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Role of insulin autoantibody affinity as a predictive marker for type 1 diabetes in young children with HLA-conferred disease susceptibility.
Published in:
Diabetes/Metabolism Research & Reviews, 2009, v. 25, n. 7, p. 615, doi. 10.1002/dmrr.998
By:
- Siljander, Heli;
- Härkönen, Taina;
- Hermann, Robert;
- Simell, Satu;
- Hekkala, Anne;
- Salonsaari, Riikka-Tiina;
- Simell, Tuula;
- Simell, Olli;
- Ilonen, Jorma;
- Veijola, Riitta;
- Knip, Mikael
Publication type:
Article
Author Correction: Maternal breast milk microbiota and immune markers in relation to subsequent development of celiac disease in offspring.
Published in:
2022
By:
- Štšepetova, Jelena;
- Simre, Kärt;
- Tagoma, Aili;
- Uibo, Oivi;
- Peet, Aleksandr;
- Siljander, Heli;
- Tillmann, Vallo;
- Knip, Mikael;
- Mändar, Reet;
- Uibo, Raivo
Publication type:
Correction Notice
Maternal breast milk microbiota and immune markers in relation to subsequent development of celiac disease in offspring.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-10679-x
By:
- Štšepetova, Jelena;
- Simre, Kärt;
- Tagoma, Aili;
- Uibo, Oivi;
- Peet, Aleksandr;
- Siljander, Heli;
- Tillmann, Vallo;
- Knip, Mikael;
- Mändar, Reet;
- Uibo, Raivo
Publication type:
Article
Autoantibodies to N-terminally Truncated GAD<sub>65</sub>(96-585): HLA Associations and Predictive Value for Type 1 Diabetes.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2022, v. 107, n. 3, p. e935, doi. 10.1210/clinem/dgab816
By:
- Pöllänen, Petra M.;
- Härkönen, Taina;
- Ilonen, Jorma;
- Toppari, Jorma;
- Veijola, Riitta;
- Siljander, Heli;
- Knip, Mikael
Publication type:
Article
Dynamics of Islet Autoantibodies During Prospective Follow-Up From Birth to Age 15 Years.
Published in:
2020
By:
- Pöllänen, Petra M.;
- Ryhänen, Samppa J.;
- Toppari, Jorma;
- Ilonen, Jorma;
- Vähäsalo, Paula;
- Veijola, Riitta;
- Siljander, Heli;
- Knip, Mikael
Publication type:
journal article
Rhinoviruses in infancy and risk of immunoglobulin E sensitization.
Published in:
Journal of Medical Virology, 2019, v. 91, n. 8, p. 1470, doi. 10.1002/jmv.25455
By:
- Korhonen, Laura;
- Oikarinen, Sami;
- Lehtonen, Jussi;
- Mustonen, Neea;
- Tyni, Iiris;
- Niemelä, Onni;
- Honkanen, Hanna;
- Huhtala, Heini;
- Ilonen, Jorma;
- Hämäläinen, Anu‐Maaria;
- Peet, Aleksandr;
- Tillmann, Vallo;
- Siljander, Heli;
- Knip, Mikael;
- Lönnrot, Maria;
- Hyöty, Heikki
Publication type:
Article
ConStrains identifies microbial strains in metagenomic datasets.
Published in:
Nature Biotechnology, 2015, v. 33, n. 10, p. 1045, doi. 10.1038/nbt.3319
By:
- Luo, Chengwei;
- Knight, Rob;
- Siljander, Heli;
- Knip, Mikael;
- Xavier, Ramnik J;
- Gevers, Dirk
Publication type:
Article
Circulating metabolites in progression to islet autoimmunity and type 1 diabetes.
Published in:
Diabetologia, 2019, v. 62, n. 12, p. 2287, doi. 10.1007/s00125-019-04980-0
By:
- Lamichhane, Santosh;
- Kemppainen, Esko;
- Trošt, Kajetan;
- Siljander, Heli;
- Hyöty, Heikki;
- Ilonen, Jorma;
- Toppari, Jorma;
- Veijola, Riitta;
- Hyötyläinen, Tuulia;
- Knip, Mikael;
- Orešič, Matej
Publication type:
Article
Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility.
Published in:
Diabetologia, 2017, v. 60, n. 7, p. 1284, doi. 10.1007/s00125-017-4258-7
By:
- Pöllänen, Petra;
- Lempainen, Johanna;
- Laine, Antti-Pekka;
- Toppari, Jorma;
- Veijola, Riitta;
- Vähäsalo, Paula;
- Ilonen, Jorma;
- Siljander, Heli;
- Knip, Mikael
Publication type:
Article
Reclassification of asymptomatic beta cell autoimmunity: a critical perspective.
Published in:
Diabetologia, 2017, v. 60, n. 1, p. 39, doi. 10.1007/s00125-016-4147-5
By:
- Knip, Mikael;
- Selvenius, Jenni;
- Siljander, Heli;
- Veijola, Riitta
Publication type:
Article
Allergy-Related Symptoms Are Poorly Predicted by IgE and Skin Prick Testing in Early Life.
Published in:
International Archives of Allergy & Immunology, 2021, v. 182, n. 7, p. 574, doi. 10.1159/000512109
By:
- Mustonen, Neea;
- Siljander, Heli;
- Niemelä, Onni;
- Ilonen, Jorma;
- Haahtela, Tari;
- Knip, Mikael
Publication type:
Article
Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes.
Published in:
Biomolecules (2218-273X), 2019, v. 9, n. 1, p. 33, doi. 10.3390/biom9010033
By:
- Lamichhane, Santosh;
- Ahonen, Linda;
- Sparholt Dyrlund, Thomas;
- Dickens, Alex M.;
- Siljander, Heli;
- Hyöty, Heikki;
- Ilonen, Jorma;
- Toppari, Jorma;
- Veijola, Riitta;
- Hyötyläinen, Tuulia;
- Knip, Mikael;
- Oresic, Matej
Publication type:
Article
Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life.
Published in:
Frontiers in Immunology, 2019, v. 10, p. 1, doi. 10.3389/fimmu.2019.02494
By:
- Ruohtula, Terhi;
- de Goffau, Marcus C.;
- Nieminen, Janne K.;
- Honkanen, Jarno;
- Siljander, Heli;
- Hämäläinen, Anu-Maaria;
- Peet, Aleksandr;
- Tillmann, Vallo;
- Ilonen, Jorma;
- Niemelä, Onni;
- Welling, Gjalt W.;
- Knip, Mikael;
- Harmsen, Hermie J.;
- Vaarala, Outi
Publication type:
Article
Insulin secretion and sensitivity in the prediction of type 1 diabetes in children with advanced β-cell autoimmunity.
Published in:
European Journal of Endocrinology, 2013, v. 169, n. 4, p. 479, doi. 10.1530/EJE-13-0206
By:
- Siljander, Heli T.;
- Hermann, Robert;
- Hekkala, Anne;
- Lähde, Jyrki;
- Tanner, Laura;
- Keskinen, Päivi;
- Ilonen, Jorma;
- Simell, Olli;
- Veijola, Riitta;
- Knip, Mikael
Publication type:
Article
Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children.
Published in:
Pediatric Allergy & Immunology, 2022, v. 33, n. 1, p. 1, doi. 10.1111/pai.13613
By:
- Reinert‐Hartwall, Linnea;
- Siljander, Heli;
- Härkönen, Taina;
- Vatanen, Tommi;
- Ilonen, Jorma;
- Niemelä, Onni;
- Luopajärvi, Kristiina;
- Dorshakova, Natalya;
- Mokurov, Sergei;
- Peet, Aleksandr;
- Tillmann, Vallo;
- Uibo, Raivo;
- Knip, Mikael;
- Vaarala, Outi;
- Honkanen, Jarno;
- Genuneit, Jon
Publication type:
Article
Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life.
Published in:
Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.567046
By:
- Ruohtula, Terhi;
- Kondrashova, Anita;
- Lehtonen, Jussi;
- Oikarinen, Sami;
- Hämäläinen, Anu-Maaria;
- Niemelä, Onni;
- Peet, Aleksandr;
- Tillmann, Vallo;
- Nieminen, Janne K.;
- Ilonen, Jorma;
- Knip, Mikael;
- Vaarala, Outi;
- Hyöty, Heikki;
- Härkönen, Taina;
- Ryhänen, Samppa;
- Siljander, Heli;
- Koski, Katriina;
- Koski, Matti;
- Nieminen, Janne;
- Ormisson, Anne
Publication type:
Article
Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability.
Published in:
Science Translational Medicine, 2016, v. 8, n. 343, p. 1, doi. 10.1126/scitranslmed.aad0917
By:
- Yassour, Moran;
- Vatanen, Tommi;
- Siljander, Heli;
- Hämäläinen, Anu-Maaria;
- Härkönen, Taina;
- Ryhänen, Samppa J.;
- Franzosa, Eric A.;
- Vlamakis, Hera;
- Huttenhower, Curtis;
- Gevers, Dirk;
- Lander, Eric S.;
- Knip, Mikael;
- Xavier, Ramnik J.
Publication type:
Article
Microbial exposure in infancy and subsequent appearance of type 1 diabetes mellitus-associated autoantibodies: a cohort study.
Published in:
2014
By:
- Virtanen, Suvi M;
- Takkinen, Hanna-Mari;
- Nwaru, Bright I;
- Kaila, Minna;
- Ahonen, Suvi;
- Nevalainen, Jaakko;
- Niinistö, Sari;
- Siljander, Heli;
- Simell, Olli;
- Ilonen, Jorma;
- Hyöty, Heikki;
- Veijola, Riitta;
- Knip, Mikael
Publication type:
Journal Article
Microbial Exposure in Infancy and Subsequent Appearance of Type 1 Diabetes Mellitus-Associated Autoantibodies.
Published in:
JAMA Pediatrics, 2014, v. 168, n. 8, p. 755, doi. 10.1001/jamapediatrics.2014.296
By:
- Virtanen, Suvi M.;
- Takkinen, Hanna-Mari;
- Nwaru, Bright I.;
- Kaila, Minna;
- Ahonen, Suvi;
- Nevalainen, Jaakko;
- Niinistö, Sari;
- Siljander, Heli;
- Simell, Olli;
- Ilonen, Jorma;
- Hyöty, Heikki;
- Veijola, Riitta;
- Knip, Mikael
Publication type:
Article
Infant Feeding, Gut Permeability, and Gut Inflammation Markers.
Published in:
Journal of Pediatric Gastroenterology & Nutrition, 2023, v. 76, n. 6, p. 822, doi. 10.1097/MPG.0000000000003756
By:
- Koivusaari, Katariina;
- Niinistö, Sari;
- Nevalainen, Jaakko;
- Honkanen, Jarno;
- Ruohtula, Terhi;
- Koreasalo, Mirva;
- Ahonen, Suvi;
- Åkerlund, Mari;
- Tapanainen, Heli;
- Siljander, Heli;
- Miettinen, Maija E.;
- Alatossava, Tapani;
- Ilonen, Jorma;
- Vaarala, Outi;
- Knip, Mikael;
- Virtanen, Suvi M.
Publication type:
Article
Role of humoral beta-cell autoimmunity in type 1 diabetes.
Published in:
Pediatric Diabetes, 2016, v. 17, p. 17, doi. 10.1111/pedi.12386
By:
- Knip, Mikael;
- Siljander, Heli;
- Ilonen, Jorma;
- Simell, Olli;
- Veijola, Riitta
Publication type:
Article
Coeliac disease and HLA‐conferred susceptibility to autoimmunity are associated with IgE sensitization in young children.
Published in:
Allergy, 2020, v. 75, n. 3, p. 692, doi. 10.1111/all.14055
By:
- Mustonen, Neea;
- Siljander, Heli;
- Peet, Aleksandr;
- Tillmann, Vallo;
- Härkönen, Taina;
- Niemelä, Onni;
- Uibo, Raivo;
- Ilonen, Jorma;
- Knip, Mikael
Publication type:
Article
Characteristics of Slow Progression to Type 1 Diabetes in Children With Increased HLA-Conferred Disease Risk.
Published in:
2019
By:
- Pöllänen, Petra M;
- Lempainen, Johanna;
- Laine, Antti-Pekka;
- Toppari, Jorma;
- Veijola, Riitta;
- Ilonen, Jorma;
- Siljander, Heli;
- Knip, Mikael
Publication type:
journal article
Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2019, v. 104, n. 6, p. 2277, doi. 10.1210/jc.2018-02094
By:
- Mäkinen, Marjaana;
- Löyttyniemi, Eliisa;
- Koskinen, Maarit;
- Vähä-Mäkilä, Mari;
- Siljander, Heli;
- Nurmio, Mirja;
- Mykkänen, Juha;
- Virtanen, Suvi M.;
- Simell, Olli;
- Hyöty, Heikki;
- Ilonen, Jorma;
- Knip, Mikael;
- Veijola, Riitta;
- Toppari, Jorma
Publication type:
Article
Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes.
Published in:
2019
By:
- Mäkinen, Marjaana;
- Löyttyniemi, Eliisa;
- Koskinen, Maarit;
- Vähä-Mäkilä, Mari;
- Siljander, Heli;
- Nurmio, Mirja;
- Mykkänen, Juha;
- Virtanen, Suvi M;
- Simell, Olli;
- Hyöty, Heikki;
- Ilonen, Jorma;
- Knip, Mikael;
- Veijola, Riitta;
- Toppari, Jorma
Publication type:
journal article
Early childhood infections and the use of antibiotics and antipyretic-analgesics in Finland, Estonia and Russian Karelia.
Published in:
2019
By:
- Mustonen, Neea;
- Siljander, Heli;
- Peet, Aleksandr;
- Tillmann, Vallo;
- Härkönen, Taina;
- Ilonen, Jorma;
- Hyöty, Heikki;
- Knip, Mikael;
- Koski, Katriina;
- Koski, Matti;
- Ryhänen, Samppa;
- Hämäläinen, Anu‐Maaria;
- Ormisson, Anne;
- Ulich, Valentina;
- Kuzmicheva, Elena;
- Mokurov, Sergei;
- Markova, Svetlana;
- Pylova, Svetlana;
- Isakova, Marina;
- Shakurova, Elena
Publication type:
journal article
Early-life exposure to common virus infections did not differ between coeliac disease patients and controls.
Published in:
2019
By:
- Simre, Kärt;
- Uibo, Oivi;
- Peet, Aleksandr;
- Puustinen, Leena;
- Oikarainen, Sami;
- Tamminen, Kirsi;
- Blazevic, Vesna;
- Tillmann, Vallo;
- Hämäläinen, Anu‐Maaria;
- Härkönen, Taina;
- Siljander, Heli;
- Virtanen, Suvi M.;
- Ilonen, Jorma;
- Hyöty, Heikki;
- Knip, Mikael;
- Uibo, Raivo;
- Hämäläinen, Anu-Maaria;
- DIABIMMUNE Study Group
Publication type:
journal article
Association of Picornavirus Infections With Acute Otitis Media in a Prospective Birth Cohort Study.
Published in:
2020
By:
- Seppälä, Elina M;
- Oikarinen, Sami;
- Lehtonen, Jussi P;
- Neupane, Subas;
- Honkanen, Hanna;
- Tyni, Iiris;
- Siljander, Heli;
- Ilonen, Jorma;
- Sillanpää, Saara;
- Laranne, Jussi;
- Knip, Mikael;
- Hyöty, Heikki;
- DIABIMMUNE Study Group
Publication type:
journal article
Incidence of Type 1 Diabetes in Relation to Exposure to Rotavirus Infections in Pre- and Postvaccine Birth Cohorts in Finland.
Published in:
Diabetes Care, 2024, v. 47, n. 1, p. 97, doi. 10.2337/dc23-1203
By:
- Parviainen, Anna;
- But, Anna;
- Sund, Reijo;
- Arffman, Martti;
- Siljander, Heli;
- Knip, Mikael
Publication type:
Article
Decreased Incidence of Type 1 Diabetes in Young Finnish Children.
Published in:
2020
By:
- Parviainen, Anna;
- But, Anna;
- Siljander, Heli;
- Knip, Mikael;
- Groop, Per-Henrik;
- Ilonen, Jorma;
- Otonkoski, Timo;
- Veijola, Riitta;
- Abram, Alar;
- Aito, Henrikka;
- Arkhipov, Ivan;
- Blanco-Sequeiros, Elina;
- Bondestam, Jonas;
- Granholm, Markus;
- Haapalehto-Ikonen, Maarit;
- Horn, Torsten;
- Huopio, Hanna;
- Janer, Joakim;
- Johansson, Christian;
- Kalliokoski, Liisa
Publication type:
journal article
Positivity for Zinc Transporter 8 Autoantibodies at Diagnosis Is Subsequently Associated With Reduced β-Cell Function and Higher Exogenous Insulin Requirement in Children and Adolescents With Type 1 Diabetes.
Published in:
2016
By:
- Juusola, Matilda;
- Parkkola, Anna;
- Harkonen, Taina;
- Siljander, Heli;
- Ilonen, Jorma;
- Akerblom, Hans K.;
- Knip, Mikael;
- Härkönen, Taina;
- Åkerblom, Hans K;
- Childhood Diabetes in Finland Study Group
Publication type:
journal article
Impact of Intranasal Insulin on Insulin Antibody Affinity and Isotypes in Young Children With HLA-Conferred Susceptibility to Type 1 Diabetes.
Published in:
Diabetes Care, 2011, v. 34, n. 6, p. 1383, doi. 10.2337/dc10-1449
By:
- RYHÄNEN, SAMPPA J.;
- HÄRKÖNEN, TAINA;
- SILJANDER, HELI;
- NÄNTÖ-SALONEN, KIRSTI;
- SIMELL, TUULA;
- HYÖTY, HEIKKI;
- ILONEN, JORMA;
- VEIJOLA, RIITTA;
- SIMELL, OLLI;
- KNIP, MIKAEL
Publication type:
Article
Early Detection of Peripheral Blood Cell Signature in Children Developing β-Cell Autoimmunity at a Young Age.
Published in:
2019
By:
- Kallionpää, Henna;
- Somani, Juhi;
- Tuomela, Soile;
- Ullah, Ubaid;
- de Albuquerque, Rafael;
- Lönnberg, Tapio;
- Komsi, Elina;
- Siljander, Heli;
- Honkanen, Jarno;
- Härkönen, Taina;
- Peet, Aleksandr;
- Tillmann, Vallo;
- Chandra, Vikash;
- Anagandula, Mahesh Kumar;
- Frisk, Gun;
- Otonkoski, Timo;
- Rasool, Omid;
- Lund, Riikka;
- Lähdesmäki, Harri;
- Knip, Mikael
Publication type:
journal article
Effect of HLA Class I and Class II Alleles on Progression From Autoantibody Positivity to Overt Type 1 Diabetes in Children With Risk-Associated Class II Genotypes.
Published in:
Diabetes, 2010, v. 59, n. 12, p. 3253, doi. 10.2337/db10-0167
By:
- Lipponen, Kati;
- Gombos, Zsofia;
- Kiviniemi, Minna;
- Siljander, Heli;
- Lempainen, Johanna;
- Hermann, Robert;
- Veijola, Riitta;
- Simell, Olli;
- Knip, Mikael;
- Ilonen, Jorma
Publication type:
Article
Predictive Characteristics of Diabetes-Associated Autoantibodies Among Children With HLA-Conferred Disease Susceptibility in the General Population.
Published in:
Diabetes, 2009, v. 58, n. 12, p. 2835, doi. 10.2337/db08-1305
By:
- Siljander, Heli T. A.;
- Simell, Satu;
- Hekkala, Anne;
- Lähde, Jyrki;
- Simell, Tuula;
- Vähäsalo, Paula;
- Veijola, Riitta;
- Ilonen, Jorma;
- Simell, Olli;
- Knip, Mikael
Publication type:
Article

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