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Prevalence of the Brazilian TP53 Founder c.1010G>A (p.Arg337His) in Lung Adenocarcinoma: Is Genotyping Warranted in All Brazilian Patients?
Published in:
Frontiers in Genetics, 2021, v. 11, p. N.PAG, doi. 10.3389/fgene.2021.606537
By:
- Vieira, Igor Araujo;
- Andreis, Tiago Finger;
- Fernandes, Bruna Vieira;
- Achatz, Maria Isabel;
- Macedo, Gabriel S.;
- Schramek, Daniel;
- Ashton-Prolla, Patricia
Publication type:
Article
Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy.
Published in:
EMBO Molecular Medicine, 2019, v. 11, n. 8, p. N.PAG, doi. 10.15252/emmm.201809266
By:
- Uribesalgo, Iris;
- Hoffmann, David;
- Zhang, Yin;
- Kavirayani, Anoop;
- Lazovic, Jelena;
- Berta, Judit;
- Novatchkova, Maria;
- Pai, Tsung‐Pin;
- Wimmer, Reiner A;
- László, Viktória;
- Schramek, Daniel;
- Karim, Rezaul;
- Tortola, Luigi;
- Deswal, Sumit;
- Haas, Lisa;
- Zuber, Johannes;
- Szűcs, Miklós;
- Kuba, Keiji;
- Dome, Balazs;
- Cao, Yihai
Publication type:
Article
ETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas.
Published in:
eLife, 2015, p. 1, doi. 10.7554/eLife.10870
By:
- Hanseul Yang;
- Adam, Rene C.;
- Keyes, Brice E.;
- Fuchs, Elaine;
- Schramek, Daniel;
- Ping Wang;
- Deyou Zheng
Publication type:
Article
The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.
Published in:
Nature Genetics, 2011, v. 43, n. 3, p. 212, doi. 10.1038/ng.767
By:
- Schramek, Daniel;
- Kotsinas, Athanassios;
- Meixner, Arabella;
- Wada, Teiji;
- Elling, Ulrich;
- Pospisilik, J. Andrew;
- Neely, G. Gregory;
- Zwick, Ralf-Harun;
- Sigl, Verena;
- Forni, Guido;
- Serrano, Manuel;
- Gorgoulis, Vassilis G.;
- Penninger, Josef M.
Publication type:
Article
A mouse model to identify cooperating signaling pathways in cancer.
Published in:
Nature Methods, 2012, v. 9, n. 9, p. 897, doi. 10.1038/nmeth.2130
By:
- Musteanu, Monica;
- Blaas, Leander;
- Zenz, Rainer;
- Svinka, Jasmin;
- Hoffmann, Thomas;
- Grabner, Beatrice;
- Schramek, Daniel;
- Kantner, Hans-Peter;
- Müller, Mathias;
- Kolbe, Thomas;
- Rülicke, Thomas;
- Moriggl, Richard;
- Kenner, Lukas;
- Stoiber, Dagmar;
- Penninger, Josef Martin;
- Popper, Helmut;
- Casanova, Emilio;
- Eferl, Robert
Publication type:
Article
RANKL/RANK-beyond bones.
Published in:
Journal of Molecular Medicine, 2011, v. 89, n. 7, p. 647, doi. 10.1007/s00109-011-0749-z
By:
- Hanada, Reiko;
- Hanada, Toshikatsu;
- Sigl, Verena;
- Schramek, Daniel;
- Penninger, Josef M.
Publication type:
Article
CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-13403-y
By:
- Chylinski, Krzysztof;
- Hubmann, Maria;
- Hanna, Ruth E.;
- Yanchus, Connor;
- Michlits, Georg;
- Uijttewaal, Esther C. H.;
- Doench, John;
- Schramek, Daniel;
- Elling, Ulrich
Publication type:
Article
The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma.
Published in:
Cancers, 2023, v. 15, n. 3, p. 737, doi. 10.3390/cancers15030737
By:
- Yan, Yue;
- Gauthier, Marc-Andre;
- Malik, Ahmad;
- Fotiadou, Iosifina;
- Ostrovski, Michael;
- Dervovic, Dzana;
- Ghadban, Logine;
- Tsai, Ricky;
- Gish, Gerald;
- Loganathan, Sampath Kumar;
- Schramek, Daniel
Publication type:
Article
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
Published in:
EMBO Journal, 2008, v. 27, n. 17, p. 2305, doi. 10.1038/emboj.2008.159
By:
- Brummer, Tilman;
- Larance, Mark;
- Herrera Abreu, Maria Teresa;
- Lyons, Ruth J.;
- Timpson, Paul;
- Emmerich, Christoph H.;
- Fleuren, Emmy D. G.;
- Lehrbach, Gillian M.;
- Schramek, Daniel;
- Guilhaus, Michael;
- James, David E.;
- Daly, Roger J.
Publication type:
Article
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.
Published in:
Nature, 2010, v. 468, n. 7320, p. 98, doi. 10.1038/nature09387
By:
- Schramek, Daniel;
- Leibbrandt, Andreas;
- Sigl, Verena;
- Kenner, Lukas;
- Pospisilik, John A.;
- Lee, Heather J.;
- Hanada, Reiko;
- Joshi, Purna A.;
- Aliprantis, Antonios;
- Glimcher, Laurie;
- Pasparakis, Manolis;
- Khokha, Rama;
- Ormandy, Christopher J.;
- Widschwendter, Martin;
- Schett, Georg;
- Penninger, Josef M.
Publication type:
Article
A CRISPR Path to Finding Vulnerabilities and Solving Drug Resistance: Targeting the Diverse Cancer Landscape and Its Ecosystem.
Published in:
Advanced Genetics, 2022, v. 3, n. 4, p. 1, doi. 10.1002/ggn2.202200014
By:
- McLean, Benjamin;
- Istadi, Aji;
- Clack, Teleri;
- Vankan, Mezzalina;
- Schramek, Daniel;
- Neely, G. Gregory;
- Pajic, Marina
Publication type:
Article
AJUBA: A regulator of epidermal homeostasis and cancer.
Published in:
Experimental Dermatology, 2021, v. 30, n. 4, p. 546, doi. 10.1111/exd.14272
By:
- Schleicher, Krista;
- Schramek, Daniel
Publication type:
Article
DIPG-13. A NOVEL MOUSE MODEL REVEALS UNEXPECTED MECHANISMS OF ACTION OF ACVR1 MUTATIONS IN DIFFUSE INTRINSIC PONTINE GLIOMA.
Published in:
Neuro-Oncology, 2019, v. 21, p. ii71, doi. 10.1093/neuonc/noz036.034
By:
- Fortin, Jerome;
- Tian, Ruxiao;
- Zarrabi, Ida;
- Hill, Graham;
- Williams, Eleanor;
- Sanchez-Duffhues, Gonzalo;
- Thorikay, Midory;
- Ramachandran, Parameswaran;
- Siddaway, Robert;
- Wong, Jong;
- Haight, Jillian;
- You-Ten, Annick;
- Snow, Bryan;
- Wakeham, Andrew;
- Schramek, Daniel;
- Bullock, Alex;
- Dijke, Peter ten;
- Hawkins, Cynthia;
- Mak, Tak
Publication type:
Article
Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.
Published in:
Nature Communications, 2015, v. 6, n. 3, p. 6285, doi. 10.1038/ncomms7285
By:
- Grabner, Beatrice;
- Schramek, Daniel;
- Mueller, Kristina M.;
- Moll, Herwig P.;
- Svinka, Jasmin;
- Hoffmann, Thomas;
- Bauer, Eva;
- Blaas, Leander;
- Hruschka, Natascha;
- Zboray, Katalin;
- Stiedl, Patricia;
- Nivarthi, Harini;
- Bogner, Edith;
- Gruber, Wolfgang;
- Mohr, Thomas;
- Zwick, Ralf Harun;
- Kenner, Lukas;
- Poli, Valeria;
- Aberger, Fritz;
- Stoiber, Dagmar
Publication type:
Article
A dual role for autophagy in a murine model of lung cancer.
Published in:
Nature Communications, 2014, v. 5, n. 1, p. 3056, doi. 10.1038/ncomms4056
By:
- Rao, Shuan;
- Tortola, Luigi;
- Perlot, Thomas;
- Wirnsberger, Gerald;
- Novatchkova, Maria;
- Nitsch, Roberto;
- Sykacek, Peter;
- Frank, Lukas;
- Schramek, Daniel;
- Komnenovic, Vukoslav;
- Sigl, Verena;
- Aumayr, Karin;
- Schmauss, Gerald;
- Fellner, Nicole;
- Handschuh, Stephan;
- Glösmann, Martin;
- Pasierbek, Pawel;
- Schlederer, Michaela;
- Resch, Guenter P.;
- Ma, Yuting
Publication type:
Article
Afatinib restrains K-RAS-driven lung tumorigenesis.
Published in:
Science Translational Medicine, 2018, v. 10, n. 446, p. 1, doi. 10.1126/scitranslmed.aao2301
By:
- Moll, Herwig P.;
- Pranz, Klemens;
- Musteanu, Monica;
- Grabner, Beatrice;
- Hruschka, Natascha;
- Mohrherr, Julian;
- Aigner, Petra;
- Stiedl, Patricia;
- Brcic, Luka;
- Laszlo, Viktoria;
- Schramek, Daniel;
- Moriggl, Richard;
- Eferl, Robert;
- Moldvay, Judit;
- Dezso, Katalin;
- Lopez-Casas, Pedro P.;
- Stoiber, Dagmar;
- Hidalgo, Manuel;
- Penninger, Josef;
- Sibilia, Maria
Publication type:
Article
Phase 1 study to evaluate the effect of the MEK inhibitor trametinib on cardiac repolarization in patients with solid tumours.
Published in:
2016
By:
- Patnaik, Amita;
- Tolcher, Anthony;
- Papadopoulos, Kyriakos;
- Beeram, Murali;
- Rasco, Drew;
- Werner, Theresa;
- Bauman, John;
- Scheuber, Anita;
- Cox, Donna;
- Patel, Bela;
- Zhou, YanYan;
- Hamid, Mohammed;
- Schramek, Daniel;
- Sharma, Sunil;
- Papadopoulos, Kyriakos P;
- Werner, Theresa L;
- Bauman, John W;
- Cox, Donna S;
- Patel, Bela R
Publication type:
journal article
Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development.
Published in:
International Journal of Cancer, 2010, v. 127, n. 6, p. 1486, doi. 10.1002/ijc.25172
By:
- Fleuren, Emmy D.G.;
- O'Toole, Sandra;
- Millar, Ewan K.;
- McNeil, Catriona;
- Lopez-Knowles, Elena;
- Boulghourjian, Alice;
- Croucher, David R.;
- Schramek, Daniel;
- Brummer, Tilman;
- Penninger, Josef M.;
- Sutherland, Robert L.;
- Daly, Roger J.
Publication type:
Article
The Many Roles of RANKL-RANK Signaling in Bone, Breast and Cancer.
Published in:
IBMS BoneKEy, 2011, v. 8, n. 5, p. 237, doi. 10.1138/20110512
By:
- Schramek, Daniel;
- Penninger, Josef M.
Publication type:
Article
In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49450-3
By:
- Martinez, Sebastien;
- Wu, Shifei;
- Geuenich, Michael;
- Malik, Ahmad;
- Weber, Ramona;
- Woo, Tristan;
- Zhang, Amy;
- Jang, Gun Ho;
- Dervovic, Dzana;
- Al-Zahrani, Khalid N.;
- Tsai, Ricky;
- Fodil, Nassima;
- Gros, Philippe;
- Gallinger, Steven;
- Neely, G. Gregory;
- Notta, Faiyaz;
- Sendoel, Ataman;
- Campbell, Kieran;
- Elling, Ulrich;
- Schramek, Daniel
Publication type:
Article
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-17549-y
By:
- Aubert, Léo;
- Nandagopal, Neethi;
- Steinhart, Zachary;
- Lavoie, Geneviève;
- Nourreddine, Sami;
- Berman, Jacob;
- Saba-El-Leil, Marc K.;
- Papadopoli, David;
- Lin, Sichun;
- Hart, Traver;
- Macleod, Graham;
- Topisirovic, Ivan;
- Gaboury, Louis;
- Fahrni, Christoph J.;
- Schramek, Daniel;
- Meloche, Sylvain;
- Angers, Stephane;
- Roux, Philippe P.
Publication type:
Article

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