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Quantitative Measurement of the Target-Mediated Internalization Kinetics of Biopharmaceuticals.
- Published in:
- Pharmaceutical Research, 2015, v. 32, n. 1, p. 286, doi. 10.1007/s11095-014-1462-8
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- Publication type:
- Article
From XenoMouse technology to panitumumab, the first fully human antibody product from transgenic mice.
- Published in:
- Nature Biotechnology, 2007, v. 25, n. 10, p. 1134, doi. 10.1038/nbt1337
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- Publication type:
- Article
A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma.
- Published in:
- BMC Pulmonary Medicine, 2010, v. 10, p. 1, doi. 10.1186/1471-2466-10-3
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- Publication type:
- Article
A Novel Pharmacodynamic Biomarker and Mechanistic Modeling Facilitate the Development of Tovetumab, a Monoclonal Antibody Directed Against Platelet-Derived Growth Factor Receptor Alpha, for Cancer Therapy.
- Published in:
- AAPS Journal, 2021, v. 23, n. 1, p. 1, doi. 10.1208/s12248-020-00523-3
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- Publication type:
- Article
A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer.
- Published in:
- AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0350-x
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- Publication type:
- Article
Selection of a Ligand-Binding Neutralizing Antibody Assay for Benralizumab: Comparison with an Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) Cell-Based Assay.
- Published in:
- AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0207-8
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- Publication type:
- Article
A Neutralizing Antibody Assay Based on a Reporter of Antibody-Dependent Cell-Mediated Cytotoxicity.
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- AAPS Journal, 2015, v. 17, n. 6, p. 1417, doi. 10.1208/s12248-015-9798-5
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- Publication type:
- Article
Coordinated intrahepatic and extrahepatic regulation of cytochrome P4502D6 in healthy subjects and in patients after liver transplantation<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 5, p. 456, doi. 10.1016/S0009-9236(03)00055-9
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- Publication type:
- Article
Integration of pharmacokinetic and pharmacodynamic studies in the discovery, development, and review of protein therapeutic agents: A conference report<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2001, v. 69, n. 6, p. 387, doi. 10.1067/mcp.2001.115455
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- Publication type:
- Article
Population pharmacokinetics, efficacy, and safety of moxetumomab pasudotox in patients with relapsed or refractory hairy cell leukaemia.
- Published in:
- British Journal of Clinical Pharmacology, 2020, v. 86, n. 7, p. 1367, doi. 10.1111/bcp.14250
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- Publication type:
- Article
An open-label, single-dose bioavailability study of the pharmacokinetics of CAT-354 after subcutaneous and intravenous administration in healthy males.
- Published in:
- British Journal of Clinical Pharmacology, 2010, v. 69, n. 6, p. 645, doi. 10.1111/j.1365-2125.2010.03647.x
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- Publication type:
- Article
Receptor occupancy assessment by flow cytometry as a pharmacodynamic biomarker in biopharmaceutical development.
- Published in:
- Cytometry. Part B, 2016, v. 90, n. 2, p. 117, doi. 10.1002/cyto.b.21259
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- Publication type:
- Article
Evaluation of assay interference and interpretation of CXCR4 receptor occupancy results in a preclinical study with MEDI3185, a fully human antibody to CXCR4.
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- Cytometry. Part B, 2016, v. 90, n. 2, p. 209, doi. 10.1002/cyto.b.21327
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- Publication type:
- Article
Multiplexing of receptor occupancy measurements for pharmacodynamic biomarker assessment of biopharmaceuticals.
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- Cytometry. Part B, 2016, v. 90, n. 2, p. 128, doi. 10.1002/cyto.b.21319
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- Publication type:
- Article
Pharmacodynamic biomarkers and differential effects of TNF‐ and GM‐CSF‐targeting biologics in rheumatoid arthritis.
- Published in:
- International Journal of Rheumatic Diseases, 2019, v. 22, n. 4, p. 646, doi. 10.1111/1756-185X.13395
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- Publication type:
- Article
A QSP Model for Predicting Clinical Responses to Monotherapy, Combination and Sequential Therapy Following CTLA-4, PD-1, and PD-L1 Checkpoint Blockade.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-47802-4
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- Publication type:
- Article
Detecting bliss synergy in in vivo combination studies with a tumor kinetic model.
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- Pharmaceutical Statistics, 2019, v. 18, n. 6, p. 688, doi. 10.1002/pst.1952
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- Publication type:
- Article
Exposure–response analysis for selection of optimal dosage regimen of anifrolumab in patients with systemic lupus erythematosus.
- Published in:
- Rheumatology, 2021, v. 60, n. 12, p. 5854, doi. 10.1093/rheumatology/keab176
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- Publication type:
- Article
Blockade of GM-CSF pathway induced sustained suppression of myeloid and T cell activities in rheumatoid arthritis.
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- Rheumatology, 2018, v. 57, n. 1, p. 175, doi. 10.1093/rheumatology/kex383
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- Publication type:
- Article
Suppression of soluble T cell-associated proteins by an anti-interferon-α monoclonal antibody in adult patients with dermatomyositis or polymyositis.
- Published in:
- 2014
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- Publication type:
- Journal Article
Suppression of soluble T cell-associated proteins by an anti-interferon-α monoclonal antibody in adult patients with dermatomyositis or polymyositis.
- Published in:
- Rheumatology, 2014, v. 53, n. 4, p. 686, doi. 10.1093/rheumatology/ket413
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- Publication type:
- Article
Suppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis.
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- Journal of Investigative Dermatology, 2015, v. 135, n. 10, p. 2402, doi. 10.1038/jid.2015.188
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- Publication type:
- Article
Relationship Between Benralizumab Exposure and Efficacy for Patients With Severe Eosinophilic Asthma.
- Published in:
- Clinical Pharmacology & Therapeutics, 2019, v. 106, n. 2, p. 383, doi. 10.1002/cpt.1371
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- Publication type:
- Article
Population Pharmacokinetics of Durvalumab in Cancer Patients and Association With Longitudinal Biomarkers of Disease Status.
- Published in:
- Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 4, p. 631, doi. 10.1002/cpt.982
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- Publication type:
- Article
Population Modeling of Tumor Kinetics and Overall Survival to Identify Prognostic and Predictive Biomarkers of Efficacy for Durvalumab in Patients With Urothelial Carcinoma.
- Published in:
- Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 4, p. 643, doi. 10.1002/cpt.986
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- Publication type:
- Article
Detection of High- and Low-Affinity Antibodies Against a Human Monoclonal Antibody Using Various Technology Platforms.
- Published in:
- Assay & Drug Development Technologies, 2007, v. 5, n. 5, p. 655, doi. 10.1089/adt.2007.089
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- Publication type:
- Article
Effects of dose and sex on the pharmacokinetics of piroxicam in the rat.
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- Biopharmaceutics & Drug Disposition, 1990, v. 11, n. 3, p. 215, doi. 10.1002/bdd.2510110306
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- Publication type:
- Article
Cabozantinib exposure–response analysis for the phase 3 CheckMate 9ER trial of nivolumab plus cabozantinib versus sunitinib in first-line advanced renal cell carcinoma.
- Published in:
- Cancer Chemotherapy & Pharmacology, 2023, v. 91, n. 2, p. 179, doi. 10.1007/s00280-022-04500-9
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- Publication type:
- Article
Combining pharmacometric models with predictive and prognostic biomarkers for precision therapy in Crohn's disease: A case study of brazikumab.
- Published in:
- CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 12, p. 1945, doi. 10.1002/psp4.13044
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- Publication type:
- Article
Mechanistic modeling of a human IgG<sub>4</sub> monoclonal antibody (tralokinumab) Fab‐arm exchange with endogenous IgG<sub>4</sub> in healthy volunteers.
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- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 4, p. 438, doi. 10.1002/psp4.12738
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- Publication type:
- Article
Model‐Based Discovery and Development of Biopharmaceuticals: A Case Study of Mavrilimumab.
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- CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 1, p. 5, doi. 10.1002/psp4.12245
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- Publication type:
- Article
Multiplex Bioanalytical Methods for Comprehensive Characterization and Quantification of the Unique Complementarity-Determining-Region Deamidation of MEDI7247, an Anti-ASCT2 Pyrrolobenzodiazepine Antibody–Drug Conjugate.
- Published in:
- Antibodies (2073-4468), 2023, v. 12, n. 4, p. 66, doi. 10.3390/antib12040066
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- Publication type:
- Article
Molecular Mechanism of HER2 Rapid Internalization and Redirected Trafficking Induced by Anti-HER2 Biparatopic Antibody.
- Published in:
- Antibodies (2073-4468), 2020, v. 9, n. 3, p. 49, doi. 10.3390/antib9030049
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- Publication type:
- Article
Population pharmacokinetics of sifalimumab, an investigational anti-interferon-α monoclonal antibody, in systemic lupus erythematosus.
- Published in:
- 2013
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- Publication type:
- journal article
Population Pharmacokinetics of Sifalimumab, an Investigational Anti-Interferon-α Monoclonal Antibody, in Systemic Lupus Erythematosus.
- Published in:
- Clinical Pharmacokinetics, 2013, v. 52, n. 11, p. 1017, doi. 10.1007/s40262-013-0085-2
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- Publication type:
- Article
Mechanistic Modeling of Antigen Sink Effect for Mavrilimumab Following Intravenous Administration in Patients With Rheumatoid Arthritis.
- Published in:
- Journal of Clinical Pharmacology, 2012, v. 52, n. 8, p. 1150, doi. 10.1177/0091270011412964
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- Publication type:
- Article
Pharmacokinetic/Pharmacodynamic Modeling of Pegfilgrastim in Healthy Subjects.
- Published in:
- Journal of Clinical Pharmacology, 2006, v. 46, n. 7, p. 747, doi. 10.1177/0091270006288731
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- Publication type:
- Article
Comparison of sequential and joint nonlinear mixed effects modeling of tumor kinetics and survival following Durvalumab treatment in patients with metastatic urothelial carcinoma.
- Published in:
- Journal of Pharmacokinetics & Pharmacodynamics, 2023, v. 50, n. 4, p. 251, doi. 10.1007/s10928-023-09848-w
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- Publication type:
- Article
Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy.
- Published in:
- American Journal of Hematology, 2001, v. 68, n. 3, p. 210, doi. 10.1002/ajh.1181
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- Publication type:
- Article
Population Pharmacokinetics and Exposure–Response Analysis for the Phase 3 COSMIC-311 Trial of Cabozantinib for Radioiodine-Refractory Differentiated Thyroid Cancer.
- Published in:
- Clinical Pharmacokinetics, 2023, v. 62, n. 4, p. 587, doi. 10.1007/s40262-023-01210-0
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- Publication type:
- Article
Population Pharmacokinetic Modeling of Benralizumab in Adult and Adolescent Patients with Asthma.
- Published in:
- 2019
- By:
- Publication type:
- journal article
Nonlinear Population Pharmacokinetics of Anifrolumab in Healthy Volunteers and Patients With Systemic Lupus Erythematosus.
- Published in:
- Journal of Clinical Pharmacology, 2022, v. 62, n. 9, p. 1106, doi. 10.1002/jcph.2055
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- Publication type:
- Article
Pharmacokinetic and Pharmacodynamic Modeling of Tezepelumab to Guide Phase 3 Dose Selection for Patients With Severe Asthma.
- Published in:
- Journal of Clinical Pharmacology, 2021, v. 61, n. 7, p. 901, doi. 10.1002/jcph.1803
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- Publication type:
- Article
Exposure–Response Analysis of Overall Survival for Tremelimumab in Unresectable Malignant Mesothelioma: The Confounding Effect of Disease Status.
- Published in:
- CTS: Clinical & Translational Science, 2019, v. 12, n. 5, p. 450, doi. 10.1111/cts.12633
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- Publication type:
- Article
Patient-reported outcomes and inflammatory biomarkers in patients with locally advanced/metastatic urothelial carcinoma treated with durvalumab in phase 1/2 dose-escalation study 1108.
- Published in:
- 2020
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- Publication type:
- journal article
Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover.
- Published in:
- Clinical Science, 2021, v. 135, n. 22, p. 2559, doi. 10.1042/CS20210713
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- Publication type:
- Article
Choice of Starting Dose for Biopharmaceuticals in First-in-Human Phase I Cancer Clinical Trials.
- Published in:
- Oncologist, 2015, v. 20, n. 6, p. 653, doi. 10.1634/theoncologist.2015-0008
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- Publication type:
- Article
The clinical pharmacology of therapeutic monoclonal antibodies.
- Published in:
- Drug Development Research, 2004, v. 61, n. 3, p. 108, doi. 10.1002/ddr.10346
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- Publication type:
- Article