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Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37598-3
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- Publication type:
- Article
Biomaterial Drug Delivery Systems for Prominent Ocular Diseases.
- Published in:
- Pharmaceutics, 2023, v. 15, n. 7, p. 1959, doi. 10.3390/pharmaceutics15071959
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- Publication type:
- Article
Intra-articular Recombinant Human Proteoglycan 4 Mitigates Cartilage Damage After Destabilization of the Medial Meniscus in the Yucatan Minipig.
- Published in:
- American Journal of Sports Medicine, 2017, v. 45, n. 7, p. 1512, doi. 10.1177/0363546516686965
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- Publication type:
- Article
Recombinant human proteoglycan-4 reduces phagocytosis of urate crystals and downstream nuclear factor kappa B and inflammasome activation and production of cytokines and chemokines in human and murine macrophages.
- Published in:
- Arthritis Research & Therapy, 2018, v. 20, n. 1, p. N.PAG, doi. 10.1186/s13075-018-1693-x
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- Publication type:
- Article
The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes
- Published in:
- Arthritis Research & Therapy, 2017, v. 19, p. 1, doi. 10.1186/s13075-017-1301-5
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- Publication type:
- Article
Recombinant Human Proteoglycan 4 (rhPRG4) Downregulates TNFα-Stimulated NFκB Activity and FAT10 Expression in Human Corneal Epithelial Cells.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 21, p. 12711, doi. 10.3390/ijms232112711
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- Publication type:
- Article
Quadruped Gait and Regulation of Apoptotic Factors in Tibiofemoral Joints following Intra-Articular rhPRG4 Injection in Prg4 Null Mice.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 8, p. 4245, doi. 10.3390/ijms23084245
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- Publication type:
- Article
Proteoglycan 4 is present within the dura mater and produced by mesenchymal progenitor cells.
- Published in:
- Cell & Tissue Research, 2022, v. 389, n. 3, p. 483, doi. 10.1007/s00441-022-03647-4
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- Publication type:
- Article
Recombinant Human Proteoglycan 4 Regulates Phagocytic Activation of Monocytes and Reduces IL-1β Secretion by Urate Crystal Stimulated Gout PBMCs.
- Published in:
- Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.771677
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- Publication type:
- Article
Passaged Articular Chondrocytes From the Superficial Zone and Deep Zone Can Regain Zone-Specific Properties After Redifferentiation.
- Published in:
- American Journal of Sports Medicine, 2024, v. 52, n. 4, p. 1075, doi. 10.1177/03635465241230031
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- Publication type:
- Article
Administration of alendronate exacerbates ammonium chloride-induced acidosis in mice.
- Published in:
- PLoS ONE, 2023, v. 18, n. 9, p. 1, doi. 10.1371/journal.pone.0291649
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- Publication type:
- Article
Proteomics Analysis of Tears and Saliva From Sjogren’s Syndrome Patients.
- Published in:
- Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.787193
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- Publication type:
- Article
Automated Indentation Demonstrates Structural Stiffness of Femoral Articular Cartilage and Temporomandibular Joint Mandibular Condylar Cartilage Is Altered in FgF2KO Mice.
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- Cartilage, 2021, v. 13, p. 1513S, doi. 10.1177/1947603520962565
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- Publication type:
- Article
Articular Joint Lubricants during Osteoarthritis and Rheumatoid Arthritis Display Altered Levels and Molecular Species.
- Published in:
- PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0125192
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- Publication type:
- Article
Non‐Newtonian rheology in suspension cell cultures significantly impacts bioreactor shear stress quantification.
- Published in:
- Biotechnology & Bioengineering, 2018, v. 115, n. 8, p. 2101, doi. 10.1002/bit.26723
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- Publication type:
- Article
Scale‐Dependent Rheology of Synovial Fluid Lubricating Macromolecules.
- Published in:
- Small, 2024, v. 20, n. 21, p. 1, doi. 10.1002/smll.202306207
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- Publication type:
- Article
PRG4 deficiency in mice alters skeletal structure, mechanics, and calvarial osteoclastogenesis, and rhPRG4 inhibits in vitro osteoclastogenesis.
- Published in:
- Journal of Orthopaedic Research, 2024, v. 42, n. 6, p. 1231, doi. 10.1002/jor.25772
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- Publication type:
- Article
Absence of Proteoglycan 4 (Prg4) Leads to Increased Subchondral Bone Porosity Which Can Be Mitigated Through Intra‐Articular Injection of PRG4.
- Published in:
- Journal of Orthopaedic Research, 2019, v. 37, n. 10, p. 2077, doi. 10.1002/jor.24378
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- Publication type:
- Article
Two compartment pharmacokinetic model describes the intra‐articular delivery and retention of rhprg4 following ACL transection in the Yucatan mini pig.
- Published in:
- Journal of Orthopaedic Research, 2019, v. 37, n. 2, p. 386, doi. 10.1002/jor.24191
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- Publication type:
- Article
Effect of counterface on cartilage boundary lubricating ability by proteoglycan 4 and hyaluronan: Cartilage‐glass versus cartilage–cartilage.
- Published in:
- Journal of Orthopaedic Research, 2018, v. 36, n. 11, p. 2923, doi. 10.1002/jor.24104
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- Publication type:
- Article
Adherent agarose mold cultures: An in vitro platform for multi‐factorial assessment of passaged chondrocyte redifferentiation.
- Published in:
- Journal of Orthopaedic Research, 2018, v. 36, n. 9, p. 2392, doi. 10.1002/jor.23896
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- Publication type:
- Article
Reduction of friction by recombinant human proteoglycan 4 in IL-1α stimulated bovine cartilage explants.
- Published in:
- Journal of Orthopaedic Research, 2017, v. 35, n. 3, p. 580, doi. 10.1002/jor.23367
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- Publication type:
- Article
Hyaluronan incorporation into model contact lens hydrogels as a built‐in lubricant: Effect of hydrogel composition and proteoglycan 4 as a lubricant in solution.
- Published in:
- Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 2018, v. 106, n. 5, p. 1818, doi. 10.1002/jbm.b.33989
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- Publication type:
- Article
Proteoglycan 4 and hyaluronan as boundary lubricants for model contact lens hydrogels.
- Published in:
- Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 2018, v. 106, n. 3, p. 1329, doi. 10.1002/jbm.b.33895
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- Publication type:
- Article
Lubricin/proteoglycan 4 detected in vocal folds of humans and five other mammals.
- Published in:
- 2019
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- Publication type:
- journal article
Investigating the effect of proteoglycan 4 on hyaluronan solution properties using confocal fluorescence recovery after photobleaching.
- Published in:
- 2019
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- Publication type:
- journal article
Transcription, Translation, and Function of Lubricin, a Boundary Lubricant, at the Ocular Surface.
- Published in:
- JAMA Ophthalmology, 2013, v. 131, n. 6, p. 766, doi. 10.1001/jamaophthalmol.2013.2385
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- Publication type:
- Article
Cleanroom‐Free Fabrication of Microneedles for Multimodal Drug Delivery.
- Published in:
- Small, 2023, v. 19, n. 29, p. 1, doi. 10.1002/smll.202207131
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- Publication type:
- Article
The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid.
- Published in:
- Arthritis Research & Therapy, 2015, v. 17, p. 1, doi. 10.1186/s13075-015-0877-x
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- Publication type:
- Article
Recombinant Human Proteoglycan‐4 Regulates Phagocytic Activation of Monocytes and Reduces IL‐1b Secretion by Urate Crystal Stimulated PBMCs.
- Published in:
- FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02860
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- Publication type:
- Article
Recombinant human proteoglycan 4 lowers inflammation and atherosclerosis susceptibility in female low‐density lipoprotein receptor knockout mice.
- Published in:
- Journal of Physiology, 2024, v. 602, n. 9, p. 1939, doi. 10.1113/JP286354
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- Publication type:
- Article
Author Correction: Cathepsin g Degrades Both Glycosylated and Unglycosylated Regions of Lubricin, a Synovial Mucin.
- Published in:
- 2021
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- Publication type:
- Correction Notice
Proteoglycan-4 is correlated with longer survival in HCC patients and enhances sorafenib and regorafenib effectiveness via CD44 in vitro.
- Published in:
- Cell Death & Disease, 2020, v. 11, n. 11, p. 1, doi. 10.1038/s41419-020-03180-8
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- Publication type:
- Article
Lubricin/Proteoglycan 4 Binding to CD44 Receptor: A Mechanism of the Suppression of Proinflammatory Cytokine-Induced Synoviocyte Proliferation by Lubricin.
- Published in:
- Arthritis & Rheumatology, 2015, v. 67, n. 6, p. 1503, doi. 10.1002/art.39087
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- Publication type:
- Article
Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican.
- Published in:
- Cells (2073-4409), 2020, v. 9, n. 7, p. 1681, doi. 10.3390/cells9071681
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- Publication type:
- Article
Dissolvable Immunomodulatory Microneedles for Treatment of Skin Wounds.
- Published in:
- Advanced Healthcare Materials, 2024, v. 13, n. 16, p. 1, doi. 10.1002/adhm.202302836
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- Publication type:
- Article
Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes.
- Published in:
- PLoS ONE, 2022, v. 17, n. 12, p. 1, doi. 10.1371/journal.pone.0267921
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- Publication type:
- Article
A competitive alphascreen assay for detection of hyaluronan.
- Published in:
- Glycobiology, 2018, v. 28, n. 3, p. 137, doi. 10.1093/glycob/cwx109
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- Publication type:
- Article
Proteoglycan 4: From Mere Lubricant to Regulator of Tissue Homeostasis and Inflammation.
- Published in:
- BioEssays, 2019, v. 41, n. 1, p. N.PAG, doi. 10.1002/bies.201800166
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- Publication type:
- Article
Proteoglycan-4 regulates fibroblast to myofibroblast transition and expression of fibrotic genes in the synovium.
- Published in:
- Arthritis Research & Therapy, 2020, v. 22, n. 1, p. 1, doi. 10.1186/s13075-020-02207-x
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- Publication type:
- Article
Recombinant human PRG4 (rhPRG4) suppresses breast cancer cell invasion by inhibiting TGFβ-Hyaluronan-CD44 signalling pathway.
- Published in:
- PLoS ONE, 2019, v. 14, n. 7, p. 1, doi. 10.1371/journal.pone.0219697
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- Publication type:
- Article
Versican is differentially regulated in the adventitial and medial layers of human vein grafts.
- Published in:
- PLoS ONE, 2018, v. 13, n. 9, p. 1, doi. 10.1371/journal.pone.0204045
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- Publication type:
- Article
Cartilage boundary lubrication synergism is mediated by hyaluronan concentration and PRG4 concentration and structure.
- Published in:
- 2015
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- Publication type:
- journal article
Full-Length Recombinant Human Proteoglycan 4 Interacts with Hyaluronan to Provide Cartilage Boundary Lubrication.
- Published in:
- Annals of Biomedical Engineering, 2016, v. 44, n. 4, p. 1128, doi. 10.1007/s10439-015-1390-8
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- Publication type:
- Article
Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration.
- Published in:
- NPJ Regenerative Medicine, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41536-022-00228-5
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- Publication type:
- Article
Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia.
- Published in:
- Arthritis & Rheumatology, 2023, v. 75, n. 5, p. 794, doi. 10.1002/art.42413
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- Publication type:
- Article
Correction to: Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration.
- Published in:
- 2021
- By:
- Publication type:
- Correction Notice
Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration.
- Published in:
- Arthritis Research & Therapy, 2021, v. 23, n. 1, p. 1, doi. 10.1186/s13075-021-02621-9
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- Publication type:
- Article
Metabolic analysis of knee synovial fluid as a potential diagnostic approach for osteoarthritis.
- Published in:
- Journal of Orthopaedic Research, 2015, v. 33, n. 11, p. 1631, doi. 10.1002/jor.22949
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- Publication type:
- Article
Characterization of proteoglycan 4 and hyaluronan composition and lubrication function of ovine synovial fluid following knee surgery.
- Published in:
- Journal of Orthopaedic Research, 2013, v. 31, n. 10, p. 1549, doi. 10.1002/jor.22399
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- Publication type:
- Article