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Physiologically Based Pharmacokinetic Modelling to Predict Imatinib Exposures in Cancer Patients with Renal Dysfunction: A Case Study.
- Published in:
- Pharmaceutics, 2023, v. 15, n. 7, p. 1922, doi. 10.3390/pharmaceutics15071922
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- Publication type:
- Article
The absorption kinetics of ketoconazole plays a major role in explaining the reported variability in the level of interaction with midazolam: Interplay between formulation and inhibition of gut wall and liver metabolism.
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- Biopharmaceutics & Drug Disposition, 2017, v. 38, n. 3, p. 260, doi. 10.1002/bdd.2058
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- Publication type:
- Article
Protein binding of aspirin and salicylate measured by in vivo ultrafiltration<sup>*</sup>.
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- Clinical Pharmacology & Therapeutics, 1998, v. 63, n. 3, p. 285, doi. 10.1016/S0009-9236(98)90160-6
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- Publication type:
- Article
Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: comparison of dynamic and static models.
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- British Journal of Clinical Pharmacology, 2011, v. 71, n. 1, p. 72, doi. 10.1111/j.1365-2125.2010.03799.x
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- Publication type:
- Article
Addressing health equity for breastfeeding women: primaquine for Plasmodium vivax radical cure.
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- Malaria Journal, 2024, v. 23, n. 1, p. 1, doi. 10.1186/s12936-024-05112-9
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- Publication type:
- Article
The use of quantitative clinical pharmacology approaches to support moxidectin dosing recommendations in lactation.
- Published in:
- PLoS Neglected Tropical Diseases, 2024, v. 18, n. 8, p. 1, doi. 10.1371/journal.pntd.0012351
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- Publication type:
- Article
Dose Optimization Informed by PBPK Modeling: State‐of‐the Art and Future.
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- Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 563, doi. 10.1002/cpt.3289
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- Publication type:
- Article
Creation of Novel Sensitive Probe Substrate and Moderate Inhibitor Models for a Comprehensive Prediction of CYP2C8 Interactions for Tucatinib.
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- Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 2, p. 299, doi. 10.1002/cpt.3104
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- Publication type:
- Article
Physiologically Based Pharmacokinetic Modeling to Determine the Impact of CYP2B6 Genotype on Efavirenz Exposure in Children, Mothers and Breastfeeding Infants.
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- Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 1, p. 182, doi. 10.1002/cpt.2912
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- Publication type:
- Article
Another Step Toward Qualification of Pediatric Physiologically Based Pharmacokinetic Models to Facilitate Inclusivity and Diversity in Pediatric Clinical Studies.
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- Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 3, p. 735, doi. 10.1002/cpt.2777
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- Publication type:
- Article
An Integrated Approach for Assessing the Impact of Renal Impairment on Pharmacokinetics of Drugs in Development: Pivotal Role of PBPK Modelling.
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- Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 5, p. 1168, doi. 10.1002/cpt.2243
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- Publication type:
- Article
Model‐Informed Drug Development for Anti‐Infectives: State of the Art and Future.
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- Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 4, p. 867, doi. 10.1002/cpt.2198
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- Publication type:
- Article
Physiologically‐Based Pharmacokinetic Models as Enablers of Precision Dosing in Drug Development: Pivotal Role of the Human Mass Balance Study.
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- Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 1, p. 51, doi. 10.1002/cpt.2092
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- Publication type:
- Article
Impact of Disease on Plasma and Lung Exposure of Chloroquine, Hydroxychloroquine and Azithromycin: Application of PBPK Modeling.
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- Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 5, p. 976, doi. 10.1002/cpt.1955
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- Publication type:
- Article
Risk–Benefit Assessment of Ethinylestradiol Using a Physiologically Based Pharmacokinetic Modeling Approach.
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- Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 6, p. 1229, doi. 10.1002/cpt.1085
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- Publication type:
- Article
Prediction of drug clearance in a smoking population: modeling the impact of variable cigarette consumption on the induction of CYP1A2.
- Published in:
- European Journal of Clinical Pharmacology, 2012, v. 68, n. 6, p. 951, doi. 10.1007/s00228-011-1189-y
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- Publication type:
- Article
Development and application of a PBPK modeling strategy to support antimalarial drug development.
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- CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 9, p. 1335, doi. 10.1002/psp4.13013
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- Publication type:
- Article
PBPK modeling of ivermectin—Considerations for the purpose of developing alternative routes to optimize its safety profile.
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- CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 5, p. 598, doi. 10.1002/psp4.12950
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- Publication type:
- Article
Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.
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- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 7, p. 822, doi. 10.1002/psp4.12794
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- Publication type:
- Article
Addressing drug safety of maternal therapy during breastfeeding using physiologically‐based pharmacokinetic modeling.
- Published in:
- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 5, p. 535, doi. 10.1002/psp4.12802
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- Publication type:
- Article
Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations.
- Published in:
- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 3, p. 373, doi. 10.1002/psp4.12764
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- Publication type:
- Article
Using physiologically‐based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination tablet.
- Published in:
- CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 9, p. 1071, doi. 10.1002/psp4.12675
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- Publication type:
- Article
A best practice framework for applying physiologically‐based pharmacokinetic modeling to pediatric drug development.
- Published in:
- CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 9, p. 967, doi. 10.1002/psp4.12678
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- Publication type:
- Article
CPT: Pharmacometrics & Systems Pharmacology – Inception, Maturation, and Future Vision.
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- CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 7, p. 649, doi. 10.1002/psp4.12680
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- Publication type:
- Article
Physiologically‐Based Pharmacokinetic Modeling for Predicting Drug Interactions of a Combination of Olanzapine and Samidorphan.
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- CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 2, p. 106, doi. 10.1002/psp4.12488
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- Publication type:
- Article
Response to "Ethnic-specific in vitro-in vivo extrapolation and physiologically based pharmacokinetic approaches to predict cytochrome P450-mediated pharmacokinetics in Chinese population: opportunities and challenges".
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- 2014
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- Publication type:
- Letter
Response to 'Ethnic-Specific In Vitro-In Vivo Extrapolation and Physiologically Based Pharmacokinetic Approaches to Predict Cytochrome P450-Mediated Pharmacokinetics in Chinese Population: Opportunities and Challenges'.
- Published in:
- 2014
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- Publication type:
- Letter to the Editor
Differences in Cytochrome P450-Mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically Based Pharmacokinetic Modelling.
- Published in:
- Clinical Pharmacokinetics, 2013, v. 52, n. 12, p. 1085, doi. 10.1007/s40262-013-0089-y
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- Publication type:
- Article
Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.
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- 2011
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- Publication type:
- journal article
Application of a Systems Approach to the Bottom-Up Assessment of Pharmacokinetics in Obese Patients.
- Published in:
- Clinical Pharmacokinetics, 2011, v. 50, n. 12, p. 809, doi. 10.2165/11594420-000000000-00000
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- Publication type:
- Article
A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance.
- Published in:
- Clinical Pharmacokinetics, 2010, v. 49, n. 3, p. 189, doi. 10.2165/11318160-000000000-00000
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- Publication type:
- Article
Emerging Areas of Research in the Assessment of Pharmacokinetics in Patients With Chronic Kidney Disease.
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- Journal of Clinical Pharmacology, 2015, v. 55, n. 3, p. 241, doi. 10.1002/jcph.444
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- Publication type:
- Article
Application of Physiologically Based Pharmacokinetic Modeling to Predict the Effect of Renal Impairment on the Pharmacokinetics of Olanzapine and Samidorphan Given in Combination.
- Published in:
- Clinical Pharmacokinetics, 2021, v. 60, n. 5, p. 637, doi. 10.1007/s40262-020-00969-w
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- Publication type:
- Article
Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug‐Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinetic Analysis
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- Journal of Clinical Pharmacology, 2018, v. 58, n. 2, p. 180, doi. 10.1002/jcph.988
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- Publication type:
- Article
Advancing the utilization of real‐world data and real‐world evidence in clinical pharmacology and translational research—Proceedings from the ASCPT 2023 preconference workshop.
- Published in:
- CTS: Clinical & Translational Science, 2024, v. 17, n. 4, p. 1, doi. 10.1111/cts.13785
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- Publication type:
- Article
The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy).
- Published in:
- Journal of Psychopharmacology, 2006, v. 20, n. 6, p. 834, doi. 10.1177/0269881106062902
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- Publication type:
- Article