristos, Dimitrios;
- Svensson, Per-Arne;
- Garner, Terence;
- Glad, Camilla A. M.;
- Walker, Brian R.;
- Bergthorsdottir, Ragnhildur;
- Ragnarsson, Oskar;
- Trimpou, Penelope;
- Stimson, Roland H.;
- Borresen, Stina W.;
- Feldt-Rasmussen, Ulla;
- Jansson, Per-Anders;
- Skrtic, Stanko;
- Stevens, Adam;
- Johannsson, Gudmundur
Publication type:
Article
Metformin Increases Cortisol Regeneration by 11βHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus.
Published in:
2016
By:
- Anderson, Anna J;
- Andrew, Ruth;
- Homer, Natalie Z;
- Jones, Gregory C;
- Smith, Kenneth;
- Livingstone, Dawn E;
- Walker, Brian R;
- Stimson, Roland H
Publication type:
journal article
The postprandial rise in plasma cortisol in men is mediated by macronutrient-specific stimulation of adrenal and extra-adrenal cortisol production.
Published in:
2014
By:
- Stimson, Roland H;
- Mohd-Shukri, Nor A;
- Bolton, Jennifer L;
- Andrew, Ruth;
- Reynolds, Rebecca M;
- Walker, Brian R
Publication type:
journal article
Reduced gluteal expression of adipogenic and lipogenic genes in Black South African women is associated with obesity-related insulin resistance.
Published in:
2011
By:
- Goedecke, Julia H;
- Evans, Juliet;
- Keswell, Dheshnie;
- Stimson, Roland H;
- Livingstone, Dawn E W;
- Hayes, Philip;
- Adams, Kevin;
- Dave, Joel A;
- Victor, Hendriena;
- Levitt, Naomi S;
- Lambert, Estelle V;
- Walker, Brian R;
- Seckl, Jonathan R;
- Olsson, Tommy;
- Kahn, Steven E
Publication type:
journal article
Marked improvement in HbA<sub>1c</sub> following commencement of flash glucose monitoring in people with type 1 diabetes.
Published in:
Diabetologia, 2019, v. 62, n. 8, p. 1349, doi. 10.1007/s00125-019-4894-1
By:
- Tyndall, Victoria;
- Stimson, Roland H.;
- Zammitt, Nicola N.;
- Ritchie, Stuart A.;
- McKnight, John A.;
- Dover, Anna R.;
- Gibb, Fraser W.
Publication type:
Article
Changes in continuous glucose monitoring metrics and predictors of improvement 12 months after conversion from Freestyle Libre to Freestyle Libre 2.
Published in:
Diabetic Medicine, 2023, v. 40, n. 11, p. 1, doi. 10.1111/dme.15130
By:
- Stimson, Roland H.;
- Dover, Anna R.;
- Strachan, Mark W. J.;
- Wright, Rohana J.;
- Forbes, Shareen;
- Gibb, Fraser W.
Publication type:
Article
Interest in hybrid closed loop is high across the socioeconomic spectrum despite current inequalities in provision in a large UK diabetes centre.
Published in:
Diabetic Medicine, 2023, v. 40, n. 5, p. 1, doi. 10.1111/dme.15058
By:
- Dover, Anna R.;
- Ritchie, Stuart A.;
- Wright, Rohana J.;
- McMurray, Emily M.;
- Strachan, Mark W. J.;
- Stimson, Roland H.;
- Forbes, Shareen;
- Gibb, Fraser W.
Publication type:
Article
Socioeconomic deprivation, technology use, C‐peptide, smoking and other predictors of glycaemic control in adults with type 1 diabetes.
Published in:
Diabetic Medicine, 2021, v. 38, n. 3, p. 1, doi. 10.1111/dme.14445
By:
- Dover, Anna R.;
- Strachan, Mark W. J.;
- McKnight, John A.;
- Stimson, Roland H.;
- Mackenzie, Scott D.;
- Lyall, Marcus J.;
- Wright, Rohana J.;
- Forbes, Shareen;
- Gibb, Fraser W.
Publication type:
Article
Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct.
Published in:
Diabetes, Obesity & Metabolism, 2017, v. 19, n. 6, p. 883, doi. 10.1111/dom.12899
By:
- Stimson, Roland H.;
- Anderson, Anna J.;
- Ramage, Lynne E.;
- Macfarlane, David P.;
- de Beaux, Andrew C.;
- Mole, Damian J.;
- Andrew, Ruth;
- Walker, Brian R.
Publication type:
Article
Substrate Utilization by Brown Adipose Tissue: What's Hot and What's Not?
Published in:
Frontiers in Endocrinology, 2020, v. 11, p. N.PAG, doi. 10.3389/fendo.2020.571659
By:
- McNeill, Ben T.;
- Morton, Nicholas M.;
- Stimson, Roland H.
Publication type:
Article
Effects of Proportions of Dietary Macronutrients on Glucocorticoid Metabolism in Diet-Induced Obesity in Rats.
Published in:
PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008779
By:
- Stimson, Roland H.;
- Lobley, Gerald E.;
- Maraki, Ioanna;
- Morton, Nicholas M.;
- Andrew, Ruth;
- Walker, Brian R.
Publication type:
Article
Health status of adults with congenital adrenal hyperplasia: a cohort study of 203 patients.
Published in:
2010
By:
- Arlt, Wiebke;
- Willis, Debbie S;
- Wild, Sarah H;
- Krone, Nils;
- Doherty, Emma J;
- Hahner, Stefanie;
- Han, Thang S;
- Carroll, Paul V;
- Conway, Gerry S;
- Rees, D Aled;
- Stimson, Roland H;
- Walker, Brian R;
- Connell, John M C;
- Ross, Richard J;
- United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE)
Publication type:
journal article
Dietary Macronutrient Content Alters Cortisol Metabolism Independently of Body Weight Changes in Obese Men.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2007, v. 92, n. 11, p. 4480, doi. 10.1210/jc.2007-0692
By:
- Stimson, Roland H.;
- Johnstone, Alexandra M.;
- Homer, Natalie Z. M.;
- Wake, Deborah J.;
- Morton, Nicholas M.;
- Andrew, Ruth;
- Lobley, Gerald E.;
- Walker, Brian R.
Publication type:
Article
Effects of Peroxisome Proliferator-Activated Receptor-α and γ- Agonists on 11β-Hydroxysteroid Dehydrogenase Type 1 in Subcutaneous Adipose Tissue in Men.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2007, v. 92, n. 5, p. 1848, doi. 10.1210/jc.2006-2713
By:
- Wake, Deborah J.;
- Stimson, Roland H.;
- Tan, Garry D.;
- Homer, Natalie Z. M.;
- Andrew, Ruth;
- Karpe, Fredrik;
- Walker, Brian R.
Publication type:
Article
UCP1 expression in human brown adipose tissue is inversely associated with cardiometabolic risk factors.
Published in:
European Journal of Endocrinology, 2024, v. 191, n. 1, p. 106, doi. 10.1093/ejendo/lvae074
By:
- Kwok, T'ng Choong;
- Ramage, Lynne E;
- Kelman, Alexandra;
- Suchacki, Karla J;
- Gray, Calum;
- Boyle, Luke D;
- Semple, Scott I;
- MacGillivray, Tom;
- MacNaught, Gillian;
- Patel, Dilip;
- Beek, Edwin J R van;
- Semple, Robert K;
- Wakelin, Sonia J;
- Stimson, Roland H
Publication type:
Article
Human brown adipose tissue as a therapeutic target: warming up or cooling down?
Published in:
European Journal of Endocrinology, 2021, v. 184, n. 6, p. R243, doi. 10.1530/EJE-20-1439
By:
- McNeill, Ben T.;
- Suchacki, Karla J.;
- Stimson, Roland H.
Publication type:
Article
Quality of life in adults with congenital adrenal hyperplasia relates to glucocorticoid treatment, adiposity and insulin resistance: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE).
Published in:
European Journal of Endocrinology, 2013, v. 168, n. 6, p. 887, doi. 10.1530/EJE-13-0128
By:
- Thang S. Han;
- Krone, Nils;
- Willis, Debbie S.;
- Conway, Gerard S.;
- Hahner, Stefanie;
- Rees, D. Aled;
- Stimson, Roland H.;
- Walker, Brian R.;
- Arlt, Wiebke;
- Ross, Richard J.
Publication type:
Article
A combination of polymorphisms in HSD11B1 associates with in vivo 11&BETA;-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome.
Published in:
European Journal of Endocrinology, 2011, v. 165, n. 2, p. 283, doi. 10.1530/EJE-11-0091
By:
- Gambineri, Alessandra;
- Tomassoni, Federica;
- Munarini, Alessandra;
- Stimson, Roland H.;
- Mioni, Roberto;
- Pagotto, Uberto;
- Chapman, Karen E.;
- Andrew, Ruth;
- Mantovani, Vilma;
- Pasquali, Renato;
- Walker, Brian R.
Publication type:
Article
Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source.
Published in:
Nature Cell Biology, 2014, v. 16, n. 4, p. 367, doi. 10.1038/ncb2922
By:
- Chau, You-Ying;
- Bandiera, Roberto;
- Serrels, Alan;
- Martínez-Estrada, Ofelia M.;
- Qing, Wei;
- Lee, Martin;
- Slight, Joan;
- Thornburn, Anna;
- Berry, Rachel;
- McHaffie, Sophie;
- Stimson, Roland H.;
- Walker, Brian R.;
- Chapuli, Ramon Muñoz;
- Schedl, Andreas;
- Hastie, Nick
Publication type:
Article
The role and regulation of 11β-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome.
Published in:
Hormone Molecular Biology & Clinical Investigation, 2013, v. 15, n. 2, p. 37, doi. 10.1515/hmbci-2013-0015
By:
- Stimson, Roland H.;
- Walker, Brian R.
Publication type:
Article
Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism.
Published in:
Science Immunology, 2017, v. 2, n. 8, p. 1, doi. 10.1126/sciimmunol.aal2861
By:
- Thompson, A. A. Roger;
- Dickinson, Rebecca S.;
- Murphy, Fiona;
- Thomson, John P.;
- Marriott, Helen M.;
- Tavares, Adriana;
- Willson, Joseph;
- Williams, Lynne;
- Lewis, Amy;
- Mirchandani, Ananda;
- Dos Santos Coelho, Patricia;
- Doherty, Catherine;
- Ryan, Eilise;
- Watts, Emily;
- Morton, Nicholas M.;
- Forbes, Shareen;
- Stimson, Roland H.;
- Hameed, Abdul G.;
- Arnold, Nadine;
- Preston, Julie A.
Publication type:
Article
ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: A rationale for safer glucocorticoid replacement therapy.
Published in:
Science Translational Medicine, 2016, v. 8, n. 352, p. 1, doi. 10.1126/scitranslmed.aaf9074
By:
- Nixon, Mark;
- Mackenzie, Scott D.;
- Taylor, Ashley I.;
- Homer, Natalie Z. M.;
- Livingstone, Dawn E.;
- Mouras, Rabah;
- Morgan, Ruth A.;
- Mole, Damian J.;
- Stimson, \Roland H.;
- Reynolds, Rebecca M.;
- Elfick, Alistair P. D.;
- Andrew, Ruth;
- Walker, Brian R.
Publication type:
Article
A cross-sectional questionnaire study: Impaired awareness of hypoglycaemia remains prevalent in adults with type 1 diabetes and is associated with the risk of severe hypoglycaemia.
Published in:
PLoS ONE, 2024, v. 19, n. 6, p. 1, doi. 10.1371/journal.pone.0297601
By:
- Baxter, Faye;
- Baillie, Nicola;
- Dover, Anna;
- Stimson, Roland H.;
- Gibb, Fraser;
- Forbes, Shareen
Publication type:
Article
The effects of caloric restriction on adipose tissue and metabolic health are sex- and age- dependent.
Published in:
eLife, 2023, p. 1, doi. 10.7554/eLife.88080
By:
- Suchacki, Karla J.;
- Thomas, Benjamin J.;
- Yoshiko M. Ikushima;
- Kuan- Chan Chen;
- Fyfe, Claire;
- Tavares, Adriana A. S.;
- Sulston, Richard J.;
- Lovdel, Andrea;
- Woodward, Holly J.;
- Xuan Han;
- Mattiucci, Domenico;
- Brain, Eleanor J.;
- Alcaide Corral, Carlos J.;
- Hiroshi Kobayashi;
- Gray, Gillian A.;
- Whitfield, Phillip D.;
- Stimson, Roland H.;
- Morton, Nicholas M.;
- Johnstone, Alexandra M.;
- Cawthorn, William P.
Publication type:
Article
Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans.
Published in:
2009
By:
- Stimson RH;
- Andersson J;
- Andrew R;
- Redhead DN;
- Karpe F;
- Hayes PC;
- Olsson T;
- Walker BR;
- Stimson, Roland H;
- Andersson, Jonas;
- Andrew, Ruth;
- Redhead, Doris N;
- Karpe, Fredrik;
- Hayes, Peter C;
- Olsson, Tommy;
- Walker, Brian R
Publication type:
journal article
Cortisol Release From Adipose Tissue by 11β-Hydroxysteroid Dehydrogenase Type 1 in Humans.
Published in:
Diabetes, 2009, v. 58, n. 1, p. 46, doi. 10.2337/db08-0969
By:
- Stimson, Roland H.;
- Andersson, Jonas;
- Andrew, Ruth;
- Redhead, Doris N.;
- Karpe, Fredrik;
- Hayes, Peter C.;
- Olsson, Tommy;
- Walker, Brian R.
Publication type:
Article
Nutritional Regulation of Human Brown Adipose Tissue.
Published in:
Nutrients, 2021, v. 13, n. 6, p. 1748, doi. 10.3390/nu13061748
By:
- Suchacki, Karla J.;
- Stimson, Roland H.
Publication type:
Article
907-P: Striking Improvements in HbA1c following Commencement of Flash Glucose Monitoring in Type 1 Diabetes.
Published in:
Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-907-P
By:
- GIBB, FRASER W.;
- STIMSON, ROLAND H.;
- MCKNIGHT, JOHN A.;
- TYNDALL, VICTORIA;
- RITCHIE, STUART A.;
- ZAMMITT, NICOLA N.;
- DOVER, ANNA R.
Publication type:
Article
Recycling Between Cortisol and Cortisone in Human Splanchnic, Subcutaneous Adipose, and Skeletal Muscle Tissues In Vivo.
Published in:
Diabetes, 2012, v. 61, n. 6, p. 1357, doi. 10.2337/db11-1345
By:
- Hughes, Katherine A.;
- Manolopoulos, Konstantinos N.;
- Iqbal, Javaid;
- Cruden, Nicholas L.;
- Stimson, Roland H.;
- Reynolds, Rebecca M.;
- Newby, David E.;
- Andrew, Ruth;
- Karpe, Fredrik;
- Walker, Brian R.
Publication type:
Article
Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization.
Published in:
2012
By:
- Nixon M;
- Wake DJ;
- Livingstone DE;
- Stimson RH;
- Esteves CL;
- Seckl JR;
- Chapman KE;
- Andrew R;
- Walker BR;
- Nixon, Mark;
- Wake, Deborah J;
- Livingstone, Dawn E;
- Stimson, Roland H;
- Esteves, Cristina L;
- Seckl, Jonathan R;
- Chapman, Karen E;
- Andrew, Ruth;
- Walker, Brian R
Publication type:
journal article
Salicylate Downregulates 11β-HSD1 Expression in Adipose Tissue in Obese Mice and in Humans, Mediating Insulin Sensitization.
Published in:
Diabetes, 2012, v. 61, n. 4, p. 790, doi. 10.2337/db11-0931
By:
- Nixon, Mark;
- Wake, Deborah J.;
- Livingstone, Dawn E.;
- Stimson, Roland H.;
- Esteves, Cristina L.;
- Seckl, Jonathan R.;
- Chapman, Karen E.;
- Andrew, Ruth;
- Walker, Brian R.
Publication type:
Article
Increased whole-body and sustained liver cortisol regeneration by 11beta-hydroxysteroid dehydrogenase type 1 in obese men with type 2 diabetes provides a target for enzyme inhibition.
Published in:
2011
By:
- Stimson RH;
- Andrew R;
- McAvoy NC;
- Tripathi D;
- Hayes PC;
- Walker BR;
- Stimson, Roland H;
- Andrew, Ruth;
- McAvoy, Norma C;
- Tripathi, Dhiraj;
- Hayes, Peter C;
- Walker, Brian R
Publication type:
journal article
Increased Whole-Body and Sustained Liver Cortisol Regeneration by 11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Men With Type 2 Diabetes Provides a Target for Enzyme Inhibition.
Published in:
Diabetes, 2011, v. 60, n. 3, p. 720, doi. 10.2337/db10-0726
By:
- Stimson, Roland H.;
- Andrew, Ruth;
- McAvoy, Norma C.;
- Tripathi, Dhiraj;
- Hayes, Peter C.;
- Walker, Brian R.
Publication type:
Article

Found: 37