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Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL.
Published in:
PLoS Genetics, 2019, v. 15, n. 6, p. 1, doi. 10.1371/journal.pgen.1008226
By:
- Upadhyay, Udita;
- Zhuang, Gerald Z.;
- Diatchenko, Luda;
- Parisien, Marc;
- Kang, Yuan;
- Sarantopoulos, Konstantinos D.;
- Martin, Eden R.;
- Smith, Shad B.;
- Maixner, William;
- Levitt, Roy C.
Publication type:
Article
Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity.
Published in:
Nature Medicine, 2012, v. 18, n. 4, p. 595, doi. 10.1038/nm.2710
By:
- Sorge, Robert E;
- Trang, Tuan;
- Dorfman, Ruslan;
- Smith, Shad B;
- Beggs, Simon;
- Ritchie, Jennifer;
- Austin, Jean-Sebastien;
- Zaykin, Dmitri V;
- Meulen, Heather Vander;
- Costigan, Michael;
- Herbert, Teri A;
- Yarkoni-Abitbul, Merav;
- Tichauer, David;
- Livneh, Jessica;
- Gershon, Edith;
- Zheng, Ming;
- Tan, Keith;
- John, Sally L;
- Slade, Gary D;
- Jordan, Joanne
Publication type:
Article
Carbonic Anhydrase-8 Regulates Inflammatory Pain by Inhibiting the ITPR1-Cytosolic Free Calcium Pathway.
Published in:
PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0118273
By:
- Zhuang, Gerald Z.;
- Keeler, Benjamin;
- Grant, Jeff;
- Bianchi, Laura;
- Fu, Eugene S.;
- Zhang, Yan Ping;
- Erasso, Diana M.;
- Cui, Jian-Guo;
- Wiltshire, Tim;
- Li, Qiongzhen;
- Hao, Shuanglin;
- Sarantopoulos, Konstantinos D.;
- Candiotti, Keith;
- Wishnek, Sarah M.;
- Smith, Shad B.;
- Maixner, William;
- Diatchenko, Luda;
- Martin, Eden R.;
- Levitt, Roy C.
Publication type:
Article
Multiple chronic pain states are associated with a common amino acid–changing allele in KCNS1.
Published in:
Brain: A Journal of Neurology, 2010, v. 133, n. 9, p. 2519, doi. 10.1093/brain/awq195
By:
- Costigan, Michael;
- Belfer, Inna;
- Griffin, Robert S.;
- Dai, Feng;
- Barrett, Lee B.;
- Coppola, Giovanni;
- Wu, Tianxia;
- Kiselycznyk, Carly;
- Poddar, Minakshi;
- Lu, Yan;
- Diatchenko, Luda;
- Smith, Shad;
- Cobos, Enrique J.;
- Zaykin, Dmitri;
- Allchorne, Andrew;
- Shen, Pei-Hong;
- Nikolajsen, Lone;
- Karppinen, Jaro;
- Männikkö, Minna;
- Kelempisioti, Anthi
Publication type:
Article
Epiregulin and EGFR interactions are involved in pain processing.
Published in:
2017
By:
- Martin, Loren J.;
- Smith, Shad B.;
- Khoutorsky, Arkady;
- Magnussen, Claire A.;
- Samoshkin, Alexander;
- Sorge, Robert E.;
- Chulmin Cho;
- Yosefpour, Noosha;
- Sivaselvachandran, Sivaani;
- Tohyama, Sarasa;
- Cole, Tiffany;
- Khuong, Thang M.;
- Mir, Ellen;
- Gibson, Dustin G.;
- Wieskopf, Jeffrey S.;
- Sotocinal, Susana G.;
- Austin, Jean Sebastien;
- Meloto, Carolina B.;
- Gitt, Joseph H.;
- Gkogkas, Christos
Publication type:
journal article
The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.
Published in:
Science Translational Medicine, 2015, v. 7, n. 287, p. 1, doi. 10.1126/scitranslmed.3009986
By:
- Wieskopf, Jeffrey S.;
- Mathur, Jayanti;
- Limapichat, Walrati;
- Post, Michael R.;
- Al-Qazzaz, Mona;
- Sorge, Robert E.;
- Martin, Loren J.;
- Zaykin, Dmitri V.;
- Smith, Shad B.;
- Freitas, Kelen;
- Austin, Jean-Sebastien;
- Feng Dai;
- Jie Zhang;
- Marcovitz, Jaclyn;
- Tuttle, Alexander H.;
- Slepian, Peter M.;
- Clarke, Sarah;
- Drenan, Ryan M.;
- Janes, Jeff;
- Sharari, Shakir Al
Publication type:
Article
A functional substitution in the L-aromatic amino acid decarboxylase enzyme worsens somatic symptoms via a serotonergic pathway.
Published in:
2019
By:
- Khoury, Samar;
- Piltonen, Marjo H.;
- Ton, Anh‐Tien;
- Cole, Tiffany;
- Samoshkin, Alexander;
- Smith, Shad B.;
- Belfer, Inna;
- Slade, Gary D.;
- Fillingim, Roger B.;
- Greenspan, Joel D.;
- Ohrbach, Richard;
- Maixner, William;
- Neely, G. Gregory;
- Serohijos, Adrian W. R.;
- Diatchenko, Luda;
- Ton, Anh-Tien
Publication type:
journal article
Evidence that Dry Eye Represents a Chronic Overlapping Pain Condition.
Published in:
Molecular Pain, 2017, v. 13, p. 1, doi. 10.1177/1744806917729306
By:
- Levitt, Alexandra E.;
- Galor, Anat;
- Chowdhury, Aneesa R.;
- Felix, Elizabeth R.;
- Sarantopoulos, Constantine D.;
- Zhuang, Gerald Y.;
- Patin, Dennis;
- Maixner, William;
- Smith, Shad B.;
- Martin, Eden R.;
- Levitt, Roy C.
Publication type:
Article
Evidence that Dry Eye Represents a Chronic Overlapping Pain Condition.
Published in:
Molecular Pain, 2017, v. 13, p. 1, doi. 10.1177/1744806917729306
By:
- Levitt, Alexandra E.;
- Galor, Anat;
- Chowdhury, Aneesa R.;
- Felix, Elizabeth R.;
- Sarantopoulos, Constantine D.;
- Zhuang, Gerald Y.;
- Patin, Dennis;
- Maixner, William;
- Smith, Shad B.;
- Martin, Eden R.;
- Levitt, Roy C.
Publication type:
Article
Reversion mutation of cDNA CA8-204 minigene construct produces a truncated functional peptide that regulates calcium release in vitro and produces profound analgesia in vivo.
Published in:
Mammalian Genome, 2020, v. 31, n. 9-12, p. 287, doi. 10.1007/s00335-020-09848-y
By:
- Upadhyay, Udita;
- Zhuang, Gerald Z.;
- Diatchenko, Luda;
- Parisien, Marc;
- Kang, Yuan;
- Sarantopoulos, Konstantinos D.;
- Martin, Eden R.;
- Smith, Shad B.;
- Maixner, William;
- Levitt, Roy C.
Publication type:
Article
Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice.
Published in:
Mammalian Genome, 2017, v. 28, n. 9/10, p. 407, doi. 10.1007/s00335-017-9694-7
By:
- Levitt, Roy;
- Zhuang, Gerald;
- Kang, Yuan;
- Erasso, Diana;
- Upadhyay, Udita;
- Ozdemir, Mehtap;
- Fu, Eugene;
- Sarantopoulos, Konstantinos;
- Smith, Shad;
- Maixner, William;
- Diatchenko, Luda;
- Martin, Eden;
- Wiltshire, Tim
Publication type:
Article
Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction.
Published in:
Nature Neuroscience, 2011, v. 14, n. 12, p. 1569, doi. 10.1038/nn.2941
By:
- Mogil, Jeffrey S;
- Sorge, Robert E;
- LaCroix-Fralish, Michael L;
- Smith, Shad B;
- Fortin, Anny;
- Sotocinal, Susana G;
- Ritchie, Jennifer;
- Austin, Jean-Sebastien;
- Schorscher-Petcu, Ara;
- Melmed, Kara;
- Czerminski, Jan;
- Bittong, Rosalie A;
- Mokris, J Brad;
- Neubert, John K;
- Campbell, Claudia M;
- Edwards, Robert R;
- Campbell, James N;
- Crawley, Jacqueline N;
- Lariviere, William R;
- Wallace, Margaret R
Publication type:
Article
Construction of a Global Pain Systems Network Highlights Phospholipid Signaling as a Regulator of Heat Nociception.
Published in:
PLoS Genetics, 2012, v. 8, n. 12, p. 1, doi. 10.1371/journal.pgen.1003071
By:
- Neely, G. Gregory;
- Shuan Rao;
- Costigan, Michael;
- Mair, Norbert;
- Racz, Ildiko;
- Milinkeviciute, Giedre;
- Meixner, Arabella;
- Nayanala, Swetha;
- Griffin, Robert S.;
- Belfer, Inna;
- Feng Dai;
- Smith, Shad;
- Diatchenko, Luda;
- Marengo, Stefano;
- Haubner, Bernhard J.;
- Novatchkova, Maria;
- Gibson, Dustin;
- Maixner, William;
- Pospisilik, J. Andrew;
- Hirsch, Emilio
Publication type:
Article
A mouse model of chronic primary pain that integrates clinically relevant genetic vulnerability, stress, and minor injury.
Published in:
Science Translational Medicine, 2024, v. 16, n. 742, p. 1, doi. 10.1126/scitranslmed.adj0395
By:
- Wang, Yaomin;
- Kim, Shin Hyung;
- Klein, Marguerita E.;
- Chen, Jiegen;
- Gu, Elizabeth;
- Smith, Shad;
- Bortsov, Andrey;
- Slade, Gary D.;
- Zhang, Xin;
- Nackley, Andrea G.
Publication type:
Article
Modeling Secondary Phenotypes Conditional on Genotypes in Case–Control Studies.
Published in:
Stats, 2022, v. 5, n. 1, p. 203, doi. 10.3390/stats5010014
By:
- Brownstein, Naomi C.;
- Cai, Jianwen;
- Smith, Shad;
- Diatchenko, Luda;
- Slade, Gary D.;
- Bair, Eric
Publication type:
Article

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