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IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H).
Published in:
2009
By:
- Jones, Joanne L.;
- Chia-Ling Phuah;
- Cox, Amanda L.;
- Thompson, Sara A.;
- Ban, Maria;
- Shawcross, Jacqueline;
- Walton, Amie;
- Sawcer, Stephen J.;
- Compston, Alastair;
- Coles, Alasdair J.;
- Phuah, Chia-Ling
Publication type:
journal article
Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls.
Published in:
Nature Genetics, 2015, v. 47, n. 7, p. 839, doi. 10.1038/ng.3330
By:
- Fortune, Mary D;
- Burren, Oliver;
- Schofield, Ellen;
- Walker, Neil M;
- Todd, John A;
- Guo, Hui;
- Ban, Maria;
- Sawcer, Stephen J;
- Bowes, John;
- Worthington, Jane;
- Barton, Anne;
- Eyre, Steve;
- Wallace, Chris
Publication type:
Article
Corrigendum: Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls.
Published in:
Nature Genetics, 2015, v. 47, n. 8, p. 962, doi. 10.1038/ng0815-962c
By:
- Fortune, Mary D;
- Guo, Hui;
- Burren, Oliver;
- Schofield, Ellen;
- Walker, Neil M;
- Ban, Maria;
- Sawcer, Stephen J;
- Bowes, John;
- Worthington, Jane;
- Barton, Anne;
- Eyre, Steve;
- Todd, John A;
- Wallace, Chris
Publication type:
Article
Interleukin 7 receptor α chain (IL7R) shows allelic and functional association with multiple sclerosis.
Published in:
Nature Genetics, 2007, v. 39, n. 9, p. 1083, doi. 10.1038/ng2103
By:
- Gregory, Simon G.;
- Schmidt, Silke;
- Seth, Puneet;
- Oksenberg, Jorge R.;
- Hart, John;
- Prokop, Angela;
- Caillier, Stacy J.;
- Ban, Maria;
- Goris, An;
- Barcellos, Lisa F.;
- Lincoln, Robin;
- McCauley, Jacob L.;
- Sawcer, Stephen J.;
- Compston, D. A. S.;
- Dubois, Benedicte;
- Hauser, Stephen L.;
- Garcia-Blanco, Mariano A.;
- Pericak-Vance, Margaret A.;
- Haines, Jonathan L.
Publication type:
Article
A Major Histocompatibility Class I Locus Contributes to Multiple Sclerosis Susceptibility Independently from HLA-DRB1 15:01.
Published in:
PLoS ONE, 2010, v. 5, n. 6, p. 1, doi. 10.1371/journal.pone.0011296
By:
- Cree, Bruce A. C.;
- Rioux, John D.;
- McCauley, Jacob L.;
- Gourraud, Pierre-Antoine F. D.;
- Goyette, Philippe;
- McElroy, Joseph;
- De Jager, Philip;
- Santaniello, Adam;
- Vyse, Timothy J.;
- Gregersen, Peter K.;
- Mirel, Daniel;
- Hafler, David A.;
- Haines, Jonathan L.;
- Pericak-Vance, Margaret A.;
- Compston, Alastair;
- Sawcer, Stephen J.;
- Oksenberg, Jorge R.;
- Hauser, Stephen L.
Publication type:
Article
Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson’s Disease.
Published in:
Journal of Neurology, 2009, v. 256, n. 3, p. 493, doi. 10.1007/s00415-009-0119-8
By:
- Williams-Gray, Caroline H.;
- Goris, An;
- Saiki, Misuzu;
- Foltynie, Thomas;
- Compston, D. Alastair S.;
- Sawcer, Stephen J.;
- Barker, Roger A.
Publication type:
Article
Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility.
Published in:
Human Genetics, 2010, v. 127, n. 5, p. 525, doi. 10.1007/s00439-010-0789-4
By:
- Zuvich, Rebecca L.;
- McCauley, Jacob L.;
- Oksenberg, Jorge R.;
- Sawcer, Stephen J.;
- De Jager, Philip L.;
- Aubin, Cristin;
- Cross, Anne H.;
- Piccio, Laura;
- Aggarwal, Neelum T.;
- Evans, Denis;
- Hafler, David A.;
- Compston, Alastair;
- Hauser, Stephen L.;
- Pericak-Vance, Margaret A.;
- Haines, Jonathan L.
Publication type:
Article
Immunoseq: the identification of functionally relevant variants through targeted capture and sequencing of active regulatory regions in human immune cells.
Published in:
BMC Medical Genomics, 2016, v. 9, p. 1, doi. 10.1186/s12920-016-0220-7
By:
- Morin, Andréanne;
- Kwan, Tony;
- Bing Ge;
- Letourneau, Louis;
- Ban, Maria;
- Tandre, Karolina;
- Caron, Maxime;
- Sandling, Johanna K.;
- Carlsson, Jonas;
- Bourque, Guillaume;
- Laprise, Catherine;
- Montpetit, Alexandre;
- Syvanen, Ann-Christine;
- Ronnblom, Lars;
- Sawcer, Stephen J.;
- Lathrop, Mark G.;
- Pastinen, Tomi
Publication type:
Article
Experience from two decades of the Cambridge Rapid Access Neurology Clinic.
Published in:
Clinical Medicine, 2015, v. 15, n. 5, p. 437, doi. 10.7861/clinmedicine.15-5-437
By:
- Axinte, Laura T.;
- Fiddes, Barnaby D.;
- Donaghy, Alastair;
- Whyte, Adam;
- Allen, Chris;
- Sawcer, Stephen J.;
- Adam, Robert J.;
- Stacpoole, Sybil R. L.
Publication type:
Article
Glucocerebrosidase mutations influence the natural history of Parkinson's disease in a community-based incident cohort.
Published in:
2013
By:
- Winder-Rhodes, Sophie E;
- Evans, Jonathan R;
- Ban, Maria;
- Mason, Sarah L;
- Williams-Gray, Caroline H;
- Foltynie, Tom;
- Duran, Raquel;
- Mencacci, Niccolo E;
- Sawcer, Stephen J;
- Barker, Roger A
Publication type:
Journal Article
Glucocerebrosidase mutations influence the natural history of Parkinson’s disease in a community-based incident cohort.
Published in:
Brain: A Journal of Neurology, 2013, v. 136, n. 2, p. 392, doi. 10.1093/brain/aws318
By:
- Winder-Rhodes, Sophie E.;
- Evans, Jonathan R.;
- Ban, Maria;
- Mason, Sarah L.;
- Williams-Gray, Caroline H.;
- Foltynie, Tom;
- Duran, Raquel;
- Mencacci, Niccolo E.;
- Sawcer, Stephen J.;
- Barker, Roger A.
Publication type:
Article
The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort.
Published in:
Brain: A Journal of Neurology, 2009, v. 132, n. 11, p. 2958, doi. 10.1093/brain/awp245
By:
- Williams-Gray, Caroline H.;
- Evans, Jonathan R.;
- Goris, An;
- Foltynie, Thomas;
- Ban, Maria;
- Brayne, Carol;
- Kolachana, Bhaskar S.;
- Weinberger, Daniel R.;
- Sawcer, Stephen J.;
- Barker, Roger A.;
- Trevor W., Robbins
Publication type:
Article
Tau and α-synuclein in susceptibility to, and dementia in, Parkinson's disease.
Published in:
Annals of Neurology, 2007, v. 62, n. 2, p. 145, doi. 10.1002/ana.21192
By:
- Goris, An;
- Williams-Gray, Caroline H.;
- Clark, Graeme R.;
- Foltynie, Thomas;
- Lewis, Simon J. G.;
- Brown, Joanne;
- Ban, Maria;
- Spillantini, Maria G.;
- Compston, Alastair;
- Burn, David J.;
- Chinnery, Patrick F.;
- Barker, Roger A.;
- Sawcer, Stephen J.
Publication type:
Article
No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.
Published in:
Human Molecular Genetics, 2014, v. 23, n. 7, p. 1916
By:
- Goris, An;
- van Setten, Jessica;
- Diekstra, Frank;
- Ripke, Stephan;
- Patsopoulos, Nikolaos A.;
- Sawcer, Stephen J.;
- van Es, Michael;
- Andersen, Peter M.;
- Melki, Judith;
- Meininger, Vincent;
- Hardiman, Orla;
- Landers, John E.;
- Brown, Robert H.;
- Shatunov, Aleksey;
- Leigh, Nigel;
- Al-Chalabi, Ammar;
- Shaw, Christopher E.;
- Traynor, Bryan J.;
- Chiò, Adriano;
- Restagno, Gabriella
Publication type:
Article
Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA–CLEC16A–SOCS1 gene complex.
Published in:
Human Molecular Genetics, 2011, v. 20, n. 17, p. 3517, doi. 10.1093/hmg/ddr250
By:
- Zuvich, Rebecca L.;
- Bush, William S.;
- McCauley, Jacob L.;
- Beecham, Ashley H.;
- De Jager, Philip L.;
- Ivinson, Adrian J.;
- Compston, Alastair;
- Hafler, David A.;
- Hauser, Stephen L.;
- Sawcer, Stephen J.;
- Pericak-Vance, Margaret A.;
- Barcellos, Lisa F.;
- Mortlock, Douglas P.;
- Haines, Jonathan L.
Publication type:
Article
Variation Within DNA Repair Pathway Genes and Risk of Multiple Sclerosis.
Published in:
American Journal of Epidemiology, 2010, v. 172, n. 2, p. 217, doi. 10.1093/aje/kwq086
By:
- Briggs, Farren B. S.;
- Goldstein, Benjamin A.;
- McCauley, Jacob L.;
- Zuvich, Rebecca L.;
- De Jager, Philip L.;
- Rioux, John D.;
- Ivinson, Adrian J.;
- Compston, Alastair;
- Hafler, David A.;
- Hauser, Stephen L.;
- Oksenberg, Jorge R.;
- Sawcer, Stephen J.;
- Pericak-Vance, Margaret A.;
- Haines, Jonathan L.;
- Barcellos, Lisa F.
Publication type:
Article
Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping.
Published in:
PLoS Genetics, 2015, v. 11, n. 6, p. 1, doi. 10.1371/journal.pgen.1005272
By:
- Wallace, Chris;
- Cutler, Antony J;
- Pontikos, Nikolas;
- Pekalski, Marcin L;
- Burren, Oliver S;
- Cooper, Jason D;
- García, Arcadio Rubio;
- Ferreira, Ricardo C;
- Guo, Hui;
- Walker, Neil M;
- Smyth, Deborah J;
- Rich, Stephen S;
- Onengut-Gumuscu, Suna;
- Sawcer, Stephen J;
- Ban, Maria;
- Richardson, Sylvia;
- Todd, John A;
- Wicker, Linda S
Publication type:
Article
Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping.
Published in:
PLoS Genetics, 2015, v. 11, n. 5, p. 1, doi. 10.1371/journal.pgen.1005272
By:
- Wallace, Chris;
- Cutler, Antony J;
- Pontikos, Nikolas;
- Pekalski, Marcin L;
- Burren, Oliver S;
- Cooper, Jason D;
- García, Arcadio Rubio;
- Ferreira, Ricardo C;
- Guo, Hui;
- Walker, Neil M;
- Smyth, Deborah J;
- Rich, Stephen S;
- Onengut-Gumuscu, Suna;
- Sawcer, Stephen J;
- Ban, Maria;
- Richardson, Sylvia;
- Todd, John A;
- Wicker, Linda S
Publication type:
Article
Genetics of multiple sclerosis severity: The importance of statistical power in replication studies.
Published in:
2024
By:
- Harroud, Adil;
- Sawcer, Stephen J;
- Baranzini, Sergio E
Publication type:
Letter
Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12 566 individuals.
Published in:
Human Molecular Genetics, 2010, v. 19, n. 21, p. 4286
By:
- Briggs, Farren B.S.;
- Bartlett, Selena E.;
- Goldstein, Benjamin A.;
- Wang, Joanne;
- McCauley, Jacob L.;
- Zuvich, Rebecca L.;
- De Jager, Philip L.;
- Rioux, John D.;
- Ivinson, Adrian J.;
- Compston, Alastair;
- Hafler, David A.;
- Hauser, Stephen L.;
- Oksenberg, Jorge R.;
- Sawcer, Stephen J.;
- Pericak-Vance, Margaret A.;
- Haines, Jonathan L.;
- Barcellos, Lisa F.
Publication type:
Article
CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis.
Published in:
Human Molecular Genetics, 2010, v. 19, n. 11, p. 2331
By:
- Bronson, Paola G.;
- Caillier, Stacy;
- Ramsay, Patricia P.;
- McCauley, Jacob L.;
- Zuvich, Rebecca L.;
- De Jager, Philip L.;
- Rioux, John D.;
- Ivinson, Adrian J.;
- Compston, Alastair;
- Hafler, David A.;
- Sawcer, Stephen J.;
- Pericak-Vance, Margaret A.;
- Haines, Jonathan L.;
- Hauser, Stephen L.;
- Oksenberg, Jorge R.;
- Barcellos, Lisa F.
Publication type:
Article
Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15.
Published in:
Human Molecular Genetics, 2006, v. 15, n. 1, p. 155, doi. 10.1093/hmg/ddi436
By:
- Traherne, James A.;
- Barcellos, Lisa F.;
- Sawcer, Stephen J.;
- Compston, Alastair;
- Ramsay, Patricia P.;
- Hauser, Stephen L.;
- Oksenberg, Jorge R.;
- Trowsdale, John
Publication type:
Article
Systematic Review and UK-Based Study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease.
Published in:
Movement Disorders, 2012, v. 27, n. 12, p. 1522, doi. 10.1002/mds.25132
By:
- Kilarski, Laura L.;
- Pearson, Justin P.;
- Newsway, Victoria;
- Majounie, Elisa;
- Knipe, M. Duleeka W.;
- Misbahuddin, Anjum;
- Chinnery, Patrick F.;
- Burn, David J.;
- Clarke, Carl E.;
- Marion, Marie-Helene;
- Lewthwaite, Alistair J.;
- Nicholl, David J.;
- Wood, Nicholas W.;
- Morrison, Karen E.;
- Williams-Gray, Caroline H.;
- Evans, Jonathan R.;
- Sawcer, Stephen J.;
- Barker, Roger A.;
- Wickremaratchi, Mirdhu M.;
- Ben-Shlomo, Yoav
Publication type:
Article
Genetic and pathological links between Parkinson's disease and the lysosomal disorder Sanfilippo syndrome.
Published in:
Movement Disorders, 2012, v. 27, n. 2, p. 312, doi. 10.1002/mds.24029
By:
- Winder-Rhodes, Sophie E.;
- Garcia-Reitböck, Pablo;
- Ban, Maria;
- Evans, Jonathan R.;
- Jacques, Thomas S.;
- Kemppinen, Anu;
- Foltynie, Thomas;
- Williams-Gray, Caroline H.;
- Chinnery, Patrick F.;
- Hudson, Gavin;
- Burn, David J.;
- Allcock, Liesl M.;
- Sawcer, Stephen J.;
- Barker, Roger A.;
- Spillantini, Maria Grazia
Publication type:
Article
No alterations in alpha-synuclein gene dosage observed in sporadic Parkinson's disease.
Published in:
2006
By:
- Williams-Gray, Caroline H;
- Goris, An;
- Foltynie, Thomas;
- Brown, Joanne;
- Maranian, Melanie;
- Walton, Amie;
- Compston, D Alastair;
- Sawcer, Stephen J;
- Barker, Roger A
Publication type:
commentary
No alterations in α-synuclein gene dosage observed in sporadic Parkinson's disease.
Published in:
Movement Disorders, 2006, v. 21, n. 5, p. 731, doi. 10.1002/mds.20863
By:
- Williams-Gray, Caroline H.;
- Goris, An;
- Foltynie, Thomas;
- Brown, Joanne;
- Maranian, Melanie;
- Walton, Amie;
- Compston, D. Alastair;
- Sawcer, Stephen J.;
- Barker, Roger A.
Publication type:
Article

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