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Towards a Better Understanding of Genotype–Phenotype Correlations and Therapeutic Targets for Cardiocutaneous Genes: The Importance of Functional Studies above Prediction.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 18, p. N.PAG, doi. 10.3390/ijms231810765
By:
- Vermeer, Mathilde C. S. C.;
- Andrei, Daniela;
- Marsili, Luisa;
- van Tintelen, J. Peter;
- Silljé, Herman H. W.;
- van den Berg, Maarten P.;
- van der Meer, Peter;
- Bolling, Maria C.
Publication type:
Article
Antisense Therapy Attenuates Phospholamban p.(Arg14del) Cardiomyopathy in Mice and Reverses Protein Aggregation.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 5, p. 2427, doi. 10.3390/ijms23052427
By:
- Eijgenraam, Tim R.;
- Stege, Nienke M.;
- Oliveira Nunes Teixeira, Vivian;
- de Brouwer, Remco;
- Schouten, Elisabeth M.;
- Grote Beverborg, Niels;
- Sun, Liu;
- Später, Daniela;
- Knöll, Ralph;
- Hansson, Kenny M.;
- Amilon, Carl;
- Janzén, David;
- Yeh, Steve T.;
- Mullick, Adam E.;
- van der Meer, Peter;
- de Boer, Rudolf A.;
- Silljé, Herman H. W.
Publication type:
Article
The Time Has Come to Explore Plasma Biomarkers in Genetic Cardiomyopathies.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 6, p. 2955, doi. 10.3390/ijms22062955
By:
- Stege, Nienke M.;
- de Boer, Rudolf A.;
- van den Berg, Maarten P.;
- Silljé, Herman H. W.;
- Rochette, Luc
Publication type:
Article
AKIP1, a Cardiac Hypertrophy Induced Protein that Stimulates Cardiomyocyte Growth via the Akt Pathway.
Published in:
International Journal of Molecular Sciences, 2013, v. 14, n. 11, p. 21378, doi. 10.3390/ijms141121378
By:
- Hongjuan Yu;
- Tigchelaar, Wardit;
- Bo Lu;
- van Gilst, Wiek H.;
- de Boer, Rudolf A.;
- Westenbrink, B. Daan;
- Silljé, Herman H. W.
Publication type:
Article
Sodium-glucose co-transporter 2 inhibition as a mitochondrial therapy for atrial fibrillation in patients with diabetes?
Published in:
2020
By:
- Yurista, Salva R.;
- Silljé, Herman H. W.;
- Rienstra, Michiel;
- de Boer, Rudolf A.;
- Westenbrink, B. Daan
Publication type:
Editorial
Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway.
Published in:
2002
By:
- Mello, Jill A.;
- Silljé, Herman H. W.;
- Roche, Danièle M. J.;
- Kirschner, Doris B.;
- Nigg, Erich A.;
- Almouzni, Geneviéve
Publication type:
Report
A Kinase Interacting Protein 1 (AKIP1) promotes cardiomyocyte elongation and physiological cardiac remodelling.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-30514-1
By:
- Nijholt, Kirsten T.;
- Sánchez-Aguilera, Pablo I.;
- Booij, Harmen G.;
- Oberdorf-Maass, Silke U.;
- Dokter, Martin M.;
- Wolters, Anouk H. G.;
- Giepmans, Ben N. G.;
- van Gilst, Wiek H.;
- Brown, Joan H.;
- de Boer, Rudolf A.;
- Silljé, Herman H. W.;
- Westenbrink, B. Daan
Publication type:
Article
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25439-0
By:
- Grote Beverborg, Niels;
- Später, Daniela;
- Knöll, Ralph;
- Hidalgo, Alejandro;
- Yeh, Steve T.;
- Elbeck, Zaher;
- Silljé, Herman H. W.;
- Eijgenraam, Tim R.;
- Siga, Humam;
- Zurek, Magdalena;
- Palmér, Malin;
- Pehrsson, Susanne;
- Albery, Tamsin;
- Bomer, Nils;
- Hoes, Martijn F.;
- Boogerd, Cornelis J.;
- Frisk, Michael;
- van Rooij, Eva;
- Damle, Sagar;
- Louch, William E.
Publication type:
Article
Polo-like kinases and the orchestration of cell division.
Published in:
Nature Reviews Molecular Cell Biology, 2004, v. 5, n. 6, p. 429, doi. 10.1038/nrm1401
By:
- Barr, Francis A.;
- Silljé, Herman H. W.;
- Nigg, Erich A.
Publication type:
Article
Cardiac Function and Architecture Are Maintained in a Model of Cardiorestricted Overexpression of the Prorenin-Renin Receptor.
Published in:
PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0089929
By:
- Mahmud, Hasan;
- Candido, Wellington Mardoqueu;
- van Genne, Linda;
- Vreeswijk-Baudoin, Inge;
- Yu, Hongjuan;
- van de Sluis, Bart;
- van Deursen, Jan;
- van Gilst, Wiek H.;
- Silljé, Herman H. W.;
- de Boer, Rudolf A.
Publication type:
Article
AKIP1 Expression Modulates Mitochondrial Function in Rat Neonatal Cardiomyocytes.
Published in:
PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0080815
By:
- Yu, Hongjuan;
- Tigchelaar, Wardit;
- Koonen, Debby P. Y.;
- Patel, Hemal H.;
- de Boer, Rudolf A.;
- van Gilst, Wiek H.;
- Westenbrink, B. Daan;
- Silljé, Herman H. W.
Publication type:
Article
The Plk1 Inhibitor BI 2536 Temporarily Arrests Primary Cardiac Fibroblasts in Mitosis and Generates Aneuploidy In Vitro.
Published in:
PLoS ONE, 2010, v. 5, n. 9, p. 1, doi. 10.1371/journal.pone.0012963
By:
- Bo Lu;
- Mahmud, Hasan;
- Maass, Alexander H.;
- Bo Yu;
- van Gilst, Wiek H.;
- de Boer, Rudolf A.;
- Silljé, Herman H. W.
Publication type:
Article
A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.
Published in:
European Heart Journal, 2023, v. 44, n. 40, p. 4284, doi. 10.1093/eurheartj/ehad292
By:
- Brouwer, Remco de;
- Rijdt, Wouter P te;
- Hoorntje, Edgar T;
- Amin, Ahmad;
- Asselbergs, Folkert W;
- Cox, Moniek G P J;
- Heijden, Jeroen F van der;
- Hillege, Hans;
- Karper, Jacco C;
- Mahmoud, Belend;
- van der Meer, Peter;
- Oomen, Anton;
- Riele, Anneline S J M te;
- Silljé, Herman H W;
- Tan, Hanno L;
- Tintelen, Jan Peter van;
- Veldhuisen, Dirk J van;
- Westenbrink, Berend Daan;
- Wiesfeld, Ans C P;
- Willems, Tineke P
Publication type:
Article
Early consequences of the phospholamban mutation PLN‐R14del<sup>+/−</sup> in a transgenic mouse model.
Published in:
Acta Physiologica, 2024, v. 240, n. 3, p. 1, doi. 10.1111/apha.14082
By:
- Maniezzi, Claudia;
- Eskandr, Marem;
- Florindi, Chiara;
- Ferrandi, Mara;
- Barassi, Paolo;
- Sacco, Elena;
- Pasquale, Valentina;
- Maione, Angela S.;
- Pompilio, Giulio;
- Teixeira, Vivian Oliveira Nunes;
- de Boer, Rudolf A.;
- Silljé, Herman H. W.;
- Lodola, Francesco;
- Zaza, Antonio
Publication type:
Article
HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension.
Published in:
2016
By:
- Kudryashova, Tatiana V.;
- Goncharov, Dmitry A.;
- Pena, Andressa;
- Kelly, Neil;
- Vanderpool, Rebecca;
- Baust, Jeff;
- Kobir, Ahasanul;
- Shufesky, William;
- Mora, Ana L.;
- Morelli, Adrian E.;
- Jing Zhao;
- Ihida-Stansbury, Kaori;
- Baojun Chang;
- De Lisser, Horace;
- Tuder, Rubin M.;
- Kawut, Steven M.;
- Silljé, Herman H. W.;
- Shapiro, Steven;
- Yutong Zhao;
- Goncharova, Elena A.
Publication type:
journal article
Heart failure-associated anemia: bone marrow dysfunction and response to erythropoietin.
Published in:
Journal of Molecular Medicine, 2011, v. 89, n. 4, p. 377, doi. 10.1007/s00109-010-0710-6
By:
- Ruifrok, Willem-Peter T.;
- Cheng Qian;
- Silljé, Herman H. W.;
- van Goor, Harry;
- van Veldhuisen, Dirk J.;
- van Gilst, Wiek H.;
- deBoer, Rudolf A.
Publication type:
Article
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.
Published in:
Oncogene, 2005, v. 24, n. 12, p. 2076, doi. 10.1038/sj.onc.1208445
By:
- Chan, Eunice H. Y.;
- Nousiainen, Marjaana;
- Chalamalasetty, Ravindra B.;
- Schäfer, Anja;
- Nigg, Erich A;
- Silljé, Herman H W
Publication type:
Article
OPLAH ablation leads to accumulation of 5-oxoproline, oxidative stress, fibrosis, and elevated fillings pressures: a murine model for heart failure with a preserved ejection fraction.
Published in:
Cardiovascular Research, 2018, v. 114, n. 14, p. 1871, doi. 10.1093/cvr/cvy187
By:
- van der Pol, Atze;
- Gil, Andres;
- Tromp, Jasper;
- Silljé, Herman H W;
- Veldhuisen, Dirk J van;
- Voors, Adriaan A;
- Hoendermis, Elke S;
- Beverborg, Niels Grote;
- Schouten, Elisabeth-Maria;
- Boer, Rudolf A de
Publication type:
Article
Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2.
Published in:
EMBO Journal, 2006, v. 25, n. 23, p. 5504, doi. 10.1038/sj.emboj.7601426
By:
- Hanisch, Anja;
- Silljé, Herman H. W.;
- Nigg, Erich A.
Publication type:
Article
The erythropoietin receptor expressed in skeletal muscle is essential for mitochondrial biogenesis and physiological exercise.
Published in:
Pflügers Archiv: European Journal of Physiology, 2021, v. 473, n. 8, p. 1301, doi. 10.1007/s00424-021-02577-4
By:
- Nijholt, Kirsten T.;
- Meems, Laura M. G.;
- Ruifrok, Willem P. T.;
- Maass, Alexander H.;
- Yurista, Salva R.;
- Pavez-Giani, Mario G.;
- Mahmoud, Belend;
- Wolters, Anouk H. G.;
- van Veldhuisen, Dirk J.;
- van Gilst, Wiek H.;
- Silljé, Herman H. W.;
- de Boer, Rudolf A.;
- Westenbrink, B. Daan
Publication type:
Article
Functional investigation of two simultaneous or separately segregating DSP variants within a single family supports the theory of a dose‐dependent disease severity.
Published in:
Experimental Dermatology, 2022, v. 31, n. 6, p. 970, doi. 10.1111/exd.14571
By:
- Vermeer, Mathilde C. S. C.;
- Andrei, Daniela;
- Kramer, Duco;
- Nijenhuis, Albertine M.;
- Hoedemaekers, Yvonne M.;
- Westers, Helga;
- Jongbloed, Jan D. H.;
- Pas, Hendri H.;
- van den Berg, Maarten P.;
- Silljé, Herman H. W.;
- van der Meer, Peter;
- Bolling, Maria C.
Publication type:
Article
Heart failure-induced microbial dysbiosis contributes to colonic tumour formation in mice.
Published in:
Cardiovascular Research, 2024, v. 120, n. 6, p. 612, doi. 10.1093/cvr/cvae038
By:
- Wit, Sanne de;
- Geerlings, Lotte;
- Shi, Canxia;
- Dronkers, Just;
- Schouten, Elisabeth M;
- Blancke, Gillian;
- Andries, Vanessa;
- Yntema, Tess;
- Meijers, Wouter C;
- Koonen, Debby P Y;
- Vereecke, Lars;
- Silljé, Herman H W;
- Aboumsallem, Joseph-Pierre;
- Boer, Rudolf A de
Publication type:
Article
The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of heart failure with preserved ejection fraction.
Published in:
Cardiovascular Research, 2021, v. 117, n. 9, p. 2108, doi. 10.1093/cvr/cvaa256
By:
- Withaar, Coenraad;
- Meems, Laura M G;
- Markousis-Mavrogenis, George;
- Boogerd, Cornelis J;
- Silljé, Herman H W;
- Schouten, Elisabeth M;
- Dokter, Martin M;
- Voors, Adriaan A;
- Westenbrink, B Daan;
- Lam, Carolyn S P;
- Boer, Rudolf A de
Publication type:
Article
Regulation of the (pro)renin-renin receptor in cardiac remodelling.
Published in:
Journal of Cellular & Molecular Medicine, 2012, v. 16, n. 4, p. 722, doi. 10.1111/j.1582-4934.2011.01377.x
By:
- Mahmud, Hasan;
- Silljé, Herman H. W.;
- Cannon, Megan V.;
- Gilst, Wiek H.;
- Boer, Rudolf A.
Publication type:
Article
Volume load-induced right ventricular dysfunction in animal models: insights in a translational gap in congenital heart disease.
Published in:
2018
By:
- Bossers, Guido P. L.;
- Hagdorn, Quint A. J.;
- Ploegstra, Mark Jan;
- Borgdorff, Marinus A. J.;
- Silljé, Herman H. W.;
- Berger, Rolf M. F.;
- Bartelds, Beatrijs
Publication type:
Letter
Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH.
Published in:
Science Translational Medicine, 2017, v. 9, n. 415, p. 1, doi. 10.1126/scitranslmed.aam8574
By:
- van der Pol, Atze;
- Gil, Andres;
- Silljé, Herman H. W.;
- Tromp, Jasper;
- Ovchinnikova, Ekaterina S.;
- Vreeswijk-Baudoin, Inge;
- Hoes, Martijn;
- Domian, Ibrahim J.;
- van de Sluis, Bart;
- van Deursen, Jan M.;
- Voors, Adriaan A.;
- van Veldhuisen, Dirk J.;
- van Gilst, Wiek H.;
- Berezikov, Eugene;
- van der Harst, Pim;
- de Boer, Rudolf A.;
- Bischoff, Rainer;
- van der Meer, Peter
Publication type:
Article
Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14<sup>Δ/+</sup> mice hearts.
Published in:
PLoS ONE, 2024, v. 19, n. 10, p. 1, doi. 10.1371/journal.pone.0311203
By:
- Foo, Brian;
- Amedei, Hugo;
- Kaur, Surmeet;
- Jaawan, Samir;
- Boshnakovska, Angela;
- Gall, Tanja;
- de Boer, Rudolf A.;
- Silljé, Herman H. W.;
- Urlaub, Henning;
- Rehling, Peter;
- Lenz, Christof;
- Lehnart, Stephan E.
Publication type:
Article
Metabolic Remodeling in the Pressure-Loaded Right Ventricle: Shifts in Glucose and Fatty Acid Metabolism-A Systematic Review and Meta-Analysis.
Published in:
2019
By:
- Koop, Anne-Marie C.;
- Bossers, Guido P. L.;
- Ploegstra, Mark-Jan;
- Hagdorn, Quint A. J.;
- Berger, Rolf M. F.;
- Silljé, Herman H. W.;
- Bartelds, Beatrijs
Publication type:
journal article
The emerging plasma biomarker Dickkopf-3 (DKK3) and its association with renal and cardiovascular disease in the general population.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-88107-9
By:
- Piek, Arnold;
- Smit, Leonie;
- Suthahar, Navin;
- Bakker, Stephan J. L.;
- de Boer, Rudolf A.;
- Silljé, Herman H. W.
Publication type:
Article
Author Correction: The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unresponsive to standard heart failure therapy.
Published in:
2020
By:
- Eijgenraam, Tim R.;
- Boukens, Bastiaan J.;
- Boogerd, Cornelis J.;
- Schouten, E. Marloes;
- van de Kolk, Cees W. A.;
- Stege, Nienke M.;
- te Rijdt, Wouter P.;
- Hoorntje, Edgar T.;
- van der Zwaag, Paul A.;
- van Rooij, Eva;
- van Tintelen, J. Peter;
- van den Berg, Maarten P.;
- van der Meer, Peter;
- van der Velden, Jolanda;
- Silljé, Herman H. W.;
- de Boer, Rudolf A.
Publication type:
Correction Notice
The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-66656-9
By:
- Eijgenraam, Tim R.;
- Boukens, Bastiaan J.;
- Boogerd, Cornelis J.;
- Schouten, E. Marloes;
- van de Kolk, Cees W. A.;
- Stege, Nienke M.;
- te Rijdt, Wouter P.;
- Hoorntje, Edgar T.;
- van der Zwaag, Paul A.;
- van Rooij, Eva;
- van Tintelen, J. Peter;
- van den Berg, Maarten P.;
- van der Meer, Peter;
- van der Velden, Jolanda;
- Silljé, Herman H. W.;
- de Boer, Rudolf A.
Publication type:
Article
Factor Xa Inhibition with Apixaban Does Not Influence Cardiac Remodelling in Rats with Heart Failure After Myocardial Infarction.
Published in:
Cardiovascular Drugs & Therapy, 2021, v. 35, n. 5, p. 953, doi. 10.1007/s10557-020-06999-7
By:
- Yurista, Salva R.;
- Silljé, Herman H. W.;
- Nijholt, Kirsten T.;
- Dokter, Martin M.;
- van Veldhuisen, Dirk J.;
- de Boer, Rudolf A.;
- Westenbrink, B. Daan
Publication type:
Article
Correction to: Factor Xa Inhibition with Apixaban Does Not Influence Cardiac Remodelling in Rats with Heart Failure After Myocardial Infarction.
Published in:
2021
By:
- Yurista, Salva R.;
- Silljé, Herman H. W.;
- Nijholt, Kirsten T.;
- Dokter, Martin M.;
- van Veldhuisen, Dirk J.;
- de Boer, Rudolf A.;
- Westenbrink, B. Daan
Publication type:
Correction Notice
Effects of Sodium–Glucose Co-transporter 2 Inhibition with Empaglifozin on Renal Structure and Function in Non-diabetic Rats with Left Ventricular Dysfunction After Myocardial Infarction.
Published in:
Cardiovascular Drugs & Therapy, 2020, v. 34, n. 3, p. 311, doi. 10.1007/s10557-020-06954-6
By:
- Yurista, Salva R.;
- Silljé, Herman H. W.;
- van Goor, Harry;
- Hillebrands, Jan-Luuk;
- Heerspink, Hiddo J. L.;
- de Menezes Montenegro, Luiz;
- Oberdorf-Maass, Silke U.;
- de Boer, Rudolf A.;
- Westenbrink, B. Daan
Publication type:
Article
In EXOG-depleted cardiomyocytes cell death is marked by a decreased mitochondrial reserve capacity of the electron transport chain.
Published in:
BioEssays, 2016, v. 38, p. S136, doi. 10.1002/bies.201670914
By:
- Tigchelaar, Wardit;
- De Jong, Anne Margreet;
- Gilst, Wiek H.;
- De Boer, Rudolf A.;
- Silljé, Herman H. W.
Publication type:
Article
A Kinase Interacting Protein 1 regulates mitochondrial protein levels in energy metabolism and promotes mitochondrial turnover after exercise.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-45961-z
By:
- Nijholt, Kirsten T.;
- Sánchez-Aguilera, Pablo I.;
- Mahmoud, Belend;
- Gerding, Albert;
- Wolters, Justina C.;
- Wolters, Anouk H. G.;
- Giepmans, Ben N. G.;
- Silljé, Herman H. W.;
- de Boer, Rudolf A.;
- Bakker, Barbara M.;
- Westenbrink, B. Daan
Publication type:
Article
Rodent heart failure models do not reflect the human circulating microRNA signature in heart failure.
Published in:
PLoS ONE, 2017, v. 12, n. 5, p. 1, doi. 10.1371/journal.pone.0177242
By:
- Vegter, Eline L.;
- Ovchinnikova, Ekaterina S.;
- Silljé, Herman H. W.;
- Meems, Laura M. G.;
- van der Pol, Atze;
- van der Velde, A. Rogier;
- Berezikov, Eugene;
- Voors, Adriaan A.;
- de Boer, Rudolf A.;
- van der Meer, Peter
Publication type:
Article

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