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Analysis of Ca2+ mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules.
Published in:
Cellular Microbiology, 2017, v. 19, n. 4, p. n/a, doi. 10.1111/cmi.12685
By:
- Stewart, Rebecca J.;
- Whitehead, Lachlan;
- Nijagal, Brunda;
- Sleebs, Brad E.;
- Lessene, Guillaume;
- McConville, Malcolm J.;
- Rogers, Kelly L.;
- Tonkin, Christopher J.
Publication type:
Article
A High-Throughput Phenotypic Screen of the 'Pandemic Response Box' Identifies a Quinoline Derivative with Significant Anthelmintic Activity.
Published in:
Pharmaceuticals (14248247), 2022, v. 15, n. 2, p. 257, doi. 10.3390/ph15020257
By:
- Shanley, Harrison T.;
- Taki, Aya C.;
- Byrne, Joseph J.;
- Jabbar, Abdul;
- Wells, Tim N. C.;
- Samby, Kirandeep;
- Boag, Peter R.;
- Nguyen, Nghi;
- Sleebs, Brad E.;
- Gasser, Robin B.
Publication type:
Article
High-Throughput Phenotypic Assay to Screen for Anthelmintic Activity on Haemonchus contortus.
Published in:
Pharmaceuticals (14248247), 2021, v. 14, n. 7, p. 616, doi. 10.3390/ph14070616
By:
- Taki, Aya C.;
- Byrne, Joseph J.;
- Wang, Tao;
- Sleebs, Brad E.;
- Nguyen, Nghi;
- Hall, Ross S.;
- Korhonen, Pasi K.;
- Chang, Bill C.H.;
- Jackson, Paul;
- Jabbar, Abdul;
- Gasser, Robin B.
Publication type:
Article
Australian chemistry and drug discovery towards the development of antimalarials†.
Published in:
Australian Journal of Chemistry, 2022, v. 75, n. 11, p. 849, doi. 10.1071/CH22141
By:
- Sleebs, Brad E.
Publication type:
Article
Retargeting azithromycin analogues to have dual-modality antimalarial activity.
Published in:
BMC Biology, 2020, v. 18, n. 1, p. N.PAG, doi. 10.1186/s12915-020-00859-4
By:
- Burns, Amy L.;
- Sleebs, Brad E.;
- Siddiqui, Ghizal;
- De Paoli, Amanda E.;
- Anderson, Dovile;
- Liffner, Benjamin;
- Harvey, Richard;
- Beeson, James G.;
- Creek, Darren J.;
- Goodman, Christopher D.;
- McFadden, Geoffrey I.;
- Wilson, Danny W.
Publication type:
Article
An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell.
Published in:
eLife, 2015, p. 1, doi. 10.7554/eLife.10809
By:
- O'Neill, Matthew T.;
- Lopaticki, Sash;
- Coffey, Michael J.;
- Sleebs, Brad E.;
- Uboldi, Alessandro D.;
- Garnham, Alexandra L.;
- Stewart, Rebecca J.;
- Dewson, Grant;
- Masters, Seth L.;
- Boddey, Justin A.;
- Tonkin, Christopher J.;
- Smyth, Gordon K.;
- Franco, Magdalena;
- Marino, Nicole D.;
- Panas, Michael W.;
- Boothroyd, John C.;
- Ferguson, David J. P.;
- Enciso, Marta;
- Smith, Brian J.
Publication type:
Article
Targeting malaria parasites with novel derivatives of azithromycin.
Published in:
Frontiers in Cellular & Infection Microbiology, 2022, v. 12, p. 1, doi. 10.3389/fcimb.2022.1063407
By:
- Burns, Amy L.;
- Sleebs, Brad E.;
- Gancheva, Maria;
- McLean, Kimberley T.;
- Siddiqui, Ghizal;
- Venter, Henrietta;
- Beeson, James G.;
- O’Handley, Ryan;
- Creek, Darren J.;
- Ma, Shutao;
- Frölich, Sonja;
- Goodman, Christopher D.;
- McFadden, Geoffrey I.;
- Wilson, Danny W.
Publication type:
Article
Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity.
Published in:
ChemMedChem, 2022, v. 17, n. 18, p. 1, doi. 10.1002/cmdc.202200306
By:
- Richardson, Lachlan W.;
- Ashton, Trent D.;
- Dans, Madeline G.;
- Nguyen, Nghi;
- Favuzza, Paola;
- Triglia, Tony;
- Hodder, Anthony N.;
- Ngo, Anna;
- Jarman, Kate E.;
- Cowman, Alan F.;
- Sleebs, Brad E.
Publication type:
Article
Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.
Published in:
Nature Structural & Molecular Biology, 2015, v. 22, n. 8, p. 590, doi. 10.1038/nsmb.3061
By:
- Hodder, Anthony N;
- Sleebs, Brad E;
- Czabotar, Peter E;
- Gazdik, Michelle;
- Xu, Yibin;
- O'Neill, Matthew T;
- Lopaticki, Sash;
- Nebl, Thomas;
- Triglia, Tony;
- Smith, Brian J;
- Lowes, Kym;
- Boddey, Justin A;
- Cowman, Alan F
Publication type:
Article
HIV-1 and Human PEG10 Frameshift Elements Are Functionally Distinct and Distinguished by Novel Small Molecule Modulators.
Published in:
PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0139036
By:
- Cardno, Tony S.;
- Shimaki, Yosuke;
- Sleebs, Brad E.;
- Lackovic, Kurt;
- Parisot, John P.;
- Moss, Rebecca M.;
- Crowe-McAuliffe, Caillan;
- Mathew, Suneeth F.;
- Edgar, Christina D.;
- Kleffmann, Torsten;
- Tate, Warren P.
Publication type:
Article
A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell.
Published in:
PLoS Pathogens, 2022, v. 18, n. 2, p. 1, doi. 10.1371/journal.ppat.1009977
By:
- Gabriela, Mikha;
- Matthews, Kathryn M.;
- Boshoven, Cas;
- Kouskousis, Betty;
- Jonsdottir, Thorey K.;
- Bullen, Hayley E.;
- Modak, Joyanta;
- Steer, David L.;
- Sleebs, Brad E.;
- Crabb, Brendan S.;
- Koning-Ward, Tania F. de;
- Gilson, Paul R.
Publication type:
Article
A phenotypic screen of the Global Health Priority Box identifies an insecticide with anthelmintic activity.
Published in:
Parasites & Vectors, 2024, v. 17, n. 1, p. 1, doi. 10.1186/s13071-024-06183-y
By:
- Shanley, Harrison T.;
- Taki, Aya C.;
- Byrne, Joseph J.;
- Nguyen, Nghi;
- Wells, Tim N. C.;
- Jabbar, Abdul;
- Sleebs, Brad E.;
- Gasser, Robin B.
Publication type:
Article
Chemo‐proteomics in antimalarial target identification and engagement.
Published in:
Medicinal Research Reviews, 2023, v. 43, n. 6, p. 2303, doi. 10.1002/med.21975
By:
- Bailey, Brodie L.;
- Nguyen, William;
- Cowman, Alan F.;
- Sleebs, Brad E.
Publication type:
Article
Mitoxantrone, More than Just Another Topoisomerase II Poison.
Published in:
Medicinal Research Reviews, 2016, v. 36, n. 2, p. 248, doi. 10.1002/med.21364
By:
- Evison, Benny J.;
- Sleebs, Brad E.;
- Watson, Keith G.;
- Phillips, Don R.;
- Cutts, Suzanne M.
Publication type:
Article
Role of Plasmepsin V in Export of Diverse Protein Families from the Plasmodium falciparum Exportome.
Published in:
Traffic, 2013, v. 14, n. 5, p. 532, doi. 10.1111/tra.12053
By:
- Boddey, Justin A.;
- Carvalho, Teresa G.;
- Hodder, Anthony N.;
- Sargeant, Tobias J.;
- Sleebs, Brad E.;
- Marapana, Danushka;
- Lopaticki, Sash;
- Nebl, Thomas;
- Cowman, Alan F.
Publication type:
Article
Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.
Published in:
BMC Biology, 2015, v. 13, n. 1, p. 1, doi. 10.1186/s12915-015-0162-0
By:
- Wilson, Danny W.;
- Goodman, Christopher D.;
- Sleebs, Brad E.;
- Weiss, Greta E.;
- de Jong, Nienke W. M.;
- Angrisano, Fiona;
- Langer, Christine;
- Baum, Jake;
- Crabb, Brendan S.;
- Gilson, Paul R.;
- McFadden, Geoffrey I.;
- Beeson, James G.
Publication type:
Article
Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.
Published in:
BMC Biology, 2015, v. 13, n. 1, p. 52, doi. 10.1186/s12915-015-0162-0
By:
- Wilson, Danny W;
- Goodman, Christopher D;
- Sleebs, Brad E;
- Weiss, Greta E;
- de Jong, Nienke WM;
- Angrisano, Fiona;
- Langer, Christine;
- Baum, Jake;
- Crabb, Brendan S;
- Gilson, Paul R;
- McFadden, Geoffrey I;
- Beeson, James G
Publication type:
Article
An appraisal of natural products active against parasitic nematodes of animals.
Published in:
Parasites & Vectors, 2019, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13071-019-3537-1
By:
- Garcia-Bustos, Jose F.;
- Sleebs, Brad E.;
- Gasser, Robin B.
Publication type:
Article
Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites.
Published in:
PLoS Biology, 2014, v. 12, n. 7, p. 1, doi. 10.1371/journal.pbio.1001897
By:
- Sleebs, Brad E.;
- Lopaticki, Sash;
- Marapana, Danushka S.;
- O'Neill, Matthew T.;
- Rajasekaran, Pravin;
- Gazdik, Michelle;
- Günther, Svenja;
- Whitehead, Lachlan W.;
- Lowes, Kym N.;
- Barfod, Lea;
- Hviid, Lars;
- Shaw, Philip J.;
- Hodder, Anthony N.;
- Smith, Brian J.;
- Cowman, Alan F.;
- Boddey, Justin A.
Publication type:
Article
Three Small Molecule Entities (MPK18, MPK334 and YAK308) with Activity against Haemonchus contortus In Vitro.
Published in:
Molecules, 2021, v. 26, n. 9, p. 2819, doi. 10.3390/molecules26092819
By:
- Taki, Aya C.;
- Jabbar, Abdul;
- Kurz, Thomas;
- Lungerich, Beate;
- Ma, Guangxu;
- Byrne, Joseph J.;
- Pflieger, Marc;
- Asfaha, Yodita;
- Fischer, Fabian;
- Chang, Bill C. H.;
- Sleebs, Brad E.;
- Gasser, Robin B.;
- Chatzopoulou, Maria
Publication type:
Article
Synthetic Kavalactone Analogues with Increased Potency and Selective Anthelmintic Activity against Larvae of Haemonchus contortus In Vitro.
Published in:
Molecules, 2020, v. 25, n. 8, p. 2004, doi. 10.3390/molecules25082004
By:
- Herath, H.M.P. Dilrukshi;
- Taki, Aya C.;
- Nguyen, Nghi;
- Garcia-Bustos, José;
- Hofmann, Andreas;
- Wang, Tao;
- Ma, Guangxu;
- Chang, Bill C.H.;
- Jabbar, Abdul;
- Sleebs, Brad E.;
- Gasser, Robin B.
Publication type:
Article
Structure-guided design of a selective BCL-XL inhibitor.
Published in:
Nature Chemical Biology, 2013, v. 9, n. 6, p. 390, doi. 10.1038/nchembio.1246
By:
- Lessene, Guillaume;
- Czabotar, Peter E;
- Sleebs, Brad E;
- Zobel, Kerry;
- Lowes, Kym N;
- Adams, Jerry M;
- Baell, Jonathan B;
- Colman, Peter M;
- Deshayes, Kurt;
- Fairbrother, Wayne J;
- Flygare, John A;
- Gibbons, Paul;
- Kersten, Wilhelmus J A;
- Kulasegaram, Sanji;
- Moss, Rebecca M;
- Parisot, John P;
- Smith, Brian J;
- Street, Ian P;
- Yang, Hong;
- Huang, David C S
Publication type:
Article
Sequence elements within the PEXEL motif and its downstream region modulate PTEX‐dependent protein export in Plasmodium falciparum.
Published in:
Traffic, 2024, v. 25, n. 1, p. 1, doi. 10.1111/tra.12922
By:
- Gabriela, Mikha;
- Barnes, Claudia B. G.;
- Leong, Dickson;
- Sleebs, Brad E.;
- Schneider, Molly Parkyn;
- Littler, Dene R.;
- Crabb, Brendan S.;
- de Koning‐Ward, Tania F.;
- Gilson, Paul R.
Publication type:
Article
The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites.
Published in:
Traffic, 2022, v. 23, n. 9, p. 442, doi. 10.1111/tra.12862
By:
- Looker, Oliver;
- Dans, Madeline G.;
- Bullen, Hayley E.;
- Sleebs, Brad E.;
- Crabb, Brendan S.;
- Gilson, Paul R.
Publication type:
Article

Found: 24

Analysis of Ca<sup>2</sup><sup>+</sup> mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules.

A High-Throughput Phenotypic Screen of the 'Pandemic Response Box' Identifies a Quinoline Derivative with Significant Anthelmintic Activity.

High-Throughput Phenotypic Assay to Screen for Anthelmintic Activity on Haemonchus contortus.

Australian chemistry and drug discovery towards the development of antimalarials<sup>†</sup>.

Retargeting azithromycin analogues to have dual-modality antimalarial activity.

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell.

Targeting malaria parasites with novel derivatives of azithromycin.

Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity.

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.

HIV-1 and Human PEG10 Frameshift Elements Are Functionally Distinct and Distinguished by Novel Small Molecule Modulators.

A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell.

A phenotypic screen of the Global Health Priority Box identifies an insecticide with anthelmintic activity.

Chemo‐proteomics in antimalarial target identification and engagement.

Mitoxantrone, More than Just Another Topoisomerase II Poison.

Role of Plasmepsin V in Export of Diverse Protein Families from the Plasmodium falciparum Exportome.

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.

An appraisal of natural products active against parasitic nematodes of animals.

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites.

Three Small Molecule Entities (MPK18, MPK334 and YAK308) with Activity against Haemonchus contortus In Vitro.

Synthetic Kavalactone Analogues with Increased Potency and Selective Anthelmintic Activity against Larvae of Haemonchus contortus In Vitro.

Structure-guided design of a selective BCL-X<sub>L</sub> inhibitor.

Sequence elements within the PEXEL motif and its downstream region modulate PTEX‐dependent protein export in Plasmodium falciparum.

The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites.