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Acute poisoning after oral intake of a toluene-containing paint thinner.
- Published in:
- 2002
- By:
- Publication type:
- journal article
Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites.
- Published in:
- 2013
- By:
- Publication type:
- journal article
Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs.
- Published in:
- 2018
- By:
- Publication type:
- journal article
Clinical Pharmacokinetics and Pharmacodynamics of Pazopanib: Towards Optimized Dosing.
- Published in:
- 2017
- By:
- Publication type:
- journal article
Development of a Pharmacokinetic Model to Describe the Complex Pharmacokinetics of Pazopanib in Cancer Patients.
- Published in:
- 2017
- By:
- Publication type:
- journal article
Patients homozygous for DPYD c.1129-5923C>G/haplotype B3 have partial DPD deficiency and require a dose reduction when treated with fluoropyrimidines.
- Published in:
- 2016
- By:
- Publication type:
- journal article
A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine.
- Published in:
- 2016
- By:
- Publication type:
- journal article
Phase 1a/1b and pharmacogenetic study of docetaxel, oxaliplatin and capecitabine in patients with advanced cancer of the stomach or the gastroesophageal junction.
- Published in:
- 2015
- By:
- Publication type:
- journal article
Transport of Topoisomerase I Inhibitors by the Breast Cancer Resistance Protein: Potential Clinical Implications.
- Published in:
- Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 188, doi. 10.1111/j.1749-6632.2000.tb07037.x
- By:
- Publication type:
- Article
Quantification of the pharmacokinetic-toxicodynamic relationship of oral docetaxel co-administered with ritonavir.
- Published in:
- Investigational New Drugs, 2020, v. 38, n. 5, p. 1526, doi. 10.1007/s10637-020-00935-0
- By:
- Publication type:
- Article
Phase I study of intermittent olaparib capsule or tablet dosing in combination with carboplatin and paclitaxel (part 2).
- Published in:
- Investigational New Drugs, 2020, v. 38, n. 4, p. 1096, doi. 10.1007/s10637-019-00857-6
- By:
- Publication type:
- Article
Phase I study of continuous olaparib capsule dosing in combination with carboplatin and/or paclitaxel (Part 1).
- Published in:
- Investigational New Drugs, 2020, v. 38, n. 4, p. 1117, doi. 10.1007/s10637-019-00856-7
- By:
- Publication type:
- Article
A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma.
- Published in:
- Investigational New Drugs, 2020, v. 38, n. 2, p. 457, doi. 10.1007/s10637-019-00783-7
- By:
- Publication type:
- Article
Translational PK-PD modeling analysis of MCLA-128, a HER2/HER3 bispecific monoclonal antibody, to predict clinical efficacious exposure and dose.
- Published in:
- Investigational New Drugs, 2018, v. 36, n. 6, p. 1006, doi. 10.1007/s10637-018-0593-x
- By:
- Publication type:
- Article
Pharmacokinetics and excretion of C-omacetaxine in patients with advanced solid tumors.
- Published in:
- Investigational New Drugs, 2016, v. 34, n. 5, p. 565, doi. 10.1007/s10637-016-0360-9
- By:
- Publication type:
- Article
Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison.
- Published in:
- Investigational New Drugs, 2016, v. 34, n. 3, p. 300, doi. 10.1007/s10637-016-0342-y
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- Publication type:
- Article
A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies.
- Published in:
- Investigational New Drugs, 2016, v. 34, n. 2, p. 184, doi. 10.1007/s10637-015-0320-9
- By:
- Publication type:
- Article
Trastuzumab and bevacizumab combined with docetaxel, oxaliplatin and capecitabine as first-line treatment of advanced HER2-positive gastric cancer: a multicenter phase II study.
- Published in:
- Investigational New Drugs, 2016, v. 34, n. 1, p. 119, doi. 10.1007/s10637-015-0309-4
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- Publication type:
- Article
Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy.
- Published in:
- Investigational New Drugs, 2015, v. 33, n. 1, p. 201, doi. 10.1007/s10637-014-0179-1
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- Publication type:
- Article
Pharmacokinetics and excretion of C-lenvatinib in patients with advanced solid tumors or lymphomas.
- Published in:
- Investigational New Drugs, 2015, v. 33, n. 1, p. 233, doi. 10.1007/s10637-014-0181-7
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- Publication type:
- Article
'Effect of the drug transporters ABCB1, ABCC2, and ABCG2 on the disposition and brain accumulation of the taxane analog BMS-275,183'.
- Published in:
- Investigational New Drugs, 2014, v. 32, n. 6, p. 1083, doi. 10.1007/s10637-014-0143-0
- By:
- Publication type:
- Article
Design of informative renal impairment studies: evaluation of the impact of design stratification on bias, precision and dose adjustment error.
- Published in:
- Investigational New Drugs, 2014, v. 32, n. 5, p. 913, doi. 10.1007/s10637-014-0103-8
- By:
- Publication type:
- Article
Effects of low-fat and high-fat meals on steady-state pharmacokinetics of lapatinib in patients with advanced solid tumours.
- Published in:
- Investigational New Drugs, 2014, v. 32, n. 3, p. 481, doi. 10.1007/s10637-013-0055-4
- By:
- Publication type:
- Article
Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA.
- Published in:
- Investigational New Drugs, 2013, v. 31, n. 5, p. 1125, doi. 10.1007/s10637-013-9923-1
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- Publication type:
- Article
Erratum to: Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA.
- Published in:
- 2013
- By:
- Publication type:
- Correction notice
Two-stage model-based design of cancer phase I dose escalation trials: evaluation using the phase I program of barasertib (AZD1152)
- Published in:
- 2012
- By:
- Publication type:
- Journal Article
Two-stage model-based design of cancer phase I dose escalation trials: evaluation using the phase I program of barasertib (AZD1152).
- Published in:
- Investigational New Drugs, 2012, v. 30, n. 4, p. 1519, doi. 10.1007/s10637-011-9694-5
- By:
- Publication type:
- Article
Phase I and pharmacokinetic study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced solid malignancies.
- Published in:
- Investigational New Drugs, 2012, v. 30, n. 4, p. 1557, doi. 10.1007/s10637-011-9723-4
- By:
- Publication type:
- Article
Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP.
- Published in:
- Investigational New Drugs, 2012, v. 30, n. 2, p. 443, doi. 10.1007/s10637-010-9569-1
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- Publication type:
- Article
Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies.
- Published in:
- Investigational New Drugs, 2011, v. 29, n. 5, p. 984, doi. 10.1007/s10637-010-9437-z
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- Publication type:
- Article
Two-stage model-based clinical trial design to optimize phase I development of novel anticancer agents.
- Published in:
- Investigational New Drugs, 2010, v. 28, n. 1, p. 61, doi. 10.1007/s10637-008-9216-2
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- Publication type:
- Article
Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820.
- Published in:
- Investigational New Drugs, 2009, v. 27, n. 2, p. 140, doi. 10.1007/s10637-008-9164-x
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- Publication type:
- Article
The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib.
- Published in:
- Investigational New Drugs, 2009, v. 27, n. 1, p. 31, doi. 10.1007/s10637-008-9138-z
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- Publication type:
- Article
Severe pulmonary toxicity in patients with leiomyosarcoma after treatment with gemcitabine and docetaxel.
- Published in:
- Investigational New Drugs, 2007, v. 25, n. 3, p. 279, doi. 10.1007/s10637-006-9030-7
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- Publication type:
- Article
In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis®, Trabectidin®), a novel marine anti-cancer drug.
- Published in:
- Investigational New Drugs, 2006, v. 24, n. 1, p. 3, doi. 10.1007/s10637-005-4538-9
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- Publication type:
- Article
Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid.
- Published in:
- Investigational New Drugs, 2005, v. 23, n. 4, p. 279, doi. 10.1007/s10637-005-1436-0
- By:
- Publication type:
- Article
Human metabolism of [14C]indisulam following i.v. infusion in cancer patients.
- Published in:
- Investigational New Drugs, 2005, v. 23, n. 4, p. 317, doi. 10.1007/s10637-005-1440-4
- By:
- Publication type:
- Article
Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam.
- Published in:
- Investigational New Drugs, 2005, v. 23, n. 3, p. 225, doi. 10.1007/s10637-005-6730-3
- By:
- Publication type:
- Article
Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants.
- Published in:
- Plant Cell, 2017, v. 29, n. 11, p. 2831, doi. 10.1105/tpc.17.00433
- By:
- Publication type:
- Article
No relation between docetaxel administration route and high‐grade diarrhea incidence.
- Published in:
- Pharmacology Research & Perspectives, 2020, v. 8, n. 4, p. 1, doi. 10.1002/prp2.633
- By:
- Publication type:
- Article
Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy.
- Published in:
- BioMed Research International, 2014, v. 2014, p. 1, doi. 10.1155/2014/897216
- By:
- Publication type:
- Article
The Impact of Structural Uncertainty on Cost-Effectiveness Models for Adjuvant Endocrine Breast Cancer Treatments: the Need for Disease-Specific Model Standardization and Improved Guidance.
- Published in:
- PharmacoEconomics, 2014, v. 32, n. 1, p. 47, doi. 10.1007/s40273-013-0106-x
- By:
- Publication type:
- Article
Prediction of treatment outcome by cisplatin-DNA adduct formation in patients with stage III/IV head and neck squamous cell carcinoma, treated by concurrent cisplatin-radiation (RADPLAT).
- Published in:
- International Journal of Cancer, 2006, v. 119, n. 4, p. 750, doi. 10.1002/ijc.21919
- By:
- Publication type:
- Article
Multiparameter Flow Cytometry Assay for Quantification of Immune Cell Subsets, PD‐1 Expression Levels and PD‐1 Receptor Occupancy by Nivolumab and Pembrolizumab.
- Published in:
- Cytometry. Part A, 2019, v. 95, n. 10, p. 1053, doi. 10.1002/cyto.a.23873
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- Publication type:
- Article
Rapid Detection of the DPYD IVS14+1G>A Mutation for Screening Patients to Prevent Fluorouracil-Related Toxicity.
- Published in:
- Molecular Diagnosis & Therapy, 2007, v. 11, n. 2, p. 105, doi. 10.1007/BF03256229
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- Publication type:
- Article
Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors.
- Published in:
- Clinical Pharmacology & Therapeutics, 2002, v. 71, n. 5, p. 334, doi. 10.1067/mcp.2002.123553
- By:
- Publication type:
- Article
Validation of techniques for the prediction of carboplatin exposure: Application of Bayesian methods<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2000, v. 67, n. 6, p. 621, doi. 10.1067/mcp.2000.106827
- By:
- Publication type:
- Article
Liquid chromatographic assay for the non-peptidic protease inhibitor tipranavir in plasma.
- Published in:
- Biomedical Chromatography, 2006, v. 20, n. 8, p. 671, doi. 10.1002/bmc.667
- By:
- Publication type:
- Article
A rapid and simple HPLC-UV method for the determination of inhibition characteristics of farnesyl transferase inhibitors.
- Published in:
- Biomedical Chromatography, 2006, v. 20, n. 2, p. 161, doi. 10.1002/bmc.545
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- Publication type:
- Article
Liquid chromatographic assay for the protease inhibitor atazanavir in plasma.
- Published in:
- Biomedical Chromatography, 2006, v. 20, n. 1, p. 72, doi. 10.1002/bmc.530
- By:
- Publication type:
- Article