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Factors influencing non-approval of new drugs in Europe.
- Published in:
- Nature Reviews Drug Discovery, 2012, v. 11, n. 12, p. 903, doi. 10.1038/nrd3894
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- Publication type:
- Article
Bridging the efficacy-effectiveness gap: a regulator's perspective on addressing variability of drug response.
- Published in:
- 2011
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- Publication type:
- review
Estimation of aqueous distributional spaces in the dual perfused rat liver.
- Published in:
- Journal of Physiology, 2000, v. 528, n. 1, p. 199, doi. 10.1111/j.1469-7793.2000.00199.x
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- Publication type:
- Article
IS THE PERIPHERAL SINK HYPOTHESIS PHYSIOLOGICALLY FEASIBLE? EVIDENCE FROM MODEL-BASED ASSESSMENT OF THE AMYLOID PATHWAY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P443, doi. 10.1016/j.jalz.2016.06.855
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- Publication type:
- Article
Are Physiologically Based Pharmacokinetic Models Reporting the Right C? Central Venous Versus Peripheral Sampling Site.
- Published in:
- AAPS Journal, 2015, v. 17, n. 5, p. 1268, doi. 10.1208/s12248-015-9796-7
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- Publication type:
- Article
Use of Dried Blood Spots in Drug Development: Pharmacokinetic Considerations.
- Published in:
- AAPS Journal, 2010, v. 12, n. 3, p. 290, doi. 10.1208/s12248-010-9188-y
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- Publication type:
- Article
Physiologically based pharmacokinetics in Drug Development and Regulatory Science: A workshop report (Georgetown University, Washington, DC, May 29–30, 2002).
- Published in:
- AAPS Journal, 2004, v. 6, n. 1, p. 56, doi. 10.1208/ps060106
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- Publication type:
- Article
Empirical versus mechanistic modelling: Comparison of an artificial neural network to a mechanistically based model for quantitative structure pharmacokinetic relationships of a homologous series of barbiturates.
- Published in:
- AAPS Journal, 1999, v. 1, n. 4, p. 5, doi. 10.1208/ps010417
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- Publication type:
- Article
Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in Humans.
- Published in:
- Annals of Internal Medicine, 1973, v. 78, n. 4, p. 499, doi. 10.7326/0003-4819-78-4-499
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- Publication type:
- Article
Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2006, v. 80, n. 3, p. 203, doi. 10.1016/j.clpt.2006.05.008
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- Publication type:
- Article
Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 1995, v. 58, n. 5, p. 492, doi. 10.1016/0009-9236(95)90168-X
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- Publication type:
- Article
Stereochemical aspects of warfarin drug interactions: Use of a combined pharmacokinetic-pharmacodynamic model.
- Published in:
- Clinical Pharmacology & Therapeutics, 1994, v. 56, n. 3, p. 286, doi. 10.1038/clpt.1994.139
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- Publication type:
- Article
Absence of effect of ranitidine on blood alcohol concentrations when taken morning, midday, or evening with or without food.
- Published in:
- Clinical Pharmacology & Therapeutics, 1994, v. 55, n. 4, p. 385, doi. 10.1038/clpt.1994.46
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- Publication type:
- Article
The racemic metoprolol H<sub>2</sub>-antagonist interaction.
- Published in:
- Clinical Pharmacology & Therapeutics, 1988, v. 43, n. 3, p. 283, doi. 10.1038/clpt.1988.34
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- Publication type:
- Article
Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage.
- Published in:
- British Journal of Clinical Pharmacology, 2008, v. 65, n. 3, p. 317, doi. 10.1111/j.1365-2125.2007.03026.x
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- Publication type:
- Article
Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations.
- Published in:
- Journal of Cerebral Blood Flow & Metabolism, 2008, v. 28, n. 2, p. 387, doi. 10.1038/sj.jcbfm.9600537
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- Publication type:
- Article
Hepatic clearance models and IVIVE predictions.
- Published in:
- Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 6, p. 1205, doi. 10.1002/cpt.2525
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- Publication type:
- Article
Commentary on “The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio”.
- Published in:
- Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 3, p. 386, doi. 10.1002/cpt.921
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- Publication type:
- Article
Commentary on ACCP Position Statement on the Use of Microdosing in the Drug Development Process.
- Published in:
- 2007
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- Publication type:
- Letter
Optimizing the Science of Drug Development: Opportunities for Better Candidate Selection and Accelerated Evaluation in Humans.
- Published in:
- Journal of Clinical Pharmacology, 2000, v. 40, n. 8, p. 803, doi. 10.1177/009127000004000801
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- Publication type:
- Article
Editorial to the Third Issue Dedicated to Lewis Sheiner.
- Published in:
- Journal of Pharmacokinetics & Pharmacodynamics, 2007, v. 34, n. 1, p. 1, doi. 10.1007/s10928-006-9044-y
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- Publication type:
- Article
DISPOSITION KINETICS OF LIDOCAINE IN NORMAL SUBJECTS*.
- Published in:
- Annals of the New York Academy of Sciences, 1971, v. 179, n. 1, p. 383, doi. 10.1111/j.1749-6632.1971.tb46915.x
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- Publication type:
- Article
Warfarin metabolites: Stereochemical aspects of protein binding and displacement by phenylbutazone.
- Published in:
- Chirality, 1993, v. 5, n. 8, p. 610, doi. 10.1002/chir.530050808
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- Publication type:
- Article
Enoxacin-warfarin interaction: Pharmacokinetic and stereochemical aspects.
- Published in:
- Clinical Pharmacology & Therapeutics, 1987, v. 42, n. 1, p. 33, doi. 10.1038/clpt.1987.104
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- Publication type:
- Article
Cyclosporine Inhibition of Hepatic and Intestinal CYP3A4, Uptake and Efflux Transporters: Application of PBPK Modeling in the Assessment of Drug-Drug Interaction Potential.
- Published in:
- Pharmaceutical Research, 2013, v. 30, n. 3, p. 761, doi. 10.1007/s11095-012-0918-y
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- Publication type:
- Article
Dedication to Professor Leslie Z. Benet: 50 Years of Scientific Excellence and Still Going Strong!
- Published in:
- 2012
- By:
- Publication type:
- Editorial
Mechanistic Approaches to Volume of Distribution Predictions: Understanding the Processes.
- Published in:
- Pharmaceutical Research, 2007, v. 24, n. 5, p. 918, doi. 10.1007/s11095-006-9210-3
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- Publication type:
- Article