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Chemogenetic Analysis of Human Protein Methyltransferases.
Published in:
Chemical Biology & Drug Design, 2011, v. 78, n. 2, p. 199, doi. 10.1111/j.1747-0285.2011.01135.x
By:
- Richon, Victoria M.;
- Johnston, Danielle;
- Sneeringer, Christopher J.;
- Jin, Lei;
- Majer, Christina R.;
- Elliston, Keith;
- Jerva, L. Fred;
- Scott, Margaret Porter;
- Copeland, Robert A.
Publication type:
Article
Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys<sup>27</sup> methylation by human polycomb repressive complex 2 and vSET.
Published in:
Biochemical Journal, 2013, v. 453, n. 2, p. 241, doi. 10.1042/BJ20130439
By:
- SWALM, Brooke M.;
- HALLENBECK, Kenneth K.;
- MAJER, Christina R.;
- JIN, Lei;
- SCOTT, Margaret Porter;
- MOYER, Mikel P.;
- COPELAND, Robert A.;
- WIGLE, Tim J.
Publication type:
Article
Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor.
Published in:
Biopharmaceutics & Drug Disposition, 2014, v. 35, n. 4, p. 237, doi. 10.1002/bdd.1889
By:
- Basavapathruni, Aravind;
- Olhava, Edward J.;
- Daigle, Scott R.;
- Therkelsen, Carly A.;
- Jin, Lei;
- Boriack‐Sjodin, P. Ann;
- Allain, Christina J.;
- Klaus, Christine R.;
- Raimondi, Alejandra;
- Scott, Margaret Porter;
- Dovletoglou, Angelos;
- Richon, Victoria M.;
- Pollock, Roy M.;
- Copeland, Robert A.;
- Moyer, Mikel P.;
- Chesworth, Richard;
- Pearson, Paul G.;
- Waters, Nigel J.
Publication type:
Article
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas.
Published in:
PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0111840
By:
- Knutson, Sarah K.;
- Warholic, Natalie M.;
- Johnston, L. Danielle;
- Klaus, Christine R.;
- Wigle, Tim J.;
- Iwanowicz, Dorothy;
- Littlefield, Bruce A.;
- Porter-Scott, Margaret;
- Smith, Jesse J.;
- Moyer, Mikel P.;
- Copeland, Robert A.;
- Pollock, Roy M.;
- Kuntz, Kevin W.;
- Raimondi, Alejandra;
- Keilhack, Heike
Publication type:
Article
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Published in:
Nature Chemical Biology, 2015, v. 11, n. 6, p. 432, doi. 10.1038/nchembio.1810
By:
- Chan-Penebre, Elayne;
- Kuplast, Kristy G;
- Majer, Christina R;
- Boriack-Sjodin, P Ann;
- Wigle, Tim J;
- Johnston, L Danielle;
- Rioux, Nathalie;
- Munchhof, Michael J;
- Jin, Lei;
- Jacques, Suzanne L;
- West, Kip A;
- Lingaraj, Trupti;
- Stickland, Kimberly;
- Ribich, Scott A;
- Raimondi, Alejandra;
- Scott, Margaret Porter;
- Waters, Nigel J;
- Pollock, Roy M;
- Smith, Jesse J;
- Barbash, Olena
Publication type:
Article
A687V EZH2 is a gain-of-function mutation found in lymphoma patients
Published in:
FEBS Letters, 2012, v. 586, n. 19, p. 3448, doi. 10.1016/j.febslet.2012.07.066
By:
- Majer, Christina R.;
- Jin, Lei;
- Scott, Margaret Porter;
- Knutson, Sarah K.;
- Kuntz, Kevin W.;
- Keilhack, Heike;
- Smith, Jesse J.;
- Moyer, Mikel P.;
- Richon, Victoria M.;
- Copeland, Robert A.;
- Wigle, Tim J.
Publication type:
Article
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
Published in:
FEBS Letters, 2011, v. 585, n. 19, p. 3011, doi. 10.1016/j.febslet.2011.08.018
By:
- Wigle, Tim J.;
- Knutson, Sarah K.;
- Jin, Lei;
- Kuntz, Kevin W.;
- Pollock, Roy M.;
- Richon, Victoria M.;
- Copeland, Robert A.;
- Scott, Margaret Porter
Publication type:
Article
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
Published in:
Nature Chemical Biology, 2012, v. 8, n. 11, p. 890, doi. 10.1038/nchembio.1084
By:
- Knutson, Sarah K;
- Wigle, Tim J;
- Warholic, Natalie M;
- Sneeringer, Christopher J;
- Allain, Christina J;
- Klaus, Christine R;
- Sacks, Joelle D;
- Raimondi, Alejandra;
- Majer, Christina R;
- Song, Jeffrey;
- Scott, Margaret Porter;
- Jin, Lei;
- Smith, Jesse J;
- Olhava, Edward J;
- Chesworth, Richard;
- Moyer, Mikel P;
- Richon, Victoria M;
- Copeland, Robert A;
- Keilhack, Heike;
- Pollock, Roy M
Publication type:
Article
Identification of a peptide inhibitor for the histone methyltransferase WHSC1.
Published in:
PLoS ONE, 2018, v. 13, n. 5, p. 1, doi. 10.1371/journal.pone.0197082
By:
- Morrison, Michael J.;
- Boriack-Sjodin, P. Ann;
- Swinger, Kerren K.;
- Wigle, Tim J.;
- Sadalge, Dipti;
- Kuntz, Kevin W.;
- Scott, Margaret Porter;
- Janzen, William P.;
- Chesworth, Richard;
- Duncan, Kenneth W.;
- Harvey, Darren M.;
- Lampe, John W.;
- Mitchell, Lorna H.;
- Copeland, Robert A.
Publication type:
Article

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