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Ein antibakterielles β-Lacton bekämpft Mycobacterium tuberculosis durch Infiltration der Mykolsäurebiosynthese.
- Published in:
- Angewandte Chemie, 2018, v. 130, n. 1, p. 354, doi. 10.1002/ange.201709365
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- Article
THERAPEUTIC STRATEGIES FOR HUMAN AMYLOID DISEASES.
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- Nature Reviews Drug Discovery, 2002, v. 1, n. 4, p. 267, doi. 10.1038/nrd769
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- Article
Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis.
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- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28078-1
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- Publication type:
- Article
An Antibacterial β-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis.
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- Angewandte Chemie International Edition, 2018, v. 57, n. 1, p. 348, doi. 10.1002/anie.201709365
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- Publication type:
- Article
Atomic structure of an aß T cell receptor (TCR) heterodimer in complex with an anti-TCR Fab fragment derived from a mitogenic antibody.
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- EMBO Journal, 1998, v. 17, n. 1, p. 10, doi. 10.1093/emboj/17.1.10
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- Article
Charged residue changes in the carboxy-terminus of α-tropomyosin alter mouse cardiac muscle contractility.
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- Journal of Physiology, 2004, v. 556, n. 2, p. 531, doi. 10.1113/jphysiol.2003.058487
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- Article
Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway.
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- eLife, 2019, p. 1, doi. 10.7554/eLife.40063
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- Article
Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment.
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- eLife, 2017, p. 1, doi. 10.7554/eLife.20420
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- Publication type:
- Article
Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis.
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- Nucleic Acids Research, 2017, v. 45, n. 18, p. 10884, doi. 10.1093/nar/gkx785
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- Article
Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists.
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- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30389-2
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- Article
CinA mediates multidrug tolerance in Mycobacterium tuberculosis.
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- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29832-1
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- Publication type:
- Article
Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28078-1
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- Publication type:
- Article
High-Throughput Differentiation and Screening of a Library of Mutant Stem Cell Clones Defines New Host-Based Genes Involved in Rabies Virus Infection.
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- Stem Cells, 2015, v. 33, n. 8, p. 2509, doi. 10.1002/stem.1983
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- Article
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.
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- Nature Medicine, 2006, v. 12, n. 9, p. 1027, doi. 10.1038/nm1466
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- Article
Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection.
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- Nature Genetics, 2011, v. 43, n. 5, p. 482, doi. 10.1038/ng.811
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- Publication type:
- Article
Gene-target recognition among members of the Myc superfamily and implications for oncogenesis.
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- Nature Genetics, 2000, v. 24, n. 2, p. 113, doi. 10.1038/72761
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- Article
Identification of differentially regulated gene targets in the Myc and Mad family proteins.
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- 1999
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- Abstract
Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.
- Published in:
- Nature Structural & Molecular Biology, 2010, v. 17, n. 9, p. 1088, doi. 10.1038/nsmb.1869
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- Article
Regulation of a muralytic enzyme by dynamic membrane topology.
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- Nature Structural & Molecular Biology, 2009, v. 16, n. 11, p. 1192, doi. 10.1038/nsmb.1681
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- Publication type:
- Article
Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis.
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- Molecular Microbiology, 2010, v. 78, n. 6, p. 1591, doi. 10.1111/j.1365-2958.2010.07446.x
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- Article
Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.
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- Molecular Microbiology, 2008, v. 69, n. 5, p. 1316, doi. 10.1111/j.1365-2958.2008.06365.x
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- Article
Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis.
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- Molecular Microbiology, 2006, v. 61, n. 4, p. 940, doi. 10.1111/j.1365-2958.2006.05297.x
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- Publication type:
- Article
M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs).
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- Molecular Microbiology, 2006, v. 60, n. 5, p. 1152, doi. 10.1111/j.1365-2958.2006.05174.x
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- Publication type:
- Article
TheMycobacterium tuberculosis iniAgene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol.
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- Molecular Microbiology, 2005, v. 55, n. 6, p. 1829, doi. 10.1111/j.1365-2958.2005.04510.x
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- Publication type:
- Article
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.
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- Molecular Microbiology, 2002, v. 46, n. 2, p. 453, doi. 10.1046/j.1365-2958.2002.03162.x
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- Article
Functional Genomics Screening Utilizing Mutant Mouse Embryonic Stem Cells Identifies Novel Radiation-Response Genes.
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- PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0120534
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- Article
Subfamily-Specific Adaptations in the Structures of Two Penicillin-Binding Proteins from Mycobacterium tuberculosis.
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- PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0116249
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- Article
High-Throughput Sequencing Enhanced Phage Display Identifies Peptides That Bind Mycobacteria.
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- PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0077844
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- Article
Identification of New Drug Targets and Resistance Mechanisms in <i>Mycobacterium tuberculosis</i>.
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- PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0075245
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- Publication type:
- Article
Use of Multiplex Allele-Specific Polymerase Chain Reaction (MAS-PCR) to Detect Multidrug-Resistant Tuberculosis in Panama.
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- PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0040456
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- Publication type:
- Article
Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis.
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- PLoS ONE, 2009, v. 4, n. 7, p. 1, doi. 10.1371/journal.pone.0006290
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- Article
Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research.
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- 2019
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- Publication type:
- journal article
Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.
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- 2019
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- Correction Notice
TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.
- Published in:
- PLoS Pathogens, 2018, v. 14, n. 3, p. 1, doi. 10.1371/journal.ppat.1006939
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- Article
Front Cover: Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes (ChemBioChem 15/2018).
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- ChemBioChem, 2018, v. 19, n. 15, p. 1570, doi. 10.1002/cbic.201800362
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- Article
Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes.
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- ChemBioChem, 2018, v. 19, n. 15, p. 1590, doi. 10.1002/cbic.201800124
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- Article
Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-47905-y
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- Article
Structural Basis of Agonist Capture by Regulatory C1 Domain of PKC.
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- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.L8086
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- Publication type:
- Article
Targeting protein biotinylation enhances tuberculosis chemotherapy.
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- Science Translational Medicine, 2018, v. 10, n. 438, p. 1, doi. 10.1126/scitranslmed.aal1803
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- Article
Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): a structure–activity relationship study of KES4 assisted by in silico structure-based drug screening.
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- Journal of Antibiotics, 2020, v. 73, n. 6, p. 372, doi. 10.1038/s41429-020-0293-6
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- Publication type:
- Article
Identification of a novel class of small compounds with anti-tuberculosis activity by in silico structure-based drug screening.
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- Journal of Antibiotics, 2017, v. 70, n. 11, p. 1057, doi. 10.1038/ja.2017.106
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- Article
Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis.
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- PLoS Pathogens, 2012, v. 8, n. 9, p. 1, doi. 10.1371/journal.ppat.1002946
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- Publication type:
- Article
Benzoxazoles as Transthyretin Amyloid Fibril Inhibitors: Synthesis, Evaluation, and Mechanism of Action ( This work was supported by the NIH (DK 46335), the Skaggs Institute for Chemical Biology, and the Lita Annenberg Hazen Foundation. H.R. thanks the Skaggs Institute for Chemical Biology for a postdoctoral fellowship. Additional support was provided by the Robert A. Welch Foundation (J.C.S). Use of the Argonne National Laboratory Structural Biology Center beam lines at the Advanced Photon Source was supported by the United States Department of Energy, Office of Energy Research, under contract W-31-109-ENG-38. Use of the BioCARS Sector 14 was supported by the National Institutes of Health National Center for Research Resources. We thank the General Clinical Research Center of The Scripps Research Institute (supported by NIH grant RR00833) for providing blood plasma through the normal donor blood drawing program. )
- Published in:
- Angewandte Chemie, 2003, v. 115, n. 24, p. 2864, doi. 10.1002/ange.200351179
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- Article
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.
- Published in:
- Nature, 2000, v. 406, n. 6797, p. 735, doi. 10.1038/35021074
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- Publication type:
- Article
High Throughput Screen for Escherichia coli Twin Arginine Translocation (Tat) Inhibitors.
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- PLoS ONE, 2016, v. 11, n. 2, p. 1, doi. 10.1371/journal.pone.0149659
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- Article
Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.
- Published in:
- Nature Structural Biology, 2000, v. 7, n. 8, p. 663, doi. 10.1038/77964
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- Publication type:
- Article
Rational design of potent human transthyretin amyloid disease inhibitors.
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- Nature Structural Biology, 2000, v. 7, n. 5, p. 431
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- Article
Rational design of potent human transthyretin amyloid disease inhibitors.
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- Nature Structural Biology, 2000, v. 7, n. 4, p. 312
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- Publication type:
- Article
Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.
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- Nature Structural Biology, 2000, v. 7, n. 2, p. 141
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- Article
Crystal structure of a plant catechol oxidase containing a dicopper center.
- Published in:
- Nature Structural Biology, 1998, v. 5, n. 12, p. 1084, doi. 10.1038/4193
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- Article