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Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease.
Published in:
Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01172-z
By:
- Zhou, Ya;
- Peskett, Thomas R.;
- Landles, Christian;
- Warner, John B.;
- Sathasivam, Kirupa;
- Smith, Edward J.;
- Chen, Shu;
- Wetzel, Ronald;
- Lashuel, Hilal A.;
- Bates, Gillian P.;
- Saibil, Helen R.
Publication type:
Article
Alternative processing of human HTT mRNA with implications for Huntington's disease therapeutics.
Published in:
Brain: A Journal of Neurology, 2022, v. 145, n. 12, p. 4409, doi. 10.1093/brain/awac241
By:
- Fienko, Sandra;
- Landles, Christian;
- Sathasivam, Kirupa;
- McAteer, Sean J;
- Milton, Rebecca E;
- Osborne, Georgina F;
- Smith, Edward J;
- Jones, Samuel T;
- Bondulich, Marie K;
- Danby, Emily C E;
- Phillips, Jemima;
- Taxy, Bridget A;
- Kordasiewicz, Holly B;
- Bates, Gillian P
Publication type:
Article
Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease.
Published in:
2011
By:
- Labbadia, John;
- Cunliffe, Helen;
- Weiss, Andreas;
- Katsyuba, Elena;
- Sathasivam, Kirupa;
- Seredenina, Tamara;
- Woodman, Ben;
- Moussaoui, Saliha;
- Frentzel, Stefan;
- Luthi-Carter, Ruth;
- Paganetti, Paolo;
- Bates, Gillian P.
Publication type:
journal article
Correction: Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues.
Published in:
2024
By:
- Hoschek, Franziska;
- Natan, Julia;
- Wagner, Maximilian;
- Sathasivam, Kirupa;
- Abdelmoez, Alshaimaa;
- Einem, Björn von;
- Bates, Gillian P.;
- Landwehrmeyer, G. Bernhard;
- Neueder, Andreas
Publication type:
Correction Notice
Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues.
Published in:
Molecular Medicine, 2024, v. 30, n. 1, p. 1, doi. 10.1186/s10020-024-00801-2
By:
- Hoschek, Franziska;
- Natan, Julia;
- Wagner, Maximilian;
- Sathasivam, Kirupa;
- Abdelmoez, Alshaimaa;
- von Einem, Björn;
- Bates, Gillian P.;
- Landwehrmeyer, G. Bernhard;
- Neueder, Andreas
Publication type:
Article
Molecular Pathology of Huntington's Disease: Animal Models and Nuclear Mechanisms.
Published in:
Neuroscientist, 1999, v. 5, n. 6, p. 383, doi. 10.1177/107385849900500613
By:
- Mangiarini, Laura;
- Sathasivam, Kirupa;
- Bates, Gillian P.
Publication type:
Article
Minocycline and doxycycline are not beneficial in a model of Huntington's disease.
Published in:
Annals of Neurology, 2003, v. 54, n. 2, p. 186
By:
- Donna L. Smith;
- Benjamin Woodman;
- Amarbirpal Mahal;
- Kirupa Sathasivam;
- Shabnam Ghazi-Noori;
- Philip A. S. Lowden;
- Gillian P. Bates;
- Emma Hockly
Publication type:
Article
Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches.
Published in:
Brain Communications, 2023, v. 5, n. 1, p. 1, doi. 10.1093/braincomms/fcad010
By:
- Smith, Edward J.;
- Sathasivam, Kirupa;
- Landles, Christian;
- Osborne, Georgina F.;
- Mason, Michael A.;
- Gomez-Paredes, Casandra;
- Taxy, Bridget A.;
- Milton, Rebecca E.;
- Ast, Anne;
- Schindler, Franziska;
- Chuangchuang Zhang;
- Duan, Wenzhen;
- Wanker, Erich E.;
- Bates, Gillian P.
Publication type:
Article
Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington's disease models.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-71111-w
By:
- Mason, Michael A.;
- Gomez-Paredes, Casandra;
- Sathasivam, Kirupa;
- Neueder, Andreas;
- Papadopoulou, Aikaterini-Smaragdi;
- Bates, Gillian P.
Publication type:
Article
Exendin-4 Improves Glycemic Control, Ameliorates Brain and Pancreatic Pathologies, and Extends Survival in a Mouse Model of Huntington's Disease.
Published in:
Diabetes, 2009, v. 58, n. 2, p. 318, doi. 10.2337/db08-0799
By:
- Martin, Bronwen;
- Golden, Erin;
- Carlson, Olga D.;
- Pistell, Paul;
- Zhou, Jie;
- Kim, Wook;
- Frank, Brittany P.;
- Thomas, Sam;
- Chadwick, Wayne A.;
- Greig, Nigel H.;
- Bates, Gillian P.;
- Sathasivam, Kirupa;
- Bernier, Michel;
- Maudsley, Stuart;
- Mattson, Mark P.;
- Egan, Josephine M.
Publication type:
Article
Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease.
Published in:
Human Molecular Genetics, 2010, v. 19, n. 1, p. 65, doi. 10.1093/hmg/ddp467
By:
- Sathasivam, Kirupa;
- Lane, Amin;
- Legleiter, Justin;
- Warley, Alice;
- Woodman, Ben;
- Finkbeiner, Steve;
- Paganetti, Paolo;
- Muchowski, Paul J.;
- Wilson, Stuart;
- Bates, Gillian P.
Publication type:
Article
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.
Published in:
Human Molecular Genetics, 2007, v. 16, n. 15, p. 1845, doi. 10.1093/hmg/ddm133
By:
- Kuhn, Alexandre;
- Goldstein, Darlene R.;
- Hodges, Angela;
- Strand, Andrew D.;
- Sengstag, Thierry;
- Kooperberg, Charles;
- Becanovic, Kristina;
- Pouladi, Mahmoud A.;
- Sathasivam, Kirupa;
- Cha, Jang-Ho J.;
- Hannan, Anthony J.;
- Hayden, Michael R.;
- Leavitt, Blair R.;
- Dunnett, Stephen B.;
- Ferrante, Robert J.;
- Albin, Roger;
- Shelbourne, Peggy;
- Delorenzi, Mauro;
- Augood, Sarah J.;
- Faull, Richard L.M.
Publication type:
Article
Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease.
Published in:
Human Molecular Genetics, 2005, v. 14, n. 20, p. 3065, doi. 10.1093/hmg/ddi340
By:
- Benn, Caroline L.;
- Landles, Christian;
- Li, He;
- Strand, Andrew D.;
- Woodman, Ben;
- Sathasivam, Kirupa;
- Li, Shi-Hua;
- Ghazi-Noori, Shabnam;
- Hockly, Emma;
- Faruque, Syed M.N.N.;
- Cha, Jang-Ho J.;
- Sharpe, Paul T.;
- Olson, James M.;
- Li, Xiao-Jiang;
- Bates, Gillian P.
Publication type:
Article
Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach.
Published in:
Human Molecular Genetics, 2004, v. 13, n. 13, p. 1389, doi. 10.1093/hmg/ddh144
By:
- Hay, David G.;
- Sathasivam, Kirupa;
- Tobaben, Sönke;
- Stahl, Bernd;
- Marber, Michael;
- Mestril, Ruben;
- Mahal, Amarbirpal;
- Smith, Donna L.;
- Woodman, Ben;
- Bates, Gillian P.
Publication type:
Article
Centrosome disorganization infibroblast cultures derived from R6/2 Huntington’sdisease (HD) transgenic mice and HD patients.
Published in:
Human Molecular Genetics, 2001, v. 10, n. 21, p. 2425, doi. 10.1093/hmg/10.21.2425
By:
- Sathasivam, Kirupa;
- Woodman, Ben;
- Mahal, Amabirpal;
- Bertaux, Fabien;
- Wanker, ErichE.;
- Shima, DaveT.;
- Bates, GillianP.
Publication type:
Article
The huntingtin interacting protein HIP1 is a clathrin and α -adaptin-binding protein involved in receptor-mediated endocytosis.
Published in:
Human Molecular Genetics, 2001, v. 10, n. 17, p. 1807, doi. 10.1093/hmg/10.17.1807
By:
- Waelter, Stephanie;
- Scherzinger, Eberhard;
- Hasenbank, Renate;
- Nordhoff, Eckhard;
- Lurz, Rudi;
- Goehler, Heike;
- Gauss, Christine;
- Sathasivam, Kirupa;
- Bates, Gillian P.;
- Lehrach, Hans;
- Wanker, Erich E.
Publication type:
Article
The huntingtin interacting protein HIP1 is a clathrin and α-adaptin-binding protein involved in receptor-mediated endocytosis.
Published in:
Human Molecular Genetics, 2001, v. 10, n. 16
By:
- Waelter, Stephanie;
- Scherzinger, Eberhard;
- Hasenbank, Renate;
- Nordhoff, Eckhard;
- Lurz, Rudi;
- Goehler, Heike;
- Gauss, Christine;
- Sathasivam, Kirupa;
- Bates, Gillian P.;
- Lehrach, Hans;
- Wanker, Erich E.
Publication type:
Article
Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington’s disease.
Published in:
Journal of Neurochemistry, 2008, v. 104, n. 3, p. 846, doi. 10.1111/j.1471-4159.2007.05032.x
By:
- Weiss, Andreas;
- Klein, Corinna;
- Woodman, Ben;
- Sathasivam, Kirupa;
- Bibel, Miriam;
- Régulier, Etienne;
- Bates, Gillian P.;
- Paganetti, Paolo
Publication type:
Article
Formation of polyglutamine inclusions in non-CNS tissue.
Published in:
Human Molecular Genetics, 1999, v. 8, n. 5, p. 813, doi. 10.1093/hmg/8.5.813
By:
- Sathasivam, Kirupa;
- Hobbs, Carl;
- Turmaine, Mark;
- Mangiarini, Laura;
- Mahal, Amarbirpal;
- Bertaux, Fabien;
- Wanker, Erich E.;
- Doherty, Pat;
- Davies, Stephen W.;
- Bates, Gillian P.
Publication type:
Article
Aberrant Processing of the Fugu HD (FrHD) mRNA in Mouse Cells and in Transgenic Mice.
Published in:
Human Molecular Genetics, 1997, v. 6, n. 12, p. 2141, doi. 10.1093/hmg/6.12.2141
By:
- Sathasivam, Kirupa;
- Baxendale, Sarah;
- Mangiarini, Laura;
- Bertaux, Fabien;
- Hetherington, Colin;
- Kanazawa, Ichiro;
- Lehrach, Hans;
- Bates, Gillian P.
Publication type:
Article

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