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Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery.
- Published in:
- Nature Reviews Drug Discovery, 2005, v. 4, n. 12, p. 1005, doi. 10.1038/nrd1900
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- Publication type:
- Article
Opinion: Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia.
- Published in:
- Nature Reviews Drug Discovery, 2004, v. 3, n. 4, p. 353, doi. 10.1038/nrd1346
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- Publication type:
- Article
DREADD: A Chemogenetic GPCR Signaling Platform.
- Published in:
- International Journal of Neuropsychopharmacology, 2015, v. 18, n. 1, p. 1, doi. 10.1093/ijnp/pyu007
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- Publication type:
- Article
LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1.
- Published in:
- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-96736-3
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- Publication type:
- Article
Structural insights into the human niacin receptor HCA2-G<sub>i</sub> signalling complex.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37177-6
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- Publication type:
- Article
Molecular Targets for Treating Cognitive Dysfunction in Schizophrenia.
- Published in:
- Schizophrenia Bulletin, 2007, v. 33, n. 5, p. 1100, doi. 10.1093/schbul/sbm074
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- Publication type:
- Article
Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype-targeted drugs.
- Published in:
- 2013
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- Publication type:
- journal article
Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype--targeted drugs.
- Published in:
- Journal of Clinical Investigation, 2013, v. 123, n. 12, p. 4986, doi. 10.1172/JCI70678
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- Publication type:
- Article
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.
- Published in:
- 2011
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- Publication type:
- journal article
Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method.
- Published in:
- Nucleic Acids Research, 2010, v. 38, n. 10, p. e118, doi. 10.1093/nar/gkq107
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- Publication type:
- Article
Comprehensive characterization of the Published Kinase Inhibitor Set.
- Published in:
- Nature Biotechnology, 2016, v. 34, n. 1, p. 95, doi. 10.1038/nbt.3374
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- Publication type:
- Article
Relating protein pharmacology by ligand chemistry.
- Published in:
- Nature Biotechnology, 2007, v. 25, n. 2, p. 197, doi. 10.1038/nbt1284
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- Publication type:
- Article
Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists.
- Published in:
- EMBO Journal, 2023, v. 42, n. 11, p. 1, doi. 10.15252/embj.2022112940
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- Publication type:
- Article
A pharmacological organization of G protein-coupled receptors.
- Published in:
- Nature Methods, 2013, v. 10, n. 2, p. 140, doi. 10.1038/nmeth.2324
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- Publication type:
- Article
Engineering GPCR signaling pathways with RASSLs.
- Published in:
- Nature Methods, 2008, v. 5, n. 8, p. 673, doi. 10.1038/nmeth.1232
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- Publication type:
- Article
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.
- Published in:
- Nature Structural & Molecular Biology, 2015, v. 22, n. 5, p. 362, doi. 10.1038/nsmb.3014
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- Publication type:
- Article
Far away from the lamppost.
- Published in:
- PLoS Biology, 2018, v. 16, n. 12, p. 1, doi. 10.1371/journal.pbio.3000067
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- Publication type:
- Article
Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice.
- Published in:
- Genesis: The Journal of Genetics & Development, 2016, v. 54, n. 8, p. 439, doi. 10.1002/dvg.22949
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- Publication type:
- Article
HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39905-4
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- Publication type:
- Article
Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters.
- Published in:
- PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0070701
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- Publication type:
- Article
The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor.
- Published in:
- PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0059334
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- Publication type:
- Article
Quantitative Analysis of Focused A-To-I RNA Editing Sites by Ultra-High- Throughput Sequencing in Psychiatric Disorders.
- Published in:
- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043227
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- Publication type:
- Article
Securinine, a Myeloid Differentiation Agent with Therapeutic Potential for AML.
- Published in:
- PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0021203
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- Publication type:
- Article
Three putative N‐glycosylation sites within the murine 5‐HT3A receptor sequence affect plasma membrane targeting, ligand binding, and calcium influx in heterologous mammalian cells.
- Published in:
- Journal of Neuroscience Research, 2004, v. 77, n. 4, p. 498, doi. 10.1002/jnr.20185
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- Publication type:
- Article
Molecular insights into psychedelic drug action.
- Published in:
- Journal of Neurochemistry, 2022, v. 162, n. 1, p. 24, doi. 10.1111/jnc.15540
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- Publication type:
- Article
l-Homocysteine Sulfinic Acid and l-Homocysteic Acid Stimulate Phosphoinositide Hydrolysis in Rat Cortical Neurons.
- Published in:
- Annals of the New York Academy of Sciences, 2003, v. 1003, n. 1, p. 461, doi. 10.1196/annals.1300.054
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- Publication type:
- Article
Activation is Hallucinogenic and Antagonism is Therapeutic: Role of 5-HT2A Receptors in Atypical Antipsychotic Drug Actions.
- Published in:
- Neuroscientist, 1999, v. 5, n. 4, p. 254, doi. 10.1177/107385849900500414
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- Publication type:
- Article
Distribution of serotonin 5-HT<sub>2A</sub> receptors in afferents of the rat striatum.
- Published in:
- Synapse, 2001, v. 39, n. 4, p. 297, doi. 10.1002/1098-2396(20010315)39:4<297::AID-SYN1012>3.0.CO;2-Q
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- Publication type:
- Article
Agonist high and low affinity state ratios predict drug intrinsic activity and a revised Ternary complex mechanism at serotonin 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> receptors.
- Published in:
- Synapse, 2000, v. 35, n. 2, p. 144, doi. 10.1002/(SICI)1098-2396(200002)35:2<144::AID-SYN7>3.0.CO;2-K
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- Publication type:
- Article
Serotonin 5-HT2A Receptors Are Expressed on Pyramidal Cells and Interneurons in the Rat Cortex
- Published in:
- Synapse, 1997, p. 79
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- Publication type:
- Article
PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors.
- Published in:
- Journal of Neuroscience, 2009, v. 29, n. 22, p. 7124, doi. 10.1523/JNEUROSCI.1090-09.2009
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- Publication type:
- Article
Novel Diketopiperazine Enhances Motor and Cognitive Recovery After Traumatic Brain Injury in Rats and Shows Neuroprotection In Vitro and In Vivo.
- Published in:
- Journal of Cerebral Blood Flow & Metabolism, 2003, v. 23, n. 3, p. 342, doi. 10.1097/01.WCB.0000046143.31247.FD
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- Publication type:
- Article
Predicting new molecular targets for known drugs.
- Published in:
- Nature, 2009, v. 462, n. 7270, p. 175, doi. 10.1038/nature08506
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- Publication type:
- Article
Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.
- Published in:
- Neuropsychopharmacology, 2015, v. 40, n. 11, p. 2614, doi. 10.1038/npp.2015.109
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- Publication type:
- Article
Chemogenetic Inactivation of Ventral Hippocampal Glutamatergic Neurons Disrupts Consolidation of Contextual Fear Memory.
- Published in:
- Neuropsychopharmacology, 2014, v. 39, n. 8, p. 1880, doi. 10.1038/npp.2014.35
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- Publication type:
- Article
Noradrenergic Synaptic Function in the Bed Nucleus of the Stria Terminalis Varies in Animal Models of Anxiety and Addiction.
- Published in:
- Neuropsychopharmacology, 2013, v. 38, n. 9, p. 1665, doi. 10.1038/npp.2013.63
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- Publication type:
- Article
A Gα<sub>s</sub> DREADD Mouse for Selective Modulation of cAMP Production in Striatopallidal Neurons.
- Published in:
- Neuropsychopharmacology, 2013, v. 38, n. 5, p. 854, doi. 10.1038/npp.2012.251
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- Publication type:
- Article
The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy.
- Published in:
- Neuropsychopharmacology, 2011, v. 36, n. 3, p. 638, doi. 10.1038/npp.2010.195
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- Publication type:
- Article
Allosteric Antipsychotics: M4 Muscarinic Potentiators as Novel Treatments for Schizophrenia.
- Published in:
- 2010
- By:
- Publication type:
- Opinion
N-Desalkylquetiapine, a Potent Norepinephrine Reuptake Inhibitor and Partial 5-HT<sub>1A</sub> Agonist, as a Putative Mediator of Quetiapine's Antidepressant Activity.
- Published in:
- Neuropsychopharmacology, 2008, v. 33, n. 11, p. 2303, doi. 10.1038/sj.npp.1301646
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- Publication type:
- Article
Opportunities and Challenges of Psychiatric Drug Discovery: Roles for Scientists in Academic, Industry, and Government Settings.
- Published in:
- 2008
- By:
- Publication type:
- Correction Notice
Opportunities and Challenges of Psychiatric Drug Discovery: Roles for Scientists in Academic, Industry, and Government Settings.
- Published in:
- Neuropsychopharmacology, 2008, v. 33, n. 10, p. 2048, doi. 10.1038/sj.npp.1301638
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- Publication type:
- Article
Evidence for the Preferential Involvement of 5-HT2A Serotonin Receptors in Stress- and Drug-Induced Dopamine Release in the Rat Medial Prefrontal Cortex.
- Published in:
- Neuropsychopharmacology, 2006, v. 31, n. 2, p. 265, doi. 10.1038/sj.npp.1300819
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- Publication type:
- Article
The Neurotensin Agonist PD 149163 Increases Fos Expression in the Prefrontal Cortex of the Rat.
- Published in:
- Neuropsychopharmacology, 2004, v. 29, n. 10, p. 1878, doi. 10.1038/sj.npp.1300494
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- Publication type:
- Article
Reply: H1-histamine Receptor Affinity Predicts Short-term Weight Gain for Typical and Atypical Antipsychotic Drugs.
- Published in:
- 2003
- By:
- Publication type:
- Letter
Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology.
- Published in:
- Neuropsychopharmacology, 2003, v. 28, n. 8, p. 1400, doi. 10.1038/sj.npp.1300203
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- Publication type:
- Article
HI-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs.
- Published in:
- Neuropsychopharmacology, 2003, v. 28, n. 3, p. 519, doi. 10.1038/sj.npp.1300027
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- Publication type:
- Article
Chemogenetics--A Transformational and Translational Platform.
- Published in:
- JAMA Neurology, 2015, v. 72, n. 11, p. 1361, doi. 10.1001/jamaneurol.2015.1921
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- Publication type:
- Article
Dianas moleculares para el tratamiento de la disfunción cognitiva en la esquizofrenia.
- Published in:
- Schizophrenia Bulletin - Edición Española, 2008, v. 3, n. 2, p. 1100, doi. 10.1093/schbul/sbm074
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- Publication type:
- Article
Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.
- Published in:
- FASEB Journal, 2018, v. 32, n. 2, p. 862, doi. 10.1096/fj.201700555R
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- Publication type:
- Article