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Ligand‐Enabled β‐Methylene C(sp<sup>3</sup>)−H Arylation of Masked Aliphatic Alcohols.
- Published in:
- Angewandte Chemie, 2020, v. 132, n. 20, p. 7857, doi. 10.1002/ange.202000632
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- Article
Mapping the landscape of genetic dependencies in chordoma.
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- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37593-8
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- Article
Catalytic Diastereoselective Petasis Reactions.
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- Angewandte Chemie International Edition, 2011, v. 50, n. 35, p. 8172, doi. 10.1002/anie.201103271
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- Article
Towards the Optimal Screening Collection: A Synthesis Strategy.
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- Angewandte Chemie International Edition, 2008, v. 47, n. 1, p. 48, doi. 10.1002/anie.200703073
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- Article
Complex α-Pyrones Synthesized by a Gold-Catalyzed Coupling Reaction.
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- Angewandte Chemie International Edition, 2007, v. 46, n. 43, p. 8250, doi. 10.1002/anie.200703276
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- Article
Fluorous-Based Small-Molecule Microarrays for the Discovery of Histone Deacetylase Inhibitors.
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- Angewandte Chemie International Edition, 2007, v. 46, n. 42, p. 7960, doi. 10.1002/anie.200703198
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- Article
Active genes are tri-methylated at K4 of histone H3.
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- Nature, 2002, v. 419, n. 6905, p. 407, doi. 10.1038/nature01080
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- Article
Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays.
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- Nature, 2002, v. 416, n. 6881, p. 653, doi. 10.1038/416653a
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- Article
A Chemical Biology View of Bioactive Small Molecules and a Binder‐Based Approach to Connect Biology to Precision Medicines.
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- Israel Journal of Chemistry, 2019, v. 59, n. 1/2, p. 52, doi. 10.1002/ijch.201800113
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- Article
Chemical Biology Towards Precision Medicine.
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- Israel Journal of Chemistry, 2017, v. 57, n. 3/4, p. 174, doi. 10.1002/ijch.201600137
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- Article
A genetic basis for the variation in the vulnerability of cancer to DNA damage.
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- Nature Communications, 2016, v. 7, n. 4, p. 11428, doi. 10.1038/ncomms11428
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- Article
Rational Design of Orthogonal Receptor-Ligand Combinations.
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- Angewandte Chemie International Edition, 1995, v. 34, n. 19, p. 2129, doi. 10.1002/anie.199521291
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- Article
Combinatorial Synthesis and Multidimensional NMR Spectroscopy: An Approach to Understanding Protein-Ligand Interactions.
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- Angewandte Chemie International Edition, 1995, v. 34, n. 9, p. 953, doi. 10.1002/anie.199509531
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- Article
Natural Products as Probes of Cellular Function: Studies of Immunophilins.
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- Angewandte Chemie International Edition, 1992, v. 31, n. 4, p. 384, doi. 10.1002/anie.199203841
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- Article
On the Conformation and Structure of Organometal Complexes in the Solid State: Two Studies Relevant to Chemical Synthesis.
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- Angewandte Chemie International Edition, 1990, v. 29, n. 3, p. 256, doi. 10.1002/anie.199002561
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- Article
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.
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- EMBO Journal, 1998, v. 17, n. 1, p. 159, doi. 10.1093/emboj/17.1.159
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- Article
Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70.
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- EMBO Journal, 1997, v. 16, n. 18, p. 5618, doi. 10.1093/emboj/16.18.5618
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- Article
Development and validation of a T7 based linear amplification for genomic DNA.
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- BMC Genomics, 2003, v. 4, p. 19, doi. 10.1186/1471-2164-4-19
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- Article
Revised Structure of the Fungal Germination Self-Inhibitor Gloeosporone.
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- Helvetica Chimica Acta, 1987, v. 70, n. 2, p. 281, doi. 10.1002/hlca.19870700203
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- Article
Selective killing of cancer cells by a small molecule targeting the stress response to ROS.
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- 2012
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- Correction notice
Selective killing of cancer cells by a small molecule targeting the stress response to ROS.
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- Nature, 2011, v. 475, n. 7355, p. 231, doi. 10.1038/nature10167
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- Article
Organic chemistry: Molecular diversity by design.
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- Nature, 2009, v. 457, n. 7226, p. 153, doi. 10.1038/457153a
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- Article
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
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- Nature, 2008, v. 452, n. 7184, p. 230, doi. 10.1038/nature06734
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- Article
Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer.
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- Oncogene, 2005, v. 24, n. 28, p. 4531, doi. 10.1038/sj.onc.1208646
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- Article
CTD<sup>2</sup> Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network.
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- Database: The Journal of Biological Databases & Curation, 2017, v. 2017, n. 1, p. 1, doi. 10.1093/database/bax054
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- Article
Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase.
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- Protein Science: A Publication of the Protein Society, 2020, v. 29, n. 3, p. 779, doi. 10.1002/pro.3825
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- Article
Fas Signal Transduction Triggers Either Proliferation or Apoptosis in Human Fibroblasts.
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- Journal of Investigative Dermatology, 1997, v. 108, n. 2, p. 215, doi. 10.1111/1523-1747.ep12334273
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- Article
Genetic basis of individual differences in the response to small-molecule drugs in yeast.
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- Nature Genetics, 2007, v. 39, n. 4, p. 496, doi. 10.1038/ng1991
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- Article
Replication and Active Demethylation Represent Partially Overlapping Mechanisms for Erasure of H3K4me3 in Budding Yeast.
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- PLoS Genetics, 2010, v. 6, n. 2, p. 1, doi. 10.1371/journal.pgen.1000837
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- Article
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres.
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- Nature Structural & Molecular Biology, 2010, v. 17, n. 10, p. 1218, doi. 10.1038/nsmb.1897
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- Article
Convergent Diversity-Oriented Synthesis of Small-Molecule HybridsWe thank the NIGMS for support of this research. C.C. is a research associate and S.L.S is an investigator with the Howard Hughes Medical Institute at the Department of Chemistry and Chemical Biology, Harvard University. C.S.N. acknowledges an NSF predoctoral fellowship.
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- Angewandte Chemie, 2005, v. 117, n. 15, p. 2289, doi. 10.1002/ange.200462798
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- Article
Synthetic Strategy toward Skeletal Diversity via Solid-Supported, Otherwise Unstable Reactive Intermediates ( We are especially grateful to John Tallarico and Max Narovlyansky at ICCB for the donation of synthesis resin. S.J.T. was supported by a postdoctoral fellowship (DRG-1735-02) of the Damon Runyon Cancer Research Foundation. A.M.T. was supported by a training grant managed by the Molecular, Cellular, and Chemical Biology Program. S.L.S. is an investigator at the Howard Hughes Medical Institute in the Department of Chemistry and Chemical Biology. We thank the National Institute for General Medical Sciences for their support of this research, the National Cancer Institute (NCI), Merck KGaA, Merck & Co., and the Keck Foundation for their support of ICCB, and the NCI for their support of the Initiative for Chemical Genetics. )
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- Angewandte Chemie, 2004, v. 116, n. 13, p. 1713, doi. 10.1002/ange.200353466
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- Article
Eine Strategie für die Diversitäts-orientierte Synthese.
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- Angewandte Chemie, 2004, v. 116, n. 1, p. 48, doi. 10.1002/ange.200300626
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- Article
Titelbild: Expanding the Functional Group Compatibility of Small-Molecule Microarrays: Discovery of Novel Calmodulin Ligands (Angew. Chem. 21/2003).
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- Angewandte Chemie, 2003, v. 115, n. 21, p. 2421, doi. 10.1002/ange.200390491
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- Article
Expanding the Functional Group Compatibility of Small-Molecule Microarrays: Discovery of Novel Calmodulin Ligands () We are especially grateful to John Tallarico and Max Narovlyansky of the Harvard Institute of Chemistry and Cell Biology (ICCB) for donation of 2 b and synthesis resin, and to Jason Gatlin and Jennifer Raggio of the ICCB for their assistance with decoding. A.N.K. was supported by an Eli Lilly Predoctoral Fellowship. S.B.P. and D.B.-S. are Research Associates and S.L.S. is an Investigator at the Howard Hughes Medical Institute in the Department of Chemistry and Chemical Biology. We thank the National Institute for General Medical Sciences for support of this research, the National Cancer Institute (NCI), Merck KGaA, Merck & Co., and the Keck Foundation for support of the ICCB, and the NCI for support of the Initiative for Chemical Genetics (formerly known as the Molecular Target Laboratory).
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- Angewandte Chemie, 2003, v. 115, n. 21, p. 2478, doi. 10.1002/ange.200351043
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- Article
Chemical Perturbation of an Intrinsically Disordered Region of TFIID Distinguishes Two Modes of Transcription Initiation.
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- eLife, 2015, p. 1, doi. 10.7554/eLife.07777
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- Article
The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.
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- eLife, 2015, p. 1, doi. 10.7554/eLife.05920
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- Article
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.
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- Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09277-9
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- Article
Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries.
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- Integrative Biology, 2009, n. 4, p. 311, doi. 10.1039/b821775k
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- Article
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines.
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- Nature Biotechnology, 2016, v. 34, n. 4, p. 419, doi. 10.1038/nbt.3460
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- Article
Chemoproteomics quantifies complexity.
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- Nature Biotechnology, 2011, v. 29, n. 3, p. 235, doi. 10.1038/nbt.1804
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- Article
Towards patient-based cancer therapeutics.
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- 2010
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- Publication type:
- Opinion
Corrigendum: Large-scale chemical dissection of mitochondrial function.
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- 2008
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- Correction notice
Large-scale chemical dissection of mitochondrial function.
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- Nature Biotechnology, 2008, v. 26, n. 3, p. 343, doi. 10.1038/nbt1387
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- Article
Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation.
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- Nature Biotechnology, 2004, v. 22, n. 5, p. 595, doi. 10.1038/nbt963
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- Article
Chemical Proteomic Discovery of Isotype‐Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2.
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- Angewandte Chemie International Edition, 2023, v. 62, n. 51, p. 1, doi. 10.1002/anie.202311924
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- Article
Modular Synthesis of Cyclopropane‐Fused N‐Heterocycles Enabled by Underexplored Diazo Reagents.
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- Angewandte Chemie International Edition, 2022, v. 61, n. 38, p. 1, doi. 10.1002/anie.202203221
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- Publication type:
- Article
Ligand‐Enabled β‐Methylene C(sp<sup>3</sup>)−H Arylation of Masked Aliphatic Alcohols.
- Published in:
- Angewandte Chemie International Edition, 2020, v. 59, n. 20, p. 7783, doi. 10.1002/anie.202000632
- By:
- Publication type:
- Article
Catalytic Diastereoselective Petasis Reactions.
- Published in:
- Angewandte Chemie, 2011, v. 123, n. 35, p. 8322, doi. 10.1002/ange.201103271
- By:
- Publication type:
- Article
Short Synthesis of Skeletally and Stereochemically Diverse Small Molecules by Coupling Petasis Condensation Reactions to Cyclization ReactionsThe NIGMS-sponsored Center of Excellence in Chemical Methodology and Library Design (Broad Institute CMLD) enabled this research. We thank Nilesh Kumar and Drs. Paul Clemons, Ryan Looper, Xiang Wang, and Damian Young for helpful discussions. G.M. is a visiting PhD student from the Dipartimento Farmacochimico, University of Bari (Italy). S.L.S. is an Investigator with the Howard Hughes Medical Institute.
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- Angewandte Chemie, 2006, v. 118, n. 22, p. 3717, doi. 10.1002/ange.200600497
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- Article