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GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression.
Published in:
Biochemical Journal, 2020, v. 477, n. 17, p. 3131, doi. 10.1042/BCJ20200335
By:
- Tolosa, Ezequiel J.;
- Fernandez-Barrena, Maite G.;
- Iguchi, Eriko;
- McCleary-Wheeler, Angela L.;
- Carr, Ryan M.;
- Almada, Luciana L.;
- Flores, Luis F.;
- Vera, Renzo E.;
- Alfonse, Germine W.;
- Marks, David L.;
- Hogenson, Tara L.;
- Vrabel, Anne M.;
- Horn, Isaac P.;
- Koenig, Amanda N.;
- Safgren, Stephanie L.;
- Sigafoos, Ashley N.;
- Erkan, Mert;
- Romecin-Duran, Paola A.;
- Gonzalez, Alejandro Sarabia;
- Bo Zhou
Publication type:
Article
Semiautomated approach focused on new genomic information results in time and effort-efficient reannotation of negative exome data.
Published in:
Human Genetics, 2024, v. 143, n. 5, p. 649, doi. 10.1007/s00439-024-02664-3
By:
- Ferrer, Alejandro;
- Duffy, Patrick;
- Olson, Rory J.;
- Meiners, Michael A.;
- Schultz-Rogers, Laura;
- Macke, Erica L.;
- Safgren, Stephanie;
- Morales-Rosado, Joel A.;
- Cousin, Margot A.;
- Oliver, Gavin R.;
- Rider, David;
- Williams, Megan;
- Pichurin, Pavel N.;
- Deyle, David R.;
- Morava, Eva;
- Gavrilova, Ralitza H.;
- Dhamija, Radhika;
- Wierenga, Klass J.;
- Lanpher, Brendan C.;
- Babovic-Vuksanovic, Dusica
Publication type:
Article
RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23186-w
By:
- Carr, Ryan M.;
- Vorobyev, Denis;
- Lasho, Terra;
- Marks, David L.;
- Tolosa, Ezequiel J.;
- Vedder, Alexis;
- Almada, Luciana L.;
- Yurcheko, Andrey;
- Padioleau, Ismael;
- Alver, Bonnie;
- Coltro, Giacomo;
- Binder, Moritz;
- Safgren, Stephanie L.;
- Horn, Isaac;
- You, Xiaona;
- Solary, Eric;
- Balasis, Maria E.;
- Berger, Kurt;
- Hiebert, James;
- Witzig, Thomas
Publication type:
Article
De novo PBX1 variant in a patient with glaucoma, kidney anomalies, and developmental delay: An expansion of the CAKUTHED phenotype.
Published in:
American Journal of Medical Genetics. Part A, 2022, v. 188, n. 3, p. 919, doi. 10.1002/ajmg.a.62576
By:
- Safgren, Stephanie L.;
- Olson, Rory J.;
- Pinto e Vairo, Filippo;
- Bothun, Erick D.;
- Hanna, Christian;
- Klee, Eric W.;
- Schimmenti, Lisa A.
Publication type:
Article
Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation.
Published in:
Genome Biology, 2020, v. 21, n. 1, p. 1, doi. 10.1186/s13059-020-02152-7
By:
- Fang, Celestia;
- Wang, Zhenjia;
- Han, Cuijuan;
- Safgren, Stephanie L.;
- Helmin, Kathryn A.;
- Adelman, Emmalee R.;
- Serafin, Valentina;
- Basso, Giuseppe;
- Eagen, Kyle P.;
- Gaspar-Maia, Alexandre;
- Figueroa, Maria E.;
- Singer, Benjamin D.;
- Ratan, Aakrosh;
- Ntziachristos, Panagiotis;
- Zang, Chongzhi
Publication type:
Article
Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer.
Published in:
2020
By:
- Jayaraman, Swaathi;
- Hou, Xiaonan;
- Kuffel, Mary J.;
- Suman, Vera J.;
- Hoskin, Tanya L.;
- Reinicke, Kathryn E.;
- Monroe, David G.;
- Kalari, Krishna R.;
- Tang, Xiaojia;
- Zeldenrust, Megan A.;
- Cheng, Jingfei;
- Bruinsma, Elizabeth S.;
- Buhrow, Sarah A.;
- McGovern, Renee M.;
- Safgren, Stephanie L.;
- Walden, Chad A.;
- Carter, Jodi M.;
- Reid, Joel M.;
- Ingle, James N.;
- Ames, Matthew M.
Publication type:
journal article
Gemcitabine and Irinotecan as First-Line Therapy for Carcinoma of Unknown Primary: Results of a Multicenter Phase II Trial.
Published in:
PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0039285
By:
- Holtan, Shernan G.;
- Steen, Preston D.;
- Foster, Nathan R.;
- Erlichman, Charles;
- Medeiros, Fabiola;
- Ames, Matthew M.;
- Safgren, Stephanie L.;
- Graham, David L.;
- Behrens, Robert J.;
- Goetz, Matthew P.
Publication type:
Article
UGT1A1 genotype-guided phase I study of irinotecan, oxaliplatin, and capecitabine.
Published in:
Investigational New Drugs, 2013, v. 31, n. 6, p. 1559, doi. 10.1007/s10637-013-0034-9
By:
- Goetz, Matthew;
- McKean, Heidi;
- Reid, Joel;
- Mandrekar, Sumithra;
- Tan, Angelina;
- Kuffel, Mary;
- Safgren, Stephanie;
- McGovern, Renee;
- Goldberg, Richard;
- Grothey, Axel;
- McWilliams, Robert;
- Erlichman, Charles;
- Ames, Matthew
Publication type:
Article
The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen.
Published in:
Breast Cancer Research & Treatment, 2007, v. 101, n. 1, p. 113, doi. 10.1007/s10549-006-9428-0
By:
- Matthew Goetz;
- Stacey Knox;
- Vera Suman;
- James Rae;
- Stephanie Safgren;
- Matthew Ames;
- Daniel Visscher;
- Carol Reynolds;
- Fergus Couch;
- Wilma Lingle;
- Richard Weinshilboum;
- Emily Fritcher;
- Andrea Nibbe;
- Zeruesenay Desta;
- Anne Nguyen;
- David Flockhart;
- Edith Perez;
- James Ingle
Publication type:
Article
Association Between CYP2D6 Polymorphisms and Outcomes Among Women With Early Stage Breast Cancer Treated With Tamoxifen.
Published in:
JAMA: Journal of the American Medical Association, 2009, v. 302, n. 13, p. 1429, doi. 10.1001/jama.2009.1420
By:
- Schroth, Werner;
- Goetz, Matthew P.;
- Hamann, Ute;
- Fasching, Peter A.;
- Schmidt, Marcus;
- Winter, Stefan;
- Fritz, Peter;
- Simon, Wolfgang;
- Suman, Vera J.;
- Ames, Matthew M.;
- Safgren, Stephanie L.;
- Kuffel, Mary J.;
- Ulmer, Hans Ulrich;
- Boländer, Julia;
- Strick, Reiner;
- Beckmann, Matthias W.;
- Koelbl, Heinz;
- Weinshilboum, Richard M.;
- Ingle, James N.;
- Eichelbaum, Michel
Publication type:
Article
Pharmacokinetics of dacarbazine (DTIC) in pregnancy.
Published in:
2018
By:
- Kantrowitz-Gordon, Ira;
- Hays, Karen;
- Kayode, Olumide;
- Kumar, Aditya R.;
- Kaplan, Henry G.;
- Reid, Joel M.;
- Safgren, Stephanie L.;
- Ames, Matthew M.;
- Easterling, Thomas R.;
- Hebert, Mary F.
Publication type:
journal article
Pharmacokinetics of endoxifen and tamoxifen in female mice: implications for comparative in vivo activity studies.
Published in:
Cancer Chemotherapy & Pharmacology, 2014, v. 74, n. 6, p. 1271, doi. 10.1007/s00280-014-2605-7
By:
- Reid, Joel;
- Goetz, Matthew;
- Buhrow, Sarah;
- Walden, Chad;
- Safgren, Stephanie;
- Kuffel, Mary;
- Reinicke, Kathryn;
- Suman, Vera;
- Haluska, Paul;
- Hou, Xiaonan;
- Ames, Matthew
Publication type:
Article
Phase 2 trial of pemetrexed in children and adolescents with refractory solid tumors: A Children's Oncology Group study.
Published in:
Pediatric Blood & Cancer, 2013, v. 60, n. 2, p. 237, doi. 10.1002/pbc.24244
By:
- Warwick, Anne B.;
- Malempati, Suman;
- Krailo, Mark;
- Melemed, Allen;
- Gorlick, Richard;
- Ames, Matthew M.;
- Safgren, Stephanie L.;
- Adamson, Peter C.;
- Blaney, Susan M.
Publication type:
Article
Phase I trial of two schedules of vincristine, oral irinotecan, and temozolomide (VOIT) for children with relapsed or refractory solid tumors: A Children's Oncology Group phase I consortium study.
Published in:
Pediatric Blood & Cancer, 2010, v. 54, n. 4, p. 538, doi. 10.1002/pbc.22407
By:
- Wagner, Lars M.;
- Perentesis, John P.;
- Reid, Joel M.;
- Ames, Matthew M.;
- Safgren, Stephanie L.;
- Nelson, Marvin D.;
- Ingle, Ashish M.;
- Blaney, Susan M.;
- Adamson, Peter C.
Publication type:
Article
Phase II NCCTG trial of RT + irinotecan and adjuvant BCNU plus irinotecan for newly diagnosed GBM.
Published in:
Journal of Neuro-Oncology, 2010, v. 99, n. 1, p. 73, doi. 10.1007/s11060-009-0103-2
By:
- Jaeckle, Kurt A.;
- Ballman, Karla V.;
- Giannini, Caterina;
- Schomberg, Paula J.;
- Ames, Matthew M.;
- Reid, Joel M.;
- McGovern, Renee M.;
- Safgren, Stephanie L.;
- Galanis, Evanthia;
- Uhm, Joon H.;
- Brown, Paul D.;
- Hammack, Julie E.;
- Arusell, Robert;
- Nikcevich, Daniel A.;
- Morton, Roscoe F.;
- Wender, Donald B.;
- Buckner, Jan C.
Publication type:
Article
Comparative Uterotrophic Effects of Endoxifen and Tamoxifen in Ovariectomized Sprague-Dawley Rats.
Published in:
Toxicologic Pathology, 2014, v. 42, n. 8, p. 1188, doi. 10.1177/0192623314525688
By:
- Schweikart, Karen M.;
- Eldridge, Sandy R.;
- Safgren, Stephanie L.;
- Parman, Toufan;
- Reid, Joel M.;
- Ames, Matthew M.;
- Goetz, Matthew P.;
- Davis, Myrtle A.
Publication type:
Article
MacroH2A histone variants modulate enhancer activity to repress oncogenic programs and cellular reprogramming.
Published in:
Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-04571-1
By:
- Mohammed Ismail, Wazim;
- Mazzone, Amelia;
- Ghiraldini, Flavia G.;
- Kaur, Jagneet;
- Bains, Manvir;
- Munankarmy, Amik;
- Bagwell, Monique S.;
- Safgren, Stephanie L.;
- Moore-Weiss, John;
- Buciuc, Marina;
- Shimp, Lynzie;
- Leach, Kelsey A.;
- Duarte, Luis F.;
- Nagi, Chandandeep S.;
- Carcamo, Saul;
- Chung, Chi-Yeh;
- Hasson, Dan;
- Dadgar, Neda;
- Zhong, Jian;
- Lee, Jeong-Heon
Publication type:
Article
Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.
Published in:
2015
By:
- Goetz, Matthew P.;
- Sun, James X.;
- Suman, Vera J.;
- Silva, Grace O.;
- Perou, Charles M.;
- Nakamura, Yusuke;
- Cox, Nancy J.;
- Stephens, Philip J.;
- Miller, Vincent A.;
- Ross, Jeffrey S.;
- Chen, David;
- Safgren, Stephanie L.;
- Kuffel, Mary J.;
- Ames, Matthew M.;
- Kalari, Krishna R.;
- Gomez, Henry L.;
- Gonzalez-Angulo, Ana M.;
- Burgues, Octavio;
- Brauch, Hiltrud B.;
- Ingle, James N.
Publication type:
journal article

Found: 18