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Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.
Published in:
Angewandte Chemie, 2019, v. 131, n. 2, p. 525, doi. 10.1002/ange.201810179
By:
- Vazquez‐Rodriguez, Saleta;
- Wright, Miranda;
- Rogers, Catherine M.;
- Cribbs, Adam P.;
- Velupillai, Srikannathasan;
- Philpott, Martin;
- Lee, Henry;
- Dunford, James E.;
- Huber, Kilian V. M.;
- Robers, Matthew B.;
- Vasta, James D.;
- Thezenas, Marie‐Laetitia;
- Bonham, Sarah;
- Kessler, Benedikt;
- Bennett, James;
- Fedorov, Oleg;
- Raynaud, Florence;
- Donovan, Adam;
- Blagg, Julian;
- Bavetsias, Vassilios
Publication type:
Article
Structure‐guided stabilization of pathogen‐derived peptide‐HLA‐E complexes using non‐natural amino acids conserves native TCR recognition.
Published in:
European Journal of Immunology, 2022, v. 52, n. 4, p. 618, doi. 10.1002/eji.202149745
By:
- Barber, Claire;
- De Souza, Victoria Arena;
- Paterson, Rachel L.;
- Martin‐Urdiroz, Magdalena;
- Mulakkal, Nitha Charles;
- Srikannathasan, Velupillai;
- Connolly, Mary;
- Phillips, Gwilym;
- Foong‐Leong, Tein;
- Pengelly, Robert;
- Karuppiah, Vijaykumar;
- Grant, Tressan;
- Dembek, Marcin;
- Verma, Anil;
- Gibbs‐Howe, Dawn;
- Blicher, Thomas H.;
- Knox, Andrew;
- Robinson, Ross A.;
- Cole, David K.;
- Leonard, Sarah
Publication type:
Article
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.
Published in:
Angewandte Chemie International Edition, 2019, v. 58, n. 2, p. 515, doi. 10.1002/anie.201810179
By:
- Vazquez‐Rodriguez, Saleta;
- Wright, Miranda;
- Rogers, Catherine M.;
- Cribbs, Adam P.;
- Velupillai, Srikannathasan;
- Philpott, Martin;
- Lee, Henry;
- Dunford, James E.;
- Huber, Kilian V. M.;
- Robers, Matthew B.;
- Vasta, James D.;
- Thezenas, Marie‐Laetitia;
- Bonham, Sarah;
- Kessler, Benedikt;
- Bennett, James;
- Fedorov, Oleg;
- Raynaud, Florence;
- Donovan, Adam;
- Blagg, Julian;
- Bavetsias, Vassilios
Publication type:
Article
Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile.
Published in:
Biochemical Journal, 2014, v. 462, n. 3, p. 581, doi. 10.1042/BJ20140511
By:
- DÍAZ-SÁEZ, Laura;
- SRIKANNATHASAN, Velupillai;
- ZOLTNER, Martin;
- HUNTER, William N.
Publication type:
Article
Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide.
Published in:
Acta Crystallographica: Section F, Structural Biology Communications, 2015, v. 71, n. 10, p. 1242, doi. 10.1107/S2053230X15015290
By:
- Srikannathasan, Velupillai;
- Wohlkonig, Alexandre;
- Shillings, Anthony;
- Singh, Onkar;
- Chan, Pan F.;
- Huang, Jianzhong;
- Gwynn, Michael N.;
- Fosberry, Andrew P.;
- Homes, Paul;
- Hibbs, Martin;
- Theobald, Andrew J.;
- Spitzfaden, Claus;
- Bax, Benjamin D.
Publication type:
Article
Deliberately Losing Control of C−H Activation Processes in the Design of Small‐Molecule‐Fragment Arrays Targeting Peroxisomal Metabolism.
Published in:
ChemMedChem, 2020, v. 15, n. 24, p. 2513, doi. 10.1002/cmdc.202000543
By:
- Khan Tareque, Raysa;
- Hassell‐Hart, Storm;
- Krojer, Tobias;
- Bradley, Anthony;
- Velupillai, Srikannathasan;
- Talon, Romain;
- Fairhead, Michael;
- Day, Iain J.;
- Bala, Kamlesh;
- Felix, Robert;
- Kemmitt, Paul D.;
- Brennan, Paul;
- Delft, Frank;
- Díaz Sáez, Laura;
- Huber, Kilian;
- Spencer, John
Publication type:
Article
New secreted toxins and immunity proteins encoded within the Type VI secretion system gene cluster of Serratia marcescens.
Published in:
Molecular Microbiology, 2012, v. 86, n. 4, p. 921, doi. 10.1111/mmi.12028
By:
- English, Grant;
- Trunk, Katharina;
- Rao, Vincenzo A.;
- Srikannathasan, Velupillai;
- Hunter, William N.;
- Coulthurst, Sarah J.
Publication type:
Article
Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA.
Published in:
2020
By:
- Holland, Christopher J.;
- Crean, Rory M.;
- Pentier, Johanne M.;
- de Wet, Ben;
- Lloyd, Angharad;
- Srikannathasan, Velupillai;
- Lissin, Nikolai;
- Lloyd, Katy A.;
- Blicher, Thomas H.;
- Conroy, Paul J.;
- Hock, Miriam;
- Pengelly, Robert J.;
- Spinner, Thomas E.;
- Cameron, Brian;
- Potter, Elizabeth A.;
- Jeyanthan, Anitha;
- Molloy, Peter E.;
- Sami, Malkit;
- Aleksic, Milos;
- Liddy, Nathaniel
Publication type:
journal article
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.
Published in:
Nature Communications, 2015, v. 6, n. 12, p. 10048, doi. 10.1038/ncomms10048
By:
- Chan, Pan F.;
- Srikannathasan, Velupillai;
- Huang, Jianzhong;
- Cui, Haifeng;
- Fosberry, Andrew P.;
- Gu, Minghua;
- Hann, Michael M.;
- Hibbs, Martin;
- Homes, Paul;
- Ingraham, Karen;
- Pizzollo, Jason;
- Shen, Carol;
- Shillings, Anthony J.;
- Spitzfaden, Claus E.;
- Tanner, Robert;
- Theobald, Andrew J.;
- Stavenger, Robert A.;
- Bax, Benjamin D.;
- Gwynn, Michael N.
Publication type:
Article
Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 by Casein Kinase 1 Family Kinases Controls the Specific Retrieval of Synaptotagmin-1.
Published in:
Journal of Neuroscience, 2015, v. 35, n. 6, p. 2492, doi. 10.1523/JNEUROSCI.4248-14.2015
By:
- Ning Zhang;
- Gordon, Sarah L.;
- Fritsch, Maximilian J.;
- Esoof, Noor;
- Campbell, David G.;
- Gourlay, Robert;
- Velupillai, Srikannathasan;
- Macartney, Thomas;
- Peggie, Mark;
- van Aalten, Daan M. F.;
- Cousin, Michael A.;
- Alessi, Dario R.
Publication type:
Article

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