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The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation.
Published in:
Science Signaling, 2017, v. 10, n. 478, p. 1, doi. 10.1126/scisignal.aal2021
By:
- Amar, Fatou;
- Sherman, Mathew A.;
- Rush, Travis;
- Larson, Megan;
- Boyle, Gabriel;
- Liu Chang;
- Götz, Jürgen;
- Buisson, Alain;
- Lesné, Sylvain E.
Publication type:
Article
Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease.
Published in:
Science Signaling, 2016, v. 9, n. 427, p. 1, doi. 10.1126/scisignal.aaf6209
By:
- Alfonso, Stephanie I.;
- Callender, Julia A.;
- Hooli, Basavaraj;
- Antal, Corina E.;
- Mullin, Kristina;
- Sherman, Mathew A.;
- Lesné, Sylvain E.;
- Leitges, Michael;
- Newton, Alexandra C.;
- Tanzi, Rudolph E.;
- Malinow, Roberto
Publication type:
Article
Human Aβ dimers bind to PrPc to activate Fyn in Alzheimer's disease
Published in:
2012
By:
- Larson, Megan;
- Sherman, Mathew;
- Nuvolone, Mario;
- Schneider, Julie;
- Bennett, David;
- Aguzzi, Adriano;
- Lesne, Sylvain
Publication type:
Abstract
Differential contribution of soluble forms of α-synuclein, TDP-43 and PrPc to Alzheimer's disease-associated cognitive impairment
Published in:
2011
By:
- Larson, Megan;
- Sherman, Mathew;
- Kuskowski, Michael;
- Schneider, Julie;
- Bennett, David;
- Lesne, Sylvain
Publication type:
Abstract
Correction: SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex.
Published in:
2024
By:
- Brown, Jennifer L.;
- Hart, Damyan W.;
- Boyle, Gabriel E.;
- Brown, Taylor G.;
- LaCroix, Michael;
- Baraibar, Andrés M.;
- Pelzel, Ross;
- Kim, Minwoo;
- Sherman, Mathew A.;
- Boes, Samuel;
- Sung, Michelle;
- Cole, Tracy;
- Lee, Michael K.;
- Araque, Alfonso;
- Lesné, Sylvain E.
Publication type:
Correction Notice
SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex.
Published in:
Acta Neuropathologica Communications, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40478-022-01480-y
By:
- Brown, Jennifer L.;
- Hart, Damyan W.;
- Boyle, Gabriel E.;
- Brown, Taylor G.;
- LaCroix, Michael;
- Baraibar, Andrés M.;
- Pelzel, Ross;
- Kim, Minwoo;
- Sherman, Mathew A.;
- Boes, Samuel;
- Sung, Michelle;
- Cole, Tracy;
- Lee, Michael K.;
- Araque, Alfonso;
- Lesné, Sylvain E.
Publication type:
Article
Brain amyloid-β oligomers in ageing and Alzheimer's disease.
Published in:
2013
By:
- Lesné, Sylvain E;
- Sherman, Mathew A;
- Grant, Marianne;
- Kuskowski, Michael;
- Schneider, Julie A;
- Bennett, David A;
- Ashe, Karen H
Publication type:
journal article
Brain amyloid-β oligomers in ageing and Alzheimer’s disease.
Published in:
Brain: A Journal of Neurology, 2013, v. 136, n. 5, p. 1383, doi. 10.1093/brain/awt062
By:
- Lesné, Sylvain E.;
- Sherman, Mathew A.;
- Grant, Marianne;
- Kuskowski, Michael;
- Schneider, Julie A.;
- Bennett, David A.;
- Ashe, Karen H.
Publication type:
Article
Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy.
Published in:
Acta Neuropathologica, 2019, v. 138, n. 4, p. 551, doi. 10.1007/s00401-019-02032-w
By:
- Singh, Balvindar;
- Covelo, Ana;
- Martell-Martínez, Héctor;
- Nanclares, Carmen;
- Sherman, Mathew A.;
- Okematti, Emmanuel;
- Meints, Joyce;
- Teravskis, Peter J.;
- Gallardo, Christopher;
- Savonenko, Alena V.;
- Benneyworth, Michael A.;
- Lesné, Sylvain E.;
- Liao, Dezhi;
- Araque, Alfonso;
- Lee, Michael K.
Publication type:
Article
Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons.
Published in:
Acta Neuropathologica, 2018, v. 136, n. 4, p. 589, doi. 10.1007/s00401-018-1886-z
By:
- Khan, Shahzad S.;
- Bloom, George S.;
- Boyle, Gabriel;
- Sherman, Mathew A.;
- Brown, Jennifer L.;
- Lesné, Sylvain E.;
- LaCroix, Michael;
- Amar, Fatou;
- Aldaco, Jacqeline;
- Lee, Michael K.
Publication type:
Article
Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport.
Published in:
Journal of Neuroscience, 2016, v. 36, n. 37, p. 9647, doi. 10.1523/JNEUROSCI.1899-16.2016
By:
- Sherman, Mathew A.;
- LaCroix, Michael;
- Amar, Fatou;
- Larson, Megan E.;
- Forster, Colleen;
- Aguzzi, Adriano;
- Bennett, David A.;
- Ramsden, Martin;
- Lesné, Sylvain E.
Publication type:
Article
Genetic Modulation of Soluble Aβ Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease.
Published in:
Journal of Neuroscience, 2014, v. 34, n. 23, p. 7871, doi. 10.1523/JNEUROSCI.0572-14.2014
By:
- Fowler, Stephanie W.;
- Chiang, Angie C. A.;
- Savjani, Ricky R.;
- Larson, Megan E.;
- Sherman, Mathew A.;
- Schuler, Dorothy R.;
- Cirrito, John R.;
- Lesné, Sylvain E.;
- Jankowsky, Joanna L.
Publication type:
Article
The Complex PrP<sup>c</sup>-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease.
Published in:
Journal of Neuroscience, 2012, v. 32, n. 47, p. 16857, doi. 10.1523/JNEUROSCI.1858-12.2012
By:
- Larson, Megan;
- Sherman, Mathew A.;
- Amar, Fatou;
- Nuvolone, Mario;
- Schneider, Julie A.;
- Bennett, David A.;
- Aguzzi, Adriano;
- Lesné, Sylvain ?.
Publication type:
Article
Soluble α-Synuclein Is a Novel Modulator of Alzheimer's Disease Pathophysiology.
Published in:
Journal of Neuroscience, 2012, v. 32, n. 30, p. 10253, doi. 10.1523/JNEUROSCI.0581-12.2012
By:
- Larson, Megan E.;
- Sherman, Mathew A.;
- Greimel, Susan;
- Kuskowski, Michael;
- Schneider, Julie A.;
- Bennett, David A.;
- Lesné, Sylvain E.
Publication type:
Article

Found: 14